Clinical trials: sponsored by Rush University Medical Center
Acquired Immune Deficiency Syndrome
Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV Disease
The ideal anti-HIV medications for patients with advanced HIV disease is unknown. There is evidence that anti-HIV regimens that contain protease inhibitors can enhance immune function better than regimens that do not contain…
- Trial name
- NCT00775606
- Testing
- Lopinavir 400 mg/ritonavir 100 mg, Efavirenz
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Rush University Medical Center
Glioblastoma, Gliosarcoma
Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas
This is a single-center, open-label, non-randomized, Phase I/IIa study to investigate the safety, tolerability, and antitumor efficacy of AXL1717 (picropodophyllin as active agent formulated in an oral suspension; PPP) in…
- Conditions
- Glioblastoma, Gliosarcoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- AXL1717 (NCT01721577)
- Testing
- AXL1717
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center
Metastatic Breast Cancer
Phase II Open-Label Trial of Tarceva in Women With Metastatic, Hormone- and HER2-Negative Breast Cancer
The goal of this trial is to determine the activity of erlotinib in a rationally selected population of women with ER-negative, PR-negative, HER2/neu-negative, EGFR-positive breast cancer.
- Trial name
- NCT00597597
- Testing
- Erlotinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Rush University Medical Center
Diabetes
Carbohydrate Consumption as a Factor in Aspart Dosing
Good sugar control in postoperative hospitalized patient has been shown to improve wound healing and infection rates. However, sugar control is difficult to achieve and suboptimal use of insulin is thought to be a contributory…
- Trial name
- CARB (NCT01333514)
- Testing
- aspart, aspart- Insulin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rush University Medical Center
Family Members, Post Intensive Care Unit Syndrome
Psychological Symptoms and Families of COVID-19 Patients
Families of patients in Intensive Care Units (ICUs) are at increased risk for developing psychological symptoms that can last for months after the patient is discharged.
- Conditions
- Family Members, Post Intensive Care Unit Syndrome, Post Traumatic Stress Disorder
- Trial name
- NCT04501445
- Testing
- Written Summary of Rounds
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rush University Medical Center
Transmission, Patient-Professional
The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations
Due to the concerns of virus transmission during COVID-19 pandemic, multiple respiratory societies postpone or limit pulmonary function test, especially cardiopulmonary exercise test (CPET), as patients may generate large amount…
- Trial name
- NCT04526925
- Testing
- Respiratory filter in-line placed with the standard mouthpiece, Standard mouthpiece
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Father - Child Relations
The Dedicated African American Dad Study
The number of children living apart from their fathers has grown nationally, and the greatest percentage is evident among African American (AA) families; two-thirds of all African American children live in households without…
- Trial name
- DAAD (NCT02412748)
- Testing
- BBTF Intervention, Financial Literacy Program
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Evaluating Vitamin D3 Supplement on Post-Op Outcomes
The aim of this study is to determine if vitamin D supplementation is associated with differences in short-term recovery in patients following total knee arthroplasty compared to patients who do not receive supplementation.
- Trial name
- NCT04177758
- Testing
- Vitamin D, Control
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Rush University Medical Center
Ruptured Aneurysm, Memory Deficits
Memory Training in Aneurysmal Subarachnoid Hemorrhage Patients
The study aim is to determine if periodic online cognitive exercises (Lumosity) improve memory function in ruptured cerebral aneurysm patients with disabling baseline memory deficits within the first 24 months after rupture.
- Conditions
- Ruptured Aneurysm, Memory Deficits, Subarachnoid Hemorrhage
- Trial name
- MASH (NCT02864940)
- Testing
- Lumosity, Crossword puzzle
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rush University Medical Center
Proliferative Diabetic Retinopathy
Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging
Diabetic neovascularization refers to a type of diabetic retinopathy which is worsening by the abnormal growth of blood vessels in the back of the eye, damaging the retina.
- Trial name
- NCT00606138
- Testing
- ranibizumab, Laser photocoagulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rush University Medical Center
Metastatic Breast Cancer, Advanced Breast Cancer
Patterns of Prescribing and Monitoring of Palbociclib
The purpose of this study is to determine if patients with ER+, human epidermal growth factor 2 negative (HER2-), advanced breast cancer are receiving dosing adjustments and monitoring based on manufacturer recommendations at a…
- Conditions
- Metastatic Breast Cancer, Advanced Breast Cancer, Estrogen Receptor-positive Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
- Trial name
- NCT03285568
- Testing
- Palbociclib
- Volunteers
- 67 people
- Sponsor
- Rush University Medical Center
Copd, Smoking Cessation
Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study
Chronic Obstructive Pulmonary Disease (COPD) is caused primarily by smoking and smoking cessation is the first-line treatment for slowing disease progression.
- Conditions
- Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use
- Trial name
- NCT04646174
- Testing
- Unified Protocol adapted for smoking cessation, American Lung Association self-management strategies for smoking cessation
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Rush University Medical Center
Mechanical Ventilation Complication
Evaluation of the CleanSweep™ Closed Suction System on Length of Mechanical Ventilation and Ventilator-Associated Events
The primary aim of this study is to evaluate the CleanSweep™ Closed Suction System on time to first successful spontaneous breathing trial in mechanically ventilated patients in the medical intensive care unit.
- Trial name
- NCT03868735
- Testing
- CleanSweep Closed Suction System
- Where
- United States
- Volunteers
- 272 people
- Sponsor
- Rush University Medical Center
Respiratory Insufficiency
RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit
Aerosol delivery during mechanical ventilation has long been a long debated topic. As evidence-based knowledge about the delivery of aerosol to the lungs of mechanically ventilated patients increases, one piece of the puzzle has…
- Trial name
- NCT02056119
- Testing
- Vibrating Mesh Nebulizer Arm, Jet Nebulizer Arm
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rush University Medical Center
Rotator Cuff Tear Repair Anchors
Evaluation of the Healicoil Suture Anchor for Rotator Cuff Repair
The purpose of the proposed study is to evaluate a new anchor for rotator cuff repair, the Smith \& Nephew Healicoil anchor. This anchor utilizes a small open-construct design to promote bone-in growth and potentially allow for…
- Trial name
- NCT02759458
- Testing
- Smith & Nephew Healicoil Anchor, Smith & Nephew Twinfix Anchor
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Degenerative Disc Disease
FLXfitTM 15 TLIF Interbody Fusion Device
The purpose of this study is post-market, patient outcome research to evaluate medical device safety and effectiveness. The data collected will assess the safety of the FLXfit 15TM (studydevice) system.
- Trial name
- NCT04208048
- Testing
- FLXfit 15TM device
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee
Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis
In this, prospective, double-blind study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of leukocyte poor, platelet-rich plasma or hyaluronic acid injections under…
- Trial name
- HA vs PRP (NCT02588872)
- Testing
- Platelet-rich Plasma (PRP), Hyaluronic Acid
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Patients Being Assessed With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson, Lexiscan
Study With Aminophylline to Attenuate of the Side Effects of Regadenoson
The routine administration of 75 mg of intravenous aminophylline following regadenoson (Lexiscan®), a commonly used medication for nuclear stress testing of the heart, can reduce the gastrointestinal (diarrhea and stomach upset)…
- Trial name
- ASSUAGE (NCT01250496)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Rush University Medical Center
Autism Spectrum Disorder
Examining an Adaptive Telehealth Intervention
The purpose of this study is to explore the acceptability and effects of internet-based approaches for helping parents learn early intervention strategies (e.g., methods or tips for improving a child's behavior and development).
- Trial name
- NCT03840642
- Testing
- Mirror Me, Remote Coaching
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Using Pressure Detecting Insoles to Reduce Knee Loading
The purpose of this study is to determine whether use of a pressure-detecting shoe improve can enhance favorable loading conditions at the knee.
- Trial name
- NCT02955225
- Testing
- Active Moticon OpenGO insole, Passive shoe insole
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rush University Medical Center