Clinical trials: sponsored by Samsung Medical Center
Lung Adenocarcinoma
Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma
This is an open label, phase II study to assess the efficacy of osimertinib (80 mg, orally, once daily) to suppress the progression of remaining GGN(s) in other lobes following surgical resection for actionable EGFR…
- Trial name
- NCT05528458
- Testing
- Osimertinib 80Mg Tab
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Parkinson's Disease and Parkinsonism
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to…
- Trial name
- NCT06350617
- Testing
- High-Frequency, ipsilateral M1, High-Frequency, bilateral M1, High-Frequency, Lt. DLPFC
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Acute Respiratory Failure
A Clinical Study for Developing Artificial Intelligence(AI)-Based Clustering Model for Personalized Medicine in Acute Respiratory Failure
The investigators will prospectively collect clinical information to develop a clustering analysis model and confirm phenotype for patients with acute respiratory failure who admit to the intensive care unit and require oxygen…
- Trial name
- NCT06479421
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Samsung Medical Center
Refractory Solid Cancer Patients Unexposed to Immunotherapy
T Cell Inflamed Gene Expression Profiling Score-guided Anti PD-1 Therapy (Tislelizumab Monotherapy) for Refractory Solid Cancer Patients Unexposed to Immunotherapy
This is a Phase 2, single-arm, multicenter study, evaluating the anti-tumor efficacy of tumor-infiltrating lymphocyte (TIL) directed tislelizumab monotherapy (also known as BGB-A317) for refractory solid tumors in approximately…
- Trial name
- NCT07300891
- Testing
- Tisleizumab(BGB-A317)
- Volunteers
- 72 people
- Sponsor
- Samsung Medical Center
Cardiovascular Diseases (CVD), Cerebro Vascular Disease
Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study
This study aims to establish a comprehensive, long-term clinical registry infrastructure for heart and brain vascular diseases (cardiovascular diseases and stroke) at Samsung Medical Center.
- Trial name
- NCT07393412
- Testing
- Standard Medical Therapy, Revascularization Procedures, Lifestyle Modification
- Where
- South Korea
- Volunteers
- 800,000 people
- Sponsor
- Samsung Medical Center
Hemophagocytic Lymphohistiocytoses
Prospective Cohort for Adult Hemophagocytosis
This prospective study enrolls subjects who have clinical and laboratory manifestations related with hemophagocytic lymphohistiocytosis.
- Trial name
- NCT03117010
- Testing
- Steroids, Etoposide
- Where
- South Korea
- Volunteers
- 81 people
- Sponsor
- Samsung Medical Center
Breast Neoplasms, Breast Cancer
Comparison of Ultrasound and Breast MRI for Breast Cancer Detection
The goal of this randomized clinical trial is to compare diagnostic results of secondary breast cancer surveillance using breast ultrasound abbreviated MRI and full protocol MRI.
- Trial name
- NCT05797545
- Testing
- Breast MRI for Breast Cancer Detection
- Where
- 3 sites in South Korea
- Volunteers
- 1,756 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Stroke
Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each hemiplegic stroke patient in subacute phase, compared to…
- Trial name
- NCT06270238
- Testing
- High-Frequency1, cTBS1, High-Frequency2
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Samsung Medical Center
Brain Disorder, Home Based Rehabilitation
Effect of Untact Upper Extremity Rehabilitation Using Smart Glove for Late Subacute and Chronic Patients With Brain Disorder
The aim is to clinically validate the clinical efficacy, usability, and safety of home-based upper limb rehabilitation training using the Neofect Smart Glove by comparing the effects between a group using the home-based Neofect…
- Trial name
- brain disorder (NCT06837324)
- Testing
- home-based Neofect Smart Glove, home-based occupational therapy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Home Based Rehabilitation, Brain Disorder
Effect of Untact Upper Extremity Rehabilitation Using a Smart Board for Late Subacute and Chronic Patients With Brain Disorder
The aim is to clinically validate the clinical efficacy, usability, and safety of home-based upper limb rehabilitation training using the Neofect Smart Board by comparing the effects between a group using the home-based Neofect…
- Trial name
- NCT06837363
- Testing
- Home-based Neofect Smart board, home-based occupational therapy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Chronic Stroke, Subacute Stroke
Safety and Efficacy of Hip Assist Powered Exoskeleton for Gait Training in Patients With Late Subacute and Chronic Stroke
The aim of this study is to evaluate the safety of gait training using a hip-assist powered exoskeleton. This will be assessed by collecting all device-related adverse events occurring during the entire intervention period, which…
- Conditions
- Chronic Stroke, Subacute Stroke, Exoskeleton
- Trial name
- brain disorder (NCT07353203)
- Testing
- gait assistance mode group, Resistance mode
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Samsung Medical Center
Head and Neck Cancer
Prospective Registration of Head and Neck Cancer
Head and neck cancers account for the sixth leading cause of cancers worldwide. The annual incidence of Head and neck cancers is more than 650,000 the patients each year.
- Trial name
- NCT02546895
- Testing
- chart review
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Samsung Medical Center
Hepatocellular Carcinoma, Portal Vein Thrombosis
Proton Beam Radiotherapy Followed by Tecentriq and Avastin for Primary Liver Cancer With Vp2-4 Portal Vein Invasion
This study is investigator initiated, single-institution, prospective, phase 2 open-label study to determine the efficacy and safety of combination therapy of atezolizumab/bevacizumab and proton beam therapy to portal vein tumor…
- Trial name
- NCT05625893
- Testing
- PBT and atezolizumab/bevacizumab
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Samsung Medical Center
B-cell Lymphoma Recurrent, B-cell Lymphoma Refractory
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma
Secondary involvement of the central nervous system (CNS), such as CNS relapse after treatment or progression during treatment, is a rare but deadly occurrence in patients with B-cell non-Hodgkin lymphoma (NHL), particularly in…
- Conditions
- B-cell Lymphoma Recurrent, B-cell Lymphoma Refractory, CNS Metastases
- Trial name
- SIENA (NCT06552559)
- Testing
- Selinexor
- Where
- 2 sites in South Korea
- Volunteers
- 37 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Chronic Coronary Syndrome
Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients…
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Acute Coronary Syndrome
- Trial name
- AIM-FFR (NCT07329699)
- Testing
- MPFFR or Invasive FFR
- Where
- 23 sites in South Korea
- Volunteers
- 2,100 people
- Sponsor
- Samsung Medical Center
Non-small Cell Lung Cancer, Surgery
Anesthesia and Non-small Cell Lung Cancer Recurrence
There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of…
- Conditions
- Non-small Cell Lung Cancer, Surgery, Anesthesia
- Trial name
- GASTIVA (NCT06330038)
- Testing
- Propofol, Inhaled anesthetics
- Where
- South Korea
- Volunteers
- 5,384 people
- Sponsor
- Samsung Medical Center
Liver Transplantation
Effectiveness Analysis of a Rehabilitation Exercise Platform for Living Donor Liver Transplantation Patients
This randomized controlled study aims to evaluate the effectiveness of a digital rehabilitation exercise platform in patients undergoing living donor liver transplantation.
- Trial name
- NCT07530913
- Testing
- Digital Rehabilitation Platform, Standard Exercise Education
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Samsung Medical Center
Prostate Cancer
Salvage Moderate Hypofractionated Versus Ultrahypofractionated Radiotherapy for Biochemical Recurrence After Radical Prostatectomy in Prostate Cancer
This study is the first prospective, randomized phase III clinical trial designed to evaluate whether ultrahypofractionated radiotherapy is non-inferior to conventionally moderately hypofractionated radiotherapy in terms of…
- Trial name
- NCT07500701
- Testing
- Moderate hypofractionated radiotherapy (Moderate-hypoRT), Ultra-hypofractionated radiotherapy (Ultra-hypoRT)
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Samsung Medical Center
Pediatric Respiratory Distress
Development of an AI Assessment System for Pediatric Respiratory Distress : A Prospective Study
This is a multicenter, prospective observational study designed to collect clinical data for the development of a vision-language model-based artificial intelligence system for automated assessment of pediatric respiratory…
- Trial name
- NCT07370623
- Where
- 3 sites in South Korea
- Volunteers
- 2,200 people
- Sponsor
- Samsung Medical Center
Cerebral Palsy
Development of a Remote Therapy Protocol for Upper Limb Function Enhancement in Children With Cerebral Palsy
The perpose of this study: Development and demonstration of a teletherapy protocol to improve upper limb function in children with cerebral palsy.
- Trial name
- NCT06272760
- Testing
- Home-based hand-arm bimanual intensive training (Tele-HABIT)
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Samsung Medical Center