Clinical trials: sponsored by Sir Run Run Shaw Hospital
Sepsis
Clinical Value of EMR3 in Sepsis Diagnosis, Monitoring, and Prognosis: A Multicenter Prospective Observational Study
Sepsis is a life-threatening condition caused by a dysregulated immune response to infection, leading to organ dysfunction and increased mortality.
- Trial name
- EMR3-SEPSIS (NCT07896018)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Cancer
Modified Short-Course Radiotherapy Combined With Tislelizumab and CAPOX for pMMR/MSS Rectal Cancer
The goal of this clinical trial is to learn if node-sparing modified short-course radiotherapy combined with tislelizumab and CAPOX works to treat pMMR/MSS locally advanced mid-to-low rectal cancer.
- Trial name
- mRCATS (NCT07900061)
- Testing
- node-sparing modified short-course radiotherapy, standard short-course radiotherapy
- Volunteers
- 210 people
- Sponsor
- Sir Run Run Shaw Hospital
Chronic Kidney Failure
BCD to Measure the ED95 of Remimazolam-Assisted Sedation in Arteriovenous Fistula Creation Surgery
This study intends to measure the ED95 of remimazolam-assisted sedation in arteriovenous fistula creation by BCD.
- Trial name
- BCD (NCT06998732)
- Testing
- remimazolam sedation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Cancer
Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma
Short-course radiotherapy combined with immunotherapy may bring revolutionary changes to the preoperative neoadjuvant treatment mode for locally advanced rectal cancer.In view of the shortcomings of the current preoperative…
- Trial name
- NCT05752136
- Testing
- Envafolimab
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Sir Run Run Shaw Hospital
Lung Cancer (NSCLC)
Construction and Application Research of a Multidisciplinary Combined Exercise Management Program for Elderly Lung Cancer Patients After Surgery Based on Social Cognitive Theory
Informed Consent Form Protocol Title: Construction and Application Research of a Multidisciplinary Combined Exercise Management Program for Elderly Lung Cancer Patients After Surgery Based on Social Cognitive Theory Version…
- Trial name
- NCT07824778
- Testing
- Exercise Management for Elderly Lung Cancer Patients After Surgery Based on Social Cognitive Theory
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Sir Run Run Shaw Hospital
Acute Kidney Injury, Cardiac Surgery
Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Acute Kidney Injury in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Acute kidney injury (AKI) is a common complication after cardiac surgery using cardiopulmonary bypass, leading to longer hospital stays and worse outcomes. Effective preventive therapies are lacking.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07549243
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sir Run Run Shaw Hospital
Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures
Electroacupuncture at ST36 for Reducing Postoperative Inflammation After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery using cardiopulmonary bypass can trigger a marked systemic inflammatory response and may contribute to postoperative organ dysfunction and delayed recovery.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures, Postoperative Complications (Cardiopulmonary)
- Trial name
- EAST36-CPB (NCT07795112)
- Testing
- Electroacupuncture at Bilateral ST36, Acupuncture Without Electrical Stimulation at Bilateral ST36
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Etrasimod, Mesalazine
Comaprison of Efficacy and Safety Between Etrasimod vs Mesalazine in Chinese Adults With Active UC
Ulcerative colitis (UC) is a chronic, relapsing inflammatory disease of the colon that causes diarrhea, bleeding, and abdominal pain.
- Conditions
- Etrasimod, Mesalazine, Ulcerative Colitis (UC), Head-to-head
- Trial name
- E-Compare (NCT07782242)
- Testing
- Etrasimod, mesalazine
- Volunteers
- 320 people
- Sponsor
- Sir Run Run Shaw Hospital
Atrial Fibrillation (AF)
Catheter Ablation for Atrial Fibrillation in Non-Fluoroscopic Lab
This randomized controlled trial investigates the efficacy and safety of atrial fibrillation (AF) catheter ablation performed in non-fluoroscopic electrophysiology (EP) labs compared to conventional fluoroscopic digital…
- Trial name
- NON-FLUORO-LAB (NCT06719921)
- Testing
- AF ablation, AF ablation in a non-fluoroscopic EP lab, AF ablation in a fluoroscopic lab
- Where
- China
- Volunteers
- 724 people
- Sponsor
- Sir Run Run Shaw Hospital
Colorectal Cancer (CRC)
Transcutaneous Electrical Acustimulation on Postoperative Bowel Function Recovery in Elderly Patients
The goal of this clinical trial is to clarify the efficacy and safety of transcutaneous electrical acustimulation (TEA) in elderly patients with colorectal cancer, and to evaluate its clinical value in promoting postoperative…
- Trial name
- NCT07574502
- Testing
- TEA
- Where
- 2 sites in China
- Volunteers
- 190 people
- Sponsor
- Sir Run Run Shaw Hospital
COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD
Remote Intervention Versus Routine Monitoring in COPD Patients With Chronic Hypercapnia Receiving Home Non-invasive Respiratory Support
This study is a randomized controlled trial designed to compare the effectiveness of active remote intervention versus passive monitoring alone in patients with Chronic Obstructive Pulmonary Disease (COPD) and chronic hypercapnic…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Acute Exacerbation of COPD, Hypercapnia
- Trial name
- NCT07751003
- Testing
- Remote Management, Remote Monitoring Only
- Where
- 4 sites in China
- Volunteers
- 236 people
- Sponsor
- Sir Run Run Shaw Hospital
Post-traumatic Stress Disorder (PTSD)
PTSD Risk Prediction Model for EICU Survivors
Brief Title: PTSD Risk Prediction Model for EICU Survivors Official Title: Development and Validation of a Risk Prediction Model for Post-Discharge Post-Traumatic Stress Disorder in Emergency Department-Admitted EICU Survivors…
- Trial name
- NCT07747415
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Sir Run Run Shaw Hospital
Problematic Internet Use
Group-based IMPROVE Therapy for Problematic Internet Use in University Students
Problematic internet use (PIU) is a growing behavioral health concern among university students. This study aims to evaluate the effectiveness and psychological mechanisms of "IMPROVE," a manualized, multimodal group-based…
- Trial name
- IMPROVE-PIU (NCT07434778)
- Testing
- IMPROVE Program, Digital Psychoeducation Newsletters
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Sir Run Run Shaw Hospital
Diaphragm, Speckle Tracking
Regional Diaphragmatic Synchrony Index for Predicting Weaning Outcomes During Pressure Support Ventilation Spontaneous Breathing Trials
The primary aim of this study is to evaluate the predictive value of the inspiratory regional diaphragmatic synchrony index (RDSI-insp) during PSV-SBT for first-attempt weaning failure.
- Trial name
- NCT07733102
- Testing
- Diagnostic Procedure: Diaphragm Ultrasound and Weaning Assessment
- Volunteers
- 110 people
- Sponsor
- Sir Run Run Shaw Hospital
Problematic Use of Mobile Phones
Cognitive Behavioral Therapy for Mobile Phone Addiction in Hospitalized Patients
Problematic mobile phone use is excessive dependence and use of electronic products and their functions, which affects the daily life of users.
- Trial name
- CBT (NCT07457658)
- Testing
- Cognitive-behavioral therapy, Traditional treatment in the ward
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
COPD (Chronic Obstructive Pulmonary Disease)
Effectiveness of DITM Versus IMT in COPD Patients
The goal of this clinical trial is to learn if digital inhaled therapy management (DITM) and inspiratory muscle training (IMT), alone or in combination, can improve outcomes in adults aged 40 years and older with symptomatic…
- Trial name
- NCT06958666
- Testing
- Digital Inhaled Therapy Management, Inspiratory Muscle Training
- Where
- 9 sites in China
- Volunteers
- 410 people
- Sponsor
- Sir Run Run Shaw Hospital
Speckle Tracking, Diaphragm
End-Expiratory Diaphragmatic Residual Contraction Index for Identifying Intrinsic PEEP and Assisting PEEP Titration: A Prospective Physiological Study
This study proposes the End-expiratory Diaphragmatic Residual Contraction (EDRC) index to quantify residual diaphragmatic activity at end-expiration during Pressure Support Ventilation (PSV) mode.
- Trial name
- NCT07697703
- Testing
- Short-term PEEP Step Trial and EDRC Ultrasound Assessment
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, PFA Ablation and LAAC Procedures
Left Atrial Appendage Closure With Versus Without Pulsed Field Ablation in Atrial Fibrillation Patients With Mild Symptoms and High Stroke Risk
This study is a prospective, multicenter, single-blinded, randomized controlled trial to investigate whether concomitant left atrial appendage closure (LAAC) and pulsed field ablation (PFA) is more effective than LAAC alone in…
- Trial name
- REVERSE-OPTION (NCT07453940)
- Testing
- LAAC plus PFA for persistent AF with high risk of stroke, LAAC for persistent AF with high risk of stroke
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Cancer
Node-sparing Short-Course Radiation Combined With CAPOX and Tislelizumab for MSS Rectal Cancer
This is a randomized, prospective, multicenter, open-label, Phase III clinical trial to evaluate node-sparing modified short-course radiation (Radiation targeting the tumor bed without irradiating surrounding tumor-draining lymph…
- Trial name
- mRCAT-III (NCT06507371)
- Testing
- node-sparing modified short-course radiotherapy, PD-1 antibody, Capecitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sir Run Run Shaw Hospital
Malignant Pulmonary Nodules, Lung Cancer
Evaluation of the Safety and Efficacy of a Wideband Electric Pulse Tumor Ablation System for Malignant Pulmonary Nodules
To evaluate the safety and efficacy of the wideband electric pulse tumor ablation system, for the treatment of malignant pulmonary nodules.
- Trial name
- NCT07638228
- Testing
- wideband electric pulse tumor ablation system treatment
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Sir Run Run Shaw Hospital