Clinical trials: sponsored by Technische Universität Dresden
Head-and-neck Carcinoma
Re-irradiation of Recurrent Head and Neck Cancer
The goal of this observational study is to evaluate the toxicity and local tumor control of proton therapy for patients with head and neck cancer in a previously irradiated field.
- Trial name
- ReKo (NCT01973179)
- Testing
- Radiation therapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technische Universität Dresden
Primary Brain Tumor
Neurocognitive Function After Proton Therapy in Children and Adolescents
Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in…
- Trial name
- ELBE-ProKids (NCT04066465)
- Where
- 3 sites in Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Melanoma of Skin
The Study Aims to Measure the Metabolome in Melanoma Patients Using NMR Spectroscopy and Gas Chromatography and to Analyse Differences Depending on the Course of the Disease.
Prospective, single-centre study with the central question of how the metabolome from blood samples, different body fluids and tissues between patients patients with malignant melanoma in different tumour tumour stages and…
- Trial name
- NCT06765850
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- Technische Universität Dresden
Brain Tumors
Comparison of Proton and Photon Radiotherapy of Brain Tumors (ProtoChoice-Hirn)
This protocol compares the toxicity of radiotherapy or radiochemotherapy applied with different radiation modalities - protons or photons.
- Trial name
- NCT02824731
- Testing
- Radiation with protons, Radiation with photons
- Where
- 2 sites in Germany
- Volunteers
- 555 people
- Sponsor
- Technische Universität Dresden
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Alcohol Use Disorder (AUD), Alcoholism
Assessing Habitual, Goal-Directed, and Pavlovian Influences in Alcohol Use Disorder
The first aim of this study is to establish the role of maladaptive reliance on habits for impaired control in addiction, employing a novel task - the Action-Sequence-Task (AST), which assesses interference between habitual and…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders
- Trial name
- ReCoDe (NCT06701500)
- Testing
- Pavlovian-to-instrumental transfer (PIT) paradigm, Action Sequence Task (AST), Basic psychological assessment (interview)
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Virus Diseases, Epidemiology
Post-COVID-19 Monitoring in Routine Health Insurance Data
The SARS-CoV-2 infection was in 2020 responsible for new disease related chronic conditions which have been referred to as Post-COVID. To date it is still unknown how common this condition is and which symptoms are related to it.
- Trial name
- POINTED (NCT05074953)
- Testing
- Exposed to a SARS-CoV-2 infection
- Where
- Germany
- Volunteers
- 157,134 people
- Sponsor
- Technische Universität Dresden
Addictive Behavior, Alcohol Use Disorder (AUD)
Volitional Dysfunction in Self-control Failures and Addictive Behaviors
The aim of this project is to elucidate whether impairments of cognitive control, performance-monitoring, and value-based decision-making and dysfunctional interactions between underlying brain systems are mediating mechanisms…
- Conditions
- Addictive Behavior, Alcohol Use Disorder (AUD), Tobacco Use Disorder, Self-Control
- Trial name
- NCT04498988
- Testing
- Observational study without interventions
- Where
- Germany
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Implementation of Indication Criteria for Total Knee Replacement in Osteoarthritis (Value-based TKR)
The aim of this trial is to investigate the effect of a medical decision aid (EKIT-Tool) on decision quality for knee arthroplasty.
- Trial name
- NCT04837053
- Testing
- Digital decision aid for physicians and patients, Routine care
- Where
- Germany
- Volunteers
- 1,092 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis
Clinical Outcome and Cytokine Expression After TKA
Comparison of coated and uncoated TKA with regard to cytokine expression and clinical results
- Trial name
- TKA (NCT03424174)
- Testing
- Coated Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technische Universität Dresden
Mental Health, Cross-sectoral Treatment
Nationwide Uniform Scientific Evaluation of Flexible and Integrated Treatment Projects From 2022 Onwards
This study is an evaluation of flexible and integrated psychiatric care models (according to § 64b of the German Social Code Book V (SGB V)) (FIT) including new FIT projects starting after 2022 and the prolongation of any of 19…
- Conditions
- Mental Health, Cross-sectoral Treatment, Flexible and Integrated Treatment, FIT
- Trial name
- EVA64_2 (NCT05855720)
- Testing
- FIT model project
- Where
- Germany
- Volunteers
- 30,000 people
- Sponsor
- Technische Universität Dresden
Bipolar Disorder
Improving Early Recognition and Intervention in At-risk Stages of Bipolar Disorders
Prospective multicentre observational study for treatment approaches in at-risk individuals. Furthermore the purpose of this study is to test feasibility of a clinical staging model and validate diagnostic tools to identify…
- Trial name
- BipoLife-A1 (NCT02456545)
- Testing
- ≥ 1 potential risk factor for BD, depressive syndrome, ADHD
- Where
- 9 sites in Germany
- Volunteers
- 1,419 people
- Sponsor
- Technische Universität Dresden
Colorectal Liver Metastasis
Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
the ARMANI trial will test the hypothesis, if an anatomic resection (AR) improves long-term outcome vs. a non-anatomical resection (NAR) in patients undergoing surgery for RAS-mutated colorectal liver metastasis (CRLM).
- Trial name
- ARMANI (NCT04678583)
- Testing
- Resection of colorectal liver metastases
- Where
- 37 sites in Germany
- Volunteers
- 240 people
- Sponsor
- Technische Universität Dresden
Esophageal Cancer
Drainless Robot-assisted Minimally Invasive Esophagectomy
The aim of this study is the evaluation of two different chest drain management strategies in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE) for esophageal cancer with regard to perioperative…
- Trial name
- RESPECT (NCT05553795)
- Testing
- Early removal of chest drain, Chest drain
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Technische Universität Dresden
Alcoholism
Investigation of the Efficacy of Acamprosate and Calcium in Comparison to Placebo as Validation of a Behavioural Test for Alcohol Dependence
Validation of a Test System to develop new medications for alcoholism (TEMA) The 'TEMA', a progressive-work alcohol self-administration paradigm, can be validated by reproducing the effect of Acamprosate and prove the effect of…
- Trial name
- TEMACA (NCT03634917)
- Testing
- Acamprosate Calcium, Calcium Carbonate
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Amyotrophic Lateral Sclerosis
Patients' and Caregivers' Views of Multidimensional Care in Amyotropic Lateral Sclerosis in Germany
The progressive loss of physical functioning resulting from ALS leads also to high psychosocial burden for those affected, and organizational challenges related to medical care and aids.
- Trial name
- NCT06418646
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Technische Universität Dresden
NAFLD, Diabetes Mellitus
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
The goal of this cross-sectional observational study is to to perform a thorough characterization of the quantitative and qualitative differences in peripheral blood cells, and circulating factors (proteins, metabolites, lipids…
- Conditions
- NAFLD, Diabetes Mellitus, Obesity
- Trial name
- PERIMED (NCT06396871)
- Testing
- Oral glucose tolerance test, Liver Ultrasound, Fibroscan of the Liver
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- Technische Universität Dresden
Acute Myeloid Leukemia
A Randomized Placebo-controlled Phase 2 Study of Decitabine With or Without Eltrombopag in AML Patients
Acute myeloid leukemia (AML) is a disease with a poor prognosis including a 5-year overall survival (OS) of app. 20% for the entire population.
- Trial name
- DELTA (NCT02446145)
- Testing
- Eltrombopag
- Where
- 15 sites in Germany
- Volunteers
- 132 people
- Sponsor
- Technische Universität Dresden
Irreversible Loss of Brain Function (ILBF)
Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death).
- Trial name
- DETECT-IVE (NCT06293170)
- Testing
- DETECT, Conventional care
- Where
- Germany
- Volunteers
- 4,800 people
- Sponsor
- Technische Universität Dresden
Breast Cancer
A Retrospective Analysis of Magnetic Resonance Imaging Data for Breast Cancer Screening in the Open Consortium for Decentralized Medical Artificial Intelligence
ODELIA is a project that aims to improve breast cancer detection in magnetic resonance imaging by utilizing artificial intelligence and swarm learning (MRI).
- Trial name
- ODELIA (NCT05698056)
- Testing
- No intervention.
- Where
- 2 sites in Germany
- Volunteers
- 25,000 people
- Sponsor
- Technische Universität Dresden