Clinical trials: sponsored by Ruijin Hospital
Parkinson's Disease (PD)
STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease
The goal of this clinical trial is to compare the efficacy and safety of different Intervention Intervals of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) in patients with Parkinson…
- Trial name
- NCT07774312
- Testing
- STN-tTIS Once Weekly, STN-tTIS Twice Weekly, STN-tTIS Five Times Weekly
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Functional Gastrointestinal Disorders (FGIDs), Infant Discomfort
Effects of Goat Milk Formula on Gastrointestinal Comfort and Growth in Infants
Infant gastrointestinal discomfort is common in early life and can affect feeding, sleep, and overall well-being. Goat milk formula, due to its unique protein composition and smaller fat globules, may be easier to digest and…
- Trial name
- NCT07778927
- Testing
- Goat Milk Formula, Cow Milk Formula
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Parkinsonian Disorders, Machine Learning
Machine Vision Based MDS-UPDRS III Machine Rating
The Movement Disorders Society (MDS) Unified Parkinson's Disease Rating Scale (UPDRS) Part III (MDS-UPDRS III) is the primary assessment method for motor symptoms in Parkinson's disease patients.
- Trial name
- NCT05906719
- Testing
- video recording
- Where
- 8 sites in China
- Volunteers
- 1,679 people
- Sponsor
- Ruijin Hospital
Solid Tumor
Clinical Applications of FAPI PET in Solid Tumors
The study systematically evaluates the diagnostic performance of FAPI-RuiJ and FAPI-04 PET/CT or PET/MR in various solid tumor types, and is expected to provide a novel molecular imaging tool for early lesion detection, accurate…
- Trial name
- NCT07776899
- Testing
- FAPI-RuiJ, FAPI-04
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Essential Tremor
Non-Invasive Neuromodulation for Essential Tremor: Long-Term Safety and Effectiveness Study
This is a prospective, single-center, single-arm, open-label clinical study designed to evaluate the long-term efficacy and safety of non-invasive neuromodulation using transcutaneous afferent patterned stimulation (TAPS) in…
- Trial name
- NCT07774598
- Testing
- Transcutaneous Afferent Patterned Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Lymphoma, B-Cell Refractory
Exploration of Circular RNA in B-cell Hematologic Malignancies
This is an investigator-initiated, open-label, single-arm, dose-escalation study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics (PD), and preliminary efficacy of an in vivo circular RNA chimeric…
- Trial name
- NCT07774572
- Testing
- Investigational product (IP)
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
DLBCL
Pirtobrutinib Combined With BEAM for ASCT in Relapsed and Refractory DLBCL
This trial is a prospective, multi-center, single-arm clinical research. The intention is to evaluate the efficacy and safety of pirtobrutinib combined with BEAM as a pretreatment regimen for ASCT in relapsed and refractory DLBCL…
- Trial name
- NCT07774299
- Testing
- pirtobrutinib combined with BEAM
- Volunteers
- 28 people
- Sponsor
- Ruijin Hospital
Multiple System Atrophy
A Prospective Exploratory Study of the Safety and Preliminary Efficacy of the α-Syn H21 Monoclonal Antibody in Patients With Multiple System Atrophy
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by autonomic dysfunction, parkinsonism, and cerebellar ataxia.
- Trial name
- NCT07774585
- Testing
- α-Syn H21 Monoclonal Antibody
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Ruijin Hospital
Health, Children, Only
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude
Microbes and the human body maintain a complex relationship of interaction and influence. Different regions, altitudes, and dietary habits have different degrees of influence on the composition of children's intestinal flora.
- Conditions
- Health, Children, Only, Gut Microbiota
- Trial name
- NCT06157346
- Where
- China
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Emergence Delirium, Anesthesia
Study on the Correlation Between Plasma Orexin Levels During the Recovery Period and Emergence Delirium in Elderly Patients
To explore the relationship between plasma orexin levels during the recovery period of elderly patients undergoing general anesthesia and the occurrence of emergence delirium, and to evaluate its sensitivity and specificity as an…
- Trial name
- NCT07726875
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Gastric Cancer
IBI343 Combined With Sintilimab Plus Chemotherapy in Gastric Cancer
This is a Single-arm, Open-label, Phase 1b/2 Study of IBI343 Combined with Sintilimab Plus Chemotherapy in Previously Untreated, Claudin (CLDN) 18.2-positive, HER2-negative, Locally Advanced Unresectable or Metastatic Gastric or…
- Trial name
- NCT07025889
- Testing
- IBI343, Sintilimab, Oxaliplatin
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Ruijin Hospital
Atrial Fibrillation, Persistent, Arrhythmias, Cardiac
Using Cryoballoon Ablation as Initial Treatment for Persistent Atrial Fibrillation
This study is to assess the effectiveness and safety of using cryoballoon ablation comparing with anti-arrhythmic drug therapy as initial treatment for naive patients with persistent atrial fibrillation.
- Trial name
- Cryo-InitialAF (NCT04942834)
- Testing
- Antiarrhythmic drug including Propafenone, Sotalol, Dronedarone and Amiodarone, cryoballoon ablation
- Where
- 17 sites in China
- Volunteers
- 320 people
- Sponsor
- Ruijin Hospital
IgA Nephropathy
The Chinese Registry of Prognostic Study of IgA Nephropathy (CRPIGA)
1. Establish an IgAN cohort collaboration group and expert committee to carry out registration research. 2. Construct IgAN structured data set standards, formulate structured data collection templates of diagnosis and treatment …
- Trial name
- NCT04858724
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Cow's Milk Protein Allergy
Dietary Restriction Efficiency Assessment in CMPA
This clinical trial aims to evaluate and compare the efficacy of amino acid formula (AAF) and extensively hydrolyzed formula (eHF) in relieving symptoms in infants suspected of cow's milk protein allergy (CMPA) during the…
- Trial name
- NCT07199023
- Testing
- Amino Acid Formula (AAF), Extensively Hydrolyzed Formula (eHF)
- Volunteers
- 360 people
- Sponsor
- Ruijin Hospital
Adult-Onset Still's Disease
Therapeutic Value of Sirolimus in Refractory Adult-Onset Still's Disease
This study aims to further evaluate the anti-inflammatory effects of the mTOR inhibitor sirolimus in patients with adult-onset Still's disease (AOSD), and to verify whether it can reduce inflammation and control disease activity…
- Trial name
- NCT07151157
- Testing
- add-on sirolimus therapy
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Ruijin Hospital
Cervical Cancer
Adjuvant Concurrent Chemoradiotherapy Versus Radiotherapy in Early-stage Cervical Cancer Patients
To evaluate if adjuvant concurrent chemoradiotherapy is associated with a recurrence-free survival benefit in comparison with radiotherapy alone in selected intermediate risk cervical cancer after radical surgery.
- Trial name
- NCT05277688
- Testing
- adjuvant concurrent chemoradiotherapy, radiotherapy
- Where
- 2 sites in China
- Volunteers
- 340 people
- Sponsor
- Ruijin Hospital
Mild Allergic Symptoms in Infants, Infant Feeding Intolerance
Partially Hydrolyzed Whey Protein Formula for Infants With Mild Allergy
This study is a prospective, multicenter, randomized controlled trial designed to evaluate the clinical efficacy, tolerance, and safety of a partially hydrolyzed whey protein formula in infants with mild allergic symptoms.
- Trial name
- NCT07449507
- Testing
- Partially Hydrolyzed Whey Protein Formula, Intact Cow's Milk Protein Formula
- Volunteers
- 160 people
- Sponsor
- Ruijin Hospital
Chronic Total Occlusion, Coronary Artery Disease
Risk Factors and Outcomes in Coronary Chronic Total Occlusion
This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
- Trial name
- NCT06137521
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
Small-cell Lung Cancer
Phase II Trial of Consolidative Thoracic Radiotherapy for ES-SCLC After Standard Care of Chemo-immunotherapy
This is an open-label, single arm Phase II study designed to evaluate the efficacy and safety of thoracic radiotherapy for extensive-stage small-cell lung cancer treated with PD-1/PD-L1 plus etoposide platinum followed by…
- Trial name
- NCT05552846
- Testing
- thoracic radiotherapy
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Ruijin Hospital
Breast Cancer Invasive
Precision Regional Node Irradiation for Sentinel Node-positive Breast Cancer
Axillary lymph node dissection has long been regarded as standard if treatment of the axilla is indicated for patients with a positive sentinel node.
- Trial name
- NCT06583655
- Testing
- SLND(clinical low risk), SLND(clinical high risk, genomic low risk), SLND alone ,clinical high risk and genomic high risk group
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Ruijin Hospital