Clinical trials: sponsored by Rennes University Hospital
Pneumothorax Spontaneous Primary
Outpatient Management of Primary Spontaneous Pneumothorax: Pigtail Catheter With Unidirectional Valve vs. Exsufflation, Randomized Prospective Study
The management of large spontaneous pneumothorax is not consensual. Current practice involves placement of a Fuhrman catheter connected to a one-way valve, with outpatient monitoring in pneumology consultation.
- Trial name
- PNEUM-AMBU (NCT03691480)
- Testing
- Fuhrman catheter insertion, Three-way stopcock open, Manual aspiration
- Where
- 5 sites in France
- Volunteers
- 148 people
- Sponsor
- Rennes University Hospital
Pain Management, Analgesia
Comparison of a Comfort Scale and a Numerical Pain Scale on Opioid Consumption After Surgery
The objective is to show that the use of therapeutic communication tools, in this case a comfort scale, a low cost and simple to implement method, can reduce pain and therefore the consumption of opioids in the postoperative care…
- Trial name
- COMFORT (NCT05234216)
- Testing
- Informed consent, Surgery, Comfort scale
- Where
- 29 sites in France, Lebanon
- Volunteers
- 885 people
- Sponsor
- Rennes University Hospital
Arrhythmogenic Right Ventricular Cardiomyopathy
Athlete's Heart or Arrhythmogenic Right Ventricular Cardiomyopathy: Contribution of Exercise Cardiovascular Magnetic Resonance (CMR)
Prospective, nonrandomized, single-center, comparative study to define if right ventricular (RV) contractile reserve assessed by exercise CMR helps to improve the differential diagnosis between pathological and physiological…
- Trial name
- CA2VD (NCT05024708)
- Testing
- Cardiac exercises and tests
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Miscarriage in First Trimester, Prenatal Genetic Diagnosis
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
- Trial name
- GRACE (NCT07639333)
- Testing
- Non invasive prenatal test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Hyperphagia
fNIRS-based Neurofeedback Intervention for Cognitive Control Improvement in Emotional Overeating
Emotional overeating is characterized by an excessive food intake in the context of intense emotional situations, such as acute stress one.
- Trial name
- Cemov (NCT05200182)
- Testing
- Neurofeedback with functional near infra-red spectroscopy, oral microbiota collection, Questionnaires
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Cerebral Palsy, Hemiparesis; Poststroke/CVA
Characterization of Muscle Activity During a Surface EMG-controlled Rehabilitation Game
The aim of this pilot study is to evaluate muscular activity during a single session of surface electromyography controlled exergame (muscle activation, number of contraction…) in cerebral palsy kids, hemiparetic adults and…
- Conditions
- Cerebral Palsy, Hemiparesis; Poststroke/CVA, Healthy (Controls)
- Trial name
- CONTRACTIV-1S (NCT07838688)
- Testing
- Surface electromyography (sEMG)-controlled rehabilitation game
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Amputation of Lower Extremity, All Causes
Gait and Energy Expenditure in Children With Lower Limb Amputation (MAPEDE)
In lower limb amputation, prosthetic gait has been shown to be particularly energy-intensive. While energy expenditure has been the focus of many studies in adult amputees, this area of research is less developed for paediatric…
- Trial name
- MAPEDE (NCT07076602)
- Testing
- Gait and energy expenditure
- Where
- 8 sites in France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital
Heart Failure
RADIATE-HF - Efficacy and Safety of Cardiac Radiation in Advanced Heart Failure
The RADIATE-HF study is a prospective, interventional, single-center, open-label, non-randomized study conducted at the Rennes University Hospital.
- Trial name
- RADIATE-HF (NCT07770230)
- Testing
- Low-dose cardiac radiation therapy (5 Gy)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Weaning Mechanical Ventilation
Airway Occlusion Pressure Derived Parameters During Spotaneous Breathing Trial for Predicting Extubation Failure
Weaning from invasive mechanical ventilation (IMV) is a critical stage of the intensive care unit (ICU) stay. Premature IMV discontinuation may expose patients to substantial cardiopulmonary stress, whereas prolonged weaning…
- Trial name
- Weaning-POP (NCT07786519)
- Where
- 4 sites in France
- Volunteers
- 225 people
- Sponsor
- Rennes University Hospital
Sudden Cardiac Arrest, Sudden Cardiac Death
Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register
The increased risk of sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to vigorous physical activity is well-documented.
- Trial name
- RESOUDRE (NCT06642168)
- Testing
- Whole exome sequencing to detect myocardial genetic mutations (SCA group only)
- Where
- 26 sites in France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Chronic Insomnia
Evaluation of the Efficacy of E2R Hypnotherapy in the Management of Chronic Insomnia in Primary Care (HypERR)
In France, the treatment of chronic insomnia relies mainly on hypnotic drugs in routine care, despite the high level of iatrogenicity.
- Trial name
- HypERR (NCT06898099)
- Testing
- "Standard care" control group (without hypnosis), Experimental group: "E2R hypnosis"
- Where
- 35 sites in France
- Volunteers
- 136 people
- Sponsor
- Rennes University Hospital
PAD - Peripheral Arterial Disease, Lumbar Spinal Stenosis
CLE-PAD : Prevalence of PAD in Patients With Surgically Lumbar Spinal Stenosis
The goal of this interventional study is to evaluate the rate of existing lower limb peripheral artery disease (PAD) in patients with surgically lumbar spinal stenosis (LSS).
- Conditions
- PAD - Peripheral Arterial Disease, Lumbar Spinal Stenosis, Lower Limb Arterial Disease
- Trial name
- CLE-PAD (NCT07469020)
- Testing
- contrast-enhanced CT scan
- Where
- 3 sites in France
- Volunteers
- 49 people
- Sponsor
- Rennes University Hospital
Cardiac Surgery
Evaluation of Preoperative Anxiety Level Based on the Day of Admission for Cardiac Surgery
Prospective, observational, non-randomized study that evaluates the impact of the admission day (J-1 vs J-0) on preoperative anxiety in cardiac surgery patients.
- Trial name
- ADMITY (NCT06794697)
- Testing
- Questionnaire including APAIS scale
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Rennes University Hospital
Prehospital Emergency, Neck Injury
IPSTRAUC : Impact on Care Pathways of a New Management of Cervical Trauma in Conscious Patients Stable in Pre-hospital Care
The aim of the study is to evaluate the application of Canadian C-Spine rules adapted to pre-hospital settings in France in order to improve the appropriateness of cervical spine immobilisation, reduce unnecessary imaging…
- Conditions
- Prehospital Emergency, Neck Injury, Neck Trauma, Emergency Medical Services
- Trial name
- IPSTRAUC (NCT06983873)
- Testing
- adapted Canadian C-Spine rules
- Where
- 14 sites in France
- Volunteers
- 840 people
- Sponsor
- Rennes University Hospital
Self-management
Self-management Education in Multi-professional Health Centres
The goal of this observational study is to learn about the best educative and organizational dimensions favouring the development of self-management education in multiprofessional health centres.
- Trial name
- ETHOPEE (NCT05950451)
- Testing
- No intervention
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Interprofessional Education
Impact of IPE in Multidisciplinary Primary Care Centres on Collaborative Competency of Healthcare Students (FLIRT-MSP)
The aim of our study is to evaluate the impact of interprofessional education program (IPEP) for healthcare students in clinical placement in MPCC on interprofessional collaboration (IPC), comparing the acquisition of…
- Trial name
- FLIRT-MSP (NCT06789939)
- Testing
- Train the trainer program for MPCC professionals
- Where
- 26 sites in France
- Volunteers
- 96 people
- Sponsor
- Rennes University Hospital
Aging, Frailty
Evaluation of a Health Monitoring Platform for Elderly in Home Care Context
This study aims at, as a primary objective, studying acceptability of elderly about a health monitoring platform for home support and home care.
- Trial name
- ACCORDS (NCT04514536)
- Testing
- Health monitors
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Stroke Sequelae
Mechanisms of Balance Disorders in a Seated Position Following a Stroke
One of the causes of disability in stroke patients is postural disturbances that result in postural asymmetry in the standing position, characterized during an evaluation on a force platform by a greater displacement of the…
- Trial name
- HEMISEAT (NCT04152616)
- Testing
- Instrumental evaluation of posture
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Infant, Premature
Preliminary Study to the Conception of a Non-invasive Neonatal Monitoring System With Development of a Database
Each year, 300 000 new borns are hospitalised in neonatology units in Europe. This period is very sensitive as newborns are exposed to a high risk of morbidity and mortality, with severe impact on neuro-developmental prognostic.
- Trial name
- Digi-NewB (NCT02863978)
- Testing
- Multimodal signal acquisitions
- Where
- 6 sites in France
- Volunteers
- 746 people
- Sponsor
- Rennes University Hospital
Metastatic Clear Cell Renal Cell Carcinoma
Validation of a Predictive Nomogram of Response or Resistance to Targeted Therapies in Metastatic Clear Cell Renal Cell Carcinoma
The purpose of this study is to validate of a predictive nomogram of response or resistance to targeted therapies in metastatic clear cell renal cell carcinoma
- Trial name
- RTKI (NCT02848768)
- Testing
- Sunitinib
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Rennes University Hospital