Clinical trials: sponsored by Sheba Medical Center
Multiple Sclerosis
Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS
This study evaluates the effects of sustained-release oral dalfampridine in the treatment of upper limb deficits in people with multiple sclerosis (MS).
- Trial name
- NCT02259361
- Testing
- Sustained-release oral dalfampridine
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Polycystic Ovary Syndrome
Endobarrier Treatment in Women With PCOS
Women with Polycystic ovary syndrome (PCOS) experience multiple fertility treatments, a long treatment duration and a low pregnancy prevalence.
- Trial name
- EPCOS (NCT02255578)
- Testing
- Endobarrier treatment in PCOS, clomiphene citrate treatment
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Parkinson
Development of a Monitoring Set-up and Algorithm Using Functional MRI (fMRI) and EEG for Prediction of Response to Repetitive Deep Transcranial Magnetic Stimulation (rDTMS) for Patients With Parkinson's Disease
To characterize physiological biomarkers of positive response to rDTMS using EEG and functional MRI (fMRI) in patients with PD. To develop a set-up and algorithm for neurophysiological monitoring for PD patients using EEG and…
- Trial name
- NCT02249715
- Testing
- Brainsway Multiway deep TMS device (two channels)
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Brain Injury, Stroke
Using Tablets for Upper Extremity Rehabilitation Post Acquired Brain Injury
The purpose of the study is to test the effectiveness of training using novel tablet applications for hand function, compared to traditional hand exercises.
- Trial name
- TBL (NCT02136433)
- Testing
- Tablet - self exercise, GRASP self exercise
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Asymmetric Parkinson's Disease
A Double Blind Sham-controled Study to Evaluate the Influence of Low Frequency Repetitive Transcranial Stimulation (r-TMS) on Motor and Cognitive Measurements in Patients With Asymmetric Parkinson's Disease
The purpose of this study is to test the effects of low frequency deep rTMS using the novel H-coil on the motor, affective and cognitive deficits in patients with asymmetric Parkinson's disease (PD), to establish its safety in…
- Trial name
- NCT01367782
- Testing
- repetitive transcranial stimulation (r-TMS)
- Where
- Israel
- Volunteers
- 51 people
- Sponsor
- Sheba Medical Center
Depressive Disorder, Major
Ketamine Infusions for Major Depression Disorder
Ketamine has been safely used for induction and maintenance of anesthesia for decades and more recently has been used for chronic pain.
- Trial name
- Ketamie (NCT02219867)
- Testing
- Ketamine
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Chronic Diarrhea, Abdominal Pain
Antiparasitic Treatment for Returning Travelers With Chronic Diarrhea
Study hypotheses is that Antiparasitic therapy in patients with chronic diarrhea after travel to a developing country, with a negative stool findings, will be significantly effective in eliminating diarrhea and other…
- Conditions
- Chronic Diarrhea, Abdominal Pain, Bloating
- Trial name
- NCT01070277
- Testing
- Tinidazole and Albendazole
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Typhoid Fever
Typhoid Fever: Combined vs. Single Antibiotic Therapy
The current study goal is to examine the effect of Cephalosporins, Azithromycin and the combination of both on typhoid fever therapy in endemic population.
- Trial name
- NCT02224040
- Testing
- ceftriaxone, ceftriaxone and azithromycin, azithromycin
- Where
- Nepal
- Volunteers
- 120 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation, Non-valvular Atrial Fibrillation
Therapy With New Oral Anticoagulants
The aim of the present registry is to characterize and follow patients prospectively and retrospectively with renal impairment who have been prescribed apixaban for the prevention of stroke in atrial fibrillation, with a…
- Trial name
- NCT02222090
- Where
- Israel
- Volunteers
- 1,500 people
- Sponsor
- Sheba Medical Center
Severe Symptomatic Aortic Stenosis
Evaluation of Association Between Apical Dysfunction and Trans Apical Access for TAVR, in Patients With Severe Aortic Stenosis, Undergoing Trans Apical Trans Catheter Aortic Valve Replacement (TAP-TAVR).
The asses and evaluate whether trans apical access for TAVR is associated with apical dysfunction.
- Trial name
- NCT02210351
- Testing
- MRI test
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Sheba Medical Center
Heart Rate Variability Ischemia Detection
HeartTrends HRV Algorithm for the Detection of Myocardial Ischemia
A total of 621 consecutive male and female subjects, without established CAD, referred to exercise stress testing (EST) due to 1) chest pain syndromes or equivocal/equivalent angina with intermediate pretest probability for CAD…
- Trial name
- NCT02201017
- Where
- 2 sites in United States, Israel
- Volunteers
- 621 people
- Sponsor
- Sheba Medical Center
Cystic Fibrosis
Effect of Probiotics on Sputum Inflammation and Pulmonary Infections in Patients With Cystic Fibrosis
Patients with Cystic Fibrosis have multiple pulmonary infections and repeated antibiotic treatment. These factors taken together with high sputum viscosity and slow motility of the gastrointestinal tract-may change the…
- Trial name
- NCT01201434
- Testing
- Bio-25 probiotic
- Volunteers
- 12 people
- Sponsor
- Sheba Medical Center
Type 2 Diabetes, Obesity
Endobarrier Treatment in Obese Subjects With T2DM
Diabesity (Diabetes accompanied by obesity) is a prevalent condition many times complicated by micro- and macrovascular disease. Many treatments for Diabesity paradoxically cause further weight gain and hypoglycemia.
- Trial name
- NCT01718457
- Testing
- Endobarrier
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Sheba Medical Center
Infertility
Ultrashort GnRH Agonist/Antagonist Versus GnRH Antagonist IVF
The purpose of this study is to evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in good prognosis patients undergoing IVF treatment.
- Trial name
- NCT02173977
- Testing
- ARM A- Agonist/Antagonist protocol, ARM B- Antagonist protocol
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Women With Poor Ovarian Response
GnRH Agonist Triggering Supplemented With Hcg in Women With Poor Ovarian Response
During the last decades, owing to the growing tendency of women to delay childbearing plans because of career and personal priorities, fertility specialists today are seeing more and more women with poor ovarian reserve and with…
- Trial name
- NCT02144818
- Testing
- Ovitrel, Decapeptyl
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Constipation
Treatment of Chronic Constipation in Children With Lactobacillus Reuteri
Lactobacillus reuteri (Biogaia) may be beneficial for treatment of chronic constipation in children 4-10 years of age.
- Trial name
- NCT01629147
- Testing
- Biogaia
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
A Comparison Study of Two Respiratory Physical Therapy Methods and Standard Medical Treatment for Treating COPD Patients During Acute Exacerbation
One of the main goals of the respiratory physical therapy is to help people who are suffering from accumulating of secretions in their airways and lungs.
- Trial name
- NCT02140892
- Testing
- respiratory physical therapy manual technique- Autogenic Drainage, respiratory physical therapy technique- IPV
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center
Pulmonary and Mediastinal Lesions
Feasibility of Confocal Laser Microscopy (CLM)in the Computed Tomography-guided Needle Biopsy of Pulmonary and Mediastinal Lesions
The hypothesis of this proposal is that needle confocal laser microscopy (nCLM) may improve the yield of trans thoracic needle biopsy (TTNB) of lung or mediastinal lesions by differentiating between viable and necrotic tissue.
- Trial name
- NCT01979692
- Testing
- confocal laser microscopy CLM at trans thoracic needle biopsy TTNB, CT guided trans thoracic needle biopsy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Sleep Deprivation
The Effect of Partial and Complete Sleep Deprivation on Heat Tolerance
The purpose of the present study is to evaluate the effect of partial and complete sleep deprivation on exercise heat tolerance. Twelve healthy young male volunteers will participate in the study.
- Trial name
- NCT01596543
- Testing
- partial and complete sleep deprivation
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cigarette Smoking
The Effect of Smoking on Thermoregulation
To the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a…
- Trial name
- NCT01596556
- Testing
- Nicotine, cigarette smoking
- Where
- Israel
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center