Clinical trials: sponsored by Rennes University Hospital
Type 1 Diabetes
Insulin Pump-RT Advisor (IPRA©): a Decision Support Software for Diabetic Patients Treated by Insulin Pump and Using Continuous Glucose Monitoring. Experimental Study. Evaluation by an Expert Patient Panel.
The purpose of the study is to assess the relevance of the advices provided by the IPRA© smartphone application for guiding the responses of insulin pump treated type 1 diabetes patients using real-time continuous glucose…
- Trial name
- IPRA (NCT01883024)
- Testing
- A decision support software, Insulin Pump, Continuous glucose monitoring
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Rennes University Hospital
Infection
Development of an Adjustment Assistance Tool Dosage of Fluoroquinolones in a Population Pharmacokinetic Model
Fluoroquinolones (FQ) are among pivotal antibiotic treatments in difficult-to-treat infections. Their efficacy has been shown to be linked to the ratio area under the curve (AUC) of their plasma concentrations over the minimum…
- Trial name
- FLUO-POP (NCT02357407)
- Testing
- Patients in intensive care : infection treated with ciprofloxacin IV, Osteoarticular infected patients : infection treated with oral ofloxacin
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Rennes University Hospital
Left-sided Hemiplegia Affecting Dominant Side as Late Effect of Cerebrovascular Accident
Balance Rehabilitation With Sensory Recalibration After Stroke
The main objective of this study is to test the effectiveness of a rehabilitation program with cervical vibration and/or prism adaptation in patients with left hemiplegia on balance.
- Trial name
- AVCPOSTIM (NCT01677091)
- Testing
- Cervical vibration, Prism adaptation, Conventional rehabilitation
- Where
- 8 sites in France
- Volunteers
- 114 people
- Sponsor
- Rennes University Hospital
Melanoma
cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project
Background: Metastatic melanoma has a devastating prognosis and is one of the top causes of cancer death in young patients. Until now, available therapies were few and unreliable, but recent understanding of melanomas' molecular…
- Trial name
- KitMel (NCT01543113)
- Testing
- sequencing
- Where
- 2 sites in France
- Volunteers
- 288 people
- Sponsor
- Rennes University Hospital
Healthy Volunteers, Overweight
Evaluation of Body Iron Stores in Overweight Healthy Volunteers
Normal body iron store value in overweight subjects is currently not described in literature. The comparison of this value with body iron levels in patients suffering from dysmetabolic iron overload syndrome (DIOS) could allow to…
- Trial name
- FERNORM (NCT02304874)
- Testing
- Phlebotomy
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Epilepsy
Contributions From the Analysis of Graphs for Identification of Neural Cliques
The aim of the study is to demonstrate that our semantic knowledge (elements of our long-term memory and the process we use them) respond to a graphic organisation and gather together following accurate patterns called cliques…
- Trial name
- BRAINGRAPH (NCT02305771)
- Testing
- Electroencephalography, MRI
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Type 1 Diabetes
Assessment of a New Closed-loop Algorithm in Type 1 Diabetes (Saddle Point Model Predictive Control : SP-MPC) (PPA)
The purpose of the study is to assess a new closed-loop algorithm in type 1 diabetes (Saddle Point Model Predictive Control : SP-MPC)
- Trial name
- PPA (NCT02061488)
- Testing
- open-loop night, closed-loop night
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Rennes University Hospital
Coronavirus
COVID 19 : Seroprevalence Study of Anti SRAS-CoV-2 Antibodies in GHT Employees in Haute Bretagne (AntiCoV-HB)
Since the start of this epidemic, numerous clinical and fundamental studies have been conducted to best adapt the individual management of COVID-19 cases [1-6].
- Trial name
- AntiCoV-HB (NCT04416308)
- Testing
- NG test, Blood test, Self-questionnary
- Where
- 9 sites in France
- Volunteers
- 9,453 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Spina Bifida
Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial
Spina Bifida is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube, leading to serious malformations of the nervous system.
- Trial name
- IRRICO (NCT02361450)
- Testing
- Retrograde Colonic Irrigation, Usual Care
- Where
- 6 sites in France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Chronic Renal Failure (CRF)
Evaluation of Electrostimulation Program During Dialysis Sessions in Chronic Renal Failure Patients
Sport improves quality of life and health, decreasing cardiovascular risks and increasing effort tolerance. Chronic renal failure (CRF) induces many clinical and biological complications leading to less effort tolerance (strength…
- Trial name
- EMS-Dialyse (NCT01282554)
- Testing
- electrostimulation program (Rehab 400)
- Where
- 11 sites in France
- Volunteers
- 68 people
- Sponsor
- Rennes University Hospital
Spine Surgery, Low Back Pain
Transverse Abdominis Plane Block for Anterior Approach Spine Surgery
Therapeutic, prospective, randomized, double blind, placebo-controlled, in intention to treat, monocentric study to evaluate the analgesic efficacy of a bilateral TAP block after spine surgery with 24 hours morphine consumption
- Conditions
- Spine Surgery, Low Back Pain, Spondylolisthesis
- Trial name
- TAP ALIF (NCT02884440)
- Testing
- TAP block ropivacaine, General anesthesia
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Rennes University Hospital
Hepatic Transplantation
Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)
The choice of an immunosuppressant after hepatic transplant is now more difficult than before because of the increasing number of drugs available.
- Trial name
- NCT01388387
- Testing
- Tacrolimus pharmacokinetics
- Where
- France
- Volunteers
- 154 people
- Sponsor
- Rennes University Hospital
Peripheral Arterial Diseases, Intermittent Claudication
Lower Extremity Peripheral Arterial Disease and Exercise Ischemia
Lower extremity peripheral arterial disease (LEPAD) is a highly prevalent chronic disease. Cardiovascular mortality of LEPAD patients at five years ranges between 18 to 30%.
- Trial name
- CLASH (NCT02041169)
- Testing
- Subsequent walking performance
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Thoracoscopy
Assessment of Cone-beam Computed Tomography (CBCT) Assistance to Video-assisted Thoracoscopic Surgery
In the coming years, an increase in lung nodule resection is expected, particularly in Video-assisted thoracoscopic surgery (VATS). In some situations, it is necessary to use a device for locating these nodules.
- Trial name
- CAVIT (NCT02966847)
- Testing
- CBCT acquisition, Anesthesia and surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Cardiac Resynchronization Therapy
Revisit the Value of Imaging in Best Using CArdiac Resynchronization Therapy
Many studies have shown the benefits of cardiac resynchronization therapy (CRT) with biventricular pacing in patients with heart failure with left ventricular dysfunction.
- Trial name
- RICART (NCT02528032)
- Testing
- Echographic evaluation of heart function
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Parkinsons's Disease
Efficacy of Continuous Apomorphine Infusion on Cognitive and Neuropsychological Functions in Parkinson's Disease
In Parkinson's disease, treatment mainly aims to improve motor functions. However, other dysfunctions are often observed in Parkinson's patients, and may have important consequences on the quality of life of patients.
- Trial name
- APO-TEP (NCT01039090)
- Testing
- Continuous Apomorphine infusion, Usual dopaminergic per os treatment
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Rennes University Hospital
Neurocognitive Correlates of Eating Habits
Hed-O-Shift: Hedonic and Neurocognitive Processes in Relation to Dietary Habits and Weight Status
This study includes an inclusion visit, 2 visits to the Rennes University Hospital and the filling of two on-line questionnaires.
- Trial name
- Hed-O-Shift (NCT03076489)
- Testing
- First Visit, on-line questionnaires, fMRI
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Premature Birth
Influence of Physical Treatments of Human Milk on the Kinetics of Gastric Lipolysis in Preterm Newborns
The optimization of newborns nutrition is a challenge especially for preterm newborns for whom nutrition plays a crucial part in cerebral and global development. Human milk is considered as the best food for newborns.
- Trial name
- ARCHILACT (NCT02112331)
- Testing
- Raw human milk, Pasteurized human milk, Pasteurized-homogenized human milk
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Rennes University Hospital
Stroke
General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke
In France, the annual incidence rate of acute ischaemic stroke is around 150 000 patients, 65 % of whom keep long-term disability.
- Trial name
- GASS (NCT02822144)
- Testing
- Etomidate, Succinylcholine, Propofol
- Where
- 4 sites in France
- Volunteers
- 351 people
- Sponsor
- Rennes University Hospital
Chronic Obstructive Pulmonary Disease
Detection of COPD in Primary Care
Chronic obstructive pulmonary disease (COPD) is a common chronic disease with a significant medical and economic impact. Its prevalence is increasing and is estimated at 7.5% of people over 40 in France.
- Trial name
- DISCO (NCT03046199)
- Testing
- Questionnaire, Coordination
- Where
- France
- Volunteers
- 3,162 people
- Sponsor
- Rennes University Hospital