Clinical trials: sponsored by Technische Universität Dresden
Glaucoma, Glaucoma, Open-Angle
Dresden Glaucoma and Treatment Study (DGTS)
To assure the quality of follow-up and treatment, data of glaucoma patients are stored and evaluated after anonymisation.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Low Tension
- Trial name
- NCT02959242
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Technische Universität Dresden
Bipolar Disorder
Smartphone-based Ambulatory Assessment of Early Warning Signs
Bipolar disorders are severe chronic disorders, marked by recurrent episodes of depression and (hypo)mania. The disorder usually emerges in early adulthood and tends to have a highly unpredictable course.
- Trial name
- BipoLife_A3 (NCT02782910)
- Testing
- Smartphone-Based Ambulatory Assessment, Feedback via physician
- Where
- Germany
- Volunteers
- 148 people
- Sponsor
- Technische Universität Dresden
AML - Acute Myeloid Leukemia, MDS (Myelodysplastic Syndrome)
Evaluation of Treosulfan Versus Melphalan Conditioning Followed by PTCy in Patients With AML and MDS Undergoing Allogeneic Transplantation
The aim of this study is to compare the effectiveness and tolerability of two conditioning chemotherapies prior to allogeneic stem cell transplantation.
- Trial name
- RELEVANT (NCT07025824)
- Testing
- Treosulfan (Treo), Melphalan (Mel), Fludarabine (Flud)
- Where
- 17 sites in Germany
- Volunteers
- 220 people
- Sponsor
- Technische Universität Dresden
Relapsed Adult AML, Refractory AML
Trial for Relapsed or Refractory AML Patients Combining Cytarabine and Mitoxantrone With Venetoclax (RELAX)
This is an open-label Phase I dose-escalation study of oral venetoclax in combination with increasing cytarabine doses plus mitoxantrone to define the safety profile and MTD of cytarabine in subjects with a histologically or…
- Trial name
- RELAX (NCT04330820)
- Testing
- Venetoclax Oral Tablet
- Where
- 12 sites in Germany
- Volunteers
- 55 people
- Sponsor
- Technische Universität Dresden
Prostate Cancer
Preference-based Comparative Study on Definitive Radiotherapy of Prostate Cancer With Protons
ProtoChoice-P is a prospective multicenter trial to evaluate proton therapy in patients suffering from prostate cancer. Primary aim of the study is a decrease of moderate or severe genito-urinary or intestinal side effects…
- Trial name
- ProtoChoiceP (NCT02766686)
- Testing
- Radiotherapy with protons, Radiotherapy with photons
- Where
- 3 sites in Germany
- Volunteers
- 180 people
- Sponsor
- Technische Universität Dresden
Oligometastatic Disease, Prostatic Cancer, Castration-Resistant
Local Ablative Radiotherapy for OLIgoprogressive Castration Resistant Prostate Cancer
The purpose of this randomized trial is to investigate the efficacy and toxicity of percutaneous high-dose radiotherapy in patients with oligometastases of hormone refractory prostate cancer.
- Trial name
- OLI-CR-P (NCT04141709)
- Testing
- local ablative radiotherapy
- Where
- 4 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Technische Universität Dresden
Atopic Dermatitis
Replication of the Heads Up Atopic Dermatitis Trial With Registry Data
The goal is the replication of the primary outcome (EASI 75 at week 16) of the Heads Up trial (Blauvelt, A, Teixeira, H, Simpson, E et al (2021) doi:10.1001/jamadermatol.2021.3023) and the evaluation of the patient reported…
- Trial name
- Re-HU-TREAT (NCT06937788)
- Testing
- Upadacitinib, Dupilumab
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Technische Universität Dresden
Acute Myeloid Leukemia
Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML
This phase II clinical trial evaluates the efficacy and tolerability of the non-intensive treatment with venetoclax and the hypomethylating agent azacitidine as compared to the standard of care chemotherapy plus gemtuzumab…
- Trial name
- VINCENT (NCT05904106)
- Testing
- Venetoclax plus Azacitidine, standard of care chemotherapy plus gemtuzumab ozogamicin
- Where
- 18 sites in Germany
- Volunteers
- 146 people
- Sponsor
- Technische Universität Dresden
Rectal Surgery
Perioperative and Postoperative Evaluation of Rectal and Urogenital Function in Patients Undergoing Rectal Resection
The aim of this study is the systematic analysis of the development of perioperative rectal and urogenital function in patients undergoing rectal resection with total mesorectal excision and the identification of risk factors for…
- Trial name
- PERIFUNC (NCT05257746)
- Testing
- Rectal resection
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technische Universität Dresden
Mental Health Care
Evaluation of a Flexible and Integrative Psychiatric Care Model at the Pfalzklinikum (EVA_Pfalz)
This study is an evaluation of the flexible and integrative psychiatric care model (according to § 64b of the German Social Code Book V (SGB V)) (FIT) at the Pfalzklinikum.
- Trial name
- EVA_Pfalz (NCT05181982)
- Testing
- FIT contract with global treatment budget
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Technische Universität Dresden
Neoplasms, Relapsed Diffuse Large B-cell Lymphoma (DLBCL)
A Phase I Trial to Establish the Safety and Maximum Tolerated Dose of High-affinity Autologous BCMA-targeting Chimeric Antigen Receptor (CAR) T-cells in Patients With Relapsed and Refractory B-cell Malignancies
The purpose of this phase I study is to determine whether MDC-CAR-BCMA001 (BCMA directed CAR T-cells) is safe and tolerable in the treatment of relapsed and refractory B-cell malignancies
- Conditions
- Neoplasms, Relapsed Diffuse Large B-cell Lymphoma (DLBCL), Refractory Diffuse Large B-cell Lymphoma (DLBCL), Multiple Myeloma, Refractory
- Trial name
- CARLOTTA01 (NCT05836896)
- Testing
- MDC-CAR-BCMA001 (BCMA directed CAR T-cells)
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Technische Universität Dresden
Pancreatectomy, Hyperamylasemia
Incidence and Clinical Impact of Serum Hyperamylasemia (POH) After Pancreatectomy on Postoperative Outcome and Patient Safety
Recent evidence suggests that postoperative hyperamylasemia (POH) is a predictor of morbidity after pancreatectomy. This is based on the assumption that pancreatitis after pancreatectomy (PPAP) is a major trigger for the…
- Conditions
- Pancreatectomy, Hyperamylasemia, Pancreatitis, Acute
- Trial name
- HYPPO (NCT06126601)
- Testing
- Pancreatectomy
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Technische Universität Dresden
Gastric Cancer, Colon Cancer
Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
Patients with gastric or colon cancer with peritoneal carcinomatosis will receive a biopsy of the tumor during their primary curative surgery.
- Conditions
- Gastric Cancer, Colon Cancer, Peritoneal Carcinomatosis
- Trial name
- Hi-STEP1 (NCT05652348)
- Testing
- Establishment of organoid cultures and in vitro sensitivity testing
- Where
- 5 sites in Germany
- Volunteers
- 48 people
- Sponsor
- Technische Universität Dresden
MDS (Myelodysplastic Syndrome), MDS/Myeloproliferative Neoplasm (MPN) Overlap Syndrome
Dresden MDS Registry With an Accompanying Biomaterial Collection
A registry for the study of the epidemiology, clinical course, and progression of myelodysplastic neoplasms (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN overlap syndromes), and their precursor syndromes (CHIP…
- Conditions
- MDS (Myelodysplastic Syndrome), MDS/Myeloproliferative Neoplasm (MPN) Overlap Syndrome, CHIP, CCUS Clonal Cytopenia of Undetermined Significance
- Trial name
- NCT07561385
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technische Universität Dresden
Rectum Cancer
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery
The aim of the study is to evaluate the technical feasibility and applicability of a surgical assistance system based on image recognition algorithms in a first-in-human pilot study.
- Trial name
- CoBot2 (NCT05652361)
- Testing
- Additional visualisation of surgical assistance during surgery
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Technische Universität Dresden
Hypertension, Blood Pressure Monitoring
Wearable Blood-Pressure Monitoring Comparison Study
The goal of this clinical trial is to compare the accuracy, clinical applicability, and usability of different wearable blood pressure monitoring methods integrated in wearable devices, such as smartwatches, in hospitalized…
- Conditions
- Hypertension, Blood Pressure Monitoring, Wearable Devices, Photoplethysmography
- Trial name
- WBPMCS (NCT07719660)
- Where
- 2 sites in Germany, Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
AML, MDS
Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation
maintenance of AML or MDS patients with known IDH1 mutation after allogeneic stem cell transplantation within past 100 days
- Trial name
- PIVOT (NCT06717958)
- Testing
- Ivosidenib 250 MG (milligram)
- Where
- 17 sites in Germany
- Volunteers
- 76 people
- Sponsor
- Technische Universität Dresden
Large Cell Neuroendocrine Carcinoma of the Lung
A Trial for the Treatment of Advanced Large-Cell Neuroendocrine Cancer of the Lung
This phase II clinical trial evaluates the efficacy, safety and tolerability of Obrixtamig in addition to standard of care chemotherapy (Platinum/Etoposide) in LCNEC.
- Trial name
- ALPINE 2 (NCT07561645)
- Testing
- Obrixtamig
- Volunteers
- 75 people
- Sponsor
- Technische Universität Dresden
Mechanical Ventilation, Intensive Care Medicine
Intelligent Lung Support in the Intensive Care Unit
The aim of this observational study is to test the IntelliLung decision support system based on artificial intelligence. This system is intended to help to set the ventilator.
- Trial name
- IntelliLung (NCT06595602)
- Testing
- Artificial intelligence based decision support system (AI-DSS); software
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 530 people
- Sponsor
- Technische Universität Dresden
Acute Promyelocytic Leukemia
Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia
Acute promyelocytic leukemia (APL) is a rare subtype of acute myeloid leukemia (AML) characterized by consistent clinical, morphologic, and genetic features.
- Trial name
- TUD-APOLLO-064 (NCT02688140)
- Testing
- Arsenic trioxide, Idarubicin, Cytarabine
- Where
- 8 sites in France, Germany and 3 more
- Volunteers
- 133 people
- Sponsor
- Technische Universität Dresden