Clinical trials: sponsored by Shanghai Chest Hospital
Pulmonary Nodules
Robotic-Assisted Bronchoscopy-Guided Synchronous Biopsy and Radiofrequency Ablation for Pulmonary Nodules
This is a prospective, single-arm, open-label clinical study. The primary study objective is to evaluate the feasibility of synchronous biopsy and radiofrequency ablation for pulmonary nodules under robotic-assisted bronchoscopy.
- Trial name
- NCT07545057
- Testing
- Robotic-assisted bronchoscopy-guided synchronous biopsy and radiofrequency ablation for pulmonary nodules
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Shanghai Chest Hospital
Stage IIB-III NSCLC, Sleeve Lobectomy
RATS Sleeve Lobectomy After Neo-Chemo-IO for NSCLC
The goal of this multicenter prospective observational study is to learn about the surgical difficulty and outcomes of robotic-assisted sleeve lobectomy in patients with non-small cell lung cancer (NSCLC) after neoadjuvant…
- Conditions
- Stage IIB-III NSCLC, Sleeve Lobectomy, Robotic Surgery, Neoadjuvant Chemoimmunotherapy
- Trial name
- RIDDLE-NSCLC (NCT07541521)
- Testing
- Robot-assisted thoracoscopic surgery (RATS) sleeve lobectomy
- Where
- 10 sites in China, France and 1 more
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Cancer, Esophagectomy
Shanghai Clinical Cohort - Esophageal Cancer
A prospective cohort of patients who received esophagectomy for esophageal cancer in participating centers.
- Trial name
- NCT07312526
- Testing
- esophagectomy
- Where
- China
- Volunteers
- 2,116 people
- Sponsor
- Shanghai Chest Hospital
Neoadjuvant Chemoimmunotherapy, Robotic Pulmonary Resection
Downstaging and RATS After Neo-Chemo-IO: Impact on Surgical Outcomes in NSCLC
The goal of this observational study is to learn whether tumor and nodal downstaging after neoadjuvant chemo-immunotherapy is associated with better surgical outcomes in patients with clinical stage IIB-III non-small cell lung…
- Conditions
- Neoadjuvant Chemoimmunotherapy, Robotic Pulmonary Resection, Stage IIB-III NSCLC
- Trial name
- DRAGON-NSCLC (NCT07528066)
- Testing
- Robotic-assisted surgery (RATS)
- Where
- 10 sites in China, France and 1 more
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer Stage IA
Transthoracic vs Transbronchial Radiofrequency Ablation for Lung Cancer
The aim of this study is to investigate the efficacy and safety of transthoracic versus transbronchial ablation in the treatment of early stage peripheral lung cancer.
- Trial name
- NCT06503744
- Testing
- ablation
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shanghai Chest Hospital
PONV
Electroacupuncture Plus 5-HT3 Receptor Inhibitor for PONV Prevention in High-Risk Patients Undergoing Thoracoscopic Lung Cancer Surgery
This prospective, randomized controlled study aims to evaluate the efficacy and safety of electroacupuncture combined with 5-HT3 receptor inhibitor for preventing postoperative nausea and vomiting (PONV) in high-risk patients…
- Trial name
- NCT07515027
- Testing
- Prophylactic administration of dolasetron, Electroacupuncture
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Nodules
RAB Versus Ultrathin Bronchoscopy With VBN in the Diagnosis of PPNs
The purpose of this study is to evaluate whether the diagnostic yield of robotic-assisted bronchoscopy is not inferior to that of the virtual bronchoscopic navigation combined with ultrathin bronchoscopy.
- Trial name
- NCT06962436
- Testing
- Robotic bronchoscopy system, Ultrathin bronchoscope combined with virtual bronchoscopic navigation
- Where
- 5 sites in China
- Volunteers
- 186 people
- Sponsor
- Shanghai Chest Hospital
Ground-Glass Opacity
Cryoablation vs Thoracoscopic Surgery for GGN
The aim of this study is to investigate the efficacy and safety of Cryoablation and Thoracoscopic Surgery in the treatment of pulmonary ground-glass nodules.
- Trial name
- NCT06848881
- Testing
- Cryoablation, Thoracoscopic Surgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Chest Hospital
Thymic Carcinoma
Neoadjuvant Adebrelimab Plus CRT for Locally Advanced Thymic Carcinoma
The goal of this clinical trial (Phase II) is to evaluate the efficacy and safety of neoadjuvant Adebrelimab combined with chemoradiation in patients with locally advanced thymic carcinoma.
- Trial name
- NCT07479628
- Testing
- adebrelimab plus chemoradiation
- Volunteers
- 31 people
- Sponsor
- Shanghai Chest Hospital
NSCLC
The Effect of Toripalimab Plus Radiotherapy in Patients With Operable Stage II-IIIA (N+) Non Small Cell Lung Cancer
This randomized phase II trial is to explore the clinical efficacy, safety and feasibility of neoadjuvant immunotherapy plus radiotherapy compared with neoadjuvant immunotherapy plus chemotherapy in operable stage II-IIIA (N+)…
- Trial name
- NCT05798845
- Testing
- SBRT+LDRT, Toripalimab, Chemotherapy drug
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Shanghai Chest Hospital
Non-squamous NSCLC
Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients
This study is designed to evaluate the efficacy and safety of Pembrolizumab in combination with Bevacizumab and chemotherapy in advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion…
- Trial name
- NCT05751187
- Testing
- Pembrolizumab, Bevacizumab, Pemetrexed
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer (NSCLC), Leptomeningeal Metastasis
Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC
This is a prospective, single-arm, phase Ia clinical study, which was designed to evaluate the efficacy and safety of Pemetrexed Combined With Bevacizumab Intrathecal Injection in Patients With Leptomeningeal Metastases in NSCLC.
- Trial name
- NCT06663306
- Testing
- Pemetrexed, Bevacizumab
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinomas, Concurrent Chemoradiotherapy
Chemoradiotherapy Following Immunotherapy Plus Chemotherapy for Locally-advanced Esophageal Squamous Cell Cancer (RICE)
This is an investigator-initiated, single-arm, exploratory clinical study.The study population consisted of non-operative Locally Advanced Esophageal Cancer .
- Conditions
- Esophageal Squamous Cell Carcinomas, Concurrent Chemoradiotherapy, Immunotherapy, Chemotherapy
- Trial name
- RICE (NCT05621707)
- Testing
- chemotherapy combined with PD-1 inhibitors
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Neuroendocrine Tumor
Surufatinib Combined With Chemo Versus Surufatinib in the Treatment of Pulmonary Neuroendocrine Tumors
The goal of this clinical trial is to investigate if chemotherapy works with surufatinib to treat pulmonary neuroendocrine tumors. It will also learn about the safety of this combination regimen.
- Trial name
- NCT07357623
- Testing
- Surufatinib Combined With Standard chemotherapy, Surufatinib
- Where
- 4 sites in China
- Volunteers
- 96 people
- Sponsor
- Shanghai Chest Hospital
Esophageal Squamous Cell Carcinoma, Esophageal Cancer
Radiotherapy Combined With Immunochemotherapy in Metastatic Esophageal Squamous Cell Carcinoma
SCR-ESCC-01 is a multicenter, randomized, phase II study aiming to investigate the benefit of early involvement of low-dose radiotherapy(LDRT) and conventionally fractionated radiotherapy(CFRT) in the first-line anti-PD-1 based…
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophageal Cancer, Metastatic Esophageal Squamous Cell Carcinoma
- Trial name
- SCR-ESCC-01 (NCT05978193)
- Testing
- LDRT+CFRT, Immunotherapy, Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation (AF)
Epicardial Adipose Tissue-Targeted DApagliflozin for Reducing Electrical Remodeling in Atrial Fibrillation
Persistent atrial fibrillation (PeAF) is associated with a high risk of recurrence following catheter ablation despite advances in ablation technology and strategies.
- Trial name
- EAT-DARE-AF (NCT07331727)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer, Neoadjuvant Therapy
Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC
The goal of this observational, retrospective, multicenter cohort study is to evaluate the surgical and oncologic outcomes of sleeve lobectomy performed via minimally invasive (RATS/VATS) or open thoracotomy approaches in…
- Trial name
- NCT07135856
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Chest Hospital
NSCLC
A Study of SHR-A1811 Combined With Adebelimumab as Neoadjuvant Therapy for Resectable HER2-Altered Non-Small Cell Lung Cancer
This is a prospective, single-arm, multi-center Phase II clinical trial designed to evaluate the efficacy and safety of neoadjuvant therapy with SHR-A1811 in combination with Adebelimumab in patients with resectable, early-stage…
- Trial name
- NCT07281209
- Testing
- SHR-A1811 + Adebrelimab
- Volunteers
- 40 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
SGLT2 Inhibitors and Survival in Lung Cancer Patients With Diabetes
The goal of this clinical trial The goal of this clinical trial is to evaluate whether SGLT2 inhibitor drugs can extend overall survival or delay the progression of the tumor in patients with both advanced lung cancer and…
- Trial name
- NCT07272057
- Testing
- SGLT-2 inhibitor
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital
Advanced Lung Cancer
The Efficacy and Safety of ARNI on the Outcome of Advanced Lung Cancer With Concurrent Hypertension
Despite the rapid development of novel anti-cancer therapeutic agents and ensuing improved prognosis, lung cancer remains the leading cause of cancer-related death globally, of which the majority of mortality could be attributed…
- Trial name
- NCT07261098
- Testing
- ARNI, Anti-hypertensive drugs except ARNI
- Volunteers
- 200 people
- Sponsor
- Shanghai Chest Hospital