Clinical trials: sponsored by Rennes University Hospital
Apnea, Bradycardia
Detection of Neonatal Bradycardia
Apnea-bradycardia is a frequent phenomenon in preterm infants which has been associated with short term complications and alterations in neurodevelopment.
- Trial name
- INTEM (NCT00950287)
- Testing
- No intervention
- Where
- 3 sites in France
- Volunteers
- 54 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Relapsing-Remitting
Efficacy and Safety of Methylprednisolone Per os Versus IV for the Treatment of Multiple Sclerosis (MS) Relapses
The efficacy of oral corticosteroids for the treatment of relapses of multiple sclerosis has not been proved. French neurologists treat such patients with intravenous corticosteroids.
- Trial name
- COPOUSEP (NCT00984984)
- Testing
- methylprednisolone PO, methylprednisolone IV
- Where
- 14 sites in France
- Volunteers
- 200 people
- Sponsor
- Rennes University Hospital
Ureterolithiasis, Ureteral Calculi
Evaluation of Tamsulosin in the Treatment of Ureteral Stones
Ureteral stones have an important place in daily urological practice, usually causing acute episodes of ureteral colic by obstructing the urinary tract.
- Trial name
- TAMSULOSINE (NCT00151567)
- Testing
- Tamsulosin
- Where
- 6 sites in France
- Volunteers
- 129 people
- Sponsor
- Rennes University Hospital
Ventilator Associated Pneumonia
Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit
Head trauma and severe cerebral hemorrhage are major risk factors for development of ventilator-associated pneumonia. In a previous open labelled, single center study the investigators showed that repeated oropharyngeal…
- Trial name
- SPIRIT-ICU (NCT00950027)
- Testing
- povidone iodine
- Where
- 7 sites in France
- Volunteers
- 179 people
- Sponsor
- Rennes University Hospital
Hemiplegia, Stroke
Efficacy of a Mechanical Gait Repetitive Training Technique in Hemiparetic Stroke Patients (AVC)
Modern concepts of gait rehabilitation after stroke favor a task-specific repetitive approach. This study aims to test the efficacy on gait recovery of a mechanized gait trainer enabling nonambulatory patients to have the…
- Trial name
- NCT00284115
- Testing
- Gait trainer, Conventional rehabilitation
- Where
- 12 sites in France
- Volunteers
- 122 people
- Sponsor
- Rennes University Hospital
Evidence of Liver Transplantation
Reduction of Tacrolimus Dose in Association With Mycophenolate Mofetil After Liver Transplantation
The prevention of graft rejection after liver transplantation benefits nowadays from a variety of newly developed immunosuppressive agents.
- Trial name
- MMF-FK (NCT00151632)
- Testing
- Mycophenolate mofetil, Tacrolimus
- Where
- 8 sites in France
- Volunteers
- 195 people
- Sponsor
- Rennes University Hospital
Hepatectomy
Effects of Propofol on Oxidative Stress and Liver Regeneration After Partial Hepatectomy
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery.
- Trial name
- NCT00219856
- Testing
- Propofol, Penthotal, Desflurane
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Hepatocellular Carcinoma
Immunotherapy of Hepatocellular Carcinoma With Gamma Delta T Cells
For most patients with hepatocellular carcinoma, surgery or other curative procedures are not possible and only palliative measures could be applied (chemoembolization, targeted drugs, best supportive cares, etc).
- Trial name
- ICAR (NCT00562666)
- Testing
- T gamma delta lymphocytes
- Where
- 3 sites in France
- Volunteers
- 2 people
- Sponsor
- Rennes University Hospital
Epilepsy, Post-Traumatic
Prevention of Post-traumatic Seizures With Levetiracetam
Post-traumatic seizures can appear frequently after a severe traumatic brain injury. Two types of seizures are usually identified: early seizures during the week following the trauma and late epilepsy afterward.
- Trial name
- TRACK (NCT00566046)
- Testing
- Levetiracetam
- Where
- 15 sites in France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Community-Acquired Infections
Role of Beta-blockers in the Prevention on the Arisen of a Severe Sepsis (TESS)
The severe sepsis (SS) and toxic shock (TS) are both frequent and severe complications of infectious diseases. They are one of the top ten causes of death in industrialized countries.
- Trial name
- NCT01606631
- Where
- 9 sites in France
- Volunteers
- 2,444 people
- Sponsor
- Rennes University Hospital
Liver Transplantation, Hepatitis C
Treatment of Recurrent Hepatitis C After Liver Transplantation
In France, 50% of the hepatitis C virus carriers develop chronic clinical hepatitis, which may lead to cirrhosis and liver transplantation. Transplant infection by hepatitis C virus is constant after transplantation.
- Trial name
- TRANSPEG (NCT00151580)
- Testing
- Ribavirin
- Where
- 16 sites in France
- Volunteers
- 200 people
- Sponsor
- Rennes University Hospital
Insulin Resistance, Iron Overload
Cytochrome P450 2E1 and Iron Overload
The aim of the study is to determine, in patients presenting hepatic iron overload (genetic haemochtomatisis or dysmetabolic iron overload syndrome), the effects of venesection therapy on cytochrome P450 2E1 activity by comparing…
- Trial name
- NCT00138684
- Testing
- venesection
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis, Urinary Tract Infections
Cranberry for Prevention of Urinary Tract Infections in Multiple Sclerosis Patients
Bladder dysfunction occurs at some time in most patients with multiple sclerosis and these patients are prone to have recurrent urinary tract infections.
- Conditions
- Multiple Sclerosis, Urinary Tract Infections, Bladder Dysfunction
- Trial name
- CANNEBERGE (NCT00280592)
- Testing
- Cranberry
- Where
- 10 sites in France
- Volunteers
- 171 people
- Sponsor
- Rennes University Hospital
Stroke, Acute
Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients
The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic.
- Trial name
- NCT01311544
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Rennes University Hospital
Healthy
NOMAC : New Tools for Managing the Fate of Cereal Nutrients in the Gut : Effects of Amylose Content on Glycemic Index.
The consumption of cereals-based foods with low glycemic indexes, high micronutrients and fibers contents are highly recommended.
- Trial name
- NOMAC (NCT01437917)
- Testing
- 20% amylose bread, 10% amylose bread, Carbohydrates
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Myelodysplastic Syndromes, Anemia
Search for Predictive Markers of Efficacy of ESAs in Patients With Non-myeloid Malignancies or Myelodysplastic Syndrome
Anemia is common among cancer patients and the treatment of choice is now Erythropoiesis-Stimulating Agents (ESAs). However, some patients do not respond to treatment.
- Conditions
- Myelodysplastic Syndromes, Anemia, Hemopathies
- Trial name
- EPO (NCT01546337)
- Where
- 5 sites in France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Traumatic Brain Injury
Anaesthesia With Propofol Versus Midazolam : Effect on Oxidative Stress in the Brain of Head Trauma Patients
Severe traumatic brain injury is associated with an increased production of free radicals causing brain damage. First line treatment of these patients aims to maintain cerebral perfusion and includes deep anaesthesia.
- Trial name
- PROMIS (NCT00336882)
- Testing
- Propofol, Midazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Abdominal Aortic Aneurysms
Prevention of Endoleaks Using Autologous Platelet Gel on Unruptured Abdominal Aortic Aneurysms
The main risk of aortic aneurysms is rupture that leads to a high risk of death. A preventive surgical treatment is thus needed.
- Trial name
- NCT00372138
- Testing
- PRP + autologous thrombin
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Chronic Hepatitis C, Evidence of Liver Transplantation
Switch From Tacrolimus to Cyclosporin in the Treatment of Recurrent Hepatitis C After Liver Transplantation
In France, 50% of hepatitis C virus carriers develop chronic clinical hepatitis, which may lead to cirrhosis and liver transplantation.
- Trial name
- NCT00375895
- Testing
- ciclosporin
- Where
- 13 sites in France
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital
Renin Angiotensin
Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression
Septic shock (associated with relative adrenal insufficiency) is characterized by decreased arterial responsiveness to catecholamines.
- Trial name
- AFLUCO2 (NCT00673270)
- Testing
- Fludrocortisone, Hydrocortisone
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital