Clinical trials: sponsored by Sir Run Run Shaw Hospital
Hepatocellular Carcinoma
Study on the Therapeutic Effect of Different Infusion Times of Tislelizumab on Postoperative High-risk Hepatocellular Carcinoma
Study on the therapeutic effect of different infusion times on tislelizumab in high-risk postoperative hepatocellular carcinoma
- Trial name
- NCT07243691
- Testing
- Tislelizumab: 200mg, intravenous infusion, Q3W
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sir Run Run Shaw Hospital
Urinary Bladder Neoplasms
The Impact of Intelligent Nursing Based on Health Cloud Platform on Active Health Management of Urostomy Patients
Research data show that the incidence of bladder tumors in China ranks first among malignant tumors of the urinary system and is on the rise .
- Trial name
- NCT07201441
- Testing
- Smart Nursing Based on the Health Cloud Platform
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sir Run Run Shaw Hospital
Cholangiocarcinoma
Exploring the Safety and Efficacy of Sacituzumab Tirumotecan Combined With Pucotenlimab in the Treatment of Advanced Cholangiocarcinoma
1. Primary Objectives (1) To evaluate the safety and tolerability of sacituzumab tirumotecan in combination with pucotenlimab in patients with advanced cholangiocarcinoma; (2) To assess the objective response rate (ORR) of…
- Trial name
- NCT07105852
- Testing
- Sacituzumab tirumotecan (iv)+Putolizumab injection (iv)
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Sir Run Run Shaw Hospital
Liver Cancer, Hepatectomy
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing…
- Conditions
- Liver Cancer, Hepatectomy, Anesthesia Techniques, Postoperative Pain
- Trial name
- NCT07097220
- Testing
- General Anesthesia (GA) group, General-Epidural Anesthesia (GEA) group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
Advanced Pancreatic Ductal Adenocarcinoma
Icaritin in Combination With AG in Patients With Previously Untreated Advanced Pancreatic Ductal Adenocarcinoma
Icaritin is a drug that has been approved by the National Medical Products Administration (NMPA) based on a multicenter, randomized, double-blind, parallel-controlled Phase III clinical trial - SNG1705 ICR-1.
- Trial name
- NCT06825546
- Testing
- Icaritin, AG chemotherapy
- Where
- 6 sites in China
- Volunteers
- 70 people
- Sponsor
- Sir Run Run Shaw Hospital
Hepatoma Resectable
The Treatment of Bioartificial Liver With hiHep Cells After Extensive Hepatectomy
It is a prospective, non-randomized, single-arm cohort study. A total of 10 patients will be included in this study. Based on standardized treatment, the treatment of bioartificial liver device will be applied 48-72 hours after…
- Trial name
- NCT05035108
- Testing
- hiHep bioartificial liver therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Sir Run Run Shaw Hospital
Substance Use Disorder (SUD)
Mobile Phone-based Smoking Cessation Program
In this online, randomized controlled trial (RCT), the participants will be randomized and allocated in 1:1 ratio to mobile phone-based intervention group or to the wait-list control group.
- Trial name
- NCT06747182
- Testing
- mobile phone-based intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Stroke, Acute Ischemic
Early Endovascular Treatment in Isolated Internal Carotid Artery Occlusion
The primary hypothesis being tested in this trial is that acute ischemic stroke with isolated internal carotid artery occlusion will have improved clinical outcomes when given early endovascular treatment compared with that of…
- Trial name
- EVT-iICAO (NCT07016854)
- Testing
- Endovascular treatment, The best medical treatment
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Incontinence-associated Dermatitis
Prevention of Incontinence-associated Dermatitis and Maintenance of Local Skin Microclimate
To explore the feasibility of Jefcare Sterile Medical Sheets in preventing incontinence-associated dermatitis and maintaining a stable local skin microclimate in adult patients in the intensive care unit.
- Trial name
- NCT06509932
- Testing
- Jefcare Sterile Medical Sheets, MoliCare Premium Bed Mats
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sir Run Run Shaw Hospital
Smoking Cessation; Tobacco Dependence
Smoking Cessation Program With CBT and Mindfulness Audio Support: A Randomized Controlled Trial
This protocol describes a randomized controlled trial evaluating the effectiveness of a smoking cessation program with two intervention methods.
- Trial name
- NCT06901713
- Testing
- cognitive behaviour thearpy, mindfulness
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Sir Run Run Shaw Hospital
Substance Use Disorder
The Effectiveness of Mindfulness-based Relapse Prevention
This study developed a Mindfulness-based Relapse Prevention targeting craving. Based on the Randomized Controlled Trial design, 600 adult USD females and 600 adult USD males with methamphetamine, heroin, or ketamine in…
- Trial name
- NCT06739304
- Testing
- Mindfulness-based Relapse Prevention
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Squamous Cell Carcinoma of Head and Neck
The Efficacy and Safety of Pucotenlimab Combined With TP Chemotherapy as Neoadjuvant Therapy for Locally Advanced HNSCC
Study Objective: To evaluate the efficacy and safety of pucotenlimab combined with TP (cisplatin + docetaxel) as neoadjuvant therapy for locally advanced head and neck squamous cell carcinoma (HNSCC).
- Trial name
- NCT06895369
- Testing
- Pucotenlimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sir Run Run Shaw Hospital
MSS Locally Advanced Rectal Adenocarcinoma
Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma (PRECAM)
Short-course radiotherapy combined with immunotherapy may bring revolutionary changes to the preoperative neoadjuvant treatment mode for locally advanced rectal cancer.
- Trial name
- NCT05216653
- Testing
- Envafolimab, Oxaliplatin, Capecitabine
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sir Run Run Shaw Hospital
Rectal Adenocarcinoma
Short-Course Radiotherapy Combined with Intracavitary Brachytherapy Followed by Pucotenlimab, Bevacizumab, Oxaliplatin, and Trifluridine/Tipiracil (TAS-102) for Total Neoadjuvant Therapy of Microsatellite Stable (MSS) Locally Advanced Low Rectal Cancer
A Prospective Single-Arm Study of Short-Course Radiotherapy Followed by PD-1 Monoclonal Antibody, Bevacizumab, Oxaliplatin, and Trifluridine/Tipiracil for Total Neoadjuvant Therapy in MSS Locally Advanced Low Rectal Cancer.
- Trial name
- SCRIPBOT (NCT06872606)
- Testing
- Pucotenlimab, Bevacizumab, Oxaliplatin
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sir Run Run Shaw Hospital
Colorectal Cancer
Clinical Application of Carbon Nanoparticles in Lymph Node Tracing and Surgery Guiding of Colorectal Cancer
This trial aims to clarify the relationship between carbon nanoparticles labeled lymph nodes and lymph node metastasis in different lymph node regions of colorectal cancer, and to clarify the application value of carbon…
- Trial name
- CNP-CRC (NCT06783985)
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Sir Run Run Shaw Hospital
Low Rectal Cancer
Nodes-sparing Short-course Radiation Combined With CAPOX and Tislelizumab for MSS Middle and Low Rectal Cancer
This is an open-label, prospective, multicenter phase II clinical trial to evaluate modified short-course radiation (Radiation targeting the tumor bed without irradiating surrounding tumor-draining lymph nodes) combined with…
- Trial name
- mRCAT (NCT05972655)
- Testing
- Modified short-course radiotherapy, PD-1 antibody, Capecitabine
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sir Run Run Shaw Hospital
Biliary Tract Carcinoma
Irinotecan Liposomes +5-FU/LV Versus Capecitabine in Patients of Recurrence After Resection of Resectable BTC
Irinotecan liposome combined with 5-FU/LV has shown good efficacy and has certain advantages in reducing the adverse reactions of conventional chemotherapy drugs.
- Trial name
- NICRRBTC (NCT06699459)
- Testing
- Irinotecan Liposome, Capecitabine
- Where
- 6 sites in China
- Volunteers
- 76 people
- Sponsor
- Sir Run Run Shaw Hospital
Incontinence-associated Dermatitis
Prevention of Incontinence-associated Dermatitis and Maintenance of Local Skin Microclimate：A Multicenter Study
To explore the feasibility of Jefcare Sterile Medical Sheets in preventing incontinence-associated dermatitis and maintaining a stable local skin microclimate in adult patients in the intensive care unit.
- Trial name
- I-and-M-m (NCT06644027)
- Testing
- Jefcare Sterile Medical Sheets, Molicare Premium Bed Mat
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Stroke, Acute, Cerebrovascular Disorders
Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy…
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- TEMPOS (NCT06633809)
- Testing
- Immediate endovascular therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
Mechanical Ventilation, Atelectasis
To Assess the Effectiveness of Three Distinct Mechanical Assisted Sputum Evacuation Apparatuses in the Treatment of Patients With Mechanical Ventilation-induced Atelectasis
Retention of airway secretions is a common clinical problem in patients with mechanical ventilation. Effective removal of airway secretions requires a balance between the production and removal of airway secretions through the…
- Trial name
- EOTEOMASE (NCT06631716)
- Testing
- CVT, HFCWO, MetaNeb
- Volunteers
- 84 people
- Sponsor
- Sir Run Run Shaw Hospital