Clinical trials: sponsored by Rush University Medical Center
Blood Loss After Primary Total Joint Arthroplasty, Need for Blood Transfusion After Total Joint Arthroplasty
Oral vs. Intravenous TXA Study Proposal: TJA
Purpose: Examine oral and intravenous Tranexamic Acid (TXA) to determine whether or not the different routes of drug administration are equivalent in terms of post-operative reduction in hemoglobin, number of transfusions, and…
- Trial name
- NCT02233101
- Testing
- Oral Tranexamic Acid, Intravenous Tranexamic Acid
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Rush University Medical Center
Asthma
Barriers to Adherence to Asthma Controller Meds in Low Income Urban Minority Adolescents
Poor adherence to appropriate asthma medications is an important risk factor contributing to high asthma morbidity and mortality in urban African American adolescents.
- Trial name
- ADEPT (NCT00967720)
- Volunteers
- 4 people
- Sponsor
- Rush University Medical Center
Diffuse Large B-Cell Lymphoma
DA-EPOCH-Rituximab/Metformin (RM) for Double Hit Lymphoma
Newly diagnosed histologically confirmed c-myc+ de novo DLBCL. Metformin 500 mg daily x 1 week, then 500 mg twice daily (BID) x 2 weeks, then 850 mg twice daily until 1 month after last cycle of chemo-immunotherapy.
- Trial name
- DLBCL (NCT02815397)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease (COPD)
Comparison of Two Positive Expiratory Pressure Devices in Stable COPD Patients
Positive expiratory pressure (PEP) therapy is a device aiding airway clearance and secretion mobilization, also prevent the small airway from collapsing.
- Trial name
- NCT02817529
- Testing
- Pulmonica, RC-Cornet
- Sponsor
- Rush University Medical Center
Hemorrhage
Fixed-dose Activated Versus Variable-dose Inactivated Prothrombin Complex Concentrate for Warfarin-associated Major Bleed
This study aims to assess a fixed-dose regimen of activated prothrombin complex concentrate (FEIBA VH, Baxter) versus the variable, manufacturer recommended, dose regimen of inactivated prothrombin complex concentrate (Kcentra…
- Trial name
- NCT02565836
- Testing
- fixed-dose activated prothrombin complex concentrate, variable-dose inactivated prothrombin complex concentrate
- Volunteers
- 342 people
- Sponsor
- Rush University Medical Center
Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes
Effect of Ischemic Strokes on Recovery From Intracerebral Hemorrhages
Intracerebral hemorrhage (ICH) occurs when small arteries in the brain rupture due to weakening by age, high blood pressure, and/or elevated cholesterol.
- Conditions
- Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes, Diffusion Weighted Imaging Lesions
- Trial name
- NCT01417117
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Rush University Medical Center
Competence, Emergencies
Development and Assessment of a Simulation Model of Focused and Ongoing Professional Practice Evaluations
Since 2007, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) has required evaluation of practicing attending physicians by management to ensure that procedural skills and medical care are meeting the…
- Trial name
- OPPE16 (NCT03229226)
- Testing
- Verbal versus procedural assessment
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Communication Barriers, Occupational Therapy
Limited English Proficiency Occupational Therapy Patients Receiving Interpreter Services Perception of Quality of Care
A systematic literature review from March through June 2014 supports the premise that limited English proficiency (LEP) persons face barriers and disparities to medical care that English-speaking persons do not face.
- Trial name
- NCT03149276
- Testing
- Interpreter services
- Volunteers
- 8 people
- Sponsor
- Rush University Medical Center
Type 2 Diabetes
Lifestyle Improvement Through Food and Exercise (LIFE)Study
The primary aim of the LIFE study is to compare low-income African American diabetes patients in a lifestyle intervention group with those in a standard of care control group on change in glycemic control at 12-months.
- Trial name
- LIFE (NCT01901952)
- Testing
- Intensive education and lifestyle support, Standard of Care control group
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Rush University Medical Center
Atrial Fibrillation, Septic Shock
Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock
Retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock.
- Trial name
- NCT02876341
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Rush University Medical Center
Healthy Controls, Delayed Sleep Phase
Circadian Phase Assessments at Home
An estimated 23 million Americans, including adolescents and the elderly, suffer from circadian rhythm sleep disorders, such as delayed sleep phase disorder, advanced sleep phase disorder and winter depression.
- Trial name
- NCT01487252
- Testing
- At home saliva sampling
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
CRPS
Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA
The Department of Anesthesiology is conducting a clinical trial to evaluate if pregabalin given prior to and for several days after Total Knee Arthroplasty (TKA) will reduce the prevalence of Complex Regional Pain Syndrome (CRPS)…
- Trial name
- PregTKA (NCT00558753)
- Testing
- pregabalin
- Volunteers
- 240 people
- Sponsor
- Rush University Medical Center
Menopause, Visceral Adipose Tissue Accumulation
Developing an Intervention to Prevent Visceral Adipose Tissue Accumulation
The aim of this study is to develop an intervention that will produce a sustained improvement in physical activity and chronic stress as a means to slow the menopause-related accumulation of visceral adipose tissue in mid-life…
- Conditions
- Menopause, Visceral Adipose Tissue Accumulation, Abdominal Obesity, Obesity
- Trial name
- NCT01778712
- Testing
- Multi-level intervention
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Bacteremia
Hub Cleansing to Prevent Hub Infection
Central venous catheter infections are common preventable adverse events among hospital patients. Microbes may enter catheter hubs, also known as needleless connectors, and result in downstream contamination.
- Trial name
- HUC-PHIN (NCT01563406)
- Testing
- 15 second scrub, 5 second scrub, 3.15% chlorhexidine/70% isopropyl alcohol
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Rush University Medical Center
Arthroplasty
Continuous Adductor Canal Block (CACB) vs. Combined Spinal Epidural (CSE) in Total Knee Arthroplasty
Purpose: Compare continuous adductor canal block (CACB) to Combined Spinal Epidural (CSE) for total knee arthroplasty in terms of mobility, post-operative pain, and analgesic use.
- Trial name
- NCT02415465
- Testing
- Continuous Adductor Canal Block, General, Epidural
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
The Effects of Specialized Footwear in Osteoarthritis
This study evaluates the effects of specialized footwear on pain and knee loading in knee osteoarthritis. The hypothesis is that this footwear will lead to decreased knee loading and knee pain.
- Trial name
- NCT01597830
- Testing
- Mobility shoe, control shoe
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Sleep Disorders
Sleep Length and Circadian Regulation in Humans
This research will examine why sleep restriction reduces the body clock's response to bright light. The results will enable the optimization of the bright light treatment of people who suffer from circadian rhythm sleep…
- Trial name
- HAM (NCT00843843)
- Testing
- Bright light box
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Subarachnoid Hemorrhage, Cerebral Vasospasm
Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage
This study will evaluate the hypothesis that the administration of intraventricular tPA reduces the rates of cerebral vasospasm and ventriculoperitoneal shunt-dependent hydrocephalus in patients with aneurysmal subarachnoid…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Cerebral Aneurysm, Hydrocephalus
- Trial name
- NCT01878136
- Testing
- Tissue Plasminogen Activator
- Where
- United States
- Sponsor
- Rush University Medical Center
Colorectal Cancer Screening
Optimizing Navigation to Successful Colorectal Cancer Screening
Colorectal cancer is the second leading cause of death from cancer in the United States. Two major barriers to successful colorectal cancer screening are appointment keeping and proper bowel preparation.
- Trial name
- NCT02192034
- Testing
- Navigation
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center