Clinical trials: active, sponsored by Shanghai Mental Health Center
Treatment-resistant Schizophrenia
Sequential Treatment Approaches for Treatment-Resistant Schizophrenia
The goal of this study is to optimize treatment strategies for Chinese patients with treatment-resistant schizophrenia (TRS). It will compare two types of treatment: 1.
- Trial name
- STATRS (NCT07918222)
- Testing
- [Phase 1] Clozapine, [Phase 1] Aripiprazole, [Phase 1] Amisulpride
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TMS for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop transcranial magnetic stimulation (TMS) targeting left-dorsolateral prefrontal cortex (l-DLPFC) can improve core clinical symptoms in individuals with…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07154160
- Testing
- Closed-loop TMS, Conventional TMS, Random TMS
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07775807
- Testing
- Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Non-suicidal Self-injury (NSSI)
Efficacy of Triple-daily 15mA tACS on Adolescent NSSI
This study aims to evaluate the clinical effectiveness of triple-daily 15 mA tACS stimulation in adolescents with Nonsuicidal Self-Injury (NSSI) by comparing the outcomes of active versus sham tACS interventions.
- Trial name
- NCT06919432
- Testing
- Active-tACS (Nexalin Technology, Inc., Houston, TX, USA)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Mental Health Center
Anorexia Nervosa
A Study on the Effects of Combined FMT on Gut Microbiota and Eating Disorder Symptoms in AN
The goal of this clinical trial is to determine if Fecal Microbiota Transplantation (FMT) is effective in treating Anorexia Nervosa (AN). The study will also explore how FMT works. The main questions it aims to answer are: 1.
- Trial name
- NCT06744751
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Use Disorder (AUD)
High Intensity Alternating Current Stimulation as a Neuromodulation Therapy for Alcohol Use Disorder: A Pilot Study
This one-arm pilot study aims to evaluate the preliminary clinical, behavioral, and neurophysiological effects of high-intensity transcranial alternating current stimulation (HI-tACS) in individuals with alcohol use disorder…
- Trial name
- HITACS-AUD (NCT07227545)
- Testing
- HI-tACS
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Insomnia
A Multicenter Observational Study of Daridorexant in the Treatment of Insomnia
This study aims to evaluate the effectiveness and safety of daridorexant, a novel dual orexin receptor antagonist (DORA), in patients with insomnia.
- Trial name
- NCT07847021
- Testing
- Daridorexant 50 mg
- Where
- 25 sites in China
- Volunteers
- 500 people
- Sponsor
- Shanghai Mental Health Center
Obsessive - Compulsive Disorder
Cohort Study of Obsessive-Compulsive Disorder
This study will establish a standardized, multi-dimensional prospective longitudinal cohort for obsessive-compulsive disorder. It seeks to explore differences in symptom trajectories, functional trajectories, treatment responses…
- Trial name
- NCT07822516
- Volunteers
- 500 people
- Sponsor
- Shanghai Mental Health Center
SCHIZOPHRENIA 1 (Disorder)
Multi-target TMS for Schizophrenia Negative Symptoms
This randomized controlled trial (RCT) is the first to evaluate the efficacy and safety of a multi-target TMS protocol targeting the right orbitofrontal cortex (R-OFC), left dorsolateral prefrontal cortex (L-DLPFC), and left…
- Trial name
- NCT07559084
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Shanghai Mental Health Center
Obsessive Compulsive Disorder (OCD)
Transcutaneous Electrical Acupoint Stimulation Combined With Exposure and Response Prevention in the Treatment of Patients With Obsessive-Compulsive Disorder: A Randomized Controlled Trial
Obsessive-compulsive disorder is a chronic and disabling mental disorder. Among them, 40-60% of obsessive-compulsive disorder patients do not respond to the current first-line drug treatment and/or psychological therapy.
- Trial name
- NCT07811778
- Testing
- Exposure and Response Prevention, Active Transcutaneous Acupoint Electrical Stimulation
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Mental Health Center
Alcohol Use Disorder
HD-tACS for Alcohol Use Disorder
This study aims to systematically explore the effectiveness of accelerated HD-tACS in treating AUD, particularly its efficacy in reducing alcohol craving and preventing relapse in AUD patients.
- Trial name
- NCT07808190
- Testing
- HD-tACS
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Mental Health Center
Depression Disorder, Chronic Pain
Transcranial Electrical Stimulation for Comorbid Depression and Chronic Pain
The goal of this clinical trial is to learn if active transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) can improve pain symptoms in patients with major depressive disorder…
- Trial name
- NCT07334561
- Testing
- tDCS, alpha-tACS
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Shanghai Mental Health Center
Amphetamine Use Disorders
Closed-loop tTIS Targeted of the Nac as an Intervention for MUD Patients
Closed-loop transcranial temporal interference stimulation (tTIS) targeting the nucleus accumbens may modulate abnormal neural responses to drug-related cues in individuals with methamphetamine use disorder (MUD), thereby…
- Trial name
- NCT07802223
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Mental Health Center
Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder
Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression
The goal of this clinical trial is to evaluate whether precision closed-loop neuromodulation treatments can improve depressive symptoms and daily functioning in people with treatment-resistant major depressive disorder (TRD).
- Trial name
- NCT07783906
- Testing
- Closed-loop Deep Brain Stimulation (DBS), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Volunteers
- 70 people
- Sponsor
- Shanghai Mental Health Center
Anorexia Nervosa, Caregiver Burden
Online FBT-DBT Caregiver Intervention for Caregivers of Individuals With Anorexia Nervosa
Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a chronic and relapsing course. Caregivers of individuals with AN often experience substantial caregiving burden, emotional distress, and impairment in…
- Trial name
- NCT07734779
- Testing
- Online FBT-DBT Intervention, Online Supportive Psychological Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Home-Based Wearable rTMS Therapy for Moderate to Severe Depression
Background and Rationale With rapid economic development and increasing societal pressures, the incidence of neuropsychiatric disorders has risen annually, ranking as the leading cause of disability worldwide and imposing a…
- Trial name
- NCT07775586
- Testing
- rTMS-Tiny Treatment
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Shanghai Mental Health Center
Deep Brain Stimulation
Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder…
- Trial name
- NCT06112067
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Antipsychotic Drug
Xingqi Daozhi Decoction for Antipsychotic-Induced Constipation
Antipsychotic medications are widely used to treat schizophrenia but may cause constipation, which can lead to abdominal discomfort, reduced quality of life, and poor treatment adherence.
- Trial name
- XQD-AIC (NCT07767526)
- Testing
- Xingqi Daozhi Decoction
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Mental Health Center
Generalized Anxiety Disorder (GAD)
Multimodal Cohort Study of Generalized Anxiety Disorder
Generalized anxiety disorder (GAD) is a common mental health condition characterized by persistent and excessive worry that is difficult to control. It can affect sleep, daily functioning, work, and quality of life.
- Trial name
- MC-GAD (NCT07764211)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Mental Health Center
High Risk, Depression / Major Depressive Disorder
Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders
This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and…
- Conditions
- High Risk, Depression / Major Depressive Disorder, Anxiety Disease, Obsessive - Compulsive Disorder
- Trial name
- TRACE (NCT07744490)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Mental Health Center