Clinical trials: sponsored by Shirley Ryan AbilityLab
Spinal Cord Injury
Effects of 4-AP on Functional SCI Recovery
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
- Trial name
- NCT05447676
- Testing
- Dalfampridine, STDP stimulation, Exercise training
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Shirley Ryan AbilityLab
SCI - Spinal Cord Injury
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
- Trial name
- NCT06853015
- Testing
- Dalfampridine, STDP stimulation, Exercise training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy
Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy
This is an intervention study to investigate the impact of a smart ankle-foot orthosis (AFO) on mobility outcomes in children with Cerebral Palsy.
- Trial name
- NCT07434492
- Testing
- Smart Ankle-Foot Orthosis, 5-Azacitidine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy
tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy.
- Trial name
- NCT07433023
- Testing
- tSCS, 5-Azacitidine, Mannitol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Parkinson Disease
Exercise Strategies in Parkinson's Disease
The goal of this clinical trial is to learn about exercise and physical activity people with Parkinson's Disease. The main questions it aims to answer are: 1) learn about the physical activity and exercise behaviors of people…
- Trial name
- NCT06104397
- Testing
- Written exercise guidance by neurologist, Physical therapy
- Where
- 7 sites in United States
- Volunteers
- 288 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Investigation Into an Innovative, Clinical Slip Inducing Device in the Chronic Incomplete Spinal Cord Population
The objective of this project is to fully test a newly developed affordable cost variable slip inducer in the ambulatory, incomplete spinal cord population.
- Trial name
- NCT03744286
- Testing
- Slip Training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Parkinson Disease
C-STAR Movement Database
The purpose of this study is to develop a database that contains movement and rehabilitation-related data collected through the use of wearable sensors and video.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
- Trial name
- NCT05471375
- Testing
- Database Entry
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy
Robot Based Gait Training Therapy for Pediatric Population With Cerebral Palsy Using the CPWalker
This trial is being conducted to determine if the CPWalker can be used as a gait training intervention for pediatric patients with gait impairments due to cerebral palsy
- Trial name
- NCT03937700
- Testing
- CPWalker Robotic Exoskeleton
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching
The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus…
- Trial name
- NCT05424172
- Testing
- Stage-I, Group 1: Self monitoring using Non-interactive App, Stage-I, Group 2: Self monitoring using Interactive App, Stage-II, Groups 1a/2a: E-Coaching 1x per month
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebrovascular Accident, Post-polio Syndrome
Nomad P-KAFO Study
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk.
- Conditions
- Cerebrovascular Accident, Post-polio Syndrome, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- NCT05644522
- Testing
- Indego Nomad® Powered Knee-Ankle-Foot Orthosis (P-KAFO) (Parker Hannifin Corp., Cleveland, OH)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Characterization and Clinical Trial of a Variable Friction Shoe
More than one million Americans present with foot drop after stroke. As the aging population grows in the United States and across the world, incidence of stroke will grow as age is a key risk factor, thus there will be a need…
- Trial name
- NCT06234124
- Testing
- Variable Friction Shoe Training, Ankle Foot Orthosis (AFO) Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury, ALS (Amyotrophic Lateral Sclerosis)
Clinical Outcome Assessment for AT & BCI
Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers.
- Trial name
- NCT07407725
- Testing
- Eye Tracker, Mouth Operated Joystick, Non-invasive electroencephalogram (EEG) Headset
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Real World Upper Extremity Activity of Stroke Survivors
The investigators want to objectively measure, through the use of accelerometers, the time, movement intensity, and bilaterality of Upper Extremity (UE) activity and see if these improve over the course of therapy.
- Trial name
- NCT07557940
- Volunteers
- 15 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Development of Low Cost Devices to Increase Access to Treadmill Training
The goals of this Model System Program are to expand upon and advance the findings and outcomes of previous and current Model Systems clinical research, to continue to develop and study the effectiveness of innovative treatment…
- Trial name
- NCT02560506
- Testing
- Elastic assisted treadmill walking
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Shirley Ryan AbilityLab
Healthy Adults
Transcutaneous Spinal Cord Stimulation in Healthy Adults
The goal of this study is to understand how transcutaneous spinal cord stimulation (tSCS) waveform, modulation frequency, and stimulation location impact lower extremity muscle activation and participant comfort in adults without…
- Trial name
- NCT06116838
- Testing
- Spinal motor evoked responses (sMERs), Continuous stimulation tolerance
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Transfemoral Amputees
Impact of Powered Knee-Ankle Prosthesis Leg on Everyday Community Mobility and Social Interaction
The overall goal of this research is to determine the efficacy of new powered prosthetic devices for individuals with transfemoral amputations.
- Trial name
- NCT03204513
- Testing
- Vanderbilt Powered Knee-Ankle Prosthesis, Microprocessor (MP) Knee Prosthesis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Shirley Ryan AbilityLab
Parkinson Disease, Multiple Sclerosis
Remote Therapeutic Monitoring Exercise Tracking
The purpose of this study is to examine physical activity and exercise behaviors in people with Parkinson's Disease and Multiple Sclerosis over the course of 1-year using a cloud-based remote monitoring platform.
- Trial name
- NCT06306768
- Testing
- Activity Monitoring
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Shirley Ryan AbilityLab
Cancer
Pilot Remote Therapeutic Monitoring in Cancer Patients
The goal of this clinical trial is to learn about exercise and physical activity in individuals who are undergoing cancer treatment. The clinical trial is embedded in a pilot implementation feasibility study.
- Trial name
- NCT07007039
- Testing
- Datos Health App
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
American Heart Association- Stroke/Hypoxia Study
Of the 795,000 people who experience a stroke every year in the US, only a small percentage will achieve full recovery. While current therapies promote strength and endurance, none directly address the unique potential of the…
- Trial name
- NCT04019522
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Shirley Ryan AbilityLab
Long Covid
Improving Attention in Individuals With Long COVID-19
This study is to find out if the Attention Processing Training program is a potential treatment for brain fog symptoms, reported by people with Long-Covid. Also investigating the feasibility of completing this program virtually.
- Trial name
- LongCovAtten (NCT06503874)
- Testing
- Attention Training, Music Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Shirley Ryan AbilityLab