Clinical trials: sponsored by Research Inc
CHF - Congestive Heart Failure, COPD
Transitional Care Model Evaluation 2020
The study is a randomized controlled trial to estimate the effects of the transitional care model (TCM) on hospital admissions and patients' experience during the year following the patient's qualifying discharge.
- Conditions
- CHF - Congestive Heart Failure, COPD, Pneumonia
- Trial name
- TCM2020 (NCT04212962)
- Testing
- Transitional care model (TCM), Usual care
- Where
- United States
- Volunteers
- 962 people
- Sponsor
- Mathematica Policy Research, Inc.
Depressive Disorder, Major
Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults With Depression
In this project, the investigators use real-time fMRI neurofeedback (rtfMRI-nf) to causally relate dysfunction of right anterior insula (rAI) and right superior temporal sulcus (rSTS) connectivity with the intensity of repetitive…
- Trial name
- CNF-RNT (NCT06219681)
- Testing
- Active neurofeedback
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Methamphetamine Abuse
Mood and Decision-making in Methamphetamine Use Disorder
In this project, the investigators examine behavior and associated brain activity during explore-exploit decision-making tasks performed pre- and post-modulation of affective state using autobiographical memory recall.
- Trial name
- MDM-MUD (NCT06410196)
- Testing
- Mood modulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Hypertension
'Eat Well' Produce Prescription RCT
This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will study how a produce prescription (PRx) program called "Eat Well" affects Veterans' health and how often they use healthcare services.
- Trial name
- NCT07534501
- Testing
- Eat Well 6-months, Eat Well 12-months
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Institute for Medical Research, Inc.
Sarcopenia, Body Composition
Validation of a Body-Composition Segmentation Software on a Diverse Public CT Scan Cohort
This study evaluates the standalone performance of Soma, a deep-learning software developed by Nucleo Research, Inc. for the automated segmentation of body-composition tissues (skeletal muscle, subcutaneous adipose tissue…
- Conditions
- Sarcopenia, Body Composition, Obesity
- Trial name
- SOMA (NCT07600866)
- Testing
- Soma Body-Composition Segmentation Software
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nucleo Research, Inc.
Myalgic Encephalomyelitis, Long-COVID
Low Dose Rapamycin in ME/CFS, Long-COVID, and Other Infection Associated Chronic Conditions
The goal of this observational study is to assess the clinical response and the effect of autophagy function in patients before, during and throughout oral low dose sirolimus (rapamycin) therapy.
- Trial name
- NCT06257420
- Testing
- Rapamycin
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Simmaron Research Inc.
Depressive Disorder, Major
Neuroimaging Study for Decoding Emotional States and Identifying Neural Circuits to Disengage From Negative Thinking
The purpose of this study is to decode different thinking states from the brain activation patterns and identify the neural circuits that disengage from these thinking patterns using functional magnetic resonance imaging (fMRI)…
- Trial name
- RNT-decoding (NCT06254144)
- Testing
- functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Major Depressive Disorder
ANTIVIRAL TREATMENT OF CYTOMEGALOVIRUS IN DEPRESSION
This study aims to determine whether treatment of CMV positive (CMV+) individuals with major depressive disorder (MDD) with valganciclovir (VGCV) alters neural circuitry, reduces inflammation, and improves depressive behavior and…
- Trial name
- NCT04724447
- Testing
- Valganciclovir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Major Depressive Disorder
Neural Response to Inflammatory Challenge in Major Depressive Disorder
This is a parallel group, double-blinded, placebo-controlled study. Participants with MDD (n=90) and HC (n=90) will be randomly assigned (2:1) to receive either lipopolysaccharide (LPS) (0.8ng/kg of body weight) or placebo (same…
- Trial name
- NCT04751331
- Testing
- LPS, Saline
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
PTSD and Trauma-related Symptoms
LIFU Mechanisms for PTSD in Healthcare Workers
The goal of this clinical trial is to evaluate whether low-intensity focused ultrasound (LIFU) of the ventral anterior cingulate cortex (vACC) can normalize dysfunctional brain activation patterns and behaviors in frontline…
- Trial name
- NCT07164105
- Testing
- Low intensity focused ultrasound
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Depression
Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression
This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression.
- Trial name
- NCT06263660
- Testing
- Keto-like supplement
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Bipolar Disorder I or II, Healthy (Controls)
Decoding Emotional Dynamics in Bipolar Disorder
The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability.
- Trial name
- NCT07221864
- Testing
- Think and Regulate Affective State Task
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Child Abuse Sexual
Evaluation of Circles of Safety
Using a matched cluster randomized control design, the proposed study will evaluate a child sexual abuse (CSA) primary prevention strategy, Circles of Safety®.
- Trial name
- NCT07526142
- Testing
- Circles of Safety
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Center for Violence Prevention Research Inc
Stress Disorders, Post-Traumatic
A Study of a Novel EEG Neurofeedback System for PTSD Treatment
The goal of this clinical trial is to learn if training with the Prism system can reduce PTSD symptoms in US military Veterans and civilians with PTSD.
- Trial name
- NCT06770998
- Testing
- EEG-neurofeedback training
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- Foundation for Atlanta Veterans Education and Research, Inc.
Disability
Vermont RETAIN Impact Evaluation
The Retaining Employment and Talent after Injury/Illness Network (RETAIN) demonstration is a collaborative effort between the U.S.
- Trial name
- NCT05146362
- Testing
- Vermont RETAIN
- Where
- United States
- Volunteers
- 798 people
- Sponsor
- Mathematica Policy Research, Inc.
Disability
Ohio RETAIN Impact Evaluation
The Retaining Employment and Talent after Injury/Illness Network (RETAIN) demonstration is a collaborative effort between the U.S.
- Trial name
- NCT05219045
- Testing
- Ohio RETAIN
- Where
- United States
- Volunteers
- 4,525 people
- Sponsor
- Mathematica Policy Research, Inc.
Treatment-Resistant Depression
Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression
Approximately one third of individuals with Major Depressive Disorder (MDD) are considered treatment-resistant, subject to severe disability and risk of suicide, and exhibit symptoms anchored in abnormalities of Research Domain…
- Trial name
- LIFU CANVAS (NCT07166289)
- Testing
- Low-intensity focused ultrasound
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Chronic Hand Eczema
Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy
This study aims to evaluate the safety, efficacy and tolerability of abrocitinib in subjects with moderate to severe chronic hand eczema, and its effects on skin biomarkers using a noninvasive method of tape stripping.
- Trial name
- NCT06283550
- Testing
- Abrocitinib 200 mg, Abrocitinib 100 mg
- Where
- 12 sites in Canada, Poland
- Volunteers
- 82 people
- Sponsor
- Innovaderm Research Inc.
Healthy
BPIT 5-Line Pilot: Interventional Study on Strength, HRV & Injury Risk Reduction (n=23)
This prospective, single-center, interventional pilot (n=23) evaluates the 5-Line Principle of Balanced Intensity Training (BPIT) over 6 weeks at GFFI Fitness Academy.
- Trial name
- BPIT 5-Line (NCT07296640)
- Testing
- BPIT 5-Line Training
- Where
- India
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.
Physical Fitness
BPIT 5-Week Multi-Site Study: Movement Efficiency, Mobility & Neuromuscular Adaptation
This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years.
- Trial name
- BPIT_5LINE_369 (NCT07256717)
- Testing
- Balanced Progressive Intensity Training (BPIT) 5-Line Method
- Where
- 10 sites in United States, India
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.