Clinical trials: sponsored by Rennes University Hospital
Prolapse Genital
iMEA : Comparison of Micro-innervation and Muscle Microstructure of the Anal Levator Muscle Between Patients With Urogenital Prolapse and Those Who Are Asymptomatic
Pelvic organ prolapse (POP) is defined by the International Continence Society (ICS) as a downward displacement of one or several of the followings: "the anterior wall of the vagina", "the posterior wall of the vagina" or "the…
- Trial name
- iMEA (NCT03947164)
- Testing
- biopsy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Rennes University Hospital
Ulcerative Colitis
EFFICACI : EFFicacy of Intravenous Infliximab Versus Vedolizumab After Failure of subCutaneous Anti-TNF in Patients With UlCerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that results from immune dysregulation. Arguably, the development of Tumor Necrosis Factor (TNF) antagonists (including infliximab, adalimumab and golimumab)…
- Trial name
- EFFICACI (NCT03679546)
- Testing
- Infliximab, Vedolizumab Injection
- Where
- 19 sites in France
- Volunteers
- 151 people
- Sponsor
- Rennes University Hospital
Chronic Obstructive Pulmonary Disease (COPD), Obesity With a BMI Greater Than 30
Interest of Hypnosis When Setting up Non-invasive Ventilation in a Conscious Patient With COPD and/or Obesity With a BMI Greater Than 30, Suffering Fromacute Respiratory Distress in Adult Intensive Care
Discomfort during respiratory decompensation of a patient with chronic obstructive pulmonary disease (COPD) and/or obesity with a BMI greater than 30, in intensive care and the establishment of non-invasive ventilation (NIV) is…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Obesity With a BMI Greater Than 30, Acute Respiratory Distress in Adult Intensive Care
- Trial name
- HYVIR (NCT04220463)
- Testing
- Hypnosis + NIV, NIV
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Peripheral Artery Disease
VIRTUOSE : Efficiency of Sildenafil on the Absolute Claudication Distance of Peripheral Arterial Disease Patients With Intermittent Claudication.
Peripheral Arterial Disease (PAD) is a highly debilitating disease that affects 202 million people around the world and about 7 million people in France. Morbi-mortality from cardiovascular events is increased in this population.
- Trial name
- VIRTUOSE (NCT03686306)
- Testing
- Sildenafil
- Where
- 11 sites in France
- Volunteers
- 106 people
- Sponsor
- Rennes University Hospital
ICU-weakness
VERARE_2 Efficacy of the Observation of Virtual Motor Actions for the Improvement of Gait in Patients With ICU-weakness
After hospitalization in Intensive Care (Intensive Care Unit or Continuing Care Unit), approximately 50% of patients usually present with intensive ICU-weakness, i.e.
- Trial name
- VERARE_2 (NCT04713345)
- Testing
- Virtual Reality Observations, Relaxation
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Rennes University Hospital
Parkinson Disease
Monocentric, Prospective Study to Assess the Pharmacokinetic Profile of Continuous and Diurnal Subcutaneous Apomorphine Infusion in Patients With Parkinson's Disease
This monocentric and prospective trial aims firstly to assess the pharmacokinetic profile of continuous and diurnal subcutaneous apomorphine infusion in patients with Parkinson's disease under stabilized treatment and, secondly…
- Trial name
- PHARM-APO (NCT04887467)
- Testing
- Apomorphine
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Rennes University Hospital
Chronic Disease
Evaluation of a Procedure for Identification and Brief Intervention of Lifestyle Advice Assisted by Application in a Care Setting
Chronic diseases share similar risk factors associated with four daily behaviours: unbalanced diet, sedentary lifestyle (physical inactivity and time spent sitting down), smoking and alcohol consumption.
- Trial name
- CliniCAP (NCT06616064)
- Testing
- personalised feedback and brief motivational, routine lifestyle advice, questionnaire CliniCAP
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Rennes University Hospital
Hematology
The Right Amount of Purge Useful for Blood Sampling on PiccLine (PiccLine)
An increasing number of patients are receiving central lines, including PiccLine systems for the administration of therapeutics and nutrition.
- Trial name
- PiccLine (NCT05763186)
- Testing
- Sampling, Sampling and rinsing
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Rennes University Hospital
Vascular Surgical Procedures
Pain Management of Amputation Wounds With AutoHypnosis
Amputation in vascular surgery mainly concerns the lower limb and is often linked to Obliterative Arterial Disease of the Lower Limbs.
- Trial name
- MODOUPAAH (NCT05779852)
- Testing
- self-hypnosis and dressing, dressing
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Rennes University Hospital
Childhood Cancer, Nausea with Vomiting Chemotherapy-Induced
Predict CHimio-or Radiation-induced NAusea and Vomiting in Children/adolescents Treated for Cancer
Chemo- or radiation-induced nausea and vomiting (CRVN) is one of the most frequent and feared side effects. It is a symptom that is few or not at all evaluated.
- Trial name
- PaNACHE (NCT06869005)
- Testing
- BARF scale
- Where
- 5 sites in France
- Volunteers
- 150 people
- Sponsor
- Rennes University Hospital
Peripheral Artery Disease
Exercise Testing in Peripheral Artery Disease Patients
The aim of this study was to evaluate exercise testing in case of patients suspected of Peripheral Artery Disease (PAD).
- Trial name
- ExercisePAD (NCT03186391)
- Testing
- Data collected
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Rennes University Hospital
Childhood Autism
Melatonin Dose-effect Relation in Childhood Autism
Melatonin is a neurohormone produced from serotonin which promotes sleep. The alterations in central and peripheral serotonin neurobiology and in circadian sleep-wake rhythms observed in autistic disorder suggest abnormalities in…
- Trial name
- MELADOSE (NCT01780883)
- Testing
- melatonin
- Where
- 4 sites in France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Large Granular Lymphocytes Leukemia
Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia
LGL leukemia represents a rare subtype of chronic T or NK lymphoproliferative disorders. It is an indolent disease, the main hematological or autoimmune complications lead to a treatment in more than 60% of patients.
- Trial name
- LGL (NCT01976182)
- Testing
- Methotrexate, Cyclophosphamide
- Where
- 59 sites in France
- Volunteers
- 166 people
- Sponsor
- Rennes University Hospital
Chilblains, COVID-19
COVID-19 and Chilblains
Chilblains (inflammatory lesion of the feet or hands) have been reported with an unusual frequency during the confinement period, most commonly in children, teenagers and young adults.
- Trial name
- ECCES (NCT04455308)
- Testing
- Biological sample collection
- Where
- 5 sites in France
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Pharmacokinetics
P-glypoprotein Inhibition Effect on the Pharmacokinetics of Two Tacrolimus Formulations: Prolonged and Extended-release
Tacrolimus is a drug administered orally available with different formulations: immediate release (Prograf®), prolonged-release (Advagraf®) and an extended-release one named LCP-Tacro (Envarsus®), formulated using the Melt-Dose…
- Trial name
- DIPLOID (NCT04489134)
- Testing
- Treatment A, Treatment B, Treament C
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Lymphoma, Follicular
MOLyF : Bone Marrow and Follicular Lymphoma
This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects.
- Trial name
- MOLyF (NCT06608147)
- Testing
- Sampling
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Aplasia, Chemotherapy Effect
HYPNONAG : Therapeutic Communication Versus Traditional Method for Naso-gastric Intubation in Haematology
Caloric intake is a determining factor in patients with hematological malignancies and hospitalized for prolonged aplasia following chemotherapy.
- Trial name
- HYPNONAG (NCT05790733)
- Testing
- Standard intubation, Hypnosis
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- Rennes University Hospital
Parkinson Disease
DetectFoG : Detection of Gait Freezing Episodes in Parkinsonian Patients Using Inertial Measurement Units
Parkinson's disease is the second most common neurodegenerative disease in the world. One of these manifestations is the freezing of gait (FOG) which affects 50 to 80% of Parkinsonian patients.
- Trial name
- DetectFoG (NCT05822258)
- Testing
- Walk under 3 conditions (normal, physical tasks, verbal tasks)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Sepsis, Septic Shock
ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock
Immunonutrition in intensive care has not yet demonstrated a beneficial effect on organ failure, the acquisition of nosocomial infections, or mortality.
- Trial name
- ICITRU (NCT04513288)
- Testing
- Experimental treatment L-citrulline (Protéocit®)
- Where
- 5 sites in France
- Volunteers
- 130 people
- Sponsor
- Rennes University Hospital
Cardiac Insufficiency
Epicardial Stimulation of the Cardiac Autonomic Nervous System
The objective of the EpiCANS study is to evaluate the technique of stimulation of the cardiac autonomic nervous system (SNAC) directly at the epicardial level in humans during heart surgery. Proof of concept study
- Trial name
- EpiCANS (NCT05255952)
- Testing
- Electrical stimulation
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Rennes University Hospital