Clinical trials: sponsored by Tampere University Hospital
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
Wrist Ganglion, Ganglion
Ganglion Resection Effectiveness Trial
The goal of this clinical trial is to learn if surgery helps with wrist ganglions in adults. The main question it aims to answer is: Does surgery result in better patient-reported outcomes and satisfaction over a 6-months…
- Conditions
- Wrist Ganglion, Ganglion, Ganglion Cyst, Connective Tissue Disease
- Trial name
- GangLion (NCT07162415)
- Testing
- Open resection, Arthroscopic resection, Conservative treatment
- Where
- 6 sites in Finland, Singapore
- Volunteers
- 220 people
- Sponsor
- Tampere University Hospital
Celiac Disease, Celiac Disease in Children
Celiac Disease in Childhood-Adulthood Transition
Aims of this study are to evaluate adolescents with celiac disease during their transition from pediatrics to adult care, and to develop better healthcare follow-up practices.
- Conditions
- Celiac Disease, Celiac Disease in Children, Transition of Care, Follow-up
- Trial name
- CeliCAT (NCT05084937)
- Testing
- CeliCAT form
- Where
- 5 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Tampere University Hospital
Obstetric Anal Sphincter Injury, Sexual Dysfunction and the Mode of Deliveries
Long-term Pelvic Floor and Sexual Health After Obstetric Anal Sphincter Injury in Finland
The goal of this observational study is to understand long-term pelvic floor symptoms and sexual dysfunction after childbirth-related anal sphincter injury in women who gave birth at Tampere University Hospital between 2009 and…
- Conditions
- Obstetric Anal Sphincter Injury, Sexual Dysfunction and the Mode of Deliveries, Pelvic Floor Disorders
- Trial name
- NCT07646340
- Where
- Finland
- Volunteers
- 600 people
- Sponsor
- Tampere University Hospital
Healthy, Newborn Infant
Smart Sock Heart Rate Monitoring in Hospitalized Newborns
The goal of this observational study is to evaluate a commercially available smart sock for heart rate monitoring in hospitalized newborn infants without known heart disease.
- Trial name
- NCT07838402
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Iron Deficiency Anaemia in Childbirth, Iron Deficiency
Maternal Iron Deficiency and Childhood Health
The aim of this prospective observational cohort study is to study maternal iron deficiency and iron deficiency anemia and the use of iron supplements in pregnancy and their impact on the health of the offspring and pregnancy…
- Conditions
- Iron Deficiency Anaemia in Childbirth, Iron Deficiency, Iron Deficiency in Pregnancy, Iron Deficiency Anemia in Pregnancy
- Trial name
- MATILDA (NCT06879080)
- Where
- Finland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Carpal Tunnel Syndrome
Effect of Night-time and Full-time Splinting for Carpal Tunnel Syndrome
Carpal tunnel syndrome is a common compression neuropathy of upper extremities. Its usual symptoms are pain, numbness and tingling of fingers, which tend to be worse at night.
- Trial name
- FINCROSS (NCT05637294)
- Testing
- splinting
- Where
- 6 sites in Finland
- Volunteers
- 110 people
- Sponsor
- Tampere University Hospital
Rectal Cancer, Rectal Adenocarcinoma
Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer
The goal of this one-arm clinical trial is to implement and study the oncological outcomes of nonoperative management of rectal cancer having complete clinical response to neoadjuvant therapy.
- Trial name
- NORPPA-1 (NCT06328361)
- Testing
- Nonoperative surveillance
- Where
- 13 sites in Estonia, Finland
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC)
Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis
The goal of this clinical trial is to learn how oral vancomycin therapy may contribute in treating paediatric inflammatory bowel disease, particularly atypical ulcerative colitis and PSC-associated colitis.
- Conditions
- Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC), Pediatric Inflammatory Bowel Diseases
- Trial name
- VERDA (NCT07646223)
- Testing
- Oral Vancomycin
- Where
- Finland
- Volunteers
- 140 people
- Sponsor
- Tampere University Hospital
IBD (Inflammatory Bowel Disease)
E-nose in Evaluating Colitis Activity
The goal of this observational study is to learn whether a rapid stool-based imaging test can help monitor inflammatory bowel disease (IBD) in children.
- Trial name
- SPECTROS (NCT07781215)
- Testing
- Differential Mobile Spectrometry analysis of the stool
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Obsessive Compulsive Disorder (OCD)
Bergen Four-Day Treatment (B4DT) for Obsessive-Compulsive Disorder
The aim of this study is to expand access to Bergen Four-Day Treatment (B4DT) in Finland and to integrate it into psychiatric care pathways at Tampere University Hospital (TAYS).
- Trial name
- NCT07644130
- Testing
- Bergen Four-Day Treatment (B4DT)
- Where
- Finland
- Volunteers
- 65 people
- Sponsor
- Tampere University Hospital
Cancer, Tumor
Three-Dimensional Molds Based on Radiological imagEs in Patients With Cancer: the DIRECT Trial
Determination of the sites from which the histopathological samples in surgically removed lesions are collected is still done by eye by a pathologist.
- Trial name
- DIRECT (NCT07778173)
- Testing
- 3D-printed tumor mold for tissue sampling
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Breast Cancer, Artificial Intelligence
Study on Female Patients' Mammographic Texture Features
Mammography is the most common method for breast imaging, and it provides information for model building and analysis. Radiomics applied to mammography has the potential to revolutionize clinical decision-making by providing…
- Conditions
- Breast Cancer, Artificial Intelligence, Mammography
- Trial name
- COMPRESS (NCT06469606)
- Testing
- AI tool
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Tampere University Hospital
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Obesity & Overweight
OBE2026 - Effect of One Year Intensive Lifestyle Treatment in Children With ISO-BMI Over 30kg/m² and Their Families.
Obesity has increased significantly in recent decades and is starting earlier than before, even before school age. In 2023, 8% of Finnish boys aged 7-12 and 4% of girls were obese, while the corresponding figures for boys aged…
- Trial name
- NCT07738029
- Testing
- Lifestyle Management
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Tampere University Hospital
Palliative Care, Breathlessness
Management of Dyspnea With High- Flow Nasal Therapy
Dyspnea in patients with incurable illness is a difficult symptom. Therefore, there is a need to identify new effective treatment modalities.
- Trial name
- HFNTpal (NCT07552935)
- Testing
- High-flow nasal therapy, Airflow directed to face by a fan
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Tampere University Hospital
Cervical Cancers, Vaginal Cancers
Quality of Life and Sexuality After Pelvic Exenteration for Gynecologic Cancer
Pelvic exenteration is an exceptionally extensive and very rare surgical procedure, most commonly used in the treatment of locally recurrent cervical cancer among gynecological malignancies.
- Conditions
- Cervical Cancers, Vaginal Cancers, Vulvar Cancers, Endometrial Cancer
- Trial name
- NCT07594327
- Where
- Finland
- Volunteers
- 21 people
- Sponsor
- Tampere University Hospital
Chronic Cough
Finnish Children´s Protracted Cough
Prolonged cough lasting more than four weeks is common in children, but the best treatment is often unclear when no underlying disease can be found.
- Trial name
- FINNCHICO (NCT07582549)
- Testing
- Fluticasone propionate inhalation, Amoxicillin-clavulanic acid oral suspension
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery
The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial)
The goal of this clinical trial is to compare the Manchester procedure and vaginal hysterectomy in treating patients with symptomatic uterine prolapse.
- Conditions
- Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)
- Trial name
- Fin-UP (NCT07566949)
- Testing
- Manchester procedure, Vaginal hysterectomy
- Where
- 6 sites in Finland
- Volunteers
- 426 people
- Sponsor
- Tampere University Hospital
Infection
Continuous Antibiotic Infusion In Children
Continuous intravenous antibiotic infusion using elastomeric pumps is well established in adult care and has been shown to be effective, safe, and cost-efficient, particularly for beta-lactams and vancomycin.
- Trial name
- NCT07575009
- Testing
- Benzylpenicillin
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Tampere University Hospital