Clinical trials: sponsored by Rennes University Hospital
High Velocity Transport Accidents
Is There a Benefit of Whole Body Computed Tomography (WBCT) for Patients With Only High Velocity Road Traffic Collision (RTC) Vittel Criteria?
For victims of high velocity RTC, with no other Vittel criteria of gravity, normal clinical examination of the thorax, abdomen and pelvis and Glasgow Coma Scale (GCS) score of 15 : Study of clinically unsuspected injuries…
- Trial name
- Cinescan (NCT03679416)
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Rennes University Hospital
Osteoporosis
General Practitioner's Place in the Treatment of Fracture Osteoporosis in the Elderly
Osteoporosis is a major public health problem. Its screening and its treatment remain largely insufficient while therapies have demonstrated their effectiveness.
- Trial name
- GEOFRAGE (NCT03402958)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Rennes University Hospital
Inflammation Eye
Evaluation of Inflammation of the Anterior Segment by Laser Flashmeter in Patients Having Undergone Surgery of the Posterior Segment (Vitrectomy or Preindentation) During the First Postoperative Year. (FLAVIC)
Observational study, monocentric, prospective, descriptive and comparative (eye operated vs fellow eye).
- Trial name
- FLAVIC (NCT03677700)
- Testing
- Laser Flare Meter
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Thoracic Surgery
Impact of Preoperative Martial Deficiency on the Level of Blood Transfusion in Programmed Cardiac Surgery
Observational study.
- Trial name
- CARMATS (NCT03261583)
- Testing
- Thoracis Surgery - Common care
- Where
- 2 sites in France
- Volunteers
- 444 people
- Sponsor
- Rennes University Hospital
Hirschsprung Disease
MICROPRUNG : Intestinal Microbiota Analysis in Patients With or Without Hirschsprung's Associated EnteroColitis
Hirschsprung disease is a congenital abnormality due to the lack of migration of neural crest cells in myenteric and submucosal plexi of the bowel wall.
- Trial name
- MICROPRUNG (NCT02857205)
- Testing
- Fecal samples
- Where
- 7 sites in France
- Volunteers
- 118 people
- Sponsor
- Rennes University Hospital
Peripheral Arterial Disease
Endovascular Procedures With Computer Assistance in the Chronic Occlusive Arthritis of the Lower Limbs on the Femoro-popliteal Stage.
Pilot study to assess the feasibility of creation of a bone and arterial panorama by 2D-2D registration technique during endovascular femoro-popliteal procedures with a mobile C-arm X-ray system using EndoNaut® software.
- Trial name
- PANORAMIC (NCT03669978)
- Testing
- Creation of a bone and arterial panorama using EndoNaut® software.
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Medication Reconciliation
Medication Reconciliation for Patients Over 65 Years Old : Cost Analysis of the Process Implemented in the Polyvalent Internal Medical Unit of Rennes University Hospital
Among the strategies to secure the patient's care path, medication reconciliation is a powerful approach for the prevention and interception of medication errors.
- Trial name
- CONTEMPS (NCT03670433)
- Testing
- Cost analysis of medication reconciliation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Anterior Cruciate Ligament Rupture
Risk Factor of Anterior Cruciate Ligament Rupture After Ligamentoplasty : What is the Importance of a Relative Deficit of Contralateral Hamstrings Assessed by Isokinetic in Postoperative ?
Anterior cruciate ligament (ACL) is a common pathology (37 000 operations in 2006, nearly 43 000 in 2012 in France) justifying more and more operating indications in younger and younger patients.
- Trial name
- DIS-RRACT (NCT03668210)
- Testing
- Isokinetic evaluation
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Multiple Myeloma
Urinary Protein/Creatinine Ratio in a Single Urine Sample Versus 24-hour Proteinuria in Patients With Multiple Myeloma
The measurement of 24-hour proteinuria allows an assessment of treatment response in patients with multiple myeloma. But it is difficult and restrictive to make.
- Trial name
- RCP-MM (NCT01572857)
- Testing
- urinary excretion of FLC immunoglobulin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Spina Bifida, Multiple Sclerosis
Urinary Markers of Detrusor Overactivity in Spina Bifida Patients
The purpose of this study is to assess diagnostic performance of urinary markers of detrusor overactivity (Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), adenosine triphosphate (ATP), Prostaglandine E2) in…
- Conditions
- Spina Bifida, Multiple Sclerosis, Spinal Cord Injury, Overactive Bladder
- Trial name
- BUHD-SPINA (NCT02852317)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Rennes University Hospital
cN0 Oral Squamous Cell Carcinomas
One-step Nucleic Acid Amplification for Detecting Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma
The investigators main objective is to show that OSNA technique is as accurate as pathological analysis (frozen section / HE staining and immunochemistry) to detect occult lymph node metastasis (micro and macrometastasis).
- Trial name
- OSNA-ORL (NCT02852343)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Rennes University Hospital
Spina Bifida
Improving Genetic Counseling for Patients With Spina Bifida Using Next Generation Sequencing
The main objective is to improve genetic counseling in patients with Spina Bifida, by the characterization of variants in new genes using high throughput sequencing either on a panel of targeted genes or on exome in families.
- Trial name
- EXOSPINA (NCT02854150)
- Testing
- characterization of variants in new genes using high throughput sequencing either on a panel of targeted genes or on exome in families.
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Rennes University Hospital
Supraventricular Arrhythmias
Atrial Function and Supraventricular Arrhythmia of the Veteran Athlete.
Supraventricular arrhythmias (including atrial fibrillation) are the most common arrhythmias of the veteran athlete and have a major impact in terms of morbidity and mortality.
- Trial name
- FA2V (NCT03665324)
- Testing
- Evaluation of the relationship between atrial remodeling evaluated by ECG and ETT with the occurrence of supraventricular arrhythmias
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Hemochromatosis
Study of the Cellular Diffusion of Tacrolimus Across the Membrane of Mononuclear Cells
Pharmacokinetics of tacrolimus are highly variable and may result in graft rejection (underdosing) or toxicity (overdosing). The risk of transplant rejection and the toxicity of tacrolimus can be reduced by pharmacological…
- Trial name
- DIFF-TAC (NCT03654794)
- Testing
- Cell pharmacokinetics of tacrolimus
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Rennes University Hospital
Arteriovenous Malformations
Fertility After Diagnosis and Management of Acquired Uterine Arteriovenous Malformation
Uterine arteriovenous malformations (UAVM) are short circuits between systemic arterial and venous networks within the uterus. They are congenital or acquired (in the course of an endo-uterine gesture such as curettage or…
- Trial name
- MAVUFERT (NCT03656211)
- Testing
- Telephone interview
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Rennes University Hospital
Treatment Resistant Depression
Coupling Repetitive Transcranial Magnetic Stimulation With a Neuronavigation System in Treatment Resistant Depression
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non invasive technique which was shown to be effective in the treatment of major depression.
- Trial name
- TMS (NCT01677078)
- Testing
- Neuronavigation system, Standard localisation method
- Where
- 5 sites in France
- Volunteers
- 107 people
- Sponsor
- Rennes University Hospital
Stroke Sequelae
Mobile and Interactive Robot's Social Acceptability for Balance and Gait Rehabilitation
The recovery of a balance and gait is a primary objective for geriatric, neurological or orthopedic rehabilitation. Since the 80s, many walking robots were proposed.
- Trial name
- ROBO-K (NCT03651960)
- Testing
- ROBOT PROTOTYPE
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Recurrent Anterior Shoulder Instability
Long-term Review of a Cohort of Arthroscopic Bankart Interventions
Recurrent instability is the most common chronic shoulder pathology of the young and athletic patient. It is a source of functional, sporting and professional disability, and a permanent apprehension to the use of the affected…
- Trial name
- ISIS-2017 (NCT03654118)
- Testing
- Phone follow-up
- Where
- 11 sites in France
- Volunteers
- 125 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Validation of a Self-questionnaire in French on the Use of the Upper Limbs in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system that causes disability in young adults.
- Trial name
- MS-SEP (NCT03655093)
- Testing
- Validation of AMSQ questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Rennes University Hospital
Healthy Volunteers
Fludrocortisone in Healthy Volunteers (AFLUCO4)
Fludrocortisone, in association with hydrocortisone, has demonstrated an improvement in survival in septic shock patients with relative adrenal insufficiency.
- Trial name
- AFLUCO4 (NCT02140918)
- Testing
- Fludrocortisone 100 μg, Fludrocortisone 200 μg, Fludrocortisone 400 μg
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital