Clinical trials: sponsored by The Netherlands Cancer Institute
Cervical Cancer
Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical Cancer to Preserve Fertility
If no metastases are observed, patients will start a short protocol of four courses of weekly neo-adjuvant chemotherapy (12 weeks).
- Trial name
- NEOCON-F (NCT03852979)
- Testing
- Paclitaxel, Carboplatin, conisation
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- The Netherlands Cancer Institute
Carcinoma, Squamous Cell of Head and Neck
Bioimmunoradiotherapy (Cetuximab/RT/Avelumab)
This is an open-label phase IB trial with Bioimmunoradiotherapy, i.e. concurrent radiotherapy with intravenous administration of cetuximab and avelumab followed by avelumab maintenance therapy in patients with locally advanced…
- Trial name
- NCT02938273
- Testing
- avelumab, radiotherapy, cetuximab
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Preoperative Breast Irradiation
The PROBI is a phase I/II trial assessing the feasibility of preoperative whole breast irradiation in female patients with low to intermediate risk breast cancer, who undergo breast conserving therapy, including a boost dose of…
- Trial name
- PROBI (NCT02941835)
- Testing
- pre-operative irradiation
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- The Netherlands Cancer Institute
Climacteric Symptoms, Breast Cancer Survivors
Internet-based Cognitive Behavioral Therapy for Breast Cancer Patients With Climacteric Symptoms
The current study will evaluate systematically the efficacy and cost-effectiveness of two internet-based CBT/relaxation programs (one guided, the other self-managed) in reducing the severity of menopausal symptoms and improving…
- Trial name
- NCT02672189
- Testing
- EVA-Online
- Where
- Netherlands
- Volunteers
- 254 people
- Sponsor
- The Netherlands Cancer Institute
Sexual Dysfunction, Intimacy Problems
RCT of an Internet-based CBT Program for Sexuality and Intimacy Problems in Women Treated for Breast Cancer
The purpose of this study is to evaluate the efficacy and cost-effectiveness of an internet-based cognitive behavioural therapy program in alleviating problems with intimacy and sexuality in women treated for breast cancer.
- Conditions
- Sexual Dysfunction, Intimacy Problems, Breast Cancer Survivors
- Trial name
- KIS (NCT02091765)
- Testing
- Internet-based cognitive behavioral therapy.
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Cancer Metastatic
Galunisertib and Capecitabine in Advanced Resistant TGF-beta Activated Colorectal Cancer
Part I of this study is designed to identify the recommended phase 2 dose (RP2D) of the combination regimen of galunisertib/capecitabine as second line treatment in patients with 5-FU or capecitabine resistant CRC.
- Trial name
- EORTC1615 (NCT03470350)
- Testing
- Galunisertib
- Where
- Netherlands
- Sponsor
- The Netherlands Cancer Institute
Head and Neck Neoplasms
Comparing Two Palliative Schemes of Radiotherapy for Head and Neck Cancer
RCT to compare two radiation schemes for palliative HeadNeck cancer
- Trial name
- COOPERATION (NCT02421458)
- Testing
- 6 x 6 Gy, 16 x 3.125 Gy
- Where
- 11 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- The Netherlands Cancer Institute
Esophageal Cancer, Chemoradiation
Organ Motion and Early Tumor Response Measurement
To quantify motion based variation of the target volume of the primary tumor over the course of chemoradiotherapy in esophageal cancer patients, and to use this information to calculate appropriate PTV (planning target volume)…
- Trial name
- NCT02139488
- Testing
- Fiducial markers, Fiducial markers, Pet and MRI
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- The Netherlands Cancer Institute
Head and Neck Cancer
Mapping of Sentinel Lymph Node Drainage Using SPECT (SUSPECT) (SUSPECT)
This study aims to explore the feasibility, safety and outcome of a non-invasive sentinel node mapping (SNM) to individually tailor the elective nodal irradiation (ENI) to the ipsilateral neck only and to exclude the…
- Trial name
- SUSPECT (NCT02572661)
- Testing
- radiation in Squamous Head and Neck Cancer
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- The Netherlands Cancer Institute
Sarcoma, Soft Tissue Sarcomas
Clinical Study of Concurrent Pazopanib and Radiotherapy for Non-metastatic Sarcoma Patients
Radiotherapy (RT) alone is able to induce a clinically significant effect with a variable pathologic response (a pathological complete remission, pCR, defined as ≥ 95%, or ≤ 5% remaining visible tumour cells) in only about 10% of…
- Trial name
- PASART-2 (NCT02575066)
- Testing
- external beam radiotherapy, pazopanib
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 25 people
- Sponsor
- The Netherlands Cancer Institute
Lung Cancer, Metastatic Lung Cancer
Irradiation of Large Lung Tumors or Two or More Lung Metastases Simultaneously
Treatment of larger tumor volumes or ≥ 2 lung metastases simultaneously in lung cancer patient using Stereotactic Body Radiation Therapy (SBRT) in a mean-lung dose escalation study.
- Trial name
- VOLUMES (NCT01543672)
- Testing
- Stereotactic Body Radiotherapy (SBRT)
- Where
- 5 sites in United States, Canada and 2 more
- Volunteers
- 62 people
- Sponsor
- The Netherlands Cancer Institute
Inoperable Locally Advanced Non Small Cell Lung Cancer
Combined CFRT and SABR in Stage II and III NSCLC With Peripheral Tumors Smaller Than 5 cm.
A phase I trial is being conducted in patients with inoperable locally advanced NSCLC to treat with a combination of Conventional Fractionated Radiotherapy (CFRT) on the mediastinal lymph nodes and Stereotactic Ablative…
- Trial name
- N12HYB (NCT01933568)
- Testing
- SABR, Cisplatin
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- The Netherlands Cancer Institute
Head and Neck Cancer
Adaptive Dose-Escalated Multi-modality Image-guided RadiothErapy
Patients with primary head and neck squamous cell carcinoma (HNSCC) planned for treatment with radiotherapy with or without chemotherapy in curative setting will be treated with an adaptive radiotherapy scheme.
- Trial name
- ADMIRE (NCT03376386)
- Testing
- Adaptive dose-Escalated multi-modality image-guided radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Carcinoma, Non-small Cell Lung
Docetaxel Versus Intercalated Erlotinib-docetaxel in Patients With Relapsed EGFR Wild Type, ALK Negative Non Squamous Cell Carcinoma
The objective of this study is to investigate the effect of docetaxel monotherapy and the combination of docetaxel intercalated erlotinib in patients with relapsed EGFR wild type, ALK negative non squamous cell carcinoma.
- Trial name
- NCT02775006
- Testing
- Docetaxel, Erlotinib
- Where
- 19 sites in Netherlands
- Volunteers
- 45 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Ovarian Cancer
Phase I of Carboplatin-Olaparib Followed by Olaparib Monotherapy in Advanced Cancer
A phase I trial to determine the recommended phase two dose of the combination of carboplatin and olaparib.
- Conditions
- Breast Cancer, Ovarian Cancer, Advanced Cancer
- Trial name
- REVIVAL (NCT02418624)
- Testing
- carboplatin, olaparib
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- The Netherlands Cancer Institute
Cancer
Weekly Administration of (bi-)Daily Oral Docetaxel in Combination With Ritonavir
Oral administration has many advantages above intravenously administrated drugs for patients. Up to now, oral administration of docetaxel as single agent has not been feasible due to low and variable bioavailability.
- Trial name
- NCT01173913
- Testing
- ModraDoc001 10mg capsules, ModraDoc003 10mg tablets and ModraDoc004 10/50 mg, ModraDoc006 10 mg tablet
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- The Netherlands Cancer Institute
Stage IV Skin Melanoma, Eye; Melanoma
Study With T-cel Receptor Gene Therapy in Metastatic Melanoma
Patients with stage IV melanoma (also eye melanoma) will be treated with TCR transduced cells.
- Trial name
- TCR (NCT02654821)
- Testing
- TCR transduced T-cells, Biopsy, Blood taking
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Neoplasms, Gastrointestinal Neoplasms
Afatinib and Selumetinib in Advanced KRAS Mutant and PIK3CA Wildtype Non-small Cell Lung Cancer
This is a multi-center open-label proof-of-concept study consisting of two parts: PART A - a phase I dose-finding study (3 + 3 classical design) evaluating the RP2D of afatinib in combination with selumetinib in KRASm NSCLC; and…
- Conditions
- Colorectal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- M14AFS (NCT02450656)
- Testing
- Afatinib, Selumetinib, Docetaxel
- Where
- 2 sites in Netherlands
- Volunteers
- 320 people
- Sponsor
- The Netherlands Cancer Institute
Ovarian Cancer
Secondary Debulking Surgery +/- Hyperthermic Intraperitoneal Chemotherapy in Stage III Ovarian Cancer
This study evaluates the efficacy and safety of the addition of hyperthermic intraperitoneal chemotherapy to secondary debulking surgery in stage III ovarian cancer.
- Trial name
- NCT00426257
- Testing
- Secondary debulking, secondary debulking with intraperitoneal chemotherapy
- Where
- Netherlands
- Volunteers
- 242 people
- Sponsor
- The Netherlands Cancer Institute
Testicular Germ Cell Tumor
Sentinel Lymph Node Procedure in Testicular Germ Cell Tumour
Assessment of accuracy of sentinel node biopsy, defined as the false negative rate.
- Trial name
- SENATOR (NCT03448822)
- Testing
- sentinel node procedure
- Volunteers
- 76 people
- Sponsor
- The Netherlands Cancer Institute