Clinical trials: sponsored by Rush University Medical Center
Depression
Brain Network Activation Analysis to Diagnose/Assess Treatment of Unipolar Major Depression and Bipolar I Depression
The investigators are conducting this study to test the usefulness of a new type of analysis of electroencephalographic (EEG) recordings called brain network activation or BNA.
- Trial name
- BNA-Mood (NCT01683214)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Radiculopathy, Central Spinal Stenosis
The Efficacy of Continuous Cold-Therapy on Postoperative Pain and Narcotics Use Following Spinal Fusion
Patient outcomes and satisfaction are an ever-increasing priority in surgical specialties. Cryotherapy has been utilized following spine surgery as an adjunct therapy to reduce postoperative inflammation and improve patient…
- Conditions
- Radiculopathy, Central Spinal Stenosis, Foraminal Stenosis, Herniated Nucleus Pulposus
- Trial name
- NCT03640338
- Testing
- Cold-Therapy System
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Dysphasia
Use of Local Intraoperative Steroid in MIS TLIF
The purpose of this study is to determine if the frequency and duration of postoperative pain are improved in participants receiving a local steroid injection (methylprednisolone) plus a systemic (intravenous (IV, by vein))…
- Trial name
- NCT03308084
- Testing
- Methylprednisolone, Dexamethasone
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Dysphagia
Effect of Local Intraoperative Steroid on Dysphagia After ACDF
The purpose of this study is to determine if the incidence and duration of postoperative dysphagia are improved in the participants receiving a local injection of methylprednisolone with systemic dexamethasone when compared to…
- Trial name
- NCT03311425
- Testing
- Methylprednisolone, Dexamethasone
- Volunteers
- 140 people
- Sponsor
- Rush University Medical Center
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
MDS
A Trial of Lenalidomide & Azacitidine in Low Risk Myelodysplastic Syndromes
This phase II study will evaluate the safety and efficacy of combining two active agents;Revlimid® (lenalidomide) and low dose Vidaza® (azacitidine) for the treatment of patients with low to intermediate-1 MDS excluding patients…
- Trial name
- NCT01379274
- Testing
- Lenalidomide and azacitidine combination
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rush University Medical Center
Osteoarthritis, Hip Infection
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Infection remains one of the most difficult-to-treat complications of total hip arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.The first stage…
- Conditions
- Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- SPACERHIP (NCT01373099)
- Testing
- Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee Infection
Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection
Infection remains a difficult-to-treat complication of total knee arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.
- Conditions
- Osteoarthritis, Knee Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- NCT01373112
- Testing
- Static Spacer, Articulating Spacer
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Rush University Medical Center
Hepatocellular Carcinoma, Metastatic Carcinoma to the Liver
Blood Volume Assessment of Hepatocellular and Metastatic Carcinomas in the Liver
This project investigates the feasibility of assessing the relative blood volume of carcinomas in patients with Hepatocellular Carcinoma (HCC) and liver metastases from pancreatic or colorectal cancer compared to normal liver…
- Trial name
- NCT02288910
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rush University Medical Center
Hepatocellular Carcinoma
Correlation Between CT Perfusion and Post Y-90 TARE PET/CT Dosimetry
The purpose of this study is to see if it is possible to establish a relationship between the blood flow and blood volume of liver tumors from CT body perfusion and the radiation dose deposited in the tumors from the…
- Trial name
- NCT02558205
- Testing
- CT Liver Perfusion, PET/CT of liver
- Where
- United States
- Sponsor
- Rush University Medical Center
Multiple Sclerosis, Relapsing-Remitting
Fecal Microbiota Transplantation (FMT) in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic immune central nervous system (CNS) disease of unknown cause. Recent studies suggest that gut microbiota could be a trigger for the neuro-inflammation in MS and abnormal gut microbiota…
- Trial name
- NCT03975413
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Autism Spectrum Disorder
Stepped-care Telehealth for Young Children With ASD
This proof-of-concept study addresses the gap in the access to care literature by examining a stepped-care version of a telehealth naturalistic developmental behavioral intervention (NDBI), Online RIT.
- Trial name
- NCT04467073
- Testing
- Online RIT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Pain, Intractable Pain
Transitioning to a Valve -Gated Intrathecal Drug Delivery System (IDDS)
Flowonix Prometra® II Programmable Pump may require a smaller dose of drug when converting from other commercially available intrathecal drug delivery systems (IDDS).
- Conditions
- Chronic Pain, Intractable Pain, Back Pain
- Trial name
- TRANSIT (NCT03876158)
- Testing
- Prometra II Programmable Pump system(Flowonix Medical)
- Where
- United States
- Sponsor
- Rush University Medical Center
COPD Asthma
The Role of Gas Flow in Transnasal Pulmonary Aerosol Delivery: A Double-blinded, Randomized Controlled Trial
Aerosol delivery via nasal cannula has gained increasing popularity, due to its combined benefits from aerosolized medication and heated warm oxygen therapy.
- Trial name
- NCT03739359
- Testing
- nasal cannula gas flow
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Rush University Medical Center
PTSD
Morning Light Treatment at Home to Reduce PTSD Symptoms
There is evidence that some of the circadian photoreceptors, the intrinsically photosensitive retinal ganglion cells (ipRGCs), project directly to the amygdala, an area of the brain implicated in PTSD.
- Trial name
- NCT03513848
- Testing
- Retimer
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rush University Medical Center
Parkinson Disease
Determining the Microbiota Composition of the Middle Meatus in Parkinson's
The exact cause of PD remains unknown, but current theories suggest that it results from a combination of hereditary or genetic factors (i.e. family traits ) and exposure to unknown substances in the environment.
- Trial name
- NCT03336697
- Testing
- Nasal swab
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Rush University Medical Center
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse)
Homeless Youth Study - Stepping Stone 2.0
Housing instability is both a cause and consequence of mental health problems. As such youth experiencing housing instability (e.g., homeless or marginally housed) have higher rates of mental health problems.Because of their…
- Trial name
- NCT03776422
- Testing
- Mobile self-help intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Sleep Disorders, Circadian Rhythm, Adolescent Behavior
Teen Sleep Health Study
The objective of this project is to develop an effective, yet feasible strategy to extend school-night sleep duration of older adolescents.
- Trial name
- NCT04087603
- Testing
- Weekend Morning Bright Light & Early Bedtime
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Advanced Cardiac Life Support, Cardiopulmonary Resuscitation, Tidal Volume, Manual Ventilation
Assessing Respiratory Rate and Tidal Volume Delivery During Manual Ventilation
Excessive minute ventilation for patients who experience cardiac arrest may cause pulmonary injury and decrease the overall effectiveness of cardiopulmonary resuscitation (CPR).
- Trial name
- NCT03544164
- Testing
- Manual Ventilation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Rush University Medical Center
Obesity
A Small Changes Weight Loss Program and Message Dissemination Via Facebook in Chicago's West Side
African-American communities experience a greater burden of obesity-related diseases such as type 2 diabetes mellitus and cardiovascular disease and higher rates of obesity, compared to other race groups.
- Trial name
- NCT03614338
- Testing
- Small changes weight loss program
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center