Clinical trials: sponsored by The Cleveland Clinic
Hepatic Encephalopathy
Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy
Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy and occurs because of impaired hepatic ureagenesis and increased…
- Trial name
- NCT04096014
- Testing
- Ensure Enlive, Standard Of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
ALD - Alcoholic Liver Disease
Comparison of ALD, NASH, and Healthy Control Patients
The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate heavy drinking, yet healthy controls and non-drinking healthy controls, is an essential first step in…
- Trial name
- NCT03224949
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Alcoholic Liver Disease, COVID 19 Pneumonia
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD) are at risk for severe illness and abrupt or sudden clinical deterioration with ventilatory failure.
- Trial name
- NCT04858412
- Testing
- β-hydroxy β-methyl butyrate (HMB) enriched amino acid, Balanced amino acid
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cleveland Clinic
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the…
- Trial name
- NCT06946368
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Alcoholic Liver Disease
Quantitative MRI for Non-invasive Assessment of Severity of Alcoholic Liver Disease (ALD)
The current goal in the treatment of Alcoholic Liver Disease (ALD) is to manage ALD-associated complications as there are no disease-specific therapies.
- Trial name
- NCT03113929
- Testing
- MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Alcoholic Hepatitis
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of…
- Trial name
- NCT04088370
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Alcoholic Hepatitis
HA35 Moderate Alcoholic Hepatitis (AH) Study
Eligible participants will be asked to take a placebo/treatment capsule for 90 days and participate in two in-person study visits, one at the start of the 90 days and the second at the completion of study supplement…
- Trial name
- NCT05018481
- Testing
- Sodium Hyaluronate
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The Cleveland Clinic
Healthy Controls
HA35 Acute Alcohol Study
Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day.
- Trial name
- NCT05025865
- Testing
- Sodium Hyaluronate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Cirrhosis
Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.
- Trial name
- NCT03225677
- Testing
- blood draw and muscle biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Cleveland Clinic
Hypertrophic Obstructive Cardiomyopathy, Thoracic Aortic Dilatation
A Cardiac Disease Quality of Life Study
A prospective, longitudinal, non-comparator, non-randomized observational cohort study to assess the quality of life in adult patients affected by hypertrophic cardiomyopathy and thoracic aortic dilatations who are not amenable…
- Conditions
- Hypertrophic Obstructive Cardiomyopathy, Thoracic Aortic Dilatation, Heart Disease Caused by Ionising Radiation, Quality of Life
- Trial name
- UPLIFT (NCT04080492)
- Testing
- QOL Survey
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- The Cleveland Clinic
Alcohol Use Disorder (AUD), Alcohol Related Liver Disease
Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism
This randomized study will examine whether a 12-week supervised home-based endurance exercise program can reduce alcohol use and alcohol craving in adults with alcohol use disorder (AUD) and alcohol-related liver disease (ALD).
- Trial name
- NCT07824089
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Stroke
I-Score: Intensive Stroke Cycling for Optimal Recovery and Economic Value
Traditional rehabilitation approaches are time and personnel intensive and costly, and leave ~75% of stroke survivors with residual disability.
- Trial name
- NCT06585943
- Testing
- Forced Rate Exercise + Rehab, Rehabilitation
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease
Identifying the Neural Signature of Exercise to Advance Treatment of PD Cognitive Declines
Twenty-five participants with PD utilizing the Medtronic Percept PC DBS system will be enrolled for this project and complete a single bout of both FE and VE.
- Trial name
- NCT05972759
- Testing
- Forced and voluntary exercise
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation
Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation
The purpose of this study is to establish a genebank repository of blood samples and data to generate information about the hereditary (genetic) basis of atrial fibrillation.
- Trial name
- NCT00599118
- Where
- United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Arrhythmias, Cardiac
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
- Trial name
- NCT00921986
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Primary Hyperparathyroidism
NIRAF-camera Versus Conventional Surgery in Preoperative Imaging Negative Primary Hyperparathyroidism
Primary hyperparathyroidism (PHPT) is a prevalent endocrine disorder, with an estimated prevalence of 0.86% in the United States. The only definitive treatment for PHPT is parathyroidectomy.
- Trial name
- NCT07812649
- Testing
- NIRAF-camera
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Adrenalectomy
Robotic Adrenalectomy With Versus Without Indocyanine Green Fluorescence Imaging
This is a prospective randomized study comparing robotic adrenalectomy with versus without intraoperative indocyanine green imaging.
- Trial name
- NCT07813247
- Testing
- indocyanine green imaging
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- The Cleveland Clinic
Pulmonary Arterial Hypertension
Pulmonary Vascular Disease Phenomics Program PVDOMICS
It is recognized that patients with various forms of heart and lung disease exhibit varying degrees of pulmonary hypertension, pulmonary vascular remodeling, and right ventricular dysfunction.
- Trial name
- PVDOMICS (NCT02980887)
- Testing
- No Intervention
- Where
- 7 sites in United States
- Volunteers
- 1,195 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Hip Osteoarthritis
Bone Marrow Aspirate Concentrate Versus Triamcinolone Injection For Hip Osteoarthritis
This is a single site, randomized single blinded, two arm study researching the effects of bone marrow aspirate concentrate (BMAC) versus Triamcinolone in patients with hip osteoarthritis.
- Trial name
- NCT04990128
- Testing
- Aspire Needle + Emcyte PureBMC, Triamcinolone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cleveland Clinic