Clinical trials: sponsored by Shanghai Chest Hospital
Lung Cancer
Label-free Femtosecond Laser Imaging Combined With the Fast Lung Artificial Intelligence Model for Rapid Intraoperative Diagnosis of Lung Surgical Specimens: A Multicentre, Prospective, Parallel-workflow, Non-inferiority Study.
This study aims to evaluate whether femtosecond laser imaging combined with FastLung AI model can provide intraoperative diagnostic performance that is non-inferior to standard frozen section diagnosis for pulmonary nodules or…
- Trial name
- NCT07681245
- Testing
- Femtosecond Laser Imaging, Frozen Section Diagnosis
- Where
- 5 sites in China
- Volunteers
- 294 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer, Pulmonary Metastases
Pulsed Field Ablation for the Treatment of Malignant Lung Tumors
This prospective, single-center, single-arm exploratory study will evaluate the safety and effectiveness of a pulsed field ablation system and a single-use pulsed field ablation catheter for the treatment of malignant lung…
- Trial name
- NCT07889297
- Testing
- Pulsed Field Ablation System and Single-Use Pulsed Field Ablation Catheter
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
5G-Enabled Remote Robotic-Assisted Bronchoscopy-Guided Cryoablation for Pulmonary Malignancies
The purpose of the study is to evaluate the technical feasibility of 5G-enabled remote robotic-assisted bronchoscopy-guided cryoablation for pulmonary malignancies.
- Trial name
- NCT07830095
- Testing
- 5G-Enabled Remote Robotic-Assisted Bronchoscopy-Guided Cryoablation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma
Immunotherapy Plus Anlotinib After Surgery for Esophageal Squamous Cell Cancer With Residual Tumor and Positive Lymph Nodes
The goal of this clinical trial is to learn whether postoperative immunotherapy combined with anlotinib can help prevent or delay cancer recurrence in adults aged 18 to 75 years with locally advanced esophageal squamous cell…
- Trial name
- NCT07830355
- Testing
- Anlotinib, Anti-PD-1 Monoclonal Antibody
- Volunteers
- 75 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma
Sacituzumab Govitecan Combined With Tislelizumab for Locally Advanced/Metastatic Esophageal Cancer
This is a prospective, single-center, single-arm Phase II clinical study designed to evaluate the efficacy and safety of sacituzumab tirumotecan in combination with tislelizumab in patients with advanced esophageal squamous cell…
- Trial name
- NCT07811752
- Testing
- Sacituzumab Tirumotecan (SKB264) plus Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 28 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Nodules
18G Ultrafine Cryoablation Needle for Coaxial Biopsy and Cryoablation of Pulmonary Nodules
This prospective, single-center clinical study will evaluate whether an 18-gauge ultrafine cryoablation needle can be used feasibly and safely during CT-guided coaxial transthoracic biopsy of pulmonary nodules.
- Trial name
- NCT07806981
- Testing
- 18G Ultrafine Cryoablation Needle
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer, Stage IA Non-Small Cell Lung Cancer
Segmentectomy Versus Lobectomy for Deep Solid-Dominant Early-Stage NSCLC
SOLID is a multicenter, open-label, randomized, controlled, phase III non-inferiority trial comparing anatomic segmentectomy with lobectomy in patients with deeply located, solid-dominant, clinical stage IA non-small cell lung…
- Trial name
- SOLID (NCT07698990)
- Testing
- Anatomic Segmentectomy, Anatomic Lobectomy
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer
Septum-guided Segmentectomy for 2-3 cm Clinical Stage IA3 Peripheral Non-Small Cell Lung Cancer
This is a single-center, prospective, single-arm, open-label clinical trial evaluating the efficacy and safety of septum-guided segmentectomy in patients with 2-3 cm clinical stage IA3 peripheral non-small cell lung cancer…
- Trial name
- SGS2606 (NCT07780591)
- Testing
- septum-guided anatomical segmentectomy
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer, Locally Advanced Non-Small Cell Lung Cancer
Induction Chemoimmunotherapy in Combination With Chemoradiotherapy and Consolidation Immunotherapy in Unresectable Locally Advanced Non-Small Cell Lung Cancer
PIVOT study is a multicenter, phase I/II clinical study designed to evaluate induction chemoimmunotherapy followed by concurrent chemoradiotherapy and consolidation immunotherapy in patients with unresectable locally advanced…
- Conditions
- Non-Small Cell Lung Cancer, Locally Advanced Non-Small Cell Lung Cancer, Unresectable Stage III NSCLC
- Trial name
- NCT07632365
- Testing
- Induction chemoimmunotherapy, Concurrent chemoradiotherapy (cCRT), consolidation immunotherapy
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Shanghai Chest Hospital
Malignant Pleural Effusions (Mpe)
Xuan Yin Ning Plus Bevacizumab for Malignant Pleural Effusion
The goal of this clinical trial is to determine whether the Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage is effective in treating malignant pleural effusion.
- Trial name
- XYN-Bev MPE (NCT07670338)
- Testing
- Treatment with Xuanyin Ning Formula combined with intrapleural injection of bevacizumab via chest tube drainage
- Where
- 7 sites in China
- Volunteers
- 308 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer
SYHX2011 in Combination With Carboplatin and Enlonstobart as First-Line Therapy for Squamous Non-Small Cell Lung Cancer
Efficacy and Safety of SYHX2011 Combined with Carboplatin and Enlonstobart versus Nab-Paclitaxel Combined with Carboplatin and Tislelizumab as First-Line Treatment for Squamous Non-Small Cell Lung Cancer
- Trial name
- NCT07662811
- Testing
- SYHX2011, Carboplatin, Enlonstobart
- Volunteers
- 396 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Nodules
Sd-RAB for the Diagnosis of PPNs
This is a single-center, prospective, and single-arm study. The purpose of this study is to evaluate the feasibility and safety of a new self-driving robotic-assisted bronchoscopic system for the diagnosis of peripheral pulmonary…
- Trial name
- NCT06719687
- Testing
- Self-driving robotic-assisted bronchoscope
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Non Small Cell Lung Cancer
A Study of Molecular Residual, Dynamic Monitoring and Recurrence of Stage III Driver Mutated NSCLC
The goal of this prospective, observational study is to explore the value of dynamic monitoring of minimal residual lesions in driver mutated stage III NSCLC for disease recurrence and prognosis assessment.
- Trial name
- NCT06443684
- Testing
- MRD
- Where
- 14 sites in China
- Volunteers
- 305 people
- Sponsor
- Shanghai Chest Hospital
Limited-stage Small Cell Lung Cancer (LS-SCLC), Chemoradiotherapy
A Study of QL1706 Combined With Chemotherapy Induction on Sequential Immunotherapy Consolidation in Patients With Limited-Stage Small Cell Lung Cancer After Chemoradiotherapy
The study is being conducted to evaluation of the Efficacy and Safety of QL1706 Combined with Chemotherapy Induction in Sequential Immunotherapy Consolidation After Concurrent Chemoradiotherapy for Limited-Stage Small Cell Lung…
- Conditions
- Limited-stage Small Cell Lung Cancer (LS-SCLC), Chemoradiotherapy, Induction Therapy, Consolidation Immunotherapy
- Trial name
- NCT07091305
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CLTA-4)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Renal Denervation Combined With Pulsed Field Ablation to Prevent Recurrence in Persistent Atrial Fibrillation
The goal of this clinical trial is to learn whether adding renal denervation (RDN) to pulsed-field ablation (PFA) reduces recurrence of atrial tachyarrhythmias in adults (≥18 years) with persistent atrial fibrillation undergoing…
- Trial name
- OFF-MED (NCT07320768)
- Testing
- renal denervation, Pulsed-Field Ablation (PFA)
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Shanghai Chest Hospital
Stage II-III Non-small Cell Lung Cancer
Neoadjuvant Therapy of SBRT Sequencial With Toripalimab and Chemotherapy in Resectable Stage II-III NSCLC Patients(neoR-TORCH)
This is a randomized, controlled, multi-center, phase III clinical study to evaluate the efficacy and safety of SBRT sequencial with Toripalimab and chemotherapy versus Toripalimab and chemotherapy for subjects with resectable…
- Trial name
- neoR-TORCH (NCT06437977)
- Testing
- SBRT, Toripalimab
- Where
- China
- Volunteers
- 478 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma (ESCC), Infiltration
Infiltration Pattern of Locally Advanced ESCC
Prospectively collect the pathological records of ESCC patients, and analyse the infiltration pattern of ESCC.
- Conditions
- Esophageal Squamous Cell Carcinoma (ESCC), Infiltration, Tumour
- Trial name
- NCT07567716
- Testing
- Esophagectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Small Cell Lung Cancer ( SCLC ), Radiotherapy
Establishment of a Prospective Clinical Cohort of Small Cell Lung Cancer Patients Receiving Radiotherapy-Involved Comprehensive Treatment
By establishing a prospective clinical cohort for small cell lung cancer (SCLC) and systematically collecting high-quality real-world data integrating clinical, imaging, pathological, and molecular dimensions, this study aims to…
- Conditions
- Small Cell Lung Cancer ( SCLC ), Radiotherapy, Immunotherapy, Personalized Cancer Treatment
- Trial name
- NCT07565532
- Testing
- radiatherapy, and chemotherapy with or without immunotherapy as clinical practice
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Chest Hospital
Non-small Cell Lung Cancer, Early-stage Lung Cancer
Septum-guided Segmentectomy for Deep Early-stage Lung Cancer (SGS2512)
The purpose of this study is to evaluate the safety and effectiveness of a specialized surgical technique called "Septum-guided Segmentectomy" for treating early-stage lung cancer located deep within the lung tissue.Standard…
- Conditions
- Non-small Cell Lung Cancer, Early-stage Lung Cancer, Deep-seated Lung Nodules, Solid-dominant Lung Cancer
- Trial name
- SGS2512 (NCT07564557)
- Testing
- Septum-guided Segmentectomy
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Shanghai Chest Hospital
Lung Neoplasms
Vebreltinib Plus Chemotherapy as First-line Treatment for MET-overexpressing NSCLC
To explore the efficacy and safety of vebreltinib plus platinum-doublet chemotherapy as first-line therapy in patients with driver gene-negative, locally advanced or metastatic non-small cell lung cancer (NSCLC) with MET…
- Trial name
- NCT07549061
- Testing
- Vebreltinib, Chemotherapy
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Shanghai Chest Hospital