Clinical trials: sponsored by Rush University Medical Center
Menopause Syndrome, Inflammation
Genetic Evaluation and Modification of Lifestyles to Improve Female Life Expectancy
The GEMLIFE Study is a 12-month clinical trial for menopausal women. The purpose of this study is to promote an improved aging process for women in menopause through lifestyle changes.
- Conditions
- Menopause Syndrome, Inflammation, Inflammatory Response, Aging
- Trial name
- GEMLIFE (NCT05715372)
- Testing
- Mediterranean diet, AHA walking program, Mindfulness-based stress reduction
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Amifostine & High-Dose Combination Chemotherapy in Treating Patients With Acute ML or CML
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Myelodysplastic Syndromes, Neutropenia
- Trial name
- NCT00003407
- Testing
- amifostine trihydrate, cytarabine, mitoxantrone hydrochloride
- Where
- 4 sites in United States
- Sponsor
- Rush University Medical Center
Epilepsy, Anxiety
Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline
The aim of the study is to compare the safety \& efficacy of sertraline (up to a dose of 200mg/day) \& pregabalin (up to a dose of 300mg/day) for the treatment of symptoms of anxiety in patients with epilepsy.
- Trial name
- NCT01309074
- Testing
- Pregabalin-Lyrica, Sertraline
- Where
- United States
- Sponsor
- Rush University Medical Center
Patients With Severe Chronic Kidney Disease Being Evaluated With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson
Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging
The routine administration of 75 mg of intravenous aminophylline in patients with severe chronic kidney disease undergoing a nuclear stress test with regadenoson (Lexiscan®) can reduce or eliminate the incidence of diarrhea and…
- Trial name
- ASSUAGE-CKD (NCT01336140)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Lewy Body Disease, Parkinson Disease Dementia
Learning to PERSEVERE: Peer Mentor Support and Caregiver Education in Lewy Body Dementia
The investigators propose to adapt, improve, and implement a peer mentor support and caregiver education (PERSEVERE) program to improve LBD-specific caregiving mastery.
- Conditions
- Lewy Body Disease, Parkinson Disease Dementia, Dementia With Lewy Bodies
- Trial name
- NCT04649164
- Testing
- Peer mentor support and caregiver intervention, Focus group to provide feedback on educational materials and mentoring program
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Cartilage Injury
Autologous Bone Marrow Concentrate in Knee Osteochondral Allograft Transplantation
The goal of this study is to establish if mesenchymal stem cell augmentation improves graft incorporation and to analyze the cytokine environment of the joint after osteochondral allograft transplantation (OCA) with and without…
- Trial name
- NCT04739930
- Testing
- Autologous bone marrow aspirate will be harvested and concentrated to a bone marrow aspirate concentrate (BMAC) containing bone marrow derived mesenchymal stem cells and delivered to site of operation, Control group incision
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Rush University Medical Center
Bipolar Disorder, Bipolar I Disorder
Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS)
The goal of this study is to evaluate the feasibility and potential benefit of a behavioral intervention designed to improve emotion regulation in individuals with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar Affective Disorder, Bipolar Disorder I
- Trial name
- BRAINS (NCT05683431)
- Testing
- Cognitive Control of Emotion (CCE) Training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Metabolic Syndrome
A Pilot Study of a Lifestyle Intervention on the Metabolic Syndrome (3ELM Study)
Approximately 24% of the US adult population meet criteria for metabolic syndrome (MetS), diagnosed by a combination of abdominal obesity, elevated blood pressure, high triglyceride and low HDL-cholesterol level, and…
- Trial name
- 3ELM (NCT02233088)
- Testing
- ELM Group, ELM Classes, ELM Individual
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Rush University Medical Center
Septic Shock
Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock
We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS…
- Trial name
- NCT00604019
- Testing
- Dopamine, Norepinephrine
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Carotid Artery Disease, Atherosclerosis
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
In this proposal, the investigators will demonstrate the feasibility and noninferiority of telerobotic ultrasonography as compared to traditional manual acquisition in performing a limited carotid Duplex examination and in…
- Conditions
- Carotid Artery Disease, Atherosclerosis, Atheromatous Plaques, Arteriosclerosis
- Trial name
- NCT05654935
- Testing
- Ultrasound for Carotid Arteries, Telerobotic Ultrasound for Carotid Arteries
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Brain and Central Nervous System Tumors
Topotecan and Thalidomide in Treating Patients With Recurrent or Refractory Malignant Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of cancer by stopping blood flow to the tumor.
- Trial name
- NCT00014443
- Testing
- thalidomide, topotecan hydrochloride
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Parkinson Disease
Varenicline for Gait and Balance Impairment in Parkinson Disease
The purpose of this study is to determine if varenicline is effective in improving gait and balance impairment in patients with Parkinson disease.
- Trial name
- Chantix-PD (NCT01341080)
- Testing
- Varenicline, Sugar pill
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Parkinson's Disease
Validation of Dyskinesia Rating Scales
This study will evaluate the responsiveness of a variety of available dyskinesia rating scales to treatment with amantadine or placebo in Parkinson's disease patients with dyskinesia.
- Trial name
- NCT01071395
- Testing
- Amantadine
- Where
- 8 sites in United States, Austria and 2 more
- Volunteers
- 68 people
- Sponsor
- Rush University Medical Center
Respiratory Insufficiency
Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population
Integrated pulmonary index (IPI) is a tool that monitors respiratory status. It takes into account four parameters: respiratory rate, end-tidal CO2, heart rate and O2 saturation using a pulse oximeter and specialized sidestream…
- Trial name
- IPI (NCT01795196)
- Where
- United States
- Sponsor
- Rush University Medical Center
Posttraumatic Stress Disorders
Eszopiclone for the Treatment of Posttraumatic Stress Disorder
The purpose of this study is to determine if eszopiclone relative to placebo (sugar pill) is effective and tolerable for people with posttraumatic stress disorder (PTSD)-related sleep disturbance.
- Trial name
- NCT01605253
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rush University Medical Center
Suicidal Ideation
Suicide Prevention in Chinese Older Adults
This project aims to develop and refine a suicide intervention protocol, and pilot test a culturally tailored randomized control trial to reduce suicidal thoughts among U.S. Chinese older adults.
- Trial name
- NCT02096432
- Testing
- Behavior Activation, Usual Community Care
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Rush University Medical Center
Driving, Intoxication
Validation of Driving Simulator to Blood Alcohol Concentration Standards for Impaired Driving
The proposed study will validate and determine sensitivity of our new driving simulator, created to evaluate driving ability in a related study to show similar driving performance between patients on chronic opioid treatment and…
- Conditions
- Driving, Intoxication, Impairment, Alcohol Impaired Driving
- Trial name
- ALCDrive (NCT00559819)
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Delirium
Preventative Delirium Protocol in Elderly Patients
The current study aims to elucidate the effectiveness of a preventative delirium protocol in patients older than 65 years of age undergoing elective surgery.
- Trial name
- NCT03541408
- Testing
- Control, Preventative Delirium Protocol
- Where
- United States
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Healthy
A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure.
- Trial name
- NCT05512585
- Testing
- awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Depression
Fermented Milk Product With Probiotic and Its Impact on Mood of Patients With Treatment Resistant Depression
This study aims to assess the impact of a chronic dietary intervention (8 weeks) with probiotics, specifically Fermented Milk Product with Probiotic (FMPP), on the mood of individuals with Major Depressive Disorder (MDD)…
- Trial name
- NCT03317678
- Testing
- BioKefir, Non-fermented milk
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center