Clinical trials: sponsored by Semmelweis University
Depression
Adherence to the iFightDepression Online Self-help Tool for Mild and Moderate Depression
Background Computerized cognitive behavioural therapy (cCBT) is proven to be an effective self-help tool for preventing depression and suicide.
- Trial name
- NCT04363086
- Testing
- iFightDepression online self-help tool, Treatment as Usual, phone call
- Where
- Hungary
- Volunteers
- 73 people
- Sponsor
- Semmelweis University
Ventilator Associated Pneumonia, Antibiotic Resistant Infection
Ceftolozane-tazobactam for the Treatment of Respiratory Infections Due to Extensively Drug-resistant Pseudomonas Aeruginosa Among Critically Ill Patients: a Retrospective Study.
The aim of this study is to report our experience with ceftolozane-tazobactam and to evaluate its safety and efficacy in the treatment of ICU dependent nosocomial respiratory tract infections due to extensively drug resistant…
- Trial name
- NCT04352855
- Testing
- Ceftolozane/tazobactam
- Where
- Hungary
- Volunteers
- 55 people
- Sponsor
- Semmelweis University
Carotid Stenosis, Carotid Artery Plaque
Evaluation of Cerebrovascular Events in Patients With Occlusive Carotid Artery Disorders
As of today, no suitable multiparametric predictive method is available to properly estimate stroke risk in patients with carotid artery stenosis.
- Conditions
- Carotid Stenosis, Carotid Artery Plaque, Cerebrovascular Embolism and Thrombosis
- Trial name
- NCT03840265
- Testing
- carotid endarterectomy
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Haemostasis Disorders
Investigation of Systemic and Regional Haemostasis During Liver Transplantation by Comparing ClotPro® and TEG®
The purpose of the research is to compare the global and the portal haemostasis during liver transplantation by functional investigations using TEG® and ClotPro® tests.
- Trial name
- NCT04246307
- Testing
- TEG® and ClotPro® parameters
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Dental Implants
Microvascular Reactivity of the Gingiva Around Implant Born Crown
Apply LSCI method for follow-up changes in regional blood flow after compression of the gingiva in order to compare the vascular reactivity of the attached gingiva at implant versus at tooth.
- Trial name
- NCT03513627
- Testing
- Post-occlusive reactive hyperemia test (PORH test)
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Fractional Flow Reserve
DSE vs Invasive FFR vs CT-FFR
Data are limited regarding the optimal treatment of the non-culprit lesions (NCL) after myocardial infarction (MI). The NON-CULPRIT study is a prospective cohort study with a primary aim to compare invasive fractional flow…
- Trial name
- NON-CULPRIT (NCT03988881)
- Testing
- Revascularization
- Where
- 2 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Intellectual Frailty of Aging, Cardiovascular Diseases
Assessment of Frailty as a Risk Factor for Cardiac and Vascular Surgery
The purpose of this study is to assess the impact of frailty as a multidimensional risk factor on the outcomes of adult cardiac and vascular surgery.
- Conditions
- Intellectual Frailty of Aging, Cardiovascular Diseases, Myocardial Infarction, Vascular Diseases
- Trial name
- NCT02224222
- Where
- Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Right Heart Failure, Right Ventricular Dysfunction
PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients
The PREPARE-MVR (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) Study aims to evaluate those preoperative factors which can predict the early postoperative right…
- Conditions
- Right Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure, Mitral Valve Disease
- Trial name
- PREPARE-MVR (NCT03438825)
- Testing
- Mitral valve replacement/repair
- Where
- Hungary
- Volunteers
- 72 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Healthy
Study of the Choroidal and Retinal Thickness in Relation to Axial Length.
The aim of the study is the non-invasive morphological evaluation of the choroid and the retina in relation to the length of the eyeball in healthy, young man and women.
- Trial name
- CHORAL (NCT03377075)
- Testing
- AL measurement, OCT
- Where
- Hungary
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Myocardial Infarction, Chronic Heart Failure
The Role of Willingness of Participation in Cardiology Trials on the Survival of Patients
It has been shown retrospectively that participation and even the willingness improves the survival of patients after myocardial infarction or heart failure.
- Trial name
- NCT03840499
- Testing
- Optimal medical therapy
- Where
- Hungary
- Volunteers
- 400 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Cilioretinal Arteries
Study of the Incidence of Cilioretinal Arteries in the Hungarian Population
The purpose of this study is to analyze the retinal arteries, to investigate the incidence, number, types, distribution and localization of cilioretinal arteries in the Hungarian Caucasian population.
- Trial name
- NCT02089893
- Testing
- Fundus photography
- Where
- Hungary
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Nitric Oxide, Vasodilation
Evidence of Spreading Vasodilation in Human Gingiva
The aim of this study is to observe the mechanism of spreading vasodilatation on human healthy gingiva. Nitric-oxide donor solutions in lower and higher concentration are used to trigger the vasoactivity.
- Conditions
- Nitric Oxide, Vasodilation, Oral Soft Tissue Conditions
- Trial name
- NCT03605095
- Testing
- nitroglycerin
- Where
- Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Infertility
Comparison of IVF and ICSI in Human IVF
In this prospective randomized clinical trial we plan to compare two fertilization method which are widely used during in vitro fertilization (IVF) treatment.
- Trial name
- NCT03513913
- Testing
- ICSI
- Where
- Hungary
- Volunteers
- 600 people
- Sponsor
- Semmelweis University
Ischemia
Post Occlusive Reactive Hyperemia on Gingiva Assessed by Laser Speckle Contrast Imaging
Apply the LASCA for follow-up the postocclusive microcirculation after strangulation of the gingiva in order to characterize the kinetics of the blood flow changes in human subjects.
- Trial name
- NCT02552498
- Testing
- strangulation
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Mucogingival Defect
Blood Flow Analysis of the Human Mucosa After Vestibuloplasty Procedures
Apply the LSCI for follow-up the postoperative microcirculation after surgical procedures to enlarge keratinized gingiva in order to characterize the kinetics of the blood flow changes during wound healing in human subjects.
- Trial name
- NCT02975024
- Testing
- laser speckle contrast imaging of the oral mucosa, wound fluid measurement, quantitative determination of VEGF
- Where
- Hungary
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Heart Transplant Failure and Rejection, Magnetic Resonance Imaging
Heart TIMING - Heart Transplantation IMagING
The cardiac allograft rejection (CAR) and cardiac allograft vasculopathy (CAV) significantly affect the prognosis of patients after heart transplantation.
- Trial name
- NCT03499197
- Testing
- cardiac magnetic resonance imaging
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Cataract, Presbyopia
Changes of Angle Kappa After Implantation of Multifocal Intraocular Lenses
The purpose of this study is to evaluate possible changes of angle kappa after multifocal intraocular lens implantation. Presumable influencing factors of postoperative visual axis shift (ie.
- Trial name
- NCT03297086
- Testing
- cataract surgery
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Persistent Atrial Fibrillation, Catheter Ablation
Left Atrial Function Analysis for Patients With Persistent Atrial Fibrillation Undergoing Pulmonary Vein Isolation
This prospective observational study is designed to describe the factors determining the success of pulmonary vein isolation (PVI) for patients with persistent atrial fibrillation (AF).
- Trial name
- LAMPP (NCT03242694)
- Testing
- LA pressure, voltage map, strain, scar-map, blood sampling, pulmonary vein isolation
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Atherosclerosis, Coronary Artery Disease
National Plaque Registry and Database
The ultimate goal of this project is to develop a risk score to identify patients with vulnerable coronary atherosclerotic plaques, who are prone to suffer acute coronary syndrome.
- Conditions
- Atherosclerosis, Coronary Artery Disease, Cardiovascular Disease
- Trial name
- OPeRA (NCT02578355)
- Where
- 11 sites in Hungary
- Volunteers
- 20,000 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Athletes Heart
Semmelweis Sport Study
The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding…
- Trial name
- NCT03025737
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center