Clinical trials: sponsored by The Netherlands Cancer Institute
Locally Advanced Malignant Neoplasm, Inflammatory Breast Carcinoma
Olaparib and Radiotherapy in Inoperable Breast Cancer
The majority of breast cancer patients receive radiotherapy as part of their treatment. Radiotherapy improves both locoregional control and overall survival.
- Conditions
- Locally Advanced Malignant Neoplasm, Inflammatory Breast Carcinoma, Triple-Negative Invasive Breast Carcinoma
- Trial name
- NCT02227082
- Testing
- radiotherapy, olaparib
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- The Netherlands Cancer Institute
Myxoid Liposarcoma of Soft Tissue
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas
To study the feasibility of reducing the dose of preoperative radiotherapy in MLS (Myxoid Liposarcomas) from 50 Gy to 36 Gy while maintaining comparable clinicopathological responses.
- Trial name
- DOREMY (NCT02106312)
- Testing
- dose reduction of preoperative radiotherapy in MLS
- Where
- 12 sites in United States, Denmark and 3 more
- Volunteers
- 80 people
- Sponsor
- The Netherlands Cancer Institute
Ovarian Neoplasms
Liquid Biopsies for Improving the Pre-operative Diagnosis of Ovarian Cancer
An accurate preoperative diagnosis of an ovarian tumor is important for the patients' surgical work-up, proper referral to oncological centers and for the patients' mental wellbeing since uncertainty about the nature (benign vs…
- Trial name
- OVI-DETECT (NCT04971421)
- Testing
- ctDNA - circulating tumor DNA, TEP - Tumor Educated Platelets
- Where
- 4 sites in Netherlands
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Neuroendocrine Carcinomas
Cisplatinum and Everolimus in Patients With Metastatic or Unresectable NEC of Extrapulmonary Origin
Phase II, open-label, multicentre national study. Patients with metastatic neuroendocrine carcinomas of extrapulmonary origin will be eligible.
- Trial name
- NCT02695459
- Testing
- cisplatinum and everolimus
- Where
- 3 sites in Netherlands
- Volunteers
- 39 people
- Sponsor
- The Netherlands Cancer Institute
Brain Tumor
Monitoring MRI Changes Before and During Radiotherapy Treatment of Brain Tumors
This study aims to evaluate anatomical and functional changes during RT for patients receiving fractionated RT for brain tumors.
- Trial name
- NCT03394716
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- The Netherlands Cancer Institute
Metastatic Gastric Cancer, Adenocarcinoma of the Gastro-oesophageal Junction
Docetaxel, Oxaliplatin, Capecitabine, Bevacizumab and Trastuzumab in Patients With Locally Advanced or Metastatic Gastric Cancer
Background: It is estimated that in the Netherlands each year approximately 900 patients with gastric cancer or adenocarcinoma of the gastro-oesophageal junction are candidates for chemotherapy.
- Trial name
- B-DOCT (NCT01359397)
- Testing
- Docetaxel, Oxaliplatin, Capecitabin, Bevacizumab, Docetaxel, Oxaliplatin, Capecitabin, Bevacizumab, Trastuzumab
- Where
- Netherlands
- Sponsor
- The Netherlands Cancer Institute
Meningeal Carcinomatosis
Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases
The purpose of this study is to determine whether the quantitative detection of circulating tumor cells (CTCs) in patients with Epcam expressing tumors can be used compared to standard qualitative method - cytology both in the…
- Trial name
- NCT01713699
- Testing
- lumbar puncture
- Where
- 2 sites in Netherlands
- Volunteers
- 146 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD
This phase II/III trial will investigate the ability of chemotherapy with 'Intensified Aklylating Agents (IAA) to achieve a high pathological complete response (pCR) rate when employed in the preoperative chemotherapy of breast…
- Trial name
- NCT00448266
- Testing
- Intensified Cyclophophamide, Carboplatin and Thiotepa, dose dense adriamycine and cyclophosphamide
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Pre-operative Hormonal Treatment for Hormone Receptor Positive Breast Cancer
To investigate prospectively whether short term endocrine treatment can induce molecular changes, predictive for therapy response.
- Trial name
- NCT00738777
- Testing
- Anastrozole, Anastrozole+Fulvestrant, Tamoxifen
- Where
- 4 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- The Netherlands Cancer Institute
Malignant Pleural Mesothelioma
Ipilimumab and Nivolumab in the Treatment of Malignant Pleural Mesothelioma
This is a prospective, monocenter, single arm, phase II trial in 33 patients with unresectable MPM, who experience disease progression or recurrence after at least one previous line of platinum-based systemic treatment.
- Trial name
- INITIATE (NCT03048474)
- Testing
- nivolumab and ipilimumab
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Neoplasms
Hepatic Arterial Infusion Pump Chemotherapy Combined With Systemic Chemotherapy (PUMP-IT)
The PUMP-IT study is designed to prove the feasibility of HAIP chemotherapy with concomitant standard systemic chemotherapy (FOLFOX and FOLFIRI) in the Netherlands.
- Trial name
- PUMP-IT (NCT04552093)
- Testing
- Floxuridine, Tricumed IP2000V infusion pump
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Surgical Menopause, BRCA1 Mutation
Health After eaRly Menopause Due to Oophorectomy
Risk-Reducing Salpingo-Oophorectomy (RRSO) at the age of 35 to 45 years is recommended for women with a high genetic risk for ovarian cancer.
- Conditions
- Surgical Menopause, BRCA1 Mutation, BRCA2 Mutation, Cardiovascular Diseases
- Trial name
- HARMOny (NCT03835793)
- Testing
- CAC-score
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- The Netherlands Cancer Institute
Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma
To Decrease Fatigue With Light Therapy
Cancer related fatigue (CRF) is one of the most prevalent and distressing long-term complaints reported by (non-) Hodgkin survivors.
- Trial name
- SPARKLE (NCT03242902)
- Testing
- Light therapy intensity 1, Light therapy intensity 2
- Where
- 9 sites in Netherlands
- Volunteers
- 166 people
- Sponsor
- The Netherlands Cancer Institute
Non-Small Cell Lung Cancer
Pembrolizumab After SBRT Versus Pembrolizumab Alone in Advanced NSCLC
To evaluate the increase in Overall Response Rate (ORR) in the pembrolizumab alone arm compared to the pembrolizumab after SBRT arm at 12 weeks
- Trial name
- PEMBRO-RT (NCT02492568)
- Testing
- pembrolizumab, Stereotactic Body Radiation Therapy
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- The Netherlands Cancer Institute
Rectal Neoplasms
"Wait-and-see" Policy for Complete Responders After Chemoradiotherapy for Rectal Cancer
The aim of this prospective observational cohort study is to provide short and long term oncological and functional outcome data on organ preserving treatment in good responders after a standard indication for neoadjuvant…
- Trial name
- NCT03426397
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 220 people
- Sponsor
- The Netherlands Cancer Institute
Prostate Cancer
Technetium Based Radioguided Surgery for Prostate Cancer (TRACE) Study
PSMA-radioguided surgery
- Trial name
- TRACE (NCT03857113)
- Testing
- PSMA-radioguided surgery
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
NSCLC
Olaparib Dose Escalating Trial + Concurrent RT With or Without Cisplatin in Locally Advanced NSCLC
Phase I dose escalating trial. Primary objective of this study is to define the maximal tolerated dose (MTD)of Olaparib in combination with high dose radiotherapy with or without daily dose Cisplatin in locally advanced NSCLC.
- Trial name
- olaparib (NCT01562210)
- Testing
- Olaparib, Cisplatin, Radiation
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- The Netherlands Cancer Institute
Neoplasms
Improving the Safety of Fluoropyrimidine-based Chemotherapy
In this study it will be determined whether the rate of severe toxicity associated with fluoropyrimidine treatment (capecitabine or 5-fluorouracil) can be significantly diminished by individualized dosing of fluoropyrimidines…
- Trial name
- Alpe2U (NCT04194957)
- Testing
- Fluoropyrimidine (capecitabine or 5-fluorouracil)
- Where
- Netherlands
- Volunteers
- 1,440 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Cancer, Peritoneal Carcinomatosis
Dedicated MR Imaging vs Surgical Staging of Peritoneal Carcinomatosis in Colorectal Cancer
MRI is a potentially powerful tool to reliably determine the intra-abdominal tumor load and relations with intra-abdominal organs.
- Conditions
- Colorectal Cancer, Peritoneal Carcinomatosis, MRI
- Trial name
- DISCO (NCT04231175)
- Testing
- DWI MRI of the pelvis, abdomen and thorax
- Where
- Netherlands
- Volunteers
- 272 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Triple Negative Breast Cancer
Avoiding Sentinel Lymph Node Biopsy in Breast Cancer Patients After Neoadjuvant Chemotherapy
This study evaluates whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve a radiological complete response on MRI after neoadjuvant systemic therapy
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, HER2-positive Breast Cancer, Sentinel Lymph Node
- Trial name
- ASICS (NCT04225858)
- Testing
- Omission of sentinel lymph node biopsy
- Volunteers
- 340 people
- Sponsor
- The Netherlands Cancer Institute