Clinical trials: sponsored by Samsung Medical Center
Multiple Myeloma
Carfilzomib, Lenalidomide, and Dexamethasone Re-induction Followed by the 2nd ASCT in Multiple Myeloma Patients Relapsed After the 1st ASCT
The purpose of this study is to evaluate the efficacy and safety of salvage treatment with carfilzomib/lenalidomide/dexamethasone (KRD) followed by 2nd autologous stem cell transplantation (ASCT) and lenalidomide maintenance in…
- Trial name
- KMM1911 (NCT05497102)
- Testing
- Lenalidomide maintenance
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Samsung Medical Center
Heart Failure With Preserved Ejection Fraction, Chronic Pulmonary Thromboembolism (Disorder)
The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echocardiography in Patients With Dyspnea on Exertion
To evaluate the role of exercise hemodynamic testing in the diagnostic workup for patients with dyspnea on exertion referred to the catheterization lab.
- Trial name
- EX_CATH (NCT05490901)
- Testing
- Exercise hemodynamic test
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma
Pembrolizumab in Advanced Hepatocellular Carcinoma as Second-line Treatment After Failure of Sorafenib
This is a single-arm, single-center, open-label trial of pembrolizumab (MK-3475) in subjects with advanced hepatocellular carcinoma as second-line treatment after failure of sorafenib.
- Trial name
- NCT03163992
- Testing
- Pembrolizumab
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Hepatitis B, Portal Hypertension
Atorvastatin Use and Portal Hypertension in Patients With Hepatitis B Virus-related Liver Cirrhosis: A Randomized Controlled Trial
To evaluate whether atorvastatin can improve portal hypertension in patients with chronic hepatitis B related compensated cirrhosis with portal hypertension
- Trial name
- STAPH (NCT05483894)
- Testing
- Atorvastatin 10mg
- Volunteers
- 36 people
- Sponsor
- Samsung Medical Center
Nursing Education
Effectiveness of AR in Ventilator Setting Education.
This study aimed to determine the feasibility and effectiveness of an augmented reality (AR)-based self-learning platform for novices to set up a ventilator without on-site assistance.
- Trial name
- AR (NCT05446896)
- Testing
- AR guidance with Hololens 2
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Ischemic Heart Disease
GENOSS Coronary Stent Clinical Trial
This study aims to evaluate the efficacy and safety of abluminal biodegradable polymer ultrathin sirolimus-eluting stent (Genoss stent) as compared with a durable-polymer everolimus-eluting stent (Xience stent) in patients with…
- Trial name
- NCT05444452
- Testing
- Implanatation of Genoss DES sirolimus-eluting coronary system, Implanatation of Xience DES everolimus-eluting coronary system
- Where
- South Korea
- Volunteers
- 850 people
- Sponsor
- Samsung Medical Center
Gastric Adenocarcinoma, Malignant Melanoma
This Study is a Phase II Study of AZD6738 in Combination With Durvalumab in Patients With Solid Tumor (Cohort A (N=30): GC Who Have Failed Secondary Chemotherapy Treatments Regimen; Cohort B (B=30): Melanoma Patients Who Have Failed to IO)
This study is a phase II study of AZD6738 in combination with durvalumab in patients with solid tumor (cohort A (N=30): GC who have failed secondary chemotherapy treatments regimen; cohort B (B=30): melanoma patients who have…
- Trial name
- NCT03780608
- Testing
- AZD6738, Durvalumab
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Samsung Medical Center
Metastatic Gastrointestinal Cancer, Genitourinary Cancer
Next Generation pErsonalized tX(Therapy) With Plasma DNA Trial-2 in Refractory Solid Tumors (The NEXT-2 Trial)
Analysis of cell free DNA(cfDNA), unlike tissue biopsy, presents a new tool for the monitoring and treatment of cancer. The investigators have developed a differentiated sequencing assay, Digital Sequencing Technology (DST) that…
- Trial name
- NCT02140463
- Where
- South Korea
- Volunteers
- 229 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
As a Second-line Treatment for Metastatic Gastric Adenocarcinoma Patients, the Safety and Effective of Vactosertib Administration in Combination With Paclitaxel+Ramucirumab is Evaluated, and a Phase 2a Clinical Trial to Biomarkers
This clinical trial is to evaluate the efficacy and safety of subjects with metastatic gastric adenocarcinoma or adenocarcinoma of the gastroesophageal junction.
- Trial name
- NCT04656002
- Testing
- Vactosertib
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Metastatic Cancer
Establishment of Patient Derived Cancer Cell Models to Interrogate Novel Molecular Targets in Metastatic Cancer
With rapid advances in molecular oncology, the availability of preclinical in vitro cell models and in vivo animal models with specific genomic aberrations is critical for improved prediction of clinical outcomes in cancer…
- Trial name
- NCT02646228
- Testing
- molecular profiling, patient derived cells
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer
Pemetrexed Alone as Salvage Treatment in Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy: A Phase II Single Arm Prospective Study
Pemetrexed is an anticancer agent that exerts its action by disrupting crucial folate-dependent metabolic processes essential for cell replication.
- Trial name
- NCT02588781
- Testing
- Pemetrexed
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Samsung Medical Center
Metastatic Cancer
Clinical Sequencing Project for Metastatic Cancer Patients for Personalized Cancer Clinic.
The next generation of personalized medical treatment according to the type of personal genetic information are evolving rapidly. The genome analysis needs systematic infra and database based on personal genetic information.
- Trial name
- NCT02593578
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Samsung Medical Center
Refractory Solid Tumors
Single-arm Study to Evaluate the Safety and Efficacy of Sunitinib, in Subjects With RET Fusion Positive or FGFR2 Amplification, Refractory Solid Tumors
This is a pilot study of sunitinib in patients with RET fusion positive or FGFR2 Amplification Refractory solid tumors. This study is a single-arm, pilot study of sunitinib in subjects with Refractory solid tumors harboring RET…
- Trial name
- NCT02450123
- Testing
- sunitinib
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Samsung Medical Center
Advanced Gastric Adenocarcinoma
Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy
This study is a single arm, single center phase II study of AZD1775 in combination with paclitaxel in patients with advanced gastric adenocarcinoma harboring TP53 mutation as a second-line chemotherapy.
- Trial name
- NCT02448329
- Testing
- AZD1775, paclitaxel
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Samsung Medical Center
Solid Tumor
Study to Evaluate the Safety and Efficacy of Gefitinib, in Subjects With EFGR Amplification Refractory Solid Tumors
This study is a single-arm,phase II study of gefitinib in patient with epidermal growth factor receptor amplification Refractory solid tumors. Gefitinib 250 mg will be administered orally daily.
- Trial name
- NCT02447419
- Testing
- Gefitinib
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Biliary Tract Cancer
Study of Pembrolizumab in Metastatic Biliary Tract Cancer as Second-line Treatment After Failing to at Least One Cytotoxic Chemotherapy Regimen: Integration of Genomic Analysis to Identify Predictive Molecular Subtypes
eligible subjects will receive treatment beginning on Day 1 of each 3-week dosing cycle for pembrolizumab. Treatment with pembrolizumab will continue until documented disease progression, unacceptable adverse…
- Trial name
- NCT03110328
- Testing
- MK3475
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Samsung Medical Center
Pancreas Cancer
Vactosertib With Nal-IRI/FL in Metastatic Pancreatic Ductal Adenocarcinoma.
To determine recommended phase 2 dose and to evaluate the safety of vactosertib in combination with nal-IRI/FL in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) who have failed first-line gemcitabine and…
- Trial name
- NCT04258072
- Testing
- Vactosertib
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Samsung Medical Center
Intrahepatic Cholangiocarcinoma
A Single-arm Study of Gemcitabine, Cisplatin, and Nab-Paclitaxel as Neoadjuvant Therapy for Resectable Oncologically High-Risk IHCC in Korea
1. Phase of Development: II 2. Patient Population: Resectable Oncologically High-Risk Intrahepatic Cholangiocarcinoma 3. Estimated Number of Patients: 34 patients 4.
- Trial name
- NCT04546828
- Testing
- Gemcitabine, Cisplatin, and Nab-Paclitaxe
- Sponsor
- Samsung Medical Center
Refractory Solid Tumors
Study to Evaluate the Safety and Efficacy of Sirolimus, in Subject With Refractory Solid Tumors
This study is a single arm, pilot study of sirolimus in patient with Phosphatidylinositide-3-kinase (PIK3CA) mutation, PIK3CA amplification , PIK3CA-AKT pathway aberration Refractory solid tumor and/or specific sensitivity to…
- Trial name
- NCT02688881
- Testing
- sirolimus
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Samsung Medical Center
Colo-rectal Cancer
Pemetrexed Plus Tarceva as Salvage Treatment in EGFR Overexpressed Metastatic Colorectal Cancer Patients Who Were Failed After Standard Chemotherapy
This study is single center single arm prospective phase II study. In this study, efficacy and side effects of pemetrexed as salvage regimen on patients who failed all standard chemotherapy and total of 29 patients will be…
- Trial name
- NCT03086538
- Testing
- Pemetrexed, Tarceva 100Mg Tablet
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center