Clinical trials: sponsored by Rush University Medical Center
Obesity, Abdominal
Effect of Body Position on Spirometry in Abdominal Obesity.
Objective: Study the effect of body position on spirometry in obese patients as defined by waist to hip ratio (WHR) of greater than 0.85 in women, and 0.9 in men Background: Spirometry is routinely ordered to work up dyspnea in…
- Trial name
- NCT03347604
- Testing
- Supine spirometry, MIPs and MEPs
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Idiopathic Parkinson's Disease, Drug Induced Dyskinesia
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
The study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of Parkinson's disease (PD)…
- Trial name
- TOP-DYSK (NCT01789047)
- Testing
- Topiramate, Amantadine
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Cholestasis, Total Parenteral Nutrition-induced Cholestasis
Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury
The purpose of this study is to provide intravenous omega-3 fatty acids and monitor tolerance in subjects with prolonged parenteral nutrition dependence and parenteral nutrition-associated cholestasis through expanded access.
- Trial name
- NCT02780193
- Testing
- Omegaven
- Where
- United States
- Sponsor
- Rush University Medical Center
Obesity
Post-Bariatric Weight Regain Behavioral Intervention
This project aims to evaluate a newly developed Internet-delivered (via e-learning modules) acceptance-based behavioral intervention (ABTi) for individuals who are experiencing weight regain after bariatric surgery.
- Trial name
- NCT03564392
- Testing
- Acceptance Based Behavioral Intervention
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Rush University Medical Center
Osteoarthritis
Ambulation Versus Standing on Postoperative Day 0
The purpose of this study is to determine the impact of the timing of physical therapy (PT) initiation on postoperative length of stay and the time to physical therapy clearance following total knee replacement.
- Trial name
- PT on POD 0 (NCT02879188)
- Testing
- Physical Therapy, Standing
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Rush University Medical Center
HIV Infection
Fish Oil for HIV-Related Inflamm-aging and Immune Senescence
HIV infection is associated with premature aging of the immune system. It is believe that the persistent inflammation that accompanies HIV infection is a major contributor to premature immune aging.
- Trial name
- NCT02102724
- Testing
- Fish oil that contains omega-3 fatty acids
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Rush University Medical Center
Dietary Habits, Adiposity
Study of Household Purchasing Patterns, Eating and Recreation
This project examines behavioral and household characteristics associated with food purchasing patterns.
- Conditions
- Dietary Habits, Adiposity, Blood Pressure
- Trial name
- SHoPPER (NCT02073643)
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Foot & Ankle
Device-Based Scribe Service (iScribes) on Patient Satisfaction
This project involves the implementation of a device-based scribe service (iScribes) for patient encounters. The objective of the proposed study is to track and compare the allocation of physician time and associated quality…
- Trial name
- NCT03854955
- Testing
- iScribes
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rush University Medical Center
Internal Derangement of Hip, Acetabular Labrum Tear
Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain
The goal of the study is to evaluate via a prospective, blinded, randomized clinical trial, whether ultrasound-guided single femoral and lateral femoral cutaneous nerve blocks with ropivacaine 0.5% with epinephrine (1:200,000) as…
- Trial name
- NCT01997567
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rush University Medical Center
Degenerative Disc Disease Lumbar, Spinal Stenosis
Multimodal Analgesia Versus Routine Care Pain Management
Most patients undergoing surgery experience significant post-operative pain. Inadequate peri-operative pain management may decrease post-operative mobilization and increase length of hospitalization.
- Conditions
- Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
- Trial name
- MMA (NCT01861743)
- Testing
- Multimodal Analgesia, Patient controlled analgesia
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Respiratory Failure
Humidity Therapy for Spontaneously Breathing Tracheostomy Patients
The goal of the study is to compare the safety and efficacy of molecular water and bland aerosol therapy (particulate water) in providing adequate humidity to the inspired gas of spontaneously breathing tracheostomy patients.
- Trial name
- NCT02686489
- Testing
- Heated humidification, Cool bland aerosol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rush University Medical Center
Mental Health
Homeless Youth Study - Stepping Stone Project
Homelessness is associated with a multitude of negative consequences including an increased risk for mental health problems. Once homeless, these individuals face significant barriers to mental health care and are therefore less…
- Trial name
- NCT03620682
- Testing
- Coaching sessions, Mobile applications
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis
Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
The purpose of this study is to investigate antibiotic treatment to target bacteria about the shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder surgeries and is thought to contribute to…
- Trial name
- NCT03115177
- Testing
- Doxycycline, Cefazolin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Rush University Medical Center
Osteoarthritis
Formal vs. Home-Based Physical Therapy After Unicompartmental Knee Arthroplasty
To determine whether home-based physical therapy (HBPT) is not clinically inferior to formal outpatient physical therapy (OPT) after hospital discharge of patients undergoing a unicompartmental knee arthroplasty (UKA).
- Trial name
- NCT02883998
- Testing
- Outpatient Physical Therapy, Home Base Physical Therapy
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee
MobilWise: Mobile Phone Remote Coaching After Worksite Joint ADventure Exposure
MobilWise, a worksite physical activity intervention for employees at high risk for knee osteoarthritis (OA), is being tested in a developmental randomized controlled trial at a collaborating worksite to determine if remotely…
- Trial name
- NCT02950090
- Testing
- MobilWise, Fitbit Only
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Rush University Medical Center
Peroneal Palsy (Foot Drop)
Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty
The purpose of this study is to compare acute nerve decompression versus nonoperative treatment in the management of peroneal nerve palsy after total knee arthroplasty (TKA).
- Trial name
- NCT02856958
- Testing
- Nerve decompression, Non-operative
- Where
- United States
- Sponsor
- Rush University Medical Center
High Flow Nasal Cannula
Evaluation on the Efficacy of Bronchodilator Nebulization Via High Flow Nasal Cannula
High-humidity nasal cannula (HFNC) has been shown to be effective in improving oxygenation and avoiding intubation in multiple randomized control trials, it is also suitable and feasible for long term use.
- Trial name
- NCT03091504
- Testing
- High flow nasal cannula, Albuterol Sulfate
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Food Choice
Delays to Influence Snack Choice
The pervasiveness of high-calorie, nutrient-poor snacks in the environment is believed to have contributed to the epidemic levels of obesity and cardiometabolic disease in the U.S.
- Trial name
- DISC (NCT02359916)
- Testing
- Time delays on delivery of less healthy snacks, 25%/$0.25 discount on healthy snacks, 25%/$0.25 tax on less healthy snacks
- Where
- United States
- Volunteers
- 32,662 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Symptomatic Osteoarthritis of the Knee
Intra-articular Injections for Knee Osteoarthritis: A Single Blinded Prospective Randomized Trial
To investigate the clinical benefit of intra-articular injections of saline in patients with symptomatic osteoarthritis of the knee and compare the clinical response of saline to the current standard treatment with…
- Trial name
- NCT02995083
- Testing
- 40 mg Depo-Medrol in 1 ml, 9 ml of 1% lidocaine, Normal Saline 10 ml, Air 10 ml
- Sponsor
- Rush University Medical Center
Osteoarthritis, Intraoperative Bleeding
Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty
Hypotheses: Primary - A weighted dose of 20 mg/kg of tranexamic acid will be more efficacious than a single uniform dose of 1 gram in primary total knee arthroplasty (TKA) cases.
- Trial name
- NCT01651806
- Testing
- Tranexamic Acid standard dose, Females Tranexamic Acid weighted dose, Females receiving a uniform dose of TA
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center