Clinical trials: sponsored by Rennes University Hospital
Fecal Incontinence
Evaluation of the Efficacy and Safety of Autologous Fat Injection Into the Intersphincter Space in Fecal Incontinence: a Randomized, Placebo-controlled, Cross-over, Double-blind Trial
Fecal incontinence is frequent and has a significant impact on the quality of life of individuals. Its therapeutic management is based primarily on transit regulation and rehabilitation and secondarily on neuromodulation of the…
- Trial name
- AUTOGRAFI (NCT04972799)
- Testing
- injection of autologous fat at Day 0 and injection of saline at 6 months, injection of saline at Day 0 and injection of autologous fat at 6 months
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Liver Transplantation
APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor
The success of orthotopic liver transplantation (OLT) in treatment of liver malignancy and endstage liver disease has led to an increase in the gap between patients on waiting-lists and available liver grafts.
- Trial name
- APCext (NCT02784119)
- Testing
- temporary porto-caval shunt
- Where
- 6 sites in France
- Volunteers
- 214 people
- Sponsor
- Rennes University Hospital
Breast Feeding
Does a Diet With the Recommended Amount of Polyunsaturated Fatty Acids, Increase Their Proportion in Maternal Milk?
During pregnancy and lactation, the consumption of PUFA n-3, through the consumption of food products that contain more ALA than conventional products, could impact nutritional and non-nutritional breast milk quality (immune…
- Trial name
- ALLAITEMENT (NCT03805997)
- Testing
- Dietary advice, Consumption of Bleu-Blanc-Coeur products, No consumption of Bleu-Blanc-Coeur products
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Tricuspid Regurgitation
Evaluation of Tricuspid Valve Percutaneous Repair System in the Treatment of Severe Secondary Tricuspid Disorders
Tricuspid regurgitation (TR) is a long-overdue valvular pathology. Its prevalence is significant and increasing with the aging of the population.
- Trial name
- TRI-FR (NCT04646811)
- Testing
- Tricuspid valve, Best medical treatment
- Where
- 26 sites in Belgium, France
- Volunteers
- 300 people
- Sponsor
- Rennes University Hospital
Parkinson Disease, Oral Infection
Oral Therapeutic Education in Stimulated Parkinsonian Patients
The effect of periodontal disease on the general condition of patients remains today underestimated in Parkinson's disease. The BUCCO-PARK project aims to carry out an exploratory study of oral therapeutic education on the…
- Trial name
- BUCCO-PARK (NCT03965390)
- Testing
- Oral education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Rennes University Hospital
Infant Premature, Growth and Development
NEOVIDEO : Impact of Monitoring Motor Activity by Video Analysis on the Sleep of Very Preterm Infants
Very premature birth and the necessary hospitalization expose to a risk of morbidity and mortality which impacts the neurodevelopmental prognosis. Sleep and behavior monitoring have not been developed in the neonatal units.
- Conditions
- Infant Premature, Growth and Development, Neurologic Disorder, Sleep Fragmentation
- Trial name
- NCT04624347
- Testing
- Access to video and movement curves
- Where
- 2 sites in France
- Volunteers
- 74 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
B Cell Differentiation in MS
Interventional study with minimal risks and constraints, prospective, monocentric.
- Trial name
- ABCD-SEP (NCT03744351)
- Testing
- Biological Samples
- Where
- France
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Stenosis of Arteriovenous Dialysis Fistula
Arteriovenous Fistulae: Drug-eluting Balloon Angioplasty
Dysfunctions such as tight stenosis or thrombosis in haemodialysis vascular accesses are the leading cause of hospitalisationand morbidity in chronic haemodialysis patients incurring significant related costs estimated at over…
- Trial name
- FAVABED (NCT02913274)
- Testing
- Paclitaxel (Taxol) eluting angioplasty balloon, high-pressure angioplasty balloon, low-pressure balloon
- Where
- 10 sites in France
- Volunteers
- 115 people
- Sponsor
- Rennes University Hospital
Alcoholism, Alcohol Dependence
Study of the Neural Substrates of Alcohol Craving by High-resolution Electroencephalography
Alcohol is the most consumed psychoactive substance in France and is responsible for 49,000 deaths per year in the country. Addictions, characterized by "the repeated impossibility of controlling a behavior and the continuation…
- Trial name
- CRAVING-NET (NCT05275166)
- Testing
- Induction of alcohol craving, Questionnaires
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis and Serum Bank
Idiopathic pulmonary fibrosis (IPF) is the most common form of chronic idiopathic diffuse interstitial lung disease (DILD) in adults.
- Trial name
- FPI (NCT04016168)
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 903 people
- Sponsor
- Rennes University Hospital
Parkinson Disease
Evaluation of the Nonmotor Symptomatology of Parkinsonian Patients Treated With Two Strategies Related to Apomorphine Pump Therapy in French Hospitals
There is currently no consensus on the adequate concomitant treatment to apomorphine pump in Parkinson's disease (PD). In practice, some centers withdraw all dopaminergic agonists when initiating apomorphine pump therapy, whereas…
- Trial name
- AGAPO (NCT03693872)
- Testing
- Apomorphine, Dopaminergic Agonist + Apomorphine
- Where
- 6 sites in France
- Volunteers
- 43 people
- Sponsor
- Rennes University Hospital
Major Haemorrhage
Major Bleeding Risk Associated With Antithrombotics
Prospective, multicenter, observational study with a three-year inclusion period (from January 1, 2012 to December 31, 2015) and a 6-month follow-up
- Trial name
- SACHA (NCT02886533)
- Testing
- Antithrombotic
- Where
- 12 sites in France
- Volunteers
- 6,484 people
- Sponsor
- Rennes University Hospital
Cancer of Head and Neck
Evaluation of an Active Swallowing Rehabilitation on Quality of Life of Patients Treated by Radiotherapy for Head and Neck Cancer
Toxicity and mainly dysphagia have increased in head and neck cancers as chemoradiation indications have risen over the last decade, leading to a significant loss of quality of life for patients.
- Trial name
- RORC (NCT02892487)
- Testing
- Swallowing therapy
- Where
- 21 sites in France
- Volunteers
- 183 people
- Sponsor
- Rennes University Hospital
Septic Shock
Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline Septic Shock Patients
The benefit of low-dose steroids in septic shock is still debated today, especially with mineralocorticoids. Fludrocortisone is a synthetic mineralocorticoid, an analogue of aldosterone, which has shown, in combination with…
- Trial name
- FLUDROSEPSIS (NCT05001854)
- Testing
- Fludrocortisone
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Rennes University Hospital
Hodgkin Lymphoma
Evaluation of the Relationship Between Anti-PD-1 Exposure and Tumour VOLUME in Patients Treated for Classical HODgkin's Lymphoma.
Anti-PD-1antibodies (iPD-1) are indicated as monotherapy in the treatment of adult patients with classical LH. The recommended dosage in LH is based on solid tumour experience and no dose-concentration-effect studies have been…
- Trial name
- REVOLUMHOD (NCT04621604)
- Testing
- blood samples
- Where
- 8 sites in France
- Volunteers
- 7 people
- Sponsor
- Rennes University Hospital
Hemiparesis/Hemiplegia (One Sided Weakness/Paralysis), Gait Disorder
Isokinetic Strength Training in Hemiparetic Patient With Knee Extension Thrust
The purpose of this study is to assess the impact of an isokinetic strength training of knee flexor and extensor muscles on walking performance in hemiparetic patients with knee extension thrust.
- Trial name
- ISOWALK (NCT05887440)
- Testing
- isokinetic strength training of knee extensor and flexor muscles
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Rennes University Hospital
Distal Pancreatectomy (DP)
REinforcement of the Pancreas in distaL pAncreatectomY (REPLAY)
Despite an improvement regarding morbidity and mortality since 30 years, especially in expert centers, pancreatic surgery remains currently associated to a significant postoperative morbidity reaching more than 60%.
- Trial name
- REPLAY (NCT03030170)
- Testing
- ENDO GIA X-tra Thick reload with Tri Staple Technology, ENDO GIA Articulating Reinforced Reload with Tri-Staple Technology
- Where
- 7 sites in France
- Volunteers
- 207 people
- Sponsor
- Rennes University Hospital
Obesity
Functional Magnetic Resonance Imaging (fMRI) Exploration of Neurocognitive Processes Involved in Food Addiction (FA) in Obese Patients: Towards New Phenotypic Markers for an Optimized Care Pathway
Identification of the cerebral fMRI phenotype of obese patients with FA in cognitive task context based on food choice making
- Trial name
- AddictO (NCT03454711)
- Testing
- fMRI, Indirect calorimetry, Bioimpedance
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Rennes University Hospital
Prostate Cancer, Androgen-deprivation Therapy
Androgen-Deprivation Therapy and Cardiovascular Risk: A Nationwide Population-based Cohort Study
The research focuses on the safety profile of androgen-deprivation therapy (ADT). The hypothesis is that safety issue, as regards to cardiovascular risk, is not homogenous across the spectrum of androgen-deprivation therapy…
- Trial name
- ADTCR (NCT02895230)
- Testing
- Standard care
- Where
- France
- Volunteers
- 38,690 people
- Sponsor
- Rennes University Hospital
Blood Concentration of Tacrolimus Metabolites
Dosage of Tacrolimus Metabolites in Blood and Bile for Prediction of Its Side Effects in Liver Transplant Recipients
The purpose of this study is to evaluate if concentration of tacrolimus metabolites is increased in patients presenting tacrolimus (TAC) side effects.
- Trial name
- STABILE 2 (NCT05277792)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital