Clinical trials: sponsored by Sheba Medical Center
Obesity
Identification of In-vivo Probe Based Confocal Laser Endomicroscopy Cellular Characteristics in Obese Women
Previous studies have shown that histological changes in the gastric mucosa between obese and non-obese individuals do exist. Understanding these histological differences (between obese and non-obese individuals) might elucidate…
- Trial name
- NCT02781961
- Testing
- cellvizio
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Hypertriglyceridemia
Characterization of Fatty Acid Composition of Triglycerides in Patients With Hypertriglyceridemia-induced Acute Pancreatitis
) Finding a unique pattern in the triglyceride composition of patients with hypertriglyceridemia that increases the chances of getting pancreatitis and which can serve as a laboratory predictive tool for patients and define them…
- Trial name
- NCT04097990
- Testing
- blood sample
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
COVID-19
Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19
Ivermectin which is an FDA-approved broad spectrum anti-parasitic agent, has also anti-viral activity. In vitro study have shown its activity against SARS-CoV-2, however its clinical effect on patients with COVID-19 never been…
- Trial name
- NCT04429711
- Testing
- Ivermectin Oral Product
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Postpartum Depression
Early Diagnosis of PPD Through Self-portraits
the target of the research is development of a predictive tool for early identification of women which are at higher risk for development of postpartum depression.
- Trial name
- ppd (NCT03791021)
- Testing
- draw a person (DAP), Edinburgh Postnatal Depression Scale (EPDS), Beck Depression Inventory- II (BDI-II)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Pelvic Floor Disorders
Manual Fascial Manipulation in Pregnant Women
Pregnancy and vaginal delivery are considered as the main risk factors for damage to the pelvic floor. There are various ways to measure the strength of the pelvic floor and to evaluate functional problems.
- Trial name
- NCT03041246
- Testing
- Pelvic floor fascial mobilization
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hernia, Inguinal
Prophylactic Antibiotic Treatment for Laparoscopic Inguinal Hernia Mesh Repair: Necessary or Not?
The purpose of this study is to find out whether it is necessary to prophylactically treat patients undergoing laparoscopic inguinal hernia repairs with antibiotics.
- Trial name
- NCT02083939
- Where
- Israel
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Pain Alleviation, Dilatation and Evacuation
Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation
To examine whether application of lidocaine spray in cervical preparation for second trimester dilatation and evacuation alleviates pain and is superior to current protocol of preparation without analgesia and superior to…
- Conditions
- Pain Alleviation, Dilatation and Evacuation, Laminaria Placement
- Trial name
- NCT02097017
- Testing
- Lidocaine
- Where
- Israel
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Type1diabetes
Safety and Efficacy of 7-day Wear Infusion Set vs. Control Infusion Set.
The purpose of this study is to evaluate the Extended Wear (EW) infusion set seven day functioning in patients with Type 1 diabetes compared to the Quick-set infusion set.
- Trial name
- NCT04208282
- Testing
- 7 day infusion set
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
COVID - 19
Open Label Study to Compare Efficacy, Safety and Tolerability of Hydroxychloroquine Combined With Azithromycin Compared to Hydroxychloroquine Combined With Camostat Mesylate and to "no Treatment" in SARS CoV 2 Virus
Patients with COVID-19 which are 60 years old or above or with comorbidities are at risk of deteriorating and developing severe illness.
- Trial name
- COSTA (NCT04355052)
- Testing
- hydroxychloroquine in combination with camostat mesylate, Hydroxychloroquine in combination of Azithromycin
- Where
- 2 sites in Israel
- Volunteers
- 250 people
- Sponsor
- Sheba Medical Center
Emergency Service, Hospital, General Surgery
The Impact of the Covid-19 Outbreak on Emergency Room Attendances of Surgical Patients
Since December 2019, when the novel coronavirus disease (Covid-19) spread throughout the world, data have been needed on the effects of the pandemic on various aspects of healthcare systems.
- Trial name
- NCT04338672
- Testing
- COVID-19 Pandemic
- Where
- Israel
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Fertility
Fertility Post Placenta Accrete
This study is the first to investigate the fertility outcome and the influence on ovarian reserve after using uterine artery embolization during cesarean delivery.
- Trial name
- CSAC (NCT02821702)
- Testing
- Vaginal ultrasound, Blood sample
- Where
- Israel
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Clothing
Physiological Examination of New Fighting Clothing During Exposure to Exercise Under Hot Conditions
The use of fighting clothing under extreme heat conditions during rest and exercise, compromises the body's ability to maintain temperature within the narrow physiological range needed for regular function, and might lead to heat…
- Trial name
- NCT04317027
- Testing
- New Fighting Clothing
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Inflammatory Bowel Disease
Bone Density in Children With IBD Treated With Amorphous Calcium or Commercial Crystalline Calcium
Patients diagnosed with, or in risk of osteoporosis regularly take calcium dietary supplements, although their contribution to BMD maintenance, prevention of bone loss or reduction of the risk of fracture is questionable.
- Trial name
- NCT02470663
- Testing
- DENSITYTM caplets (marketed as Amorphical), Calcium carbonate 600 mg once daily
- Sponsor
- Sheba Medical Center
Attention Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder
Methylphenidate vs. Risperidone for the Treatment of Children and Adolescents With ADHD and Disruptive Disorders
Attention Deficit/Hyperactivity Disorder (ADHD) is one the most prevalent mental disorders among children and adolescents, with a prevalence of 5% in western culture.
- Conditions
- Attention Deficit/Hyperactivity Disorder, Oppositional Defiant Disorder, Conduct Disorder
- Trial name
- NCT02063945
- Testing
- Methylphenidate, Risperidone
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Sheba Medical Center
Ovarian Cancer, Ovarian Carcinoma
Biomarkers for Early Detection of Ovarian Cancer Using Uterine Lavage
Screening programs for high-grade ovarian carcinoma failed to reduce disease-specific mortality, since they do not offer early enough detection of the disease.
- Conditions
- Ovarian Cancer, Ovarian Carcinoma, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- BEDOCA (NCT03150121)
- Testing
- Uterine lavage, Blood sample, Uterine lavage catheter
- Where
- 4 sites in Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Crystallization of Cholesterol in Atherosclerosis
Pathological Crystallization of Cholesterol in Atherosclerosis
Endarterectomy of the carotid artery procedure will be performed at Sheba Medical center vascular surgery department, followed by fixation and histology.
- Trial name
- NCT04257942
- Testing
- carotid endarterectomy
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Followin Ketamine Treatment
Ketamine Long Therm Follow Up Study
Results of the study and of 5 years follow up of depressed patients who participated in the study during 2014-2015. We will locate the participants and will interview them will use the same questionnaires to evaluate their…
- Trial name
- ket_Fol_Up (NCT04238039)
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- The Chaim Sheba Medical Center
Infertility Female
IVM for Patients With Low Ovarian Response. Does it Improve IVFoutcomes and Does it Improve the Following IVF Cycle?
Poor ovarian response (POR) is one of the major therapeutic challenges in in vitro fertilization. Several therapeutic approaches for POR have been explored; yet, a single effective strategy has not yet been established.
- Trial name
- NCT02498210
- Testing
- In Vitro Maturation Procedure
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Suicide
Suicide Risk Assessment by Digital Means
This study is an observational study, without intervention. Using a tablet application that developed for this study. In addition, sensors are used to examine the possibility of using the system to assess the risk of suicide.
- Trial name
- NCT04169958
- Testing
- safe mood
- Volunteers
- 50 people
- Sponsor
- The Chaim Sheba Medical Center
Acute Lymphoblastic Leukemia
A Retrospective Study of Patients With Leukemia Relapse in the CNS Treated With CAR T Cells
CAR T cells targeting CD19 have been approved for patients with relapsed or refractory ALL, failing two or more prior protocols.
- Trial name
- NCT04158011
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Sheba Medical Center