Clinical trials: sponsored by Rennes University Hospital
Trigger Finger Disorder
Wide Awake Local Anesthesia No Tourniquet
The main objective is to assess patient's satisfaction regarding pure local anaesthesia and without use of a tourniquet (WALANT Technique) for trigger finger release surgery.
- Trial name
- WALANT (NCT03663608)
- Testing
- WALANT Technique
- Where
- 2 sites in France
- Volunteers
- 57 people
- Sponsor
- Rennes University Hospital
Pain, Anxiety
Anxiety, Pain et Analgesia Nociception Index (ANI) in Palliative Care
The main objective of this study is to evaluate the correlation between ANI and pain scores and the correlation of ANI and anxiety scores in communicative patients in palliative care.
- Conditions
- Pain, Anxiety, Palliative Care
- Trial name
- ADA-Pallia (NCT03983590)
- Testing
- Visual Analogic Scale
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Rennes University Hospital
Otosclerosis, Otosclerosis Surgery
Patient Satisfaction After Surgery for Otosclerosis Under Local ou General Anesthesia
Main purpose of this study is to compare comfort level of patients, after otosclerosis surgery, under local or general anesthesia.
- Trial name
- SPOC (NCT03888079)
- Testing
- Local anesthetic, general anesthetic
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Rennes University Hospital
Systemic Sclerosis
RElevance of UltraSonography for Assessing Salivary Gland Involvement in Systemic Sclerosis (SSc)
As fibrosis of salivary glands is supposed to be the main mechanism involved in Systemic sclerosis (SSc)-associated sicca syndrome, Ultrasonography , biopsy and measuring gland elasticity (by ARFI (Acoustic Radiation Force…
- Trial name
- REUSSI-SSc (NCT04001556)
- Testing
- Minor Salivary gland Biopsy, ARFI, MSG US
- Where
- 3 sites in France
- Volunteers
- 75 people
- Sponsor
- Rennes University Hospital
Systemic Scleroderma
Clinical and Paraclinical Characteristics of the Systemic Scleroderma Cohort According to the Criteria ACR 2013 and the History of Professional Exposure or of Agricultural Environment
The aim of the study is to compare the exposure to environmental and professional toxics by patients with systemic scleroderma and by patients not achieved by this pathology.
- Trial name
- PRESSY (NCT03262922)
- Where
- France
- Volunteers
- 327 people
- Sponsor
- Rennes University Hospital
Fetal Membranes, Premature Rupture
Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes
All included patients will have their fetal heart rate recording performed with an EDAN F3 fetal monitor that allowed the back up recording of the fetal heart rate beat to beat detection.
- Trial name
- AiRPM (NCT02901795)
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Investigation of Novel Immunological Biomarkers by Mass Cytometry in Patients With Early Multiple Sclerosis (CISCO)
The objective of CISCO is therefore to identify prognostic biomarkers of MS activity in early-stage patients.
- Trial name
- CISCO (NCT04510350)
- Testing
- Biomarkers analysis
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Children, Ambulatory Surgery
Analysis of the Link Between Flow State and Preoperative Anxiety in Children Undergoing Playful Distraction
This study focuses on preoperative anxiety in children and non-drug methods to reduce anxiety. During surgery under general anesthesia, children may be anxious because of separation from their parents, fear of anesthesia, or loss…
- Conditions
- Children, Ambulatory Surgery, General Anesthesia
- Trial name
- ALFA (NCT04079244)
- Testing
- Video game, Animated cartoon
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Iron Hepatic Overload, Fat Hepatic Overload
Comparison of the Variability of Hepatic Load Quantification in Iron and Fat Estimated by MRI at 1.5 and 3 Tesla
The study proposes to compare the results of two examinations at 1.5 and 3 Tesla obtained on the same day on a series of 80 patients.
- Trial name
- HEMOCOMPARE (NCT03200457)
- Testing
- 1,5 Tesla abdominal MRI, 3 Tesla abdominal MRI
- Where
- 2 sites in France
- Volunteers
- 92 people
- Sponsor
- Rennes University Hospital
Patient Hospitalized in Intensive Care Unit
Study of Immunosuppression Biomarkers Acquired in Patients Hospitalized in Intensive Care Unit
Open-label, non-randomized, prospective, single center, observational, translational study
- Trial name
- IMPRIM (NCT02881268)
- Testing
- blood sample
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Rennes University Hospital
History of Exposure to Silica or Asbestosis, Positive Testing for ANA as a Marker of Systemic Autoimmune Diseases
Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages
Evaluation of the efferocytosis capacities of blood Monocyte Derived Macrophages (MDM) from patients with a history of asbestosis or silica exposure and comparison of these capacities with those of MDM from healthy donors.
- Trial name
- MacFibOsis (NCT04473742)
- Testing
- Blood collection, Blood sample
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Holoprosencephaly
Retrospective Study Using Next Generation Sequencing (NGS) on Biological Samples to Improve Genetic Counseling for Patients With Previously Explored Craniofacial Midline Defects.
Holoprosencephaly, or HPE, is the most common congenital cerebral malformation in humans and the most severe of a group of pathologies related to a deficiency of the SHH signalling pathway (Sonic Hedgehog SHH-D).
- Trial name
- EXOMEDIANE (NCT04691414)
- Testing
- NGS
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Acute Kidney Injury, Cardiac Surgery
Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is common after cardiac surgery. The diagnosis is based on the criteria defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification: oliguria and elevation of serum creatinine.
- Trial name
- NEPHROCAR (NCT03396770)
- Testing
- Standard clinical routine, Nephrocheck test
- Where
- France
- Volunteers
- 848 people
- Sponsor
- Rennes University Hospital
Severe Septic Syndrome, Septic Shock
Community Acquired Sepsis Cohort
The aim of this project is to constitute a prospective cohort of all the patients presenting to the adult emergencies of the University Hospital Centre (CHU) of Rennes for a septic syndrome of community origin.
- Trial name
- CASC (NCT03280992)
- Where
- France
- Volunteers
- 796 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
MUltiple Sclerosis : T Cell / B Cell Exploration
This study, an ancillary to ABCD-SEP (NCT03744351), will be interested in more precisely characterizing circulating and infiltrating TH cells in Multiple Sclerosis whether at the transcriptomic level or at the functional level.
- Trial name
- MUST-BE (NCT04231253)
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Smoking Cessation, Pulmonary Disease, Chronic Obstructive
Impact of Primary Care COPD Screening Strategies on the Smoking Cessation Process (DISCO-SET)
The general practitioner is confronted with unselected smokers whose attempts to quit smoking are often repeated over time before leading to a definitive cessation.
- Trial name
- DISCO-SET (NCT04833933)
- Testing
- Phone survey about smoking cessation process since intervention in DISCO trial
- Where
- 12 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
MRI
OSV-IRM - Volunteer MRI Sequence Optimization
Optimization of magnetic resonance imaging (MRI) protocols on healthy volunteers and voluntary patients. In MRI, a large number of technical parameters (sequence, parameters in sequence, antenna, reconstruction method, etc.) can…
- Trial name
- OSV-IRM (NCT05107232)
- Testing
- MRI
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Osteoarticular Infection
EVRIOS : Comparative Evaluation of Low Versus High Doses of Rifampicin
Rifampicin is an antibiotic usually required to treat susceptible Staphylococcus spp. osteo-articular infections, most frequently in association with a fluoroquinolone when the strain is susceptible to both agents.
- Trial name
- EVRIOS (NCT02599493)
- Testing
- Rifampicin
- Where
- 16 sites in France
- Volunteers
- 544 people
- Sponsor
- Rennes University Hospital
Ovarian Cancer
Study of Predictive Factors of Chemoresistance in Ovarian Cancer
Epithelial ovarian cancer (EOC) has a poor prognosis. EOC management requires debulking surgery and chemotherapy based on taxol and carboplatine.
- Trial name
- FaCliBioCCo (NCT02878122)
- Testing
- Cancer treatment
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Rennes University Hospital
Joint Effusion
Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis
To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion
- Trial name
- SYNOFRESH (NCT04004962)
- Testing
- Infrared spectroscopy
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- Rennes University Hospital