Clinical trials: sponsored by St. Olavs Hospital
Surgical Wound, Bleeding
Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery
Tranexamic acid is a drug that prevents clotted blood from dissolving and hence reduces bleeding. It is routinely given intravenously in many surgical situations where there is a risk of major bleeding.
- Trial name
- NCT03101124
- Testing
- Tranexamic Acid 25 mg/ml for wound surface moistening, Tranexamic Acid 5 mg/ml as bolus in wound cavity, Tranexamic Acid Injectable Solution
- Where
- Norway
- Volunteers
- 36 people
- Sponsor
- St. Olavs Hospital
Eye Diseases
Intravitreal Injections by Nurses and Physicians Compared
Anti-VEGF agents are given for a variety of previously untreatable eye diseases. The last years indications for their use and consequently the number of patients needing treatment, have been increasing.
- Trial name
- NCT02359149
- Testing
- intravitreal injections given by a nurse, intravitreal injections given by a physician, Intravitreal injections
- Where
- Norway
- Volunteers
- 328 people
- Sponsor
- St. Olavs Hospital
Pain, Postoperative, Postoperative Hemorrhage
The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain
After surgical procedures, interventions to reduce postoperative pain and bleeding are of great importance. In this study, the effect will be investigated of smearing common drugs, which are designed for injection, directly onto…
- Trial name
- NCT01964781
- Testing
- Tranexamic Acid, Bupivacaine, Adrenaline
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Brain Neoplasms, Glioma
Improving Ultrasound Images in Brain Tumour Surgery With the Use of an Acoustic Coupling Fluid Mimicking Brain Tissue.
Tools for improving brain tumor surgery, in particular for gliomas, are increasing. There seems to be an agreement that achieving extensive resections, when done safely without jeopardizing neurological function, improves…
- Trial name
- NCT03181581
- Testing
- acoustic coupling fluid, Ringer's acetate
- Where
- Norway
- Volunteers
- 5 people
- Sponsor
- St. Olavs Hospital
Brain Neoplasms, Glioma
Improving Ultrasound Images in Brain Tumor Surgery With the Use of Brain Mimicking Fluid
Prognosis in patients with glioblastomas (the most aggressive high-grade glioma) remains unfavourable. Tools for improving brain tumor surgery, in particular for gliomas, are increasing.
- Trial name
- BMF (NCT02105233)
- Testing
- brain mimicking fluid
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- St. Olavs Hospital
Pelvic Pain, Varicose Veins
Embolization of Pelvic Varicosities in Patients With Pelvic Congestion Syndrome
Results of recent systematic reviews suggest favorable results of embolization for the treatment of Pelvic Congestion Syndrome (PCS) compared with pre-procedure symptoms for several outcomes, including pain reduction, overall…
- Trial name
- NCT03057067
- Testing
- Embolization of pelvic vein varicosities
- Where
- Norway
- Volunteers
- 3 people
- Sponsor
- St. Olavs Hospital
Retinopathy of Prematurity
Infant-parent Skin-to-skin Contact During Screening for Retinopathy
Retinopathy of prematurity (ROP) is a feared complication of premature birth. If discovered in time, the disease can be treated, and impaired vision or blindness can be reduced.
- Trial name
- NCT02780544
- Testing
- skin-to-skin contact, incubator, Sucrose
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- St. Olavs Hospital
Depressive Disorder, Depressive Disorder, Major
Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.
Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits.
- Trial name
- NCT02741622
- Testing
- High aerobic intensity training (HIT), Long slow distance training (LSD)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Systemic Inflammatory Response Syndrome
Can Biomarkers Aid in the Prediction of Postoperative Pain and Circulatory Instability After Major Abdominal Surgery?
Patients undergoing major surgery are exposed to extensive damage of tissues, which induces widespread activation of the inflammatory system, called 'systemic inflammatory response syndrome' (SIRS).This activation of the…
- Trial name
- NCT02563652
- Where
- 2 sites in Italy, Norway
- Volunteers
- 101 people
- Sponsor
- St. Olavs Hospital
Lung Neoplasms
Extensive Staging in Lung Cancer
The overall aim of this study is to compare standard staging of lung cancer (which includes clinical examination, CT, MRI, bone scan and PET-CT) with comprehensive staging - which includes the new staging methods (PET-MRI and…
- Trial name
- ExtStaging (NCT02030444)
- Testing
- PET-MRI and EBUS-TBNA
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- St. Olavs Hospital
Pulmonary Disease, Chronic Obstructive
Calprotectin I Serum as a Diagnostic Marker
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03474484
- Where
- Norway
- Volunteers
- 113 people
- Sponsor
- St. Olavs Hospital
Infertility, Female
Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
The number of children conceived by assisted reproductive technology is increasing in Nordic countries as well as worldwide. An important factor of success in treatment of infertility is a short "time to pregnancy" with impact on…
- Trial name
- NCT01882166
- Testing
- fostimon, puregon
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Spinal Stenosis, Intermittent Claudication
Outcome of Surgery for Lumbar Spinal Stenosis - a Comparison of Data From Three National Quality Registries
There is no international consensus on evaluation and surgical treatment of Lumbar Spinal Stenosis (LSS). The indication for operative treatment is relative, and the variation in surgical rates and procedures is significant, both…
- Trial name
- NCT02897947
- Testing
- Surgery for lumbar spinal stenosis in Norway, Surgery for lumbar spinal stenosis in Sweden, Surgery for lumbar spinal stenosis in Denmark
- Volunteers
- 7,500 people
- Sponsor
- St. Olavs Hospital
Heart Arrest, Death, Sudden, Cardiac
In-hospital Cardiac Arrest - Dynamics and State Transitions
The purpose of this study is to analyse transitions in cardiac rhythm and hemodynamic variables during resuscitation of patients with in-hospital cardiac arrest.
- Trial name
- NCT00920244
- Testing
- Cardiopulmonary resuscitation (CPR), Epinephrine, Atropine
- Where
- Norway
- Volunteers
- 285 people
- Sponsor
- St. Olavs Hospital
Intracranial Hemorrhages, Stroke
Risk of Intracranial Hemorrhage in Users of Oral Antithrombotic Drugs
The true incidence and risks of intracranial hemorrhage (ICH) in patients on various antithrombotic treatments remain unknown. Here a nationwide study is conducted to investigate the risk for and incidence rates of ICH in users…
- Trial name
- RICH (NCT02481011)
- Testing
- antithrombotic drugs
- Where
- Norway
- Volunteers
- 22,111 people
- Sponsor
- St. Olavs Hospital
Stomach Neoplasms
Density of Neurons in the Stomach and Prognosis of Gastric Adenocarcinoma
Preclinical studies at our institution, based on a genetic mouse model of stomach cancer, strongly suggest that innervation of the stomach wall is deeply involved in tumorigenesis of stomach cancer.
- Trial name
- NCT01821196
- Testing
- biopsy
- Sponsor
- St. Olavs Hospital
Stomach Neoplasms
Botulinum Toxin for Stomach Cancer Treatment
Preclinical studies at our institution, using a genetic mouse model of gastric cancer, strongly suggest that innervation of the stomach wall is required not only for the development, but also for the progression of gastric…
- Trial name
- NCT01822210
- Testing
- Botox
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- St. Olavs Hospital
Premature Birth
Changes in Respiratory Effort in Preterm Infants
Continuous Positive Airway Pressure (CPAP) is used to treat preterm infants with an immature respiratory center and having respiratory distress. CPAP requires intensive care monitoring and special qualified staff.
- Trial name
- NCT02014493
- Testing
- High Flow Nasal Cannulae (HFNC), Continuous Positive Airway Pressure (CPAP)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Coronary Disease
Circulatory Oscillations in Post Cardiac Surgery Patients
In this observational study investigators examine the presence of circulatory oscillations in blood pressure, heart rate, and doppler laser flow before and after planned cardiac surgery.
- Trial name
- NCT02765607
- Testing
- Heart surgery
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Prostatic Neoplasms
Pre-operative PET-MR of High Risk Prostate Cancer Patients for Assessment of Cancer Aggressiveness and Lymph Node Status
Prostate cancer is the most frequent cancer in Norwegian men. For optimal treatment, accurate staging of the disease at the time point of diagnosis is important.
- Trial name
- NCT02076503
- Testing
- PET-MR 18f-FACBC, histology (gold standard)
- Where
- Norway
- Volunteers
- 28 people
- Sponsor
- St. Olavs Hospital