Clinical trials: sponsored by Rennes University Hospital
Surgical Technique
Impact of Side to Side Gastrojejunostomy on the Rate of Delayed Gastric Emptying After Pancreaticoduodenectomy (IPAD)
Prospective bi-centric randomized open-label study comparing side to side and end to side gastrojejunostomy in pancreaticoduodenectomy
- Trial name
- IPAD (NCT04742166)
- Testing
- Reconstruction
- Where
- 2 sites in France
- Volunteers
- 166 people
- Sponsor
- Rennes University Hospital
Hypertension in Pregnancy
Hypertensive Pregnant Women Monitored by Teletransmitted Self-measurements of Blood Pressure
The occurrence of arterial hypertension (AH) during pregnancy is a major cause of fetal, neonatal and maternal morbidity and mortality in western countries.
- Trial name
- FETH (NCT03648645)
- Testing
- Self measurement of blood pressure
- Where
- 5 sites in France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Stroke
HAptic Neurofeedback Design for Stroke
Interventional study with minimal risks and constraints, prospective, monocentric.
- Trial name
- HANDS (NCT04130711)
- Testing
- Visual virtual Conditions, Standard EEG, Neurofeedback Training Stroke Patients
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Craniocerebral Trauma
Pilot Study of the Use of a Portable Cranial Scanner in Intensive Care for Cerebro-injured Patients
Cerebral scans are a key examination in the management of serious brain-injured patients in intensive care, and are often repeated in the initial phase.
- Trial name
- ESPER (NCT05891522)
- Testing
- portable scanner, fixed scanner
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Rennes University Hospital
Acute Lymphoblastic Leukemia (ALL)
Potential Role of CD9 and Implication of Motility Process in Pathogenesis of TEL/ALM1-positive ALL Relapses (LAL TEL/ALM1 and CD9).
Down regulation of CD9 in TEL/AML1-positive ALL is addressed in motility assays to explore its role in B-ALL pathogenesis and its potential implication in relapses (and prognosis).
- Trial name
- LAL TEL/ALM1 (NCT01282593)
- Testing
- Impact of CD9 expression level on motility assays, Post-transcriptional regulation of CD9
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Rennes University Hospital
Iron Overload, Metabolic Syndrome X
Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging
Iron excess is increasingly regarded as an important cofactor in the morbidity attributed to many disorders. Assessment of body iron stores by measurement of serum ferritin concentrations has poor specificity and the most…
- Conditions
- Iron Overload, Metabolic Syndrome X, Hepatitis B, Hepatitis C
- Trial name
- SURFER (NCT00401336)
- Testing
- Magnetic resonance imaging multiecho gradient-echo sequence
- Where
- 10 sites in France, Spain
- Volunteers
- 250 people
- Sponsor
- Rennes University Hospital
Effects of Neurotoxicants on the Brain
PERINE : Effect of Prenatal Exposure to Neurotoxicants on the Developing Brain : an MRI Study
This project aims at evaluating the consequences of prenatal exposure to neurotoxicants (solvents, organophosphate pesticides) on the developing brain, in children aged from 10 to 12 years.
- Trial name
- PERINE (NCT02125110)
- Testing
- MRI, neuropsychological assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Cystic Fibrosis, Aspergillus Infections
ATCF (Azole Therapy in Cystic Fibrosis)
Aspergillus infection is an infectious complication which frequently occurs in cystic fibrosis. The efficacy of azole therapy in patients with cystic fibrosis with persistent positive sputums for Aspergillus is still unknown.
- Trial name
- ATCF (NCT01576315)
- Testing
- Itraconazole/voriconazole
- Where
- 15 sites in France, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital
Hemiplegic Cerebral Palsy
PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy
This is a randomized and comparative prospective test, monocentric and controlled (mirror therapy versus bimanual rehabilitation exercises), in single-blind (investigator and occupational therapist " 1 " do not know the type of…
- Trial name
- PC MIROIR (NCT02131909)
- Testing
- mirror therapy, bimanual rehabilitation exercises
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Atrioventricular Block
Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing
The SEPTAL-PM study is aimed to compare the right ventricular apical and right ventricular septal position of the right ventricular lead in patients implanted with a pacemaker for conventional anti-bradycardia pacing indications…
- Trial name
- SEPTAL-PM (NCT00925691)
- Testing
- RV lead
- Where
- 5 sites in France
- Volunteers
- 141 people
- Sponsor
- Rennes University Hospital
Epilepsy
Contribution of High Resolution EEG Functional Connectivity Measures to Presurgical Evaluation of Patients With Intractable Epilepsy
Electroencephalography (EEG) with very high spatial resolution (HR-EEG, 256 electrodes) allow for better analysis of local and global activity of the cerebral cortex, as compared with conventional EEG.
- Trial name
- conneXion (NCT01738516)
- Testing
- Electroencephalography, Electroencephalography and additional experimental tasks
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Congenital Malformation
Pregnancy Environment and Newborn Malformations
Congenital malformations rate is about 3% in France. There are already 5 registries in France, covering about 16% of French births: Paris Registry, (about 38 000 births /year), Alsace Registry, (about 23 000 births/year)…
- Trial name
- PENEW (NCT01613638)
- Testing
- meconium samples + maternal self-questionnaire
- Where
- 11 sites in France
- Volunteers
- 1,657 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Nephropathy
Interest of Remote Ischemic Preconditioning for Prevention of Contrast Medium-induced Nephropathy in High Risk Patients
Diagnostic imaging for vascular investigations and endovascular procedures frequently require the use of contrast medium. Besides contrast medium-induced hypersensitivity, an acute kidney injury can appear: the contrast-induced…
- Trial name
- IPC-Angio (NCT02470247)
- Testing
- Remote Ischemic Preconditioning (RIPC)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Rennes University Hospital
Traumatic Injuries
Utility of Whole-body MRI in the Detection of Traumatic Injuries of Undetermined Origin in Children
The diagnosis of abuse in children relies heavily on the presence of skeletal and extraskeletal injuries. However, some lesions are not seen by initial skeletal survey.
- Trial name
- PEDIMA (NCT01743703)
- Testing
- diagnostic whole body MRI
- Where
- France
- Volunteers
- 199 people
- Sponsor
- Rennes University Hospital
Alzheimer's Disease
Knowing and Remembering: Cognitive and Neural Influences of Familiarity on Recognition Memory in Early Alzheimer's Disease
Unrandomized, unblinded, monocentric comparative Functional Magnetic Resonance Imaging study.
- Trial name
- EPMR-MA (NCT02492529)
- Testing
- Neuropsychological tests, A cranial MRI, Experimental procedure
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
IL-2 Signaling and Polarization of Regulatory LBs: Involvement in Multiple Sclerosis
Multiple sclerosis (MS) has long been considered a disease mediated primarily by CD4+ T cells. However, recent clinical trials demonstrating significant efficacy of B-lymphocyte depletive therapies have highlighted the major role…
- Trial name
- BREGS (NCT04697407)
- Testing
- Blood sampling, CSF sampling
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Acute Lymphoblastic Leukemia, Philadelphia Chromosome
Safety and Efficacy of Imatinib Added to Chemotherapy in Treatment of Ph+ Acute Lymphoblastic Leukemia in Children
The purpose of this study is to determine whether Imatinib is safe and effective in association with intensive treatment of Ph+ALL in children.
- Trial name
- ESPHALL (NCT00287105)
- Testing
- Standard chemotherapy + Imatinib
- Where
- 22 sites in France
- Volunteers
- 49 people
- Sponsor
- Rennes University Hospital
Asthma
Clinical Effectiveness and Economical Impact of Medical Indoor Environment Counselors Visiting Homes of Asthma Patients
Asthma is one of the most prevalent chronic respiratory diseases, with potential lifethreatening impacts. Indeed, asthma is still responsible for about a thousand deceases per year in France, and constitutes a public health…
- Trial name
- ECENVIR (NCT02212483)
- Testing
- First home intervention with advice, First home intervention without any advice, Final home visit
- Where
- 16 sites in France
- Volunteers
- 107 people
- Sponsor
- Rennes University Hospital
Double Enterostomy
Restoring the Beneficial Effects of Enterohepatic Bile Salt Signalling by Chyme Reinfusion in Patients With a Double Enterostomy
Multicentre prospective human experimental study to determine the effect of chyme reinfusion in patients with a double enterostomy on plasma levels of Fibroblast Growth Factor (FGF19)
- Trial name
- RESCUE (NCT02990195)
- Testing
- Chyme reinfusion
- Where
- 3 sites in France, Netherlands
- Volunteers
- 13 people
- Sponsor
- Rennes University Hospital
Physical Activity
Sensors for HEalth Recording and Physical Activity Monitoring
The SHERPAM project is part of a scientific and technological context which aim is to record, transmit, analyse the physiological parameters of a patient, as well as to record the feedback to the patient and health professional…
- Trial name
- SHERPAM (NCT03673189)
- Testing
- sensors
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital