Clinical trials: sponsored by Rennes University Hospital
Type 2 Diabetes, Chronic Kidney Disease
Kidney Biopsy Indications in Type 2 Diabetes Patients
The WHO (World Health Organisation) estimated the prevalence of diabetes to be 422 million people in 2014, compared to 108 million in 1980.
- Trial name
- RIB-R2D2 (NCT04006028)
- Where
- 4 sites in France
- Volunteers
- 500 people
- Sponsor
- Rennes University Hospital
Ovarian Carcinoma
Impact of Fas/FasL in Chemotherapy Response in Epithelial Ovarian Carcinoma
Ovarian carcinoma has poor prognosis and new therapeutic strategies are required. Many patients with ovarian carcinoma showed resistance to chemotherapy.
- Trial name
- IFFaLCCO (NCT02297958)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Rennes University Hospital
Pleuropulmonary Blastoma
Review of the Paediatric Pleuropulmonary Blastoma French Series
Pleuropulmonary blastoma is a rare embryonic malignant tumour that remains the most frequent malignant tumour of the lung in childhood.
- Trial name
- PPB (NCT03044834)
- Testing
- PPB
- Where
- 18 sites in France
- Volunteers
- 41 people
- Sponsor
- Rennes University Hospital
Non-Alcoholic Fatty Liver Disease
Combining MRI Steatosis Assessment and Transient Elastography to Improve Liver Fibrosis Diagnosis in Non Alcoholic Fatty Liver Disease
The main objective is to compare the accuracy of transient elastography taking into account liver steatosis determined by MRI, to liver biopsy for the diagnosis of liver fibrosis ≥F2 in patient with NAFLD.
- Trial name
- FibroMR (NCT03245606)
- Testing
- Liver biopsy, Abdominal MRI, Transient elastography
- Where
- 9 sites in France
- Volunteers
- 270 people
- Sponsor
- Rennes University Hospital
Chronic Subdural Hematomas
Treatment of Chronic Subdural Hematoma by Corticosteroids
Chronic subdural hematomas are a frequent neurosurgical pathology in the elderly. Gold standard is surgical evacuation of these hematomas.
- Trial name
- SUCRE (NCT02650609)
- Testing
- Methylprednisolone
- Where
- 17 sites in France
- Volunteers
- 202 people
- Sponsor
- Rennes University Hospital
Intubation, Pulmonary Ventilation
Immuno Nutrition by L-citrulline for Critically Ill Patients
The main objective of this study is to demonstrate that the only administration of L-citrulline, can improve immune functions in critically ill patients at high risk of nosocomial infection.
- Trial name
- Immunocitre (NCT02864017)
- Testing
- Enteral nutrition, L-Citrulline
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Rennes University Hospital
Parturition
Evaluation of the Psychological Consequences of Complicated Childbirth
Prospective, non-interventional, monocentric, case-control study
- Trial name
- ESPT Obst (NCT03441243)
- Where
- France
- Volunteers
- 256 people
- Sponsor
- Rennes University Hospital
Obstructive Sleep Apnea Syndrome
Management of Obstructive Sleep Apnea (OSA) in Children and Maxillary and Mandibular Development
Assessment of the association of maxillary expansion using a rapid palatal expansion, use of a mandibular advancement appliance (MGA™) and of a device allowing sleep in a semi-seated position (Yoobreath™) in patients with…
- Trial name
- SAOS (NCT03267927)
- Testing
- Rapid palatal expansion, MGA™ system, Yoobreath™ system
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Rennes University Hospital
Aortic Valve Stenosis
Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve
Investigators sought to demonstrate that the increase in the stroke volume during a dobutamine stress echocardiography might impact the prognosis of a patient addressed for a low flow low gradient suspected severe aortic valve…
- Trial name
- LOWAS (NCT02727504)
- Testing
- Electrocardiogram, 2D and 3D echocardiography, Dobutamine stress echocardiography
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Rennes University Hospital
Major Depressive Disorder, Recurrent Depressive Disorder
Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression
Major depressive disorders are real public health issues in terms of diagnosis and treatment. Some forms of depression are chronic and resistant to treatment (TRD). In these forms suicide risk is important.
- Conditions
- Major Depressive Disorder, Recurrent Depressive Disorder, Bipolar Disorder
- Trial name
- STHYM (NCT01973478)
- Testing
- DBS
- Where
- 5 sites in France
- Volunteers
- 9 people
- Sponsor
- Rennes University Hospital
Ventricular Dysfunction
Hemodynamic Indices Predictive of a Beneficial Response to Fluid Expansion in Case of Hemodynamic Failure After Cardiac Surgery With Altered Preoperative Ejection Fraction (LVEF≤45%)
Low Cardiac Output Syndrome occurs frequently after cardiac surgery, especially when pre-operative LVEF is altered (LVEF≤45%). The correction of hemodynamic failure requires adapted treatments: fluid expansion and/or inotropic or…
- Trial name
- ALTERVOL (NCT01673230)
- Testing
- cardiac surgery for ventricular dysfunction
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Severe Sepsis
Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation.
This study aims to assess the effect of acute inflammation on arterial stiffness and microcirculation. Patients with severe sepsis will be compared with age-, sex- and cardiovascular risk factors-matched controls.
- Trial name
- IRIGA (NCT01556373)
- Testing
- NA : non interventional study
- Where
- 2 sites in France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Cardiac Arrest
Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest
Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography (TCD) in comatose survivors after cardiac arrest.
- Trial name
- DOTAC (NCT03270683)
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Rennes University Hospital
Patients Scheduled for Iliac Crest Bone Graft Harvest During Upper or Lower Limb Surgery
Ultrasound TFP (Transversalis Fascia Plane) for Analgesia After Iliac Crest Bone Graft Harvest
Iliac crest bone graft harvest is associated with acute pain that can lead to chronic postoperative pain. Local anesthetic infiltration and regional anesthesia could be of interest to reduce opioid consumption during and after…
- Trial name
- TFP (NCT02398474)
- Testing
- TFP block ropivacaine, ropivacaine infiltration of the iliac crest bone
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Rennes University Hospital
DLBCL
SMOLY : Phenotype and Functions of Monocyte Subtypes in High Grade B Lymphoma: Towards New Biomarkers?
Large-cell B-cell lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma and accounts for about 40% of new cases. Although the DLBCL is a single entity in the WHO classification, several subgroups with different prognoses are…
- Trial name
- SMOLY (NCT03672682)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Postoperative Nausea and Vomiting
Dexamethasone, Can it Replace Ketoprofen in the Strategy of Intraoperative Multimodal Analgesia in Paediatric Surgery ? A Prospective Randomized Double-blinded Study. DEXA OP
Postoperative pain and nausea-vomiting (PONV) are the first causes of failure in ambulatory care in pediatric surgery. Actually, the paracetamol/ketoprofen combination in intraoperative care is recommended for effective…
- Trial name
- DEXA OP (NCT02400047)
- Testing
- Dexamethasone 0.2 mg/kg, Dexamethasone 0.4 mg/kg, Ketoprofen 1 mg/kg
- Where
- France
- Volunteers
- 580 people
- Sponsor
- Rennes University Hospital
Depression
NEUROFEEDSTIM : Therapeutic Use of Neurofeedback in Depression in Association With TMS
Neurofeedback is an increasingly researched technique for the treatment of many psychological disorders, such as attention deficit / hyperactivity disorder (AD / HD), depression, or substance abuse.
- Trial name
- NEUROFEEDSTIM (NCT03279913)
- Testing
- EEG-neurofeedback training in association with TMS.
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Rennes University Hospital
Diffuse Large B-cell Lymphoma, Hodgkin Lymphoma
BMS_PD-L1_onco : Assessment of the PD-L1 Protein as a Biomarker in Oncology and Hematology
Diffuse large B-cell lymphomas (DLBCLs) represent 25 to 30% of adult non-Hodgkin lymphomas in western countries. DLBCLs are aggressive cancer but potentially curable with multi-agent chemotherapy.
- Conditions
- Diffuse Large B-cell Lymphoma, Hodgkin Lymphoma, Metastatic Breastcancer, Non-small Cell Lung Cancer
- Trial name
- BMS_PD-L1 (NCT01660776)
- Where
- 4 sites in France
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Renal Colic
35RC17_8826_NEPHROPAIN Phase APRES : Interest of the Equimolar Oxygen Nitride Mixture (MEOPA) in the Treatment of Pain in Patients Presenting to the Emergency Department for Suspected Renal Colic: a Study BEFORE AFTER
MEOPA (Equimolar Oxygen-Nitrogen Protoxide Mix) is a gas used in emergencies for short-term painful acts. It is often very effective with an analgesic, anxiolytic and muscle relaxant action.
- Trial name
- NEPHROPAIN (NCT03638921)
- Testing
- MEOPA
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Intubation in ICU
Transcutaneous PCO2 Assessment During Intubation in ICU
PtcCO2 assessement during intubation in ICU. Comparison of three different preoxygenation methods.
- Trial name
- C-TOP (NCT03888430)
- Testing
- PtcCO2 measure during intubation
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Rennes University Hospital