Clinical trials: sponsored by Rush University Medical Center
Musculoskeletal Pain, Osteoarthritis
Clinical Outcomes of Autologous Bone Marrow Aspirate Concentrate Injections for Musculoskeletal Conditions
The use of Bone Marrow Autologous Collection (BMAC) in musculoskeletal conditions including osteoarthritis and tendon injuries has been growing. Outcome evidence continues to be sparse.
- Conditions
- Musculoskeletal Pain, Osteoarthritis, Tendinopathy, Sprains Strain
- Trial name
- NCT02981394
- Testing
- Bone Marrow Aspirate Concentrate Injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Doxorubicin Adverse Reaction, Cardiomyopathies, Secondary
The Role of suPAR Biomarker in Blood Samples of Breast Cancer Patients During and Post Doxorubicin Chemotherapy: Causative vs. Predictor
This study looks to find a causative or predictive aspect of the suPAR biomarker for heart failure in breast cancer patients receiving Doxorubicin drug chemo regimen.
- Conditions
- Doxorubicin Adverse Reaction, Cardiomyopathies, Secondary, Breast Cancer
- Trial name
- NCT03505164
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Transmission, Patient Professional, High-flow Nasal Cannula
Investigate the Aerosol Particle Distribution During Aerosol Generating Procedures
Massive number of clinicians were infected during the outbreak of COVID-19, which raised the concerns of utilizing "aerosol generating procedures", particularly the use of high-flow nasal cannula, noninvasive ventilation…
- Trial name
- NCT04353531
- Testing
- High-flow nasal cannula, Surgical mask, bronchoscopy examination
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rush University Medical Center
Hypoxemia
The Effects of Flow Settings During High Flow Nasal Cannula for Adult Hypoxemia Patients
High flow nasal cannula (HFNC) delivers oxygen at a flow which exceeds the patient's inspiratory flow demand in order to improve oxygenation.
- Trial name
- NCT03738345
- Testing
- HFNC flow
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Revision Total Knee Arthroplasty, Revision Total Hip Arthroplasty
Tranexamic Acid in Revision Total Joint Arthroplasty
To determine the optimal dosing regimen and route of administration of tranexamic acid (TXA) [single dose intravenous (IV), double dose intravenous, intravenous + topical, and oral repeated dosing] to minimize post-operative…
- Conditions
- Revision Total Knee Arthroplasty, Revision Total Hip Arthroplasty, Acute Blood Loss Anemia
- Trial name
- NCT02877381
- Testing
- Revision Total Knee Arthroplasty (TKA), Revision Total Hip Arthroplasty (THA)
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- Rush University Medical Center
Transmission, Patient-Professional
Different Modalities in Reducing Airborne Particulate Concentrations During AGP for Health Volunteers
Several clinical procedures have been described as aerosol generating procedure (AGP), including nebulization, high-flow nasal cannula oxygen therapy, noninvasive ventilation, and bronchial hygiene treatment, etc.
- Trial name
- NCT04681599
- Testing
- Filter, Scavenger face tent
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Mechanical Ventilation Complication, Extubation
Early Identification and Prevention of Extubation Failure in Adults Using Integrated Pulmonary Index
The primary aim of this study is to compare reintubation rate when using standard medical therapy (SMT) versus a monitoring tool, Integrated Pulmonary Index (IPI), to alert clinicians of the patient's respiratory status and need…
- Trial name
- IPI (NCT04231890)
- Testing
- IPI monitoring
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Rush University Medical Center
Copd, Smoking Cessation
Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start Study
Chronic Obstructive Pulmonary Disease (COPD) is caused primarily by smoking and smoking cessation is the first-line treatment for slowing disease progression.
- Conditions
- Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use
- Trial name
- NCT04043728
- Testing
- Unified Protocol adapted for smoking cessation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Rush University Medical Center
Aging, Mobility Limitation
Physical Activity to Improve Physical Function in a Community-Based Health Ministry
This study is being conducted to test if a program with physical activity and learning about movement (including goal setting, benefits of physical activity, and how to increase physical activity gradually) helps people to become…
- Trial name
- NCT04203030
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Post-Traumatic Neuralgia, Occipital Neuralgia
Post-traumatic Occipital Neuralgia - Surgical Versus Medical Management
Occipital neuralgia and subsequent headaches are associated with significant morbidity and impact quality of life and ability to work.
- Trial name
- NCT03253523
- Testing
- Occipital neurolysis
- Where
- United States
- Sponsor
- Rush University Medical Center
Acute Respiratory Failure, Intensive Care Unit Syndrome
Rounding Summaries for Families of Critically Ill Patients
Many patients in intensive care units (ICUs) rely on family members or surrogates to make medical decisions on their behalf. One of the recommended ways to improve a surrogate's experience is to invite him or her to participate…
- Conditions
- Acute Respiratory Failure, Intensive Care Unit Syndrome, Communication
- Trial name
- NCT03969810
- Testing
- Rounding Summary
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Rush University Medical Center
Acute Pain Management, Analgesic, Nonopioid
A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery
The purpose of this pilot study is to test the safety of oral ketamine to treat acute pain after amputation surgery. The objective of the proposed research is to conclusively determine if oral ketamine is a safe alternative…
- Conditions
- Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
- Trial name
- NCT02341963
- Testing
- Oral Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Postoperative Infection, Postoperative Complications
Dilute Betadine Soak and Scrub for Foot and Ankle Surgery
Infection and wound complications are the most common complications following orthopaedic foot and ankle procedures, and the infection rate following these procedures is higher than in procedures involving other areas of the…
- Trial name
- NCT03926208
- Testing
- Soak and Scrub, Clorhexadine scrub
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Rush University Medical Center
Metabolic Complications
Metformin for the Prevention of the Metabolic Side-effects of Zyprexa
We hypothesize that metformin co-administered with olanzapine will be well tolerated and associated with significantly less insulin resistance, weight gain and dyslipidemia as compared to olanzapine plus placebo.
- Trial name
- NCT00682448
- Testing
- Metformin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Rush University Medical Center
Ulcerative Colitis
Mind-Body Medicine and Ulcerative Colitis
Stress has been linked to chronic health problems, particularly diseases involving inflammation-mediated tissue injury and organ failure.
- Trial name
- NCT01491997
- Testing
- Mind/Body Medicine Course 1, Mind/Body Medicine Course 2
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Rush University Medical Center
Cerebral Aneurysm, Menopause
Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial
This study aims to determine if hormone replacement therapy, given during perimenopause may prevent the progression of saccular cerebral aneurysms.
- Conditions
- Cerebral Aneurysm, Menopause, Treatment
- Trial name
- EPPA (NCT01895881)
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Parent Training, Primary Care
Parent Training in Pediatric Care: A Self Directed Tablet-Based Approach
High quality and effective parenting in the preschool years is connected with long term positive child behavior and mental health outcomes.
- Trial name
- NCT02723916
- Testing
- ezParent Program, Health-e Kids Control App
- Where
- United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Fall Accident, Fall, Accidental
An Occupational Therapist Fall Prevention Intervention in a Geriatric Primary Care Setting
Purpose of the study: To identify if an intervention focused on decreasing fear of falling (FOF) in a geriatric primary care setting implemented by an occupational therapist (OT) has the potential to decrease falls and improve…
- Trial name
- NCT03294447
- Testing
- Fall Prevention by the Occupational Therapist
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease, Patient Education
An Educational Intervention to Improve Disease Management Knowledge of Hospitalized Patients With COPD
The objective of this study is to determine if inpatient COPD education would result in improved patient knowledge of COPD.
- Conditions
- Chronic Obstructive Pulmonary Disease, Patient Education, Inpatients
- Trial name
- NCT03323190
- Testing
- Inpatient COPD education
- Where
- United States
- Sponsor
- Rush University Medical Center
Rotator Cuff, Subacromial Impingement Syndrome
Comparison of Strength and Constant Score Pre- and Post-Subacromial Injection for Full Thickness Rotator Cuff Tears
Clinical manifestations of rotator cuff tear include shoulder pain, weakness, and stiffness. The level of pain is often a limiting factor when assessing shoulder range of motion and strength pre-operatively.
- Trial name
- NCT02693444
- Testing
- Lidocaine, Saline
- Sponsor
- Rush University Medical Center