Clinical trials: sponsored by Samsung Medical Center
Heart Failure, Preserved Ejection Fraction
The Efficacy of Enavogliflozin in Heart Failure With Preserved Ejection Fraction
The aim of prospective, open label, single center, randomized controlled trial is to investigate the efficacy of enavogliflozin on exercise performance, diastolic dysfunction, and quality of life in patients with heart failure…
- Trial name
- ENRICH-PEF (NCT06350487)
- Testing
- SGLT2 inhibitor
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Samsung Medical Center
Cardiogenic Shock
The Effects of oXiris in Cardiogenic Shock Requiring VA-ECMO
Cardiogenic shock (CS) defines a state of systemic hypo-perfusion leading to end-organ dysfunction related to cardiac pump failure and with mortality rates in the range of 27-50% according to recent reviews.
- Trial name
- CLEAN ECMO (NCT05642273)
- Testing
- oXiris membrane, Blood tests
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Myocardial Infarction, Coronary Artery Disease
Emulation of Randomized Clinical Trial in Cardiovascular Disease
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- RCT-BigData (NCT06241833)
- Testing
- PPI
- Where
- South Korea
- Volunteers
- 118,420 people
- Sponsor
- Samsung Medical Center
Breast Cancer, Brain Metastasis
Brain Metastasis Development Mechanism in BCBM Patients
This study is the experimental study for brain metastasis development mechanism in patients with breast cancer with brain metastasis
- Trial name
- NCT06330870
- Testing
- WGS/TME evaluation
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
HER2-positive Breast Cancer
The Resistance Mechanism of Trastuzumab Deruxtexan in HER2 Positive Breast Cancer Patients.
This study is the spatial transcriptomic approach for revealing the resistance mechanism of trastuzumab deruxtexan in HER2 positive breast cancer patients.
- Trial name
- NCT06330012
- Testing
- GeoMx data analysis with clinical outcome
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Critical Illness
Effectiveness and Safety of an Early Mobilization Protocol in a Pediatric Intensive Care Unit
This study evaluates the safety and effectiveness of an early rehabilitation program in a pediatric intensive care unit (PICU). Half of the participants will receive intensive and frequent an early mobilization program and others…
- Trial name
- NCT04524065
- Testing
- Early rehabilitation protocol for children hospitalized in the PICU
- Where
- South Korea
- Volunteers
- 142 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Pembrolizumab + Capecitabine／Oxaliplatin (CapeOx) -HER2 Nagative and Pembrolizumab + Trastuzumab + Cisplatin/Capecitabine HER2 Positive
This study is an open-label, single arm, phase II trial the efficacy and safety of pembrolizumab + CapeOx (HER2 negative ARM) or pembrolizumab + Trastuzumab + Capecitabine/Cisplatin (HER2 positive ARM) as first line therapy in…
- Trial name
- NCT04249739
- Testing
- Pembrolizumab
- Where
- South Korea
- Volunteers
- 93 people
- Sponsor
- Samsung Medical Center
Hip Replacement Surgery
Korea Hip Replacement Surgery Registry
This cohort study obtained data from the Korean National Health Insurance Service (K-NHIS) database. For the hip replacement registry, we included all adult patients older than 19 who received total or hemiarthroplasty surgery…
- Trial name
- NCT06307145
- Volunteers
- 124,556 people
- Sponsor
- Samsung Medical Center
Stroke, Rehabilitation
Effect of Intensive Motor Rehabilitation in Subacute Stroke Patient
Early stroke rehabilitation is known to be an effective and essential therapy in gaining functional independence and preventing complications.
- Conditions
- Stroke, Rehabilitation, Motor Function
- Trial name
- NCT03168386
- Testing
- Intensive motor rehabilitation
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Samsung Medical Center
Stroke, Rehabilitation
Effect of Intensive Cognitive Rehabilitation in Subacute Stroke Patient
Early stroke rehabilitation is known to be an effective and essential therapy in gaining functional independence and preventing complications.
- Conditions
- Stroke, Rehabilitation, Cognitive Function
- Trial name
- NCT03168360
- Testing
- Cognitive rehabilitation
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Stroke, Rehabilitation
Effect of Intensive Nutritional Support in Subacute Stroke Patient
Proper nutritional support during early rehabilitation may be beneficial for functional improvements in gaining functional independence and preventing complications in stroke patients.
- Conditions
- Stroke, Rehabilitation, Nutrition
- Trial name
- NCT04259307
- Testing
- Omapone Peri 724mL or Winuf Peri 654mL
- Where
- South Korea
- Volunteers
- 97 people
- Sponsor
- Samsung Medical Center
Stroke, Rehabilitation
Effect of Intensive Language Therapy in Subacute Stroke Patients
Early stroke rehabilitation is known to be an effective and essential therapy in gaining functional independence and preventing complications.
- Conditions
- Stroke, Rehabilitation, Language
- Trial name
- NCT03168373
- Testing
- language rehabilitation therapy
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Aging
Long-term Exercise Effect of EX1 Exercise Program
The purpose of this study was to investigate the effect of a long-term exercise program using a wearable exoskeleton robot (EX1) on muscular strength in healthy adults aged 19 to under 65 years, compared to an exercise program…
- Trial name
- NCT05862077
- Testing
- Wearable Hip Assist Robot(EX1), Exercise Program 1, Exercise Program 2
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Frontotemporal Dementia
The Safety and The Efficacy Evaluation of ET-STEM in Patients With Frontotemporal Dementia
The primary purpose of this study is to evaluate the safety and the tolerability of 3 repeated doses of ET-STEM (Mesenchymal stem cells preconditioned with ethionamide) in patients with FTD.
- Trial name
- FTD_ET-STEM (NCT05315661)
- Testing
- ET-STEM
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Triple Negative Breast Cancer, Immune Checkpoint Inhibitor
LAG3 Expression in Triple Negative Breast Cancer
This study is the experimental study for relationship between LAG-3 expression / immue checkpoint protein expression and neoadjuvant chemotherapy plus immune checkpoint inhibitor in triple negative breast cancer.
- Trial name
- NCT06259162
- Testing
- LAG-3 expression / immune checkpoint protein expression
- Where
- South Korea
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Heart Failure, Microvascular Angina
Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology
This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with…
- Conditions
- Heart Failure, Microvascular Angina, Non-ischemic Cardiomyopathy
- Trial name
- HFrEF-CMD (NCT06243653)
- Testing
- CMD test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Heart Failure With Preserved Ejection Fraction, Coronary Microvascular Dysfunction
Distribution and Clinical Implication of CMD in Patients With HFpEF Without Significant CAD
To evaluate the incidence of coronary microvascular dysfunction (CMD) and its' prognostic implication in patients who have diagnosed as heart failure with preserved ejection fraction (HFpEF) confirmed by HFA-PEFF scoring system…
- Trial name
- HFpEF-CMD (NCT04788576)
- Testing
- Invasive physiologic evaluation (fractional flow reserve, coronary flow reserve, index of microcirculatory resistance)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Pancreatic Cyst
Genomic Profiling of Pancreatic Cystic Tumors
This study aims to find out whether quantitative and qualitative analysis, including genetic mutation analysis, of samples obtained from patients with pancreatic cysts is associated with the risk of malignancy, and helpful in the…
- Trial name
- NCT06195904
- Testing
- NA (No intervention)
- Where
- 2 sites in South Korea
- Volunteers
- 250 people
- Sponsor
- Samsung Medical Center
Stage IA Non-small Cell Lung Cancer
Optimal Extent of Pulmonary Resection in Clinical Stage IA Non-Small Cell Lung Cancer
The investigatros hypothesized that selection of surgical procedure according to the pre-defined institutional decision-making algorithm will not compromise the treatment outcomes including overall survival and disease-free…
- Trial name
- OREX-IA (NCT03066297)
- Testing
- Extent of pulmonary resection
- Where
- South Korea
- Volunteers
- 1,018 people
- Sponsor
- Samsung Medical Center
Duchenne Muscular Dystrophy
Correlation Between Functional Capacity and Functional Capability in Duchenne Muscular Dystrophy
This study investigates the correlation between assessments measuring functional capacity and functional capability in patients with Duchenne muscular dystrophy.
- Trial name
- NCT05249361
- Testing
- no intervention
- Where
- 2 sites in South Korea
- Volunteers
- 48 people
- Sponsor
- Samsung Medical Center