Clinical trials: sponsored by Shanghai Chest Hospital
Lung Cancer
Augmented Reality Assisted Lung Nodule Localization: a Multicentered, Prospective, Randomly Controlled, Non-inferiority Trial
With the popularization of CT screening, the detection rate of small lung nodules has greatly increased. Therefore, the clinical thoracoscopic lung nodule biopsy and sub-lobectomy for radical resection of lung cancer are greatly…
- Trial name
- NCT06548451
- Testing
- Augmented reality guided localization
- Where
- 8 sites in China
- Volunteers
- 270 people
- Sponsor
- Shanghai Chest Hospital
Locally Advanced or Metastatic EGFRm Non-small Cell Lung Cancer (NSCLC)
A Study of Osimertinib-based Adaptive Treatment Guided by ctDNA EGFRm+ Monitoring in NSCLC
The goal of this adaptive, interventional study is to assess the efficacy and safety of osimertinib-based adaptive treatment based on ctDNA dynamic monitoring in locally advanced or metastatic EGFRm NSCLC participants with ctDNA…
- Trial name
- NCT07058519
- Testing
- Osimertinib-based adaptive treatment, Osimertinib 80 MG
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation, Cathter Ablation
A Randomized Controlled Study of Ablation Pursuing Atrial Fibrillation Termination as a Procedural Endpoint in Patients With Persistent Atrial Fibrillation
This is a prospective, randomized, multi-center trial that aims to investigate whether termination of atrial fibrillation can be used as an ablation endpoint for persistent atrial fibrillation (PersAF).
- Conditions
- Atrial Fibrillation, Cathter Ablation, Endpoint
- Trial name
- NCT05921734
- Testing
- AF-termination Group, Prespecified-ablation Group
- Where
- 2 sites in China
- Volunteers
- 480 people
- Sponsor
- Shanghai Chest Hospital
Severe Emphysema
A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema
To compare the efficacy and safety of subsegmental treatment and segmental treatment with InterVapor in patients with severe emphysema
- Trial name
- BTVA (NCT06152107)
- Testing
- BTVA treatment plus optimal medical therapy (GOLD guidelines)
- Where
- 9 sites in China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Lesions (PPLs)
Clinical Validation Study on the Imaging Efficacy of Mobile 4D CBCT Technology for Peripheral Pulmonary Lesions
The purpose of this study is to evaluate the clinical value of mobile 4D CBCT technology in the diagnosis and treatment of peripheral pulmonary lesions and to validate its intraoperative dynamic three-dimensional CT imaging…
- Trial name
- NCT07149597
- Testing
- Mobile CBCT Three-Dimensional Scanning
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Non-small Cell Lung Cancer Metastatic, EGF-R Positive Non-Small Cell Lung Cancer
Dacomitinib in Lung Cancer With Uncommon EGFR Mutations
This is a single center and exploratory study, aiming to analyze the efficacy and safety of dacomitinib-a pan-HER and irreversible TKI in subjects with diagnosed stage IIIB/IV or recurrent NSCLC.
- Trial name
- NCT04504071
- Testing
- Dacomitinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Non-small Cell Lung Cancer
Toripalimab Combined With Cryoablation for First-line Oligo-progression in Driver-negative Advanced NSCLC
Immunotherapy with programmed death-1(PD-1) inhibitors is now standard therapy for first-line use in patients with driver-negative advanced NSCLC, whether as single-agent or in combination with chemotherapy.
- Trial name
- NCT06127303
- Testing
- Toripalimab, Cryoablation
- Where
- 3 sites in China
- Volunteers
- 54 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer (Diagnosis)
Novel Thin Bronchoscope Versus Ultrathin Bronchoscope for the Diagnosis of Peripheral Pulmonary Nodules
This is a prospective, randomised, non-inferior, multicenter study in consecutive patients with solid or sub-solid PPLs 8 to 30 mm in diameter.The subjects will be randomly assigned in a 1:1:1 ratio to the 3.0mm outer…
- Trial name
- NCT07135297
- Testing
- Ultrathin bronchoscope (UTB), Thin bronchoscope (TB1), Thin bronchoscope (TB2)
- Where
- 5 sites in China
- Volunteers
- 465 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
The design of this study is an intervention, randomized, controlled study and contains three randomized groups：（1）PVI group；（2）PVI+PWI group;（3）PVI+PWI+EGM group.
- Trial name
- NCT07122336
- Testing
- PVI, PWI, EGM
- Where
- China
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
NSCLC
A Study to Evaluate Pembrolizumab Plus Lenvatinib in PD-L1 Positive TKI Resistant NSCLC Patients
This study will investigate the efficacy and safety of the combination of pembrolizumab and lenvatinib in PD-L1 positive patients with TKI-resistant EGFR-mutated advanced NSCLC.
- Trial name
- NCT05078931
- Testing
- Pembrolizumab, Lenvatinib
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Shanghai Chest Hospital
OligoProgressive Metastatic Disease, Non-Small Cell Lung Cancer
Standard-of-care Systemic Therapy With or Without Local Therapy in Patients With Oligoprogressive Non-Small Cell Lung Cancer(NSCLC）
This is a randomized, controlled, phase II/III clinical study to evaluate the efficacy and safety of stand-of-care systemic therapy with local therapy versus stand-of-care systemic therapy in patients with oligoprogressive…
- Trial name
- NCT07076693
- Testing
- Radiotherapy or Surgery, Standard Medical Therapy
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Transbronchial MWA for Pulmonary Tumors
The purpose of the study is to evaluate the efficacy and safety of transbronchial microwave ablation for lung cancer.
- Trial name
- NCT06969014
- Testing
- Microwave ablation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Chest Hospital
Extensive-stage Small Cell Lung Cancer (ES-SCLC)
Small Extracellular Vesicle miRNAs as Predictive Biomarkers for Immunochemotherapy Efficacy in Extensive-stage Small Cell Lung Cancer
This study aims to investigate the clinical value of small extracellular vesicle (sEV) miRNAs as predictive biomarkers for immunochemotherapy efficacy in extensive-stage small cell lung cancer (ES-SCLC).
- Trial name
- NCT07070011
- Testing
- EC/EP + ICIs
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Chest Hospital of Shanghai Jiao Tong University
Lung Lesions, Mediastinal and Hilar Lymph Node Enlargement
A Study of Contrast-enhanced EBUS in Lung Lesions and Intrathoracic Lymph Nodes
Exploring the Clinical Application Value of Contrast Enhancement Features in CE-EBUS Images for the Diagnosis of Pulmonary Lesions and Intrapulmonary Lymph Nodes
- Trial name
- NCT07060378
- Testing
- Contrast-enhanced endobronchial ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Intrathoracic Lymphadenopathy
Optical Biopsy and Cytological Evaluation for Intrathoracic Lymphadenopathy
The purpose of this study is to describe and validate confocal laser endomicroscopy(CLE) and rapid on-site evaluation(ROSE) interpretation criteria for different types of intrathoracic lymphadenopathy.
- Trial name
- NCT07047417
- Testing
- CLE and ROSE
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Chest Hospital
COPD, Lung Cancers
Assessment the Effectiveness of BTVA in COPD and Ablation in Pulmonary Nodules by Pulmonary MRI
A Clinical Study Based on Magnetic Resonance Imaging of the Lungs to Assess the Efficacy of Thermal Vapor Ablation and Pulmonary Nodule Ablation in Chronic Obstructive Pulmonary Disease After Surgery.
- Trial name
- NCT07045532
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Chest Hospital
Tracheal Disease, Bronchial Disease
The Novel Special Light for Endotracheal/Bronchial Lesions.
This is a single-center study. The purpose of this study is o evaluate the diagnostic value of special light (TXI, NBI, RDI) in endotracheal/bronchial lesions.
- Trial name
- NCT07036614
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Lesions
Feasibility of Thin Cp-EBUS Scope BF-UC290F for the Diagnosis of PPLs
The purpose of the study is to evaluate the diagnostic value and safety of Thin Convex Probe Endobronchial Ultrasound (TCP-EBUS) Scope for peripheral pulmonary lesions (PPLs)
- Trial name
- NCT05512533
- Testing
- Linear Ultrasound Bronchoscope BF-UC290F (Olympus)
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Improving Patient-reported Outcomes After Lung Cancer Surgery With Mobile Internet Platform
This study focuses on the significant impact of lung cancer in China, highlighted by its high incidence and mortality rates, influenced by factors like aging populations, smoking, and environmental issues.
- Trial name
- NCT06483295
- Testing
- Using mobile internet platforms for follow-up management of postoperative symptoms in lung cancer patients.
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Shanghai Chest Hospital
NSCLC, NSCLC Stage IV
Molecular Landscape Analysis and Clinical Implications for NSCLC Patients With Rare Mutations
Lung cancer is the most common primary cancer of the lung and is responsible for the ever increasing number of cancer-related deaths worldwide.
- Conditions
- NSCLC, NSCLC Stage IV, NSCLC, Recurrent
- Trial name
- NCT05701787
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Shanghai Chest Hospital