Clinical trials: sponsored by St. Olavs Hospital
Depression Moderate, Anxiety, Social
Effects and Cost-effectiveness of e-Meistring - a Guided Internet-delivered Psychological Treatment
The goal of this observational multicentre study is to address the effectiveness and cost-effectiveness of providing a therapist guided internet based cognitive behavioural therapy (ICBT) for common mental disorders in a routine…
- Conditions
- Depression Moderate, Anxiety, Social, Panic Disorder
- Trial name
- NCT05868135
- Testing
- eMeistring
- Where
- 4 sites in Norway
- Volunteers
- 800 people
- Sponsor
- St. Olavs Hospital
Cancer, Palliative Care, Patient Care
Dexmedetomidine for Refractory Pain in Palliative Cancer Patients
The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids).
- Conditions
- Cancer, Palliative Care, Patient Care, Pain Management, Dexmedetomidine Analgesia
- Trial name
- DEX-PAL (NCT07885475)
- Where
- 4 sites in Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Stress Disorders, Post-Traumatic, Mental Disorders
Group-based Stabilization and Skill Training for Patients With Lasting Posttraumatic Reactions in Mental Health Care
This study evaluates the addition of a group based stabilization and skill-training intervention to individual out-patient treatment for long lasting post-traumatic reactions.
- Conditions
- Stress Disorders, Post-Traumatic, Mental Disorders, Trauma and Stressor Related Disorders
- Trial name
- NCT03887559
- Testing
- Group-based stabilization and skill training in addition to individual treatment, Treatment as usual
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- St. Olavs Hospital
Gastro Esophageal Reflux Disease
Endoscopic Treatment of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) occurs when stomach acid repeatedly flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the inner lining of the esophagus.
- Trial name
- NCT05678491
- Testing
- Endoscopic mucosal band ligation
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- St. Olavs Hospital
Type 1 Diabetes
Premixed Glucagon/Insulin Solution for Faster Insulin Absorption in Type 1 Diabetes
We will investigate if Lyumjev premixed with nanogram amounts of glucagon speed up the absorption of insulin and the effect on whole body glucose consumption compared to native lyumjev in patients with type 1 diabetes.
- Trial name
- MicroGlucag2 (NCT06854861)
- Testing
- Lyumjev 100 UNT/ML Injectable Solution, Premixed Lyumjev
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- St. Olavs Hospital
Pre-Eclampsia
Screening for Preeclampsia in Norway With Aspirin Discontinuation at 24-28 Weeks
Study population Around 3500 pregnant women attending a routine ultrasound scan at 11-14 weeks at St. Olavs hospital, Trondheim, Norway.
- Trial name
- PEScreenNor (NCT06108947)
- Testing
- Aspirin
- Where
- Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Adolescent Idiopathic Scoliosis (AIS)
Hypnosis for Pain and Nausea Reduction in Scoliosis Surgery: An Interventional Study
This study evaluates whether preoperative hypnosis can reduce postoperative pain, nausea, and opioid use in adolescents undergoing scoliosis surgery. Participants aged 12-18 years will receive hypnosis training before surgery.
- Trial name
- HYP-SCOL (NCT07854951)
- Testing
- Hypnosis
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Benzodiazepine Dependence
Effects of Intranasal Oxytocin in the Treatment of Benzodiazepine Withdrawal: A Pilot RCT
The goal of this clinical trial is to learn if oxytocin administered as a nasal spray will reduce withdrawal symptoms in adults during benzodiazepine tapering for 21 days. It will also learn about the safety of oxytocin.
- Trial name
- NCT06757517
- Testing
- Oxytocin nasal spray
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- St. Olavs Hospital
Musculoskeletal Diseases, Mental Disorder
Expert@Work - Effectiveness of a Digital Expert Team on Return to Work
Long-term sick leave is a challenge in Norway, and the healthcare and labor- and welfare services are often not coordinated in helping the sick-listed employees return to work.
- Trial name
- Expert@Work (NCT05575908)
- Testing
- Digital expert team
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital
Psychotic Disorder, SCHIZOPHRENIA 1 (Disorder)
Ultrasound Assessment of Gluteal Muscle in Patients Receiving Depot Antipsychotics and Healthy Volunteers
This observational study will use ultrasound to assess the gluteal musculature in patients receiving depot antipsychotic medication and in healthy volunteers.
- Conditions
- Psychotic Disorder, SCHIZOPHRENIA 1 (Disorder), Intramuscular Injection
- Trial name
- ULPSYK (NCT07815587)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Heart Failure, Left-sided
Cardio-vascular Energy Transfer and Ventriculo-arterial Coupling in Heart Failure
The goal of this pilot study is to investigate energy transfer fram the ventricle to the arteries in patients with heart failure, primary by investigating the total power.
- Trial name
- NCT06200246
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Trigeminal Neuralgia
A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adults With Trigeminal Neuralgia
The CryoGem Trial is a research study that tests a freezing technique called cryoneurolysis to see if it helps relieve pain in adults with trigeminal neuralgia. Trigeminal neuralgia is a condition that causes severe facial pain.
- Trial name
- CryoGem (NCT06213155)
- Testing
- Cryoneurolysis, Stimulation
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- St. Olavs Hospital
Chronic Migraine
A Study Investigating Peripheral Cryoneurolysis in Adults With Chronic Migraine
The trial is a research study that tests a freezing technique called cryoneurolysis to see if it helps relieve pain in adults with chronic migraine. Chronic migraine is a condition that causes moderate to severe headache.
- Trial name
- NCT06554886
- Testing
- Cryoneurolysis
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- St. Olavs Hospital
Pelvic Floor Disorder, Female Pelvic Floor Dysfunction
Late Side-effects After Cervical Cancer Treatment - Prevention and Treatment
Late side-effects following gynecological cancer are predominantly symptoms from the pelvic region originating from the bowels, urinary tract, lymphatic system, genitals and musculoskeletal system.
- Conditions
- Pelvic Floor Disorder, Female Pelvic Floor Dysfunction, Female Sexual Dysfunction, Female Urinary Incontinence
- Trial name
- NCT06786091
- Testing
- Pelvic floor muscle training rehabilitation
- Where
- 2 sites in Norway
- Volunteers
- 25 people
- Sponsor
- St. Olavs Hospital
Back Pain With Radiation, Pain, Postoperative
Burst Crossover Trial
Spinal cord stimulation (SCS) is a widely applied therapy to treat chronic neuropathic pain, and one of the most common indications is persisting radicular neuropathic pain following lumbar spine surgery.
- Trial name
- NCT05372822
- Testing
- Burst Spinal Cord Stimulation, SCS implant
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- St. Olavs Hospital
Erythromelalgia
Spinal Cord Stimulation for Refractory Pain in Erythromelalgia
Erythromelalgia is a rare disorder characterized by red, warm, and painful extremities, which is often precipitated by warm conditions. The pathophysiology is incompletely understood.
- Trial name
- NCT04039633
- Testing
- Burst Spinal Cord Stimulation
- Where
- 4 sites in Norway
- Volunteers
- 6 people
- Sponsor
- St. Olavs Hospital
Surgical Complication
The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery
Study objective: This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound…
- Trial name
- TRANOP (NCT06270407)
- Testing
- Tranexamic Acid 100 MG/ML, 0.9%sodium chloride
- Where
- 11 sites in Denmark, Finland and 1 more
- Volunteers
- 3,000 people
- Sponsor
- St. Olavs Hospital
Brain Concussion, Post-Concussion Syndrome
Exercise in Postconcussion Symptoms and Posttraumatic Headache
The goal of this clinical trial is to compare two models of delivery of guided exercise in patients with exercise intolerance after mild head injury.
- Conditions
- Brain Concussion, Post-Concussion Syndrome, Post-Traumatic Headache, Craniocerebral Trauma
- Trial name
- NCT06015451
- Testing
- Sub-symptom threshold exercise
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
Migraine Disorders
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine
This is a clinical trial to assess the efficacy of botox treatment of the sphenopalatine ganglion as an add-on treatment in drug resistant migraine.
- Trial name
- MiBlock (NCT04069897)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital
Non-ST Elevated Myocardial Infarction
Coronary CT Angiography in Non ST-elevation Myocardial Infarction
Non ST-elevation myocardial infarction (NSTEMI) represents 70-75% of all myocardial infarctions. Current guidelines recommend invasive angiography and this patient group represents a major burden on the invasive catheterization…
- Trial name
- CT-NSTEMI (NCT04537741)
- Testing
- Coronary CT angiography, Invasive coronary angiography
- Where
- 8 sites in Norway
- Volunteers
- 300 people
- Sponsor
- St. Olavs Hospital