Clinical trials: sponsored by Tang-Du Hospital
Traumatic Brain Injury
Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Brain Injury
The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and…
- Trial name
- NCT05279599
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Carcinoma, Non-Small-Cell Lung, Next-Generation Sequencing
Clinical Value of MRD Monitoring for Adjuvant Therapy in Postoperative NSCLC
This clinical trial aims to explore the minimal residual disease (MRD) status of early NSCLC after curative surgery and the clinical outcomes of adjuvant chemotherapy.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Next-Generation Sequencing, Chemotherapy, Adjuvant, Neoplasm, Residual
- Trial name
- NCT05167604
- Testing
- Adjuvants, Pharmaceutic
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tang-Du Hospital
NSCLC Stage IV, Oligometastasis
Toripalimab in Combination With Platinum-based Chemotherapy for Mutation-negative Stage IV Oligometastatic NSCLC
In recent years, immune checkpoint inhibitors targeting cytotoxic T-lymphocyte antigen-4, programmed death-1, and programmed death-ligand 1 have achieved milestones in the treatment of NSCLC, from back-line to first-line, and…
- Trial name
- NCT05055583
- Testing
- Toripalimab in Combination With Platinum-based Chemotherapy, Surgical treatment stage, Adjuvant treatment stage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang-Du Hospital
Healthy, Adults
RF Based QIMT & QAS Study on Chinese Adults
This study intends to establish the normal reference values of carotid artery intima-media thickness and vascular elasticity of Chinese adults based on ultrasound radio frequency technology through a multi-center large-sample…
- Conditions
- Healthy, Adults, Carotid Intima-media Thickness, Vascular Stiffness
- Trial name
- NCT04881292
- Where
- 34 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Familial Hypercholesterolemia
Exosome-based Nanoplatform for Ldlr mRNA Delivery in FH
mRNA therapy is a highly promising gene therapeutic strategy in the treatment of Homozygous Familial Hypercholesterolemia (HoFH).
- Trial name
- ENDFH (NCT05043181)
- Testing
- Low Density Lipoprotein Receptor mRNA Exosomes
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang-Du Hospital
Intracerebral Hemorrhage；Circulating Exosomes
Application of Circulating Exosomes in Early Diagnosis and Prognosis Evaluation After Intracerebral Hemorrhage
The purpose of this study is to observe the relationship between the changes of circulating exosomes and the development and outcome of the disease in patients with intracerebral hemorrhage, and to search for early serum markers…
- Trial name
- NCT05035134
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Posterior Fossa Hemorrhage
The Treatment Effect of Endoscopic Evacuation Versus Suboccipital Craniotomy for Spontaneous Intracerebellar Hemorrhage.
The purpose of the present study is to compare the effectiveness and safety of two surgery evacuation methods (endoscopic surgery and suboccipital craniotomy) in the treatment of acute spontaneous cerebellar hemorrhage (SCH).
- Trial name
- NCT04991233
- Testing
- Endoscopic surgery, Suboccipital craniotomy surgery
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Tang-Du Hospital
Non Small Cell Lung Cancer
A Neoadjuvant Study of Sintilimab Plus Platinum Doublet Chemotherapy in IIIA(N2) Stage NSCLC
The purpose of this study is to determine the feasibility and evaluate the safety of delivering chemotherapy, the usual approach to non-small cell lung cancer, in combination with Sintilimab (PD-1 antibody), followed by adjuvant…
- Trial name
- NCT04840290
- Testing
- Biological: Sintilimab Drug: Cisplatin Drug: Paclitaxel for Injection (Albumin Bound) Drug: Carboplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang-Du Hospital
Coronavirus Disease 2019 (COVID-19)
Clinical Study of Anti-CD147 Humanized Meplazumab for Injection to Treat With 2019-nCoV Pneumonia
To evaluate the safety and efficacy of humanized Meplazumab for Injection in patients infected by 2019-nCoA.
- Trial name
- NCT04275245
- Testing
- Meplazumab for Injection
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Tang-Du Hospital
Lumbar Spinal Stenosis
Oblique Lateral Interbody Fusion Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion
The investigators will retrospectively study lumbar spinal stenosis patients who underwent OLIF or MIS-TLIF with percutaneous pedicle screw fixation between January 2016 and December 2019.The investigators will measure estimated…
- Trial name
- NCT04778943
- Testing
- Surgery(OLIF and MIS-TLIF)
- Volunteers
- 130 people
- Sponsor
- Tang-Du Hospital
Heroin Addiction, Relapse
PET/MRI Study on the Neurological Mechanism of rTMS Treatment for Heroin Addiction
Heroin addiction is a serious problem and the relapse rate of existing treatment methods is extremely high. Recently, international journals such as Science reported that repetitive transcranial magnetic stimulation (rTMS) can…
- Trial name
- NCT04086459
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Thymoma and Thymic Carcinoma
Chemotherapy Combined With Pembrolizumab in Treating Patients With Thymoma and Thymic Carcinoma
This is an investigational, single arm study.
- Trial name
- NCT04554524
- Testing
- Chemotherapy+Pembrolizumab.
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Tang-Du Hospital
Neuromyelitis Optica Spectrum Disorder
Rituximab at Low dosE for neuromyelitiS optiCa spectrUm disordEr (RESCUE)
In this research, a prospective, multicenter(Tangdu Hospital of Fourth Military Medical University, Xi'an Gaoxin Hospital of Xi'an Medical College, Xianyang Central Hospital, Baoji Central Hospital, Xi'an Central Hospital, The…
- Trial name
- NCT04256252
- Testing
- Rituximab
- Volunteers
- 108 people
- Sponsor
- Tang-Du Hospital
Fertilization
Artificial Assisted Activation Following in Fertilization Failure
Fertilization failure is a common problem in assisted reproductive Technology (ART). The main reason for fertilization failure of conventional IVF fertilization is sperm penetration failure, and the main reason of ICSI is…
- Trial name
- NCT04523103
- Testing
- Artificial Assisted Activation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Fertilization
Lipidic Differences of Sperm Between Normal and Low Fertilization Patients
Although in vitro fertilization (IVF) involve the use of semen samples, there is little scientific methodology applied when selecting sperm.
- Trial name
- NCT04537481
- Testing
- Lipid extraction
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Fertilization
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its cytoplasm, regulating a…
- Trial name
- NCT04519918
- Testing
- AOA
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Brown Fat and Muscle Metabolic, Differential Diagnosis
PET/MRI Study on Changes of Fat and Muscle Metabolism.
False positives for Brown Fat \& Muscle（F\&M） always affect the evaluation of metabolic disease treatment. Recently, using PET/CT，international journals such as Journal of Nuclear Medicine reported that the amount of active brown…
- Trial name
- NCT04334720
- Testing
- Comprehensive treatment of tumor
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Traumatic Brain Injury, Coagulation Disorder
Coagulopathy on the First Postoperative Day Predicts the Long-term Survival of Traumatic Brain Injury Patients
The purpose of this study was to identify the relationship between coagulopathy during the perioperative period (before the operation and on the first day after the operation) and the long-term survival of traumatic brain injury…
- Trial name
- NCT04322721
- Where
- China
- Volunteers
- 447 people
- Sponsor
- Tang-Du Hospital
Traumatic Brain Injury, Coagulation Disorder
The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders
The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.
- Trial name
- NCT04274777
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Chronic HIV Infections
Chidamide in Combination With Antiretroviral Therapy for Eradication of the Latent HIV-1 Reservoir
HIV replication can be effectively suppressed and acquired immunodeficiency syndrome(AIDS) can be prevented with highly active antiretroviral therapy (HAART).
- Trial name
- CHARTER (NCT02513901)
- Testing
- Chidamide
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Tang-Du Hospital