Clinical trials: sponsored by Technical University of Munich
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Munich ME/CFS Cohort Study
The Munich cohort study MUC-CFS aims at the characterization and long-term follow-up of myalgic encephalitis/chronic fatigue syndrome (ME/CFS) in young people aged up to 25 years, as well as at the identification of…
- Trial name
- MUC-CFS (NCT06005246)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Radiotherapy, Breast Cancer
Respiratory Training and Relaxation Techniques to Improve Adjuvant Radiation Therapy in DIBH in Breast Cancer
The goal of this prospective clinical trial is to improve patient compliance and performance of deep inspiration breath hold (DIBH) to further reduce the cardiac dose from left breast radiation, and to improve cooperation and…
- Conditions
- Radiotherapy, Breast Cancer, Relaxation, Breathholding
- Trial name
- B-REST (NCT05975190)
- Testing
- Respiratory training and relaxation techniques under adjuvant radiation therapy in DIBH in breast cancer
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Technical University of Munich
Light Sensitivity
Eye Movement Behaviour and Pupil Size in Natural Outdoor and Indoor Scenes
In this study, the researchers will be using eye tracking and detailed lighting measurements to understand how different types of indoor and outdoor lighting affect the eye movements and pupil sizes of our participants.
- Trial name
- NCT05971238
- Testing
- Indoor vs. outdoor scenes
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Glioma, Brain Metastases
nTMS for Motor Mapping of Rolandic Lesions
To compare presurgical motor mapping by navigated transcranial magnetic stimulation for surgery (nTMS) of rolandic lesions to surgery with mapping without implementing these data into neuronavigation as control.
- Trial name
- Motorstim (NCT02879682)
- Testing
- nTMS data available for the surgeon, nTMS data not available for the surgeon
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 330 people
- Sponsor
- Technical University of Munich
Adult Brain Tumor
Induction of Cortical Plasticity
The study aims to induce plastic reorganization by a therapeutic protocol to increase the rate of gross total resection (GTR) and to optimize the oncological result.
- Trial name
- NCT04553341
- Testing
- Navigated repetitive transcranial magnetic stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Traumatic Brain Injuries
Standard Craniectomy Against Laparotomy for the Treatment of Traumatic Rise in Intracranial Pressure and the Effect on Long-term Outcome
Intractable high intracranial pressures (ICP) are associated with poor functional outcomes and mortality, so the SCALPEL trials aims to evaluate the effect of decompressive craniectomy against decompressive laparotomy to lower…
- Trial name
- SCALPEL (NCT05115929)
- Testing
- Decompressive Laparotomy, Decompressive Craniectomy
- Where
- 4 sites in France, Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Head and Neck Squamous Cell Carcinoma
Liquid Biopsy of Head and Neck Cancer Patients in Blood and Saliva
Prospective study for therapy monitoring of locally advanced and metastatic head and neck cancer patients by detection of circulating tumor nucleic acids in peripheral blood and saliva
- Trial name
- KOHACIN (NCT05122507)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Pyoderma Gangrenosum
Single-arm Study to Assess a Potential Effect of Anti-IL-17 (Secukinumab) in the Treatment of Pyoderma Gangrenosum
The purpose of this study is to explore the efficacy and safety of anti-Interleukin-(IL)17 therapy (secukinumab, administered weekly for 4 weeks followed by four-weekly administration until week 16) for the treatment of pyoderma…
- Trial name
- NCT02733094
- Testing
- Secukinumab
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Technical University of Munich
Polytrauma
Genderspecific Differences in Hormone Levels After Trauma
The goal of this prospective study with the aim to establish a registry is to learn about the role of steroid hormones in severely injured patients.
- Trial name
- SteroPoly (NCT05794256)
- Testing
- No interventions are planned
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Gastroesophageal Reflux
Anti Reflux Mucosal Ablation Therapy in PPI Dependent GERD
This is a prospective, randomized, single-blinded, interventional, controlled trial to evaluate the efficacy and safety of endoscopic anti reflux mucosal ablation (ARMA) in PPI dependent gastroesophageal reflux disease (GERD) in…
- Trial name
- APDG (NCT05763485)
- Testing
- Anti reflux mucosal ablation (ARMA)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Experimental Pain in Healthy Human Subjects
Intra- and Inter-individual Differences of Pain
Pain is a highly subjective and variable phenomenon. Different persons perceive objectively identical nociceptive stimuli differently.
- Trial name
- NCT05616091
- Testing
- painful stimulation by using a laser device (DEKA Stimul 1340, Calenzano, Italy)
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Leukemia, Stem Cell Transplantation
Study of the Trifunctional Antibody FBTA05 and Donor Lymphocyte Infusion in B-cell Lymphoma After Allogeneic Stem Cell Transplantation
This study is an investigator driven, open-label, non-randomized, uncontrolled, dose escalating Phase I/II study evaluating the safety and preliminary efficacy of the trifunctional bispecific antibody FBTA05 in combination with…
- Trial name
- STP-LYM-01 (NCT01138579)
- Testing
- FBTA05
- Where
- Germany
- Sponsor
- Technical University of Munich
Long Covid19, Post COVID-19 Condition
All Eyes on PCS - Analysis of the Retinal Microvasculature in Patients With Post-COVID-19 Syndrome
The goal of this observational, prospective study is to in depth analyze the retinal microvasculature in patients with Post-COVID-19 Syndrome (PCS).
- Conditions
- Long Covid19, Post COVID-19 Condition, Endothelial Dysfunction
- Trial name
- NCT05635552
- Testing
- Dynamic retinal vessel analysis (DVA), Optical coherence tomography (OCT), Biochemistry and immune phenotyping
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Intracranial Tumor
Comparison of Fluorescein-INtra-VItal Microscopy Versus Conventional Frozen Section Diagnosis for intraOperative Histopathological Evaluation
With the appliance of the in-vivo microscopy after Fluorescein staining, the investigators hypothesize that the preliminary in-vivo histopathological diagnostic accuracy is not inferior to conventional frozen section analysis…
- Trial name
- INVIVO (NCT04597801)
- Testing
- Alcon
- Where
- 3 sites in Germany
- Volunteers
- 210 people
- Sponsor
- Technical University of Munich
Castration-resistant Prostate Cancer
Liquid Biopsy-based Detection of Resistance to Targeted Therapy in Prostate Cancer Patients
This study will prospectively compare liquid-biopsy based methods for prediction of resistance under androgen-receptor signaling inhibitors.
- Trial name
- PEARL (NCT03601143)
- Testing
- Blood samples prior to a new line of AR-targeted therapy
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Urinary Bladder Cancer
Radio-Immunotherapy Before Cystectomy in Locally Advanced Urothelial Carcinoma of the Bladder
A prospective, single arm, multicenter, Phase II-Trial to assess safety and efficacy of preoperative Radiation therapy before radical CystEctomy combined with ImmunoTherapy in locally advanced urothelial carcinoma of the bladder
- Trial name
- RACE IT (NCT03529890)
- Testing
- Nivolumab, Radiation therapy of the pelvis, Radical cystectomy with standardized pelvic lymphadenectomy
- Where
- 3 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Technical University of Munich
Pre-operative Assessment, Adults
Software-guided Guideline Implementation in Premedication
Aim of the project is the development of a software for implementation of anesthesiology guidelines in the preoperative evaluation.
- Conditions
- Pre-operative Assessment, Adults, Non-cardiac Surgery
- Trial name
- SGGIP (NCT04058769)
- Testing
- Premedication Guide
- Where
- Germany
- Volunteers
- 203 people
- Sponsor
- Technical University of Munich
Burst Suppression, General Anesthesia
Interrater Variability for the Identification of Anesthetic-induced Burst Suppression EEG
Burst suppression describes a specific EEG pattern that can generally indicate a too deep general anesthesia. The pathophysiology of anesthetic-induced Burst Suppression may be distinctly different from the pathophysiology of…
- Conditions
- Burst Suppression, General Anesthesia, Electroencephalogram
- Trial name
- NCT05508386
- Testing
- MATLAB-based interface, showing 50 EEG traces, classification of the EEG-pattern as Burst Suppression possible, yes, no.
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Other Tracheostomy Complication
LipoAerosol© Inhalation After Tracheostomy
Patients after tracheostomy represent a substantial part in the ear nose throat clinic. Long-term intubated patients in intensive care units also profit from tracheostomy due to an improved respiratory toilet.
- Trial name
- NCT02157129
- Testing
- LipoAerosol© inhalation, Physiologic saline inhalation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Breast Cancer
Improvement of the Operative Outcome in Patients With Primary VEGF + Unifocal Breast Cancer or DCIS Through the Intraoperative Visualization of the Tumor Using Molecular Imaging and Bevacizumab-IRDye-800CW
It is a prospective, open, non-randomized, multicenter, one-armed, blinded (surgeon), diagnostic clinical trial according to AMG and MPG.
- Trial name
- DoT-FMI (NCT05359874)
- Testing
- Bevacizumab-IRDye800CW
- Sponsor
- Technical University of Munich