Clinical trials: sponsored by Technical University of Munich
Chronic Pain
EEG-characteristics of Neuropsychiatric Symptoms in Chronic Pain
Chronic pain is a challenge for patients, physicians and society due to its high prevalence and its substantial individual and socio-economic burden.
- Trial name
- NCT05261243
- Testing
- EEG / questionnaires / working memory task
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technical University of Munich
Brain Metastases, Resection Cavity
Hypofractionated Versus Single Fraction Stereotactic Adjuvant Radiotherapy to the Resection Cavity of Brain Metastases
This prospective, randomized, controlled, monocentric clinical phase III study focuses on stereotactic irradiation of resection cavities of brain metastases after surgical resection and seeks to demonstrate the superiority of…
- Trial name
- SATURNUS (NCT05160818)
- Testing
- Hypofractionated stereotactic radiotherapy (HFSRT) versus single fraction stereotactic radiotherapy radiosurgery (SRS)
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- Technical University of Munich
Heart Failure With Preserved Ejection Fraction
Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure
Aim of the clinical multicenter study (OptimEx-CLIN) is to assess the optimal exercise intervention in patients with Heart Failure with preserved Ejection Fraction (HFpEF; also termed diastolic heart failure) that will best…
- Trial name
- OptimEx-Clin (NCT02078947)
- Testing
- High Intensity Exercise, Moderate Continuous Exercise, Usual Care
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 180 people
- Sponsor
- Technical University of Munich
Childhood Cancer
The Munich Adrenaline Cancer Study
Observational studies report associations between physical activity and survival in some types of adult cancer. In addition, some exercise-induced molecules such as catecholamines (e.g., adrenaline) are known to change cancer…
- Trial name
- MACS (NCT04847908)
- Testing
- Single high-intensity interval exercise intervention
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Technical University of Munich
Polytrauma
Analysis of Urogenital Injuries in Polytraumatized Patients
Urogenital injuries occur in approximately 5-10 % of all severly injured patients. The literature lacks a thorough investigation into the mechanisms of trauma, the analysis of the whole urogenital tract and especially the…
- Trial name
- NCT05074095
- Testing
- retrospective analysis
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Nummular Eczema, Eczema
An Investigator-initiated Study of Apremilast to Demonstrate Efficacy Nummular Eczema
This is an investigator-initiated, single-center, prospective, randomized, double-blind, interventional phase IIb study. Forty patients with clinically and histologically confirmed nummular eczema will be enrolled according to…
- Conditions
- Nummular Eczema, Eczema, Dermatitis Eczema, Nummular Dermatitis
- Trial name
- APREMINUM (NCT03160248)
- Testing
- Apremilast
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Technical University of Munich
Non-cardiac Surgery, Adults
Clinical Guidelines in Premedication Visit
The purpose of the study is to determine the frequency with which individual guideline recommendations on preoperative evaluation of patients scheduled for non-cardiac surgery are implemented as well as identifying the guidelines…
- Trial name
- NCT04843202
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Technical University of Munich
Prosthetic Joint Infection, Prosthetic Infection
Calprotectin in Chronic Prosthetic Joint Infection
A bacterial infection of an artificial joint is a serious complication that often requires additional surgery to exchange the arthroplasty.
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Arthroplasty Complications
- Trial name
- NCT05060952
- Testing
- Calprotectin Lateral Flow Test
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Postoperative Complications
QoR-9 AS predicTor of postopErative Complications
Aim of the study is to evaluate, whether the self administered quality of recovery (QoR-9) questionnaire can predict postoperative complications after non-cardiac surgery and whether preoperative risk estimates can be improved by…
- Trial name
- NCT03669419
- Testing
- QoR 9 Questionnaire
- Where
- Germany
- Volunteers
- 3,854 people
- Sponsor
- Technical University of Munich
Diabetes Mellitus, Type 1
PINIT Study: Primary Intranasal Insulin Trial
Type 1 diabetes (T1D) results from an autoimmune destruction of the insulin-producing beta cells. Administration of mucosal insulin in islet autoantibody-negative children who are genetically predisposed for T1D offers the…
- Trial name
- NCT03182322
- Testing
- intranasal insulin
- Where
- 2 sites in Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Childhood Cancer
Strength Training and ADLs in Childhood Leukemia and Lymphoma Patients
Reduced activity levels and reduced muscular strength could severely impair the activities of daily living (ADLs) in pediatric leukemia and Non-Hodgkin lymphoma patients.
- Trial name
- NCT03934060
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Burst Suppression, EEG With Abnormally Slow Frequencies
Reduction of Intraoperative EEG Burst Suppression
Burst suppression (BS) is a not physiological pattern in the electroencephalogram (EEG). BS during general anesthesia is mainly seen as a sign for too deep hypnosis and may increase the risk of postoperative delirium (POD), a…
- Conditions
- Burst Suppression, EEG With Abnormally Slow Frequencies, Postoperative Delirium
- Trial name
- BsR (NCT03775356)
- Testing
- Treatment of hypotension and/or reduction of anesthetics
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- Technical University of Munich
Hypoalbuminemia
SUbstition of PERioperative Albumin Deficiency Disorders
Aim of this study is to reduce postoperative complications (assessed by POMS-Score and graded by Clavien-Dindo-Score) by substitution of perioperative hypoalbuminaemia in high-risk patients or patients undergoing high risk…
- Trial name
- SUPERADD (NCT03167645)
- Testing
- Human albumin
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Technical University of Munich
Delirium
Avoidance of Delirium in Older Patients After Major Non-cardiac Surgery
This study is designed to compare the incidence of postoperative delirium in older patients after major non-cardiac surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group and a…
- Trial name
- ADOM (NCT01827501)
- Testing
- PulsioflexTM Monitoring
- Where
- Germany
- Volunteers
- 172 people
- Sponsor
- Technical University of Munich
Experimental Pain in Healthy Human Participants
Sensory Evidence and Expectations in Pain Processing
Pain is a highly complex and subjective phenomenon which is not only rooted in sensory information but also shaped by cognitive processes such as expectation.
- Trial name
- NCT04296968
- Testing
- Painful stimulation using a laser device (DEKA Stimul 1340, Calenzano, Italy), Visual cueing
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Tibia Plateau Fracture
Polyaxial Locking Plate Osteosynthesis in Proximal Tibia Fractures
From October 2013 28 patients with proximal tibia fractures (AO/ASIF 41 B-C) were included in this study. According to our treatment algorithm for this entity Patients were assigned into two groups and treated with different…
- Trial name
- NCT04680247
- Testing
- VA-LCP, NCB-PT
- Volunteers
- 28 people
- Sponsor
- Technical University of Munich
Advanced Dementia Stages, Palliative Care
IssuEs in Palliative Care for People in Advanced and Terminal Stages of Young-onset and Late-Onset Dementia in GErmany
From a scientific view, palliative care issues in dementia are neglected in Germany. Neither in Germany nor internationally research has been conducted on palliative care issues in young onset dementia (YOD), although significant…
- Trial name
- EPYLOGE (NCT03364179)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Technical University of Munich
Subacute/Chronic Myocardial Infarction
Comparison of Gadobutrol and Gadobenate Dimeglumin for Delayed Enhancement Cardiac MRI
This study aims at evaluating the diagnostic efficacy of Gadobutrol versus Gadobenate dimeglumine at similar dose of 0.1mmol/kg for assessment of myocardial infarction by delayed enhancement cardiac Magnetic Resonance Imaging
- Trial name
- Gadovit (NCT01655290)
- Testing
- Gadovist® (Gadobutrol), Multihance® (Gadobenate dimeglumin)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Chronic Pain, Interdisciplinary Multimodal Pain Therapy, Electroencephalography, Functional Connectivity
The Influence of Interdisciplinary Multimodal Pain Therapy on Cerebral Connectivity in Chronic Pain Patients
Due to its high prevalence and the substantial individual and socio-economic burden chronic pain is a huge challenge for patients, physicians and the society.
- Trial name
- NCT03634670
- Testing
- Interdisciplinary multimodal pain therapy (IMPT)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Technical University of Munich
Acute Pancreatitis
Early Goal-directed Volume Resuscitation in Severe Acute Pancreatitis
Acute pancreatitis (AP) is a common disorder with rising incidence varying between 35 and 80 per 100,000 in Europe and the USA. About 15% of patients develop necrotizing pancreatitis (NP) with a mortality of up to 42% and…
- Trial name
- EAGLE (NCT00894907)
- Testing
- PiCCO-parameter-guided volume resuscitation, Control-group
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- Technical University of Munich