Clinical trials: sponsored by Rennes University Hospital
Insulin Resistance, Iron Overload
Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients
The purpose of this study is to evaluate efficacy of phlebotomy on insulin sensitivity as evaluated by euglycemic-hyperinsulinic clamp in insulin resistance-associated hepatic iron overload patients.
- Trial name
- SAINPOS (NCT01572818)
- Testing
- phlebotomy, dietary and lifestyle counseling
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- Rennes University Hospital
Left Ventricular Assist Devices Patients
REVADE : Right Ventricular Function and Exercise in Left Ventricular Assist Device Patients : Echocardiographic Study
Heart failure is a public health problem, responsible for 150.000 admissions, 32.000 deaths, 1% of public health expenditure each year in France.
- Trial name
- REVADE (NCT02067455)
- Testing
- adding 2 cardiopulmonary exercise testings : peak oxygen consumption (VO2 max) and stress echocardiography
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Rennes University Hospital
Cancer
Determinants of End-of-life Place of Care for Children Suffering From Cancer.
Cancer is the second cause of over-one-year-old children mortality after accident. Survival rate is more than 70%, but in some cases, curative treatments are not sufficient and palliative support is implemented for those children…
- Trial name
- DELI-DEVI (NCT02060578)
- Testing
- Questionnaire and interview
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Multiple Sclerosis (MS), Inflammatory Disease
The Inflammatory Process and the Medical Imaging in Patients With an Inflammatory Disease of the Central Nervous System.
While significant progress has been made on medical imagery in recent years in the individualization of different lesions in the nervous system for demyelination, axonal loss, atrophy, little progress has been made in the…
- Trial name
- USPIO-CIS (NCT01567553)
- Testing
- USPIO MRI - Gadolinium MRI
- Where
- 5 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
Mechanical Ventilation Complication
Effect of Intermittent Versus Continuous Subglottic Secretion Drainage on Tracheal Mucosa Damages
Endotracheal tubes with subglottic secretion drainage (incorporating a suction port above the cuff) have been shown to reduce the incidence of ventilator-associated pneumonia.
- Trial name
- ASPIRE (NCT01555229)
- Testing
- Intermittent subglottic secretion drainage, Continuous subglottic secretion drainage
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Patients Hospitalized in Infectious Disease
Interest of Contact Precautions for Preventing Micro-organisms Acquisition in Patients Hospitalized in Infectious Disease Unit of University-affiliated Hospital in Rennes
Application of isolation (=contact precautions) in hospitalized patients is recommended when patient is colonized (or infected) by micro-organism known for its outbreak capacity or high pathogenicity.
- Trial name
- ISOL/STAND (NCT01562769)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Rennes University Hospital
Healthy
TEXTO : Total EXposure To Organic Pollutants
People are, especially in industrialized countries, exposed to a growing number of ubiquitous chemical substances. It thus increases human exposure pathways: diet, inhalation, soil and dust dermal contact…), notably for…
- Trial name
- TEXTO (NCT02210299)
- Testing
- Exposure study
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Hemiplegia, Stroke
Immediate Effect of Postural Muscle's Vibrations on Gait in Chronic Vascular Hemiplegia
Balance disorders are very common after strokes and often last for long periods of time. Their origin is multifactorial and their impact on the daily lives of patients are particularly important, especially on gait.
- Trial name
- VIBR-AVC (NCT02096367)
- Testing
- Gait analysis, Kinematic gait analysis in lower limb, Analysis of static posture
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Rennes University Hospital
Major Depressive Disorder, Recurrent, Unspecified
Deep Brain Stimulation of Nucleus Accumbens for Chronic and Resistant Major Depressive Disorder
Depression is a common, recurrent and disabling disorder. Among patients with a chronic course of the disease, 20 to 30% are resistant to antidepressant medications.
- Trial name
- PRESTHYM (NCT01569711)
- Testing
- Deep brain stimulation of nucleus accumbens
- Where
- 10 sites in France
- Volunteers
- 6 people
- Sponsor
- Rennes University Hospital
Healthy Women
Study of Serum Hepcidin Rate Variations During Menstrual Cycle
Hepcidin is the major hormone regulating Iron Metabolism. In a normal organism decrease iron stock causes a decrease in hepcidin synthesis thus promoting intestinal absorption of iron.
- Trial name
- HEPMEN (NCT01764412)
- Where
- 4 sites in France
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Rare Iron Overloads Except C282Y Homozygosity
Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization.
Chronic iron overload is responsible for morbidity and mortality. There are many genetic and acquired causes. One of them is an hepcidin deficiency. Hepcidin is the regulating hormone for iron.
- Trial name
- HEPCIDEF (NCT01541813)
- Where
- 10 sites in France
- Volunteers
- 62 people
- Sponsor
- Rennes University Hospital
Muscle; Fatigue, Heart
FACEFI : Cardiac Fatigue During Intense Exercises - Pilot Study
To attest if a cardiac fatigue appears (and to measure it if it does) during intense physical exercises in two groups of subjects: Canoeists from a training center of the French canoeing team during an intensive session of three…
- Trial name
- FACEFI (NCT02126891)
- Testing
- Tests
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Scoliosis
A New 3D Geometrical Modelisation of Adolescent Idiopathic Scoliosis and Conception of a Personal Brace
Adolescent idiopathic scoliosis (AIS) involves complex tridimensional deformities of the spine. In case of progressive curve deformity, the use of spinal bracing remains the standard non operative treatment of moderate AIS.
- Trial name
- MODEL MAKER (NCT01336114)
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital
Ovarian Cancer
Influence of Chemotherapy on Gamma-delta T Cells in Patients With Epithelial Ovarian Cancer
In patients with an ovarian cancer, the treatment is currently based on surgery and chemotherapy. The impact of chemotherapy on the expansion and functional abilities of Vgamma9Vdelta2 T cells has never been evaluated.
- Trial name
- IClyCO (NCT01606358)
- Testing
- Carboplatin and / or taxol chemotherapy
- Where
- France
- Sponsor
- Rennes University Hospital
Hereditary Hemochromatosis C282Y Homozygous
HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis
HFE(High iron FE)-related hereditary hemochromatosis has a highly variable penetrance. No phenotypic or genetic markers can predict the disease.
- Trial name
- HEPFER (NCT01784939)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Rennes University Hospital
Temporomandibular Disorders
Interest of Behavioural Reeducation in Dysfunctions of Masticatory Apparatus. Relations Between Parafunctions and Dysfunctions of Mastixatory Apparatus
If etiologies of temporomandibular disorders (TMD) are various, parafunctions become more and more important. Treatment of patients presenting TMD is based on conservative and reversible therapeutics.
- Trial name
- PARADYSAM (NCT01535378)
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Rennes University Hospital
Alcohol Abuse, Alcohol Problem
Efficacy of a Brief Alcohol Intervention for Non Dependant Alcohol-misusing Patients Undergoing a Scheduled Surgery
Excessive alcohol consumption is a worldwide major public health problem. Brief interventions have shown to be an efficient treatment modality for problem drinkers, but have never been tested in scheduled surgery.
- Conditions
- Alcohol Abuse, Alcohol Problem, AOD Misuse
- Trial name
- ITBCHIR (NCT01348113)
- Testing
- Brief Alcohol intervention
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Rennes University Hospital
Septic Shock
Effects of Fludrocortisone on Norepinephrine-mean Arterial Pressure Dose-response in Septic Shock
Septic shock (associated with relative adrenal insufficiency) is characterized by decreased arterial responsiveness to catecholamines.
- Trial name
- FLUDRO (NCT02069288)
- Testing
- Fludrocortisone
- Where
- France
- Sponsor
- Rennes University Hospital
Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Signification
Prognostic Study of Markers of Angiogenesis and Coagulability in Patients With Monoclonal Gammopathy
Blood circulating endothelial cells (CEC) and microparticles (MPs) are described in the literature to be associated with vascular failures and dysfunction that reflect neo-angiogenesis and risk of thrombosis, respectively.
- Conditions
- Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Signification, Myeloma
- Trial name
- PACMoG (NCT01543100)
- Testing
- blood and bone marrow samples
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Respiratory Distress Syndrome, Adult
Optimization of Arterial Oxygen Transport by Positive End-expiratory Pressure Variation in Acute Respiratory Distress Syndrome
Despite improving in the treatment of acute respiratory distress syndrome (ARDS), this affection keep an elevate rate of death. The strategy of mechanical ventilation is more and more under definite protocol, following large…
- Trial name
- OPTIPEP (NCT01256333)
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Rennes University Hospital