Clinical trials: sponsored by Shanghai Chest Hospital
NSCLC, SBRT
SBRT in Multi-metastatic NSCLC Patients Which Are Pan-negative for Driver Mutations
This protocol is a phase II multi-center randomized controlled trial (RCT) evaluating the efficacy of SBRT in multi-metastatic NSCLC patients who are pan-negative for driver mutations.
- Conditions
- NSCLC, SBRT, GM-CSF
- Trial name
- NCT02940990
- Testing
- SBRT concurrent with GM-CSF, two-drug chemotherapy containing platinum, including carboplatin/Cisplatin + pemetrexed/docetaxel/paclitaxel/etoposide/gemcitabine/vinorelbine/albumin-bound paclitaxel
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
NSCLC
Phase II Trial of SBRT Compared With Conventional Radiotherapy for Oligometastatic Non-Small Cell Lung Cancer
This protocol is a phase II randomized controlled trial (RCT) evaluating the efficacy of SBRT compared with conventional fractionated radiotherapy for oligometastatic Non-Small Cell Lung Cancer
- Trial name
- NCT02975609
- Testing
- Conventional Fractionated Radiotherapy, Stereotactic Body Radiation Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Lung Adenocarcinoma
Chemotherapy Plus Gefitinib for Advanced Lung Adenocarcinoma and Sensitive EGFR Mutations: a Randomized Controlled Trial
The purpose of this study is to compare chemotherapy and gefitinib in combination with gefitinib alone as first-line therapy for adenocarcinoma, in terms of efficacy and safety.
- Trial name
- NCT02951637
- Testing
- Pemetrexed plus carboplatin combined with gefitinib, Gefitinib
- Volunteers
- 300 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Precision Diagnosis for Intraoperative Frozen Section of Early Stage Lung Cancer
The purpose of this study is: 1. To establish a set of diagnostic criteria of intraoperative frozen section of early stage lung adenocarcinoma, including clinicopathologic and molecular characteristics. 2.
- Trial name
- NCT02941003
- Testing
- microscope, immunostaining, NGS
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Large Cell Neuroendocrine Carcinoma
Optimization for the Treatment of Advanced Pulmonary Large Cell Neuroendocrine Carcinoma
The primary endpoint is to compare the PFS (progress-free survival ) of etoposide plus carboplatin with paclitaxel combined with carboplatin as first-line treatment for advanced pulmonary large cell neuroendocrine carcinoma.
- Trial name
- NCT02943798
- Testing
- etoposide plus carboplatin, Paclitaxel plus carboplatin
- Volunteers
- 118 people
- Sponsor
- Shanghai Chest Hospital
Non-small-cell Lung Cancer
18F-FDG Metabolism Imaging Monitoring Non-small Cell Lung Cancer Curative Effect of Chemotherapy Multicenter Clinical Study
The subject is going to use 18F-FDG PET/CT to assess different genetic NSCLC metabolism after cisplatin chemotherapy and targeted therapy, define the assessment criteria for the role of 18F-FDG PET/CT in NSCLC treatment respone…
- Trial name
- NCT02938546
- Testing
- 18F-FDG
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation
Catheter Ablation of Longstanding Persistent Atrial Fibrillation
This randomized prospective study compared three ablation strategies in patients with longstanding persistent atrial fibrillation (LPeAF).
- Trial name
- NCT02929836
- Testing
- PVI, LA linear ablation, CFAE ablation
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Precision Diagnosis and Therapy for Early Stage Lung Cancer
The present study is a single arm clinical trial aiming to improve the key technology in the diagnosis and treatment of early stage lung cancer.
- Trial name
- NCT02936804
- Testing
- Low Dose Computed Tomography
- Where
- China
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Esophageal Cancer, Chemoradiation
Phase II Study of Neo-adjuvant Chemoradiotherapy for Squamous Cell Esophageal Cancer
The investigators designed a new preoperative chemoradiotherapy regimen to focus on the most important radiation area and hope to reduce the radiation volume and try to reduce the postoperative mortality and treatment-related…
- Conditions
- Esophageal Cancer, Chemoradiation, Surgery
- Trial name
- NCT02938195
- Testing
- radiotherapy, Surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Early Stage Lung Cancer Screening With Low-dose Computed Tomographic
The present study is a randomized controlled trial of LDCT screening for lung cancer versus usual care. 6000 high-risk subjects (age 45-70) were recruited and randomized to the Active arm (Baseline + 2 biennial repeated LDCT…
- Trial name
- NCT02898441
- Testing
- Low Dose Computed Tomography
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Esophageal Neoplasms
Adjuvant Therapies or Surgery Alone for High Risk pN0 Esophageal Cancer
Histological Node Negative thoracic esophageal squamous cell carcinoma（pN0 ESCC） after radical resection still carries the risk of recurrence after complete surgical resection, especially in some high-risk patients.
- Trial name
- NCT02891083
- Testing
- Adjuvant chemotherapy (Paclitaxel and Cisplatin), Adjuvant radiotherapy, Control group (Surgery alone)
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Percutaneous Cryoablation Peripheral Lung Cancer
This study is focus on percutaneous cryoablation,which was for the treatment of medically inoperable Peripheral lung cancer.The patients who were agreed to attend the study will accept the operation.
- Trial name
- PCPLC (NCT02665390)
- Testing
- Percutaneous cryoablation
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Non Small Cell Lung Cancer
Cellular Immunotherapy Synergize Chemotherapy in Patients With Stage IV NSCLC
This is a randomized, open-label, phaseⅡ study evaluating efficacy and safety of DC (dendritic cells) vaccine concurrent with chemotherapy compared to chemotherapy alone in patients with stage IV NSCLC (non small cell lung…
- Trial name
- NCT02669719
- Testing
- chemotherapy followed dendritic cells, pemetrexed and carboplatin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
ENB-GS-TBLB for the Diagnosis of PPLs
The purpose of this study is to evaluate the efficacy and safety of electromagnetic navigation bronchoscopy with a Guide Sheath(ENB-GS) for the diagnosis of peripheral pulmonary lesions (PPLs) .
- Trial name
- NCT02207478
- Testing
- ENB, GS-TBLB-X-ray
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Chest Hospital
Non-Small Cell Lung Cancer, Brain Metastases
Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases)
1. Compare the effect and safety of gefitinib alone with gefitinib plus concomitant WBRT(whole-brain radiotherapy ) in treatment of NSCLC patients harboring an EGFR mutation with multiple BM. 2.
- Conditions
- Non-Small Cell Lung Cancer, Brain Metastases, EGFR Gene Mutation
- Trial name
- EGFR (NCT02338011)
- Testing
- Gefitinib, WBRT
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
EBUS-GS-TBLB With or Without Fluoroscopy for the Diagnosis of PPLs
The purpose of this study is to evaluate the efficacy and safety of endobronchial ultrasound-guide sheath(EBUS-GS) for the diagnosis of peripheral pulmonary lesions (PPLs) without radiographic fluoroscopy.
- Trial name
- NCT01895166
- Testing
- EBUS-GS, X-ray
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Acute Heart Failure, Acute Renal Failure
Recombinant BNP on Heart and Renal Function in Acute Heart Failure
The purpose of this study is to evaluate the efficacy and safety of recombinant human B-type natriuretic peptide (rhBNP) on heart and renal function in patients with acute decompensated heart failure (ADHF) and acute renal injury…
- Trial name
- NCT01625403
- Testing
- rhBNP, standard of care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Non-small Cell Lung Cancer
Evaluating Efficacy and Safety of Erlotinib Versus Gemcitabine Plus Cisplatin as Neoadjuvant Chemotherapy
The aim of this study is to investigate the efficacy and safety of Tarceva versus combination of Gemcitabine plus Cisplatin as neoadjuvant treatment in patients with stage IIIA-N1,N2 NSCLC with EGFR activating mutation in exon 19…
- Trial name
- NCT01297101
- Testing
- Erlotinib
- Sponsor
- Shanghai Chest Hospital