Clinical trials: sponsored by St. Olavs Hospital
Pelvic Floor; Rupture, Childbirth Problems
Levator Hiatal Dimensions and Mode of Delivery
The aim of this observational study is to learn about how muscle dimensions of the pelvic floor measured during pregnancy in primigravida impact birth mecanics and mode of delivery. Tha main aims are to 1.
- Conditions
- Pelvic Floor; Rupture, Childbirth Problems, Pelvic Floor Dyssynergia
- Trial name
- LEVDIM (NCT05849584)
- Testing
- Transperineal ultrasound
- Where
- 2 sites in Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Arthritis Knee, Arthroplasty
Robotic Assisted Knee Arthroplasty - Retain the Anterior Cruciate Ligament or Not
The goal of this clinical trial is to compare the function of the knee after retaining or sacrificing the anterior cruciate ligament in robotic assisted knee arthroplasty.
- Conditions
- Arthritis Knee, Arthroplasty, Gait Analysis
- Trial name
- NCT06264999
- Testing
- Journey II CR, Journey II XR
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Type 1 Diabetes
Glucagon Enhanced Insulin Absorption in Diabetes Mellitus Type 1
The investigators will study the effect of microdoses of glucagon at the site of subcutaneous insulin injection. The investigators have unpublished data from anesthetized pigs indicating a major enhancement of insulin absorption.
- Trial name
- NCT05960565
- Testing
- Glucagon
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- St. Olavs Hospital
Substance Abuse, Cognitive Dysfunction
Aerobic Exercise for Cognitive Functioning in Patients With Substance Use Disorder
Impaired cognitive function is common among patients with substance use disorder (SUD). This is particularly related to executive functions (EF), which includes abilities like decision-making, consequence analysis and…
- Trial name
- SO_CogEx (NCT05324085)
- Testing
- High-intensity interval training, Treatment as usual
- Where
- Norway
- Volunteers
- 84 people
- Sponsor
- St. Olavs Hospital
Substance Use Disorders
Exercise Training as Medicine for Substance Use Disorder Patients
This study compares the effects of high dose and low dose, high intensity, endurance training and strength training in substance use disorder patients.
- Trial name
- NCT04065334
- Testing
- High dose training, low dose training
- Where
- Norway
- Volunteers
- 171 people
- Sponsor
- St. Olavs Hospital
Wet Macular Degeneration
Optimizing the Treatment Strategy for Age-related Macular Degeneration
The purpose of this study is to compare two different treatment protocols for wet macular degeneration; the new protocol called "Observe and Plan" against the current standard protocol "Treat and Extend".
- Trial name
- OnP2 (NCT04420923)
- Testing
- Observe and Plan, Treat-and-Extend
- Where
- 3 sites in Norway
- Volunteers
- 250 people
- Sponsor
- St. Olavs Hospital
Myocardial Infarction, Acute
Biomarkers in Patients Hospitalized With Suspected Acute Myocardial Infarction
The concentration of troponins in plasma is used for diagnosing acute myocardial infarction. Different types of heart-specific troponins can be measured and with different analytical methods.
- Trial name
- BIOMAC (NCT04167904)
- Where
- Norway
- Volunteers
- 4,446 people
- Sponsor
- St. Olavs Hospital
Chronic Myeloid Leukemia
Long-acting Low Dose Ropeginterferon for Chronic Myeloid Leukemia Treated With Bosutinib From Diagnosis
To study the efficacy and safety of combination of Ro-Peg-interferon-α2b (RoPegIFN) with Bosutinib (BOS) in comparison to BOS monotherapy, as frontline therapy for newly diagnosed chronic myeloid leukemia patients, and to…
- Trial name
- BosuPeg (NCT03831776)
- Testing
- Bosutinib, Ropeginterferon
- Where
- 18 sites in Denmark, Finland and 2 more
- Volunteers
- 212 people
- Sponsor
- St. Olavs Hospital
ACL, ACL Injury
Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon Group
Background: Bone-patellar tendon-bone (BPTB) and a double-looped semitendinosus gracilis (hamstring group) graft are commonly used for ACL reconstruction.
- Conditions
- ACL, ACL Injury, Cruciate Ligament Rupture, ACL Tear
- Trial name
- Studie ACL (NCT05876013)
- Testing
- ACL reconstruction
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- St. Olavs Hospital
Prostatic Neoplasms
Curative Image Guided Radiotherapy for Prostate Cancer
The clinical importance of cone beam computer tomography based image guided radiotherapy (CT- IGRT) has not been established. The primary aim of the present trial is to investigate whether CT- IGRT and consequently reduced safety…
- Trial name
- RIC (NCT01550237)
- Testing
- radiotherapy daily verification reduced safety margins, radiotherapy weekly verification standard safety margins
- Where
- 2 sites in Norway
- Volunteers
- 260 people
- Sponsor
- St. Olavs Hospital
Mental Disorder, Insomnia
Digital Cognitive Behavior Therapy for Insomnia Compared With Digital Patient Education About Insomnia in Individuals Referred to Public Mental Health Services in Norway
Sleep is a fundamental human need with large impact on both psychological and somatic functioning. However, for patients with mental disorders, sleep is often disturbed.
- Trial name
- Norse4 (NCT04621643)
- Testing
- digital cognitive behavioral therapy (dCBT-I), Digital patient education about insomnia (PE)
- Where
- 4 sites in Norway
- Volunteers
- 911 people
- Sponsor
- St. Olavs Hospital
Mental Disorders
The Genetic and Affective Prediction Study
A major proportion of patients admitted to psychiatric acute and emergency departments have symptoms, behaviors or function influenced by implicit or explicit suicidal intention (tendency towards self-harm, or suicide attempt).
- Trial name
- GAP (NCT02625818)
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- St. Olavs Hospital
Cardio-pulmonary Bypass, AORTIC VALVE DISEASES
Clinical Validation of a Novel Handsfree Doppler Ultrasound Device, RescueDoppler, in Adult Cardiac Surgery Patients
The goal of this study is to evaluate a new device called RescueDoppler (RD), which measures continuous blood flow in the common carotid artery. The device is handsfree and operator- independent.
- Conditions
- Cardio-pulmonary Bypass, AORTIC VALVE DISEASES, Coronary Arterial Disease (CAD), Aortic Aneurysm of the Proximal Arch
- Trial name
- RD_CPB (NCT06637540)
- Testing
- RescueDoppler
- Where
- 3 sites in Norway
- Volunteers
- 42 people
- Sponsor
- St. Olavs Hospital
Post-Concussion Syndrome, Post-Traumatic Headache
Digital Solutions for Concussion
The objective of this study is to develop new digital solutions for patients with prolonged postconcussion symptoms, and investigate its usability, feasibility, and safety.
- Trial name
- DiSCo (NCT05635656)
- Testing
- Digital symptom mapping and biofeedback treatment
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- St. Olavs Hospital
Bronchial Neoplasms
Navigated EBUS and Functional Imaging in Lung Cancer
Electromagnetic navigation systems have proved feasible for precise intraoperative guiding during videobronchoscopy and endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA), based on maps made of preoperative CT…
- Trial name
- NCT02745002
- Testing
- navigated bronchoscopy
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- St. Olavs Hospital
Aorta Aneurysm
Graft Thrombosis After Endovascular Aortic Repair - a Single Center Experience With the Cook Zenith Alpha Spiral-Z®
The purpose of this study is to assess the extent of thrombosis in the Zenith Alpha Spiral-Z® stent graft.
- Trial name
- NCT04564560
- Testing
- Endovascular aortic repair with Zenith Alpha Spiral-Z®
- Where
- Norway
- Volunteers
- 161 people
- Sponsor
- St. Olavs Hospital
Lung Cancer, Postoperative Pain
Paravertebral Block Versus Thoracic Epidural Analgesia
Thoracic epidural analgesia (TEA) is the basic method of analgesia in patients undergoing pulmonary lobectomy. TEA is considered to be a safe and thoroughly investigated method of pain relief that rarely causes serious…
- Trial name
- NCT04025606
- Testing
- Thoracic epidural, Paravertebral block
- Where
- Norway
- Volunteers
- 94 people
- Sponsor
- St. Olavs Hospital
Postoperative Hemorrhage, Injuries and Wounds
The Effect of Topical Tranexamic Acid on Postoperative Bleeding From Superficial Wounds
After surgical procedures, interventions to reduce postoperative bleeding are of great importance. In this study, the effect will be investigated of administering tranexamic acid, which is designed for injection, directly onto…
- Trial name
- NCT02918201
- Testing
- Tranexamic Acid, saline
- Where
- 2 sites in Norway
- Volunteers
- 36 people
- Sponsor
- St. Olavs Hospital
Heart Arrest
Adrenaline During Resuscitation From Pulseless Electrical Activity
This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest.
- Trial name
- NCT04149730
- Where
- 2 sites in United States, Norway
- Volunteers
- 280 people
- Sponsor
- St. Olavs Hospital
Tachycardia, Ventricular, Defibrillators, Implantable
Physical Activity and Ventricular Arrhythmias
The purpose of the study is to determine the effect of aerobic interval training in patients with an implantable cardioverter defibrillator (ICD) on physical fitness, quality of life and the amount of serious ventricular…
- Trial name
- NCT04070300
- Testing
- Interval exercise
- Where
- Norway
- Volunteers
- 55 people
- Sponsor
- St. Olavs Hospital