Clinical trials: sponsored by Rush University Medical Center
Chronic Low-back Pain
Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain
Chronic Pain Management (CPM) has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (a greater exposure in vulnerable individuals), non-pain health consequences (hormone…
- Trial name
- NCT04744883
- Testing
- Spinal Manipulation Therapy (SMT), Naloxone, Mindfulness Based Stress Reduction Therapy (MT)
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Rush University Medical Center
PTSD - Post Traumatic Stress Disorder
Evaluating Evidenced Based Options for PTSD Treatment
This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.
- Trial name
- NCT06733376
- Testing
- Cognitive Processing Therapy, Prolonged Exposure, Skills Training for Affective and Interpersonal Regulation
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Rush University Medical Center
Inflammatory Bowel Disease
A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis
Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the most significant chronic conditions of the gastrointestinal tract (GIT) and affects over 1.5 million…
- Trial name
- NCT05579392
- Testing
- Bright Light Therapy
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Spontaneous Breathing Trial in ICU
Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults
For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs.
- Trial name
- NCT07005505
- Testing
- Pressure Support Ventilation (PSV), Automatic tube compensation (ATC)
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- Rush University Medical Center
Total Knee Arthroplasty
Oral Tranexamic Acid After Total Knee Arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA).
- Trial name
- NCT06894719
- Testing
- tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm
- Volunteers
- 351 people
- Sponsor
- Rush University Medical Center
Type 2 Diabetes
E3 Diabetes - Closing the Gap in Diabetes Control
This study aims to decrease the racial gap in type 2 diabetes control in African American and Latinx patients in Rush University Medical Center clinics.
- Trial name
- E3Diabetes (NCT06643936)
- Testing
- E3 Multidisciplinary Team, E3 Self-Guided Type 2 Diabetes Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Rush University Medical Center
Hypertension
E3 Hypertension - A Team-based, Multidisciplinary Model in Addressing Barriers to Hypertension Control
This study aims to compare a multidisciplinary clinical hypertension and social needs intervention to enhanced standard of care for hypertension management in primary care clinics with regards to hypertension control outcomes.
- Trial name
- NCT06899750
- Testing
- E3 Multidisciplinary Team, E3 Self-Guided Hypertension Education Program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
COPD
COPD Resources, Education, and Activity Designed for You Study
Although COPD self-management treatment programs are effective in reducing COPD-related hospitalizations and increasing quality of life, there is a limited understanding of 'how and why' they work.
- Trial name
- COPD READY (NCT07125053)
- Testing
- Education (self-guided), Education (counselor-led), Physical Activity
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- Rush University Medical Center
Cognitive Decline, Dementia, Vascular
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular…
- Conditions
- Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia
- Trial name
- NCT04337255
- Testing
- Behavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rush University Medical Center
Degenerative Disc Disease, Herniated Nucleus Pulposus
The Course of Hip Flexion Weakness Following LLIF or ALIF
The purpose of this study is to assess the course of hip weakness after LLIF or ALIF procedures. These outcomes include measures of hip strength using a dynamometer, which is a device used to measure muscle strength.
- Conditions
- Degenerative Disc Disease, Herniated Nucleus Pulposus, Spondylolisthesis
- Trial name
- NCT04204135
- Testing
- LLIF or ALIF procedures
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Rush University Medical Center
Heart Diseases
Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department
The goal of this clinical trial is to learn if using point-of-care ultrasound (POCUS) can increase participant engagement and changes in behavior among adults with risk factors for pre-symptomatic heart failure presenting to the…
- Trial name
- NCT06769880
- Testing
- Ultrasound and Educational Intervention, Educational Intervention Alone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Respiration, Artificial, Weaning
Optimal Timing for Spontaneous Breathing Trials
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU.
- Trial name
- NCT06561295
- Testing
- Later Morning Timing of Spontaneous Breathing Trials
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Rush University Medical Center
Ulcerative Colitis
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis
The hypothesis of this study is that appropriate time of day of administration of oral, once daily 5-ASA therapy in alignment with the host circadian rhythms will improve subclinical inflammation and microbial structure/function…
- Trial name
- NCT05213234
- Testing
- Chronotherapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Rush University Medical Center
Mechanical Ventilation
Prognostic Estimates Among ICU Clinicians
One challenge with decision making for mechanically ventilated is that their prognosis is often uncertain. The ProVent-14 score incorporates clinical variables measured on the 14th day of mechanical ventilation to predict risk of…
- Trial name
- NCT06452797
- Testing
- ProVent-14 score
- Where
- 3 sites in United States
- Volunteers
- 238 people
- Sponsor
- Rush University Medical Center
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Cardiac Arrest (CA)
Ventilation During CPR and Return of Spontaneous Circulation
During cardiopulmonary resuscitation (CPR), rescue breaths help move air into the lungs, but the amount of air delivered is rarely measured.
- Trial name
- NCT07834294
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Telomeric 22Q13 Monosomy Syndrome, Tuberous Sclerosis
Web Intervention for Parents of Youth With Genetic Syndromes (WINGS)
The purpose of this study is to evaluate the effectiveness of an adapted, telehealth functional behavioral therapy (FBTsIDD) specifically focused on promoting appropriate communication and behavioral strategies in individuals…
- Conditions
- Telomeric 22Q13 Monosomy Syndrome, Tuberous Sclerosis, Hamartoma Syndrome, Multiple, Fragile X Syndrome
- Trial name
- NCT06139172
- Testing
- Functional Behavioral Training (FBT), Positive Parenting Strategies-Treatment as Usual
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Rush University Medical Center
Colorectal Cancer
Abnormal Food Timing and Circadian Dyssynchrony in Alcohol Induced Colon Carcinogenesis
The purpose of this study is to study the impact of Western lifestyle, including moderate alcohol consumption and delayed eating patterns on studying individuals' susceptibility to colorectal cancer.
- Trial name
- AFT (NCT03955510)
- Testing
- Right time eating, Delayed time eating, Sigmoidoscopy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rush University Medical Center
Chronobiology, Light
Light Timing Study
Chronic circadian misalignment and sleep restriction peak during late adolescence, and are associated with morning daytime sleepiness, poor academic performance, conduct problems, depressed mood, suicidal ideation, substance use…
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- ALT (NCT04753190)
- Testing
- Baseline Sleep Satiation and Phase Stabilization, Gradually Shifted Sleep
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Warts, Verruca (Warts)
Intralesional Gardasil-9 for the Treatment of Recalcitrant Warts
This study will evaluate whether Gardasil-9, a vaccine normally used to prevent human papillomavirus (HPV) infection, may be effective for treating recurring warts that have not responded to standard treatments.
- Conditions
- Warts, Verruca (Warts), Verruca Vulgaris
- Trial name
- NCT07806617
- Testing
- 9-valent human papillomavirus vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Rush University Medical Center