Clinical trials: sponsored by Tang-Du Hospital
Healthy Volunteers
Multi-Field-Strength MRI Brain Atlas Construction in Healthy Chinese Population
This prospective imaging study aims to construct a multi-field-strength magnetic resonance imaging (MRI) brain atlas for healthy Chinese adults.
- Trial name
- NCT07786233
- Testing
- Multi-Field-Strength Brain MRI
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Locally Advanced Rectal Cancer
A Prospective, Single-center, Phase II Study of Neoadjuvant Serplulimab Plus XELOX and Bevacizumab in Locally Advanced Rectal Cancer
The purpose of this clinical trial is to understand the treatment effects of serplulimab combined with XELOX and bevacizumab as neoadjuvant therapy for locally advanced rectal cancer. 1.
- Trial name
- NCT07854964
- Testing
- Serplulimab, Bevacizumab, Oxaliplatin
- Volunteers
- 48 people
- Sponsor
- Tang-Du Hospital
Knee Joint
Feature Analysis of Knee Joint Magnetic Resonance Imaging Based on Artificial Intelligence
This retrospective observational study aims to investigate imaging features of the knee joint on magnetic resonance imaging (MRI) using artificial intelligence (AI)-based image analysis.
- Trial name
- NCT07784686
- Where
- China
- Volunteers
- 9,500 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Non-small Cell Lung Cancer
Neoadjuvant Furmonertinib and Cisplatin/Pemetrexed as in EGFR Mutated Stage IIA-IIIB Resectable NSCLC (FORESEE)
In this single-arm, phase II clinical trial, patients with resectable, EGFR-mutated, stage II-IIIB NSCLC received neoadjuvant therapy with furmonertinib (oral, 80 mg once daily, stopped 1 week preoperatively) in combination with…
- Trial name
- NCT05430802
- Testing
- Furmonertinib+cisplating/pemetrexed
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Tang-Du Hospital
Pancreatic Cancer
Retlirafusp Alfa Plus Apatinib and Chemotherapy as Second-Line Treatment for Pancreatic Cancer
This is a prospective, open-label, single-arm clinical study designed to evaluate the efficacy and safety of retlirafusp alfa combined with apatinib and chemotherapy as second-line treatment in patients with unresectable locally…
- Trial name
- NCT07773363
- Testing
- Retlirafusp Alfa, Apatinib, Fluoropyrimidine-Based Chemotherapy
- Volunteers
- 37 people
- Sponsor
- Tang-Du Hospital
Head & Neck Cancer
Penpulimab Combined With Chemotherapy for Patients With Locally Advanced Hypopharyngeal Carcinoma
This is a prospective, single-arm, phase II clinical study aimed to evaluate the efficacy and safety of penpulimab combined with chemotherapy in the treatment of locally advanced hypopharyngeal carcinoma.
- Trial name
- NCT07752394
- Testing
- Finotonlimab, Nab-paclitaxel, carboplatin
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tang-Du Hospital
Ulcerative Colitis (UC)
Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy（PRECAL）
This is a national prospective, multicenter, observational study. A total of 200 eligible patients will be enrolled from 10 hospitals across the country.
- Trial name
- PRECAL (NCT07721441)
- Testing
- fecal calprotectin test
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Tang-Du Hospital
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Conversion Therapy With Retlirafusp Alfa Plus Chemotherapy in Gastric or Gastroesophageal Junction Adenocarcinoma
This is a prospective, single-arm, exploratory clinical study designed to evaluate the efficacy and safety of retlirafusp alfa plus CAPOX as conversion therapy in patients with potentially resectable gastric or gastroesophageal…
- Trial name
- NCT07709767
- Testing
- Retlirafusp Alfa, Oxaliplatin, Capecitabine
- Volunteers
- 21 people
- Sponsor
- Tang-Du Hospital
Ulcerative Colitis (UC)
A National Multicenter Study of Etrasimod for the Treatment of Patients With Active UC
Ulcerative colitis (UC) is a chronic inflammatory bowel disease that causes symptoms such as bloody diarrhea, abdominal pain, and frequent bowel movements. It can significantly affect patients' quality of life.
- Trial name
- E-Heal China (NCT07705126)
- Testing
- Etrasimod
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tang-Du Hospital
Ovarian Response
The Effects of Coenzyme Q10 Pretreatment on Ovarian Function and Assisted Reproductive Outcomes in Patients With Ovarian Hyporesponsiveness.
This prospective, randomized, double-blind, controlled study will be conducted at Tangdu Hospital, Air Force Medical University. It plans to enroll 128 patients with poor ovarian response for a 2-year study.
- Trial name
- NCT07260773
- Testing
- Coenzyme Q10
- Volunteers
- 128 people
- Sponsor
- Tang-Du Hospital
Neuromyelitis Optica Spectrum Disorders (NMOSD), Neuropathic Pain
Crisugabalin in NMOSD Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial
This study is a multicenter, prospective, randomized, double-blind, placebo-controlled exploratory investigation conducted in China.
- Trial name
- TERMINATOR (NCT07699770)
- Testing
- Crisugabalin
- Where
- 10 sites in China
- Volunteers
- 110 people
- Sponsor
- Tang-Du Hospital
Critical Illness, Diarrhea
Bristol Stool Scale-Based Care Pathway for Enteral Nutrition-Associated Diarrhea in Critically Ill Patients
Enteral nutrition-associated diarrhea (ENAD) is one of the most common gastrointestinal complications in critically ill patients receiving enteral nutrition, with a reported incidence of 22.3%-63.1%.
- Trial name
- NCT07683364
- Testing
- BSFS-Based Diarrhea Care Pathway, Routine ICU Enteral Nutrition Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tang-Du Hospital
Ruptured Aneurysm of Intracranial Artery, Stent-Assisted Coiling
Safety and Efficacy Analysis of Stent-assisted Coil Embolization in the Treatment of Acute Ruptured Intracranial Aneurysms in the Perioperative Period.
To determine the perioperative safety and efficacy of stent-assisted coil embolization of intracranial aneurysms in the acute phase.
- Conditions
- Ruptured Aneurysm of Intracranial Artery, Stent-Assisted Coiling, Efficacy and Safety
- Trial name
- NCT07683377
- Testing
- Perform stent-assisted aneurysm embolization on patients who meet the enrollment criteria, and administer antiplatelet drugs postoperatively according to the established trial protocol.
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Tang-Du Hospital
Vascular Parkinsonism
Exploration of the Association Between White Matter Lesion Burden and Dalfampridine Response in Insidious-Onset Vascular Parkinsonism
This single-center observational cohort study will be conducted at Tangdu Hospital, Fourth Military Medical University. Patients presenting parkinsonism and poor levodopa response will be enrolled, including insidious-onset…
- Trial name
- DAL-VaP (NCT07682428)
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Tang-Du Hospital
Esophageal Squamous Cell Carcinoma (ESCC)
Neoadjuvant Short-Course Radiotherapy Plus Tislelizumab and Chemotherapy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
Neoadjuvant Short-Course Radiotherapy Followed by Tislelizumab Plus Chemotherapy for Locally Advanced Resectable Esophageal Squamous Cell Carcinoma This is a prospective, randomized, two-arm, parallel-group, multicenter…
- Trial name
- NCT07678580
- Testing
- Albumin-bound paclitaxel, Low-dose Short-course Radiotherapy, High-dose Short-course Radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tang-Du Hospital
Irritable Bowel Syndrome (IBS), Anxiety
Anxiety and Depression in IBS: A Brain-Gut Axis Study
This study aims to understand how the gut and the brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety and depression.
- Conditions
- Irritable Bowel Syndrome (IBS), Anxiety, Depression
- Trial name
- NCT07646834
- Testing
- Observational Study (No Intervention)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Breast Cancer, HR Positive/HER2 Low Breast Cancer
Neoadjuvant Dalpiciclib + AI → SHR-A1811 for HR+/HER2-Low Breast Cancer
This is a phase II, single-arm, prospective exploratory study to evaluate the efficacy and safety of neoadjuvant dalpiciclib (a CDK4/6 inhibitor) plus an aromatase inhibitor (AI) followed by SHR-A1811 (an anti-HER2 antibody-drug…
- Trial name
- TD-DASHER-01 (NCT07618923)
- Testing
- Dalpiciclib 125mg, Aromatase Inhibitor, SHR-A1811
- Volunteers
- 20 people
- Sponsor
- Tang-Du Hospital
Gastric Cancer
Clinical Study of Taurine Combined With Neoadjuvant Chemo-Immunotherapy for Treatment of Locally Advanced Gastric Cancer
This project aims to evaluate the efficacy and safety of oral taurine supplementation combined with PD-1 inhibitor (serplulimab) and chemotherapy in inducing systemic CD8+ T cell responses and achieving improved gastric cancer…
- Trial name
- NCT06128252
- Testing
- Taurine, Serplulimab, XELOX regimen
- Where
- 15 sites in China
- Volunteers
- 96 people
- Sponsor
- Tang-Du Hospital
IgA Nephropathy (IgAN)
Exploring the Brain - Gut Microbiota - Kidney Interactive Damage Mechanisms Underlying Cognitive Decline in Patients With IgA Nephropathy Using Ultra-high Field Magnetic Resonance Imaging
IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Its progression is often accompanied by cognitive decline, manifesting as multi-dimensional cognitive deficits in areas such as memory, attention…
- Trial name
- NCT07617402
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Esophageal Squamous Cell Carcinoma
Retlirafusp Alfa Plus Chemotherapy as Neoadjuvant Therapy for Thoracic ESCC
This is a prospective, single-arm, exploratory clinical study designed to evaluate the efficacy and safety of retlirafusp alfa combined with chemotherapy (nab-paclitaxel and cisplatin) as a neoadjuvant therapy for patients with…
- Trial name
- NCT07618910
- Testing
- Retlirafusp alfa, Nab paclitaxel, Cisplatin for injection
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Tang-Du Hospital