Clinical trials: sponsored by Tel-Aviv Sourasky Medical Center
Metastatic Breast Cancer, Hormon Receptor Positive Breast Cancer
Organ Culture for Endocrine Resistant Next Line: A Treatment Selection Study in Metastatic Breast Cancer
This study evaluates whether testing fresh tumor samples outside the body can help guide treatment selection for patients with hormone receptor-positive, HER2-negative metastatic breast cancer that has progressed during endocrine…
- Trial name
- OCEAN (NCT07895160)
- Testing
- cResponse Ex Vivo Organ Culture (EVOC) Drug Sensitivity Assay
- Where
- Israel
- Volunteers
- 39 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation
Tele-Pulmonary Rehabilitation For COPD Patients Living in Peripheral Areas
Pulmonary rehabilitation (PR) is a key non-pharmacological intervention for patients with chronic obstructive pulmonary disease (COPD), yet it remains underutilized, particularly among patients living in peripheral areas due to…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation, Peripheral
- Trial name
- TELE-PR-PRPRL (NCT07666854)
- Testing
- Tele-Rehabilitation
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD, COPD Exacerbation (AECOPD)
COPD Flare-Up Clinic After Severe Exacerbations
This prospective randomized controlled trial evaluates whether a specialized "COPD flare-up clinic service" improves outcomes in patients following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- FLARE-COPD (NCT07629869)
- Testing
- Follow-up in a flare-up clinic
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Asthma Acute, Asthma Attack
Post Exacerbation Asthma Clinic Telecare Intervention to Reduce Recurrent Exacerbations
Asthma exacerbations leading to emergency department visits or hospitalization are associated with a high risk of recurrent exacerbations, poor disease control, and increased healthcare utilization in the months following…
- Trial name
- PACT (NCT07629830)
- Testing
- Follow-up in a remote flare-up clinic
- Where
- Israel
- Volunteers
- 220 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation
Tele-Pulmonary Rehabilitation For Patients With Chronic Lung Diseases
Pulmonary rehabilitation is a key treatment for lung diseases, but many patients struggle to attend sessions due to travel distances, physical limitations, or logistical barriers.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rehabilitation, Bronchiectasis Adult, Pulmonary Arterial Hypertension (PAH)
- Trial name
- TELE-PRIME (NCT07666841)
- Testing
- Tele-Rehabilitation
- Where
- 2 sites in Israel
- Volunteers
- 90 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Reconstructive Surgical Procedures, Free Tissue Flaps
Energy Expenditure Assessment in Head and Neck Cancer Patients Treated With Free Flap Surgery
What is the purpose of this study? Patients with head and neck cancer who undergo surgery with free flap reconstruction often need careful nutritional support during recovery.
- Conditions
- Reconstructive Surgical Procedures, Free Tissue Flaps, Head and Neck Cancer, Perioperative Care
- Trial name
- NCT07759193
- Testing
- Indirect Calorimetry (Diagnostic Test)
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD (Chronic Obstructive Pulmonary Disease), Cardiovascular Diseases
Cardiovascular Assessment and Treatment During COPD Exacerbation to Improve Diagnosis and Outcomes
This is a research study involving patients hospitalized for COPD flare-ups. Patients will be assigned using a non-randomized, sequential allocation strategy (a control cohort followed by an intervention cohort) to two groups…
- Trial name
- CATCH (NCT06723795)
- Testing
- Cardiologist evaluation, Pulmonologist evaluation
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy
Predicting Progression of Developing Myeloma in a High-Risk Screened Population and General Population
We will seek consent from participants to use the data and biospecimens collected according study protocol to address additional research questions for MGUS, SMM, MM, and other conditions.
- Trial name
- NCT05837884
- Testing
- blood sampling
- Where
- 4 sites in Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Follicular Lymphoma
Trial to Evaluate Efficacy and Safety of Subcutaneous Mosunetuzumab in Previously Untreated Low Tumor Burden Follicular Lymphoma .
This is a multi-center, open-label, interventional clinical trial designed to evaluate the efficacy and safety of subcutaneous (SC) Mosunetuzumab as a first-line immunotherapy in patients with low tumor burden follicular lymphoma…
- Trial name
- SUNFLOW (NCT07191249)
- Testing
- Mosunetuzumab is a bispecific monoclonal antibody targeting CD20 on B cells and CD3 on T cells, redirecting T cells to eliminate malignant B cells.
- Where
- 4 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Multiple Myeloma in Relapse, Refractory Multiple Myeloma
Ixazomib-pomalidomide-dexamethasone as Second or Third-line Combination Treatment for Patients With Relapsed and Refractory Multiple Myeloma Previously Treated With Daratumumab, Lenalidomide and Bortezomib
Adult patients with a confirmed diagnosis of symptomatic and relapsed and/or refractory MM, after receiving bortezomib, lenalidomide and daratumumab during first and second lines, will be eligible to be enrolled in this study.
- Trial name
- IPoD-790 (NCT04790474)
- Testing
- ixazomib-pomalidomide-dexamethasone
- Where
- 7 sites in Israel
- Volunteers
- 61 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Post-Traumatic Stress Disorder, PTSD
Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSD
This is an open-label pilot study designed to evaluate the safety, tolerability, and preliminary clinical effects of psilocybin-enhanced trauma-focused psychotherapy in individuals with post-traumatic stress disorder (PTSD).
- Trial name
- TiPAP-PTSD (NCT07737054)
- Testing
- Psilocybin (drug), Trauma-Focused Psychotherapy
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy Volunteers
Pilot Clinical Trial of Ultrasound Guided Aortic Compression for Arresting Abdominal Aortic Blood Flow in Healthy Volunteers. This Isn't Device Feasibility, But Rather the Feasibility of a Clinical Maneuver; Specifically, Evaluating Whether the Technique Can Achieve the Anticipated Out
As point-of-care ultrasound (POCUS) is becoming more available in the prehospital setting, it can be potentially used for more accurate and directed pressure application, thanks to its ability to image the artery and the…
- Trial name
- NCT07707921
- Testing
- An Ultrasound Guided Aortic Compression for Arresting Abdominal Aortic Blood Flow
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Asthma, Asthma Attack
The Effect of Asthma Flare-up Clinic After Exacerbation
The goal of this interventional study is to examine the effect of asthma flare-up clinic follow-up in adult subjects after an asthma flare-up. This study aim to answer the following questions: 1.
- Trial name
- NCT06201728
- Testing
- Follow-up in a flare-up clinic
- Where
- Israel
- Volunteers
- 230 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hormone Receptor Positive Breast Cancer
EVERST- Everolimus After Alpelisib in Women With Hormone Receptor-positive (HR+) Metastatic Breast Cancer (MBC)
This phase II, open-label, single-arm, study investigates the clinical benefit of everolimus combined with endocrine therapy (ET) in hormone receptor-positive (HR+), metastatic breast cancer (MBC) patients who progressed on prior…
- Trial name
- MBC (NCT07646171)
- Testing
- Everolimus (Afinitor) tablets with endocrine therapy, Blood draw for biomarker and genetic analysis
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Large B-Cell Lymphoma (LBCL)
Investigator Initiated Study to Assess the Safety of Combination of CLS-015 With Anti-CD-19 CAR-T Cells in Patients With Stable/Progressive Large B Cell Lymphoma at Lymphodepletion.
This is a Phase 1, single-center, open-label study to evaluate the safety of CLS-015 in combination with anti-CD19 CAR-T therapy in patients with large B-cell lymphoma.
- Trial name
- NCT07361224
- Testing
- rhDNase I
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
COPD (Chronic Obstructive Pulmonary Disease), Adherence to Care
Improving Adherence to COPD Treatments in Primary Care
The goal of this clinical trial is to learn whether a special training program for primary care doctors can help improve treatment adherence and overall outcomes for people with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07104136
- Testing
- COPD-care seminar
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease
Feasibility and Preliminary Effects of the Walking Tall App for Home-Based Gait Training in Parkinson's Disease: A Pilot Study
This is a pilot study designed to assess the feasibility, adherence, and preliminary effects of a 6-week home-based gait training intervention using the Walking Tall mobile app in individuals with Parkinson's disease.
- Trial name
- NCT07380737
- Testing
- Walking Tall App
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
TNBC, Triple Negative Breast Cancer, Early Breast Cancer
MRI-Guided Neoadjuvant Treatment De-Escalation in Stage II-III TNBC
Breast cancer is the most common malignancy among women worldwide. Triple-negative breast cancer (TNBC), defined by the lack of estrogen receptor, progesterone receptor, and HER2 expression, comprises approximately 15% of all…
- Trial name
- NOGA (NCT07327021)
- Testing
- Treatment De-Escalation and Early Surgery
- Where
- 2 sites in Israel
- Volunteers
- 54 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Environmental Exposure; Dietary Patterns; Nutritional Epidemiology; Human Biomonitoring
Assessing Toxic Metal Exposure From Vegetarian/Vegan, Omnivorous, and Low-carb Diets in Israel.
Different dietary intake may pose various health risks as as these have different potential exposure to heavy metals, which may originate from soils, irrigation systems, infrastructure, packaging, and other environmental…
- Trial name
- NCT07235332
- Testing
- Screening
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Diabetes Mellitus, Type 2, Sarcopenia
Mediterranean Diet, Circuit Resistance Training, Empagliflozin in Elderly With Type 2 Diabetes: a Study Protocol
Primary objective: To assess the effects of a modified plant-based Mediterranean diet (vegeterranean diet), circuit resistance training (CRT) and empagliflozin alone or in combination on metabolic and physical function in elderly…
- Conditions
- Diabetes Mellitus, Type 2, Sarcopenia, Weight Loss
- Trial name
- NCT03560375
- Testing
- Circuit resistance training (CRT), Vegeterranean diet (V-Med diet), Empagliflozin 10 MG
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center