Clinical trials: sponsored by Singapore General Hospital
Metabolic Dysfunction Associated Fatty Liver Disease
Dietary Glycine Supplementation in Metabolic Dysfunction-associated Steatotic Liver Disease
This study aims to investigate abnormalities in glycine-dependent metabolic pathways in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and evaluate whether dietary glycine supplementation improves…
- Trial name
- NCT07285135
- Testing
- Glycine
- Where
- Singapore
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Obesity
Investigating the Prevalence and Risk Factors for Sarcopenia Amongst Adults Seeking Treatment for Obesity
Sarcopenia, a condition where individuals lose muscle mass and strength, is associated with poorer health and function. While aging is a well-known cause of sarcopenia, obesity is increasingly recognised as a significant factor.
- Trial name
- NCT07541677
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- Singapore General Hospital
Knee Osteoarthristis
Outpatient Physiotherapy vs. mHealth Exercise and Self-Management for Knee Osteoarthritis (MOKneeTOR)
Symptomatic osteoarthritis (OA) of the knee affects approximately one-fifth (~300K) of Singaporeans aged 50 years or older, with the disease prevalence increasing with age.
- Trial name
- MOKneeTOR (NCT07767409)
- Testing
- MOKneeTOR with standard app configuration, Hospital-based outpatient rehabilitation program, MOKneeTOR with standard app configuration and enhanced personalisation
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- Singapore General Hospital
Urolithiasis, Tamsulosin
Medication Facilitated Ureteral Access Sheath Deployment During Ureteroscopy: The Impact of One Week of Preoperative Tamsulosin
The goal of this clinical trial is to assess whether tamsulosin given one week prior to renal or ureteric stone surgery would improve the success rate of ureteral access sheath deployment and decrease ureteral injury
- Conditions
- Urolithiasis, Tamsulosin, Pre-operative, Ureteral Access Sheath Placement
- Trial name
- NCT07847866
- Testing
- Tamsulosin 0.4 MG, Control
- Where
- 2 sites in Singapore
- Volunteers
- 111 people
- Sponsor
- Singapore General Hospital
Palliative Care, Advanced Cancer
Coaching in Palliative Surgical Oncology
This study aims to evaluate the effectiveness of a serious illness coaching intervention (CONCORD) in improving quality of serious illness conversation (SIC), treatment decision-making, goal-concordant care delivery and quality…
- Trial name
- NCT07789093
- Testing
- CONCORD coaching intervention
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- Singapore General Hospital
Interstitial Lung Disease, Myositis
Treatment Response in Immune-mediated Myositis Associated Rapidly-progressing Interstitial Lung Disease
Idiopathic inflammatory myopathies (IIM) are a group of autoimmune conditions characterized by inflammation of muscles with possible extra-muscular manifestations which can include skin and interstitial lung disease (ILD).
- Trial name
- NCT07775235
- Testing
- Immunosuppressant Regimen
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Singapore General Hospital
Knee Osteoarthritis
Formative Evaluation of a Mobile Application Facilitated Self-directed Rehabilitation Programme for Knee Osteoarthritis
In Singapore, knee osteoarthritis (OA) is a prevalent musculoskeletal condition, reflecting global trends of an aging population and lifestyle factors.
- Trial name
- NCT07773480
- Testing
- Self-directed rehabiliation using the mobile application
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore General Hospital
Peripheral Arterial Disease(PAD), Imaging Evaluation
Assessment of Revascularization in Plantar Foot of Diabetic Patients Pre and Post Angioplasty Using Spatial Frequency Domain Imaging
To explore the usefulness of SFDI in the assessment of revascularization pre and post intervention
- Trial name
- NCT07097857
- Testing
- SFDI
- Where
- Singapore
- Volunteers
- 15 people
- Sponsor
- Singapore General Hospital
Rheumatoid Arthritis (RA)
Complementary Herbal Approach to Rheumatoid Management Study (CHARMS)
Rheumatoid Arthritis (RA) is a chronic disease characterised by symmetric, polyarticular pain and swelling, involving small joints of the hands and feet.
- Trial name
- CHARMS (NCT07627893)
- Testing
- Shu Bi Ning (modified Si Miao Xiao Bi), Methotrexate
- Where
- Singapore
- Volunteers
- 132 people
- Sponsor
- Singapore General Hospital
Aromatherapy
Inhalation Aromatherapy for Patients Undergoing Conservative Sharp Wound Debridement:
The goal of this pilot clinical trial is to learn if inhalation aromatherapy works to reduce anxiety and pain in patients with venous leg ulcers undergoing conservative sharp wound debridement (CSWD).
- Trial name
- NCT07732036
- Testing
- Inhalation Aromatherapy
- Where
- 2 sites in Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Type 2 Diabetes
Durian Consumption in Adults With Type 2 Diabetes Mellitus
This single-arm clinical trial investigates the effects of daily durian consumption on the gut microbiome, host metabolome, and glucose metrics in adults with type 2 diabetes mellitus (T2DM).
- Trial name
- DURIOME-T2D (NCT07697612)
- Testing
- Durian pulp
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Immune System Responses and Trained Immunity After AS01 Administration, Healthy Adult
Improving Vaccine Protection for Adults
As people grow older, their immune system - the body's natural defence against diseases - becomes weaker, making them more vulnerable to infections and less responsive to vaccines.
- Trial name
- NCT07527247
- Testing
- AS01 adjuvant (0.5 mL intramuscular), YF17D (Stamaril, Sanofi-Pasteur)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Peritoneal Dialysis Catheter Exit Site Infection, Peritoneal Dialysis Catheter Tunnel Infection
Silver-Impregnated Dressings for Catheter Exit-Site and Tunnel Infections in Peritoneal Dialysis Patients
The goal of this clinical trial is to evaluate the feasibility and acceptability of using silver-impregnated dressings, compared to standard daily topical antibiotic exit-site dressings, for the management of catheter exit-site…
- Trial name
- NCT07641491
- Testing
- Silver-Impregnated Dressing, Standard Exit-Site Care With Topical Antibiotic Dressing
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Singapore General Hospital
Colorectal Neoplasms, Incisional Hernia
AP-NOSES: A Prospective Multicentre Registry of Natural Orifice Specimen Extraction in Minimally Invasive Colorectal Surgery
Natural orifice specimen extraction (NOSE) is a minimally invasive colorectal surgical technique in which the surgical specimen is removed through a natural orifice, including transanal or transvaginal routes, thereby avoiding an…
- Trial name
- AP-NOSES (NCT07615036)
- Testing
- Natural Orifice Specimen Extraction, Transabdominal Specimen Extraction
- Where
- Singapore
- Volunteers
- 800 people
- Sponsor
- Singapore General Hospital
Doctor-Patient Relation
Doctor-patient Partnerships: the Key to a Better Standard of Medical Advice?
Background: The current legal standard of advice in Singapore has three components: distinction of advice from the other parts of clinical consultation (i.e.
- Trial name
- NCT05588856
- Testing
- In depth Interview
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Singapore General Hospital
Peritoneal Dialysis Catheter Exit Site Infection
Hydrocolloid Dressing for Catheter Exit Site Care in Peritoneal Dialysis Patients
The study aims to examine the use of hydrocolloid dressing for catheter exit-site care in peritoneal dialysis patients. It is a pilot study, and participants will be randomized to either receiving weekly hydrocolloid dressing or…
- Trial name
- NCT05143164
- Testing
- hydrocolloid dressing, Gentamicin Sulfate, Topical
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Singapore General Hospital
Consent Forms, Anesthesia
Effectiveness of Large Language Model for Anaesthesia and Procedural Consent
Patient understanding of anaesthesia risks remains inconsistent due to time constraints, language barriers, and variable clinician communication styles.
- Conditions
- Consent Forms, Anesthesia, Artificial Intelligence (AI)
- Trial name
- PEAR (NCT06949462)
- Testing
- PEAR
- Where
- 2 sites in Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Kidney Transplant Infection, Kidney Transplant Rejection
Immune Monitoring of Prevalent Kidney Transplant Recipients Using Torque Teno Virus: A Single-Center, Prospective Cohort Study
Kidney transplant recipients (KTRs) suffer from immunosuppression-related adverse events (iRAEs), such as infections and malignancy from chronic immunosuppression exposure but are also at risk of graft loss from rejection with…
- Conditions
- Kidney Transplant Infection, Kidney Transplant Rejection, Kidney Transplant; Complications
- Trial name
- TTV-KTR-SGH (NCT05836636)
- Testing
- Torque teno virus DNA measurement
- Where
- Singapore
- Volunteers
- 172 people
- Sponsor
- Singapore General Hospital
Chronic Pain, Anxiety
Music Therapy to Reduce Anxiety and Pain in Chronic Pain Patients During Procedures
This study aims to find out whether listening to music before, during, and after pain procedures can help reduce anxiety, pain catastrophising, and acute pain in patients with chronic pain.
- Conditions
- Chronic Pain, Anxiety, Music Therapy, Pain Perception
- Trial name
- NCT07252648
- Testing
- Music Therapy
- Volunteers
- 110 people
- Sponsor
- Singapore General Hospital
Pressure Injuries, Caregiver
Evaluate the Feasibility and Effectiveness of a Community-based Care Bundle in Managing and Preventing Pressure Injuries
Community-acquired pressure injuries are pressure injuries that developed outside of hospital, typically in the patient's own home environment. Pressure injuries (PI) used to be commonly known as bedsores or pressure ulcers.
- Conditions
- Pressure Injuries, Caregiver, Community Dwelling Older Adult
- Trial name
- NCT07074743
- Testing
- community-based PI care bundle, Wait-list
- Where
- 2 sites in Singapore
- Volunteers
- 216 people
- Sponsor
- Singapore General Hospital