Clinical trials: sponsored by Thomas Jefferson University
Peripheral Artery Disease, Hypertension
Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
This is a 26-week, prospective double-blind, randomized pilot trial of nebivolol versus an active control, metoprolol succinate, in patients with established lower-extremity peripheral artery disease, hypertension, and at least…
- Trial name
- ENCOMPASS (NCT01499134)
- Testing
- nebivolol, Metoprolol succinate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Thomas Jefferson University
Cancer of the Head and Neck, Cancer of the Lung
Incidence and Patterns of Nausea/Vomiting With Combined Chemotherapy and Radiation
Questionnaire study to observe the incidence and pattern or nausea and vomiting in patients receiving combined chemotherapy and radiation.
- Conditions
- Cancer of the Head and Neck, Cancer of the Lung, Cancer of the Esophagus, Gastro-esophageal Junction Cancer
- Trial name
- NCT00716157
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Thomas Jefferson University
Age-related Macular Degeneration, Depression
Low Vision Depression Prevention Trial for Age Related Macular Degeneration
This randomized, controlled clinical trial, the Low Vision Depression Prevention TriAL (VITAL), will test the efficacy of collaborative low vision rehabilitation (LVR) to prevent depressive disorders in Age-Related Macular…
- Trial name
- VITAL (NCT00769015)
- Testing
- BA-LVR, ST-LVR
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Thomas Jefferson University
Increased Intracranial Pressure
Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure
The overall purpose of this study is to compare the effects of mannitol and hypertonic saline on patients with increased intracranial pressure.
- Trial name
- NCT00359697
- Testing
- Hypertonic Saline, Mannitol
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Chronic Migraine, Olfactory Acuity
Smell Sensitivity in Chronic Migraine: A Case-Control Study
Olfactory impairment is a common symptom of neurologic disorders and may be related to dopaminergic dysfunction. Studies show that patients with migraine show increased sensitivity to light and sound.
- Trial name
- NCT01687088
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Migraine
Prevalence of Phonophobia and Cutaneous Allodynia in Episodic Migraineurs
Cutaneous allodynia is an increased skin sensitivity experienced during a headache. It has been noted in several studies that in patients with migraine, seventy nine percent of the patients experienced allodynia on the facial…
- Trial name
- NCT00386880
- Testing
- Sounds
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Thomas Jefferson University
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Cesarean Section
A Study Comparing Two Different Techniques for Closing the Skin After a Cesarean Delivery
We hypothesize that the use of absorbable staples to close cesarean skin incisions will cause less pain, have better long-term cosmetic results, and result in improved patient satisfaction over standard metal staples.
- Trial name
- NCT00293683
- Testing
- Insorb absorbable skin staple
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Thomas Jefferson University
Migraine
A Study Examining the Use of a Migraine Medicine in the Treatment of Two Migraine Attacks in Patients Who Have Increased Skin Sensitivity
This is a research study examining a migraine medicine dihydroergotamine mesylate (DHE-45).It will be used to treat two migraine attacks in subjects who have a history of skin sensitivity associated with their headaches.This skin…
- Trial name
- NCT00203268
- Testing
- dihydroergotamine mesylate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Thomas Jefferson University
Myocardiopathies, Ischemia, Myocardial
Extracellular Matrix Marker of Arrhythmia Risk (EMMA)
Assess whether serum levels of MMP 2 and or MMP 9 correlate with episodes of ventricular tachycardia or fibrillation in patients who have implantable cardioverter defibrillator devices.
- Conditions
- Myocardiopathies, Ischemia, Myocardial, Arrythmia, Death, Sudden, Cardiac
- Trial name
- EMMA (NCT00376532)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Thomas Jefferson University
Trigeminal Neuralgia
Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia
This research study will look at the safety (e.g., the occurrence of side effects) and efficacy (how well the drug works in reducing trigeminal neuralgia attacks) of a drug called lamotrigine in adults with trigeminal neuralgia.
- Trial name
- NCT00203229
- Testing
- lamotrigine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Migraine
A Research Study Examining The Use Of Duloxetine In The Prevention Of Migraine Headache
This is a single-center, open-label, pilot trial to collect and evaluate data on the safety and efficacy of duloxetine in the preventive treatment of subjects experiencing episodic migraine headaches.
- Trial name
- NCT00443352
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Thomas Jefferson University
Coronary Artery Disease, Chronic Kidney Disease
Effect of Vitamin D Supplement on Inflammation Markers in High-Risk Cardiovascular Patients With Chronic Kidney Disease
The purpose of this study is to determine if vitamin D supplementation changes the results of certain tests associated with inflammation in the body using an oral, synthetic form of vitamin D called paricalcitol.
- Conditions
- Coronary Artery Disease, Chronic Kidney Disease, Hypovitaminosis D, Secondary Hyperparathyroidism
- Trial name
- VINCA-CKD (NCT01012414)
- Testing
- paricalcitol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University
Migraine
A Research Study to Examine the Difference Between Local Anesthetics Alone and Local Anesthetics Plus Steroids in the Treatment of Chronic Headache
Subjects are scheduled to undergo a Greater Occipital Nerve Block (GONB) as treatment for your chronic daily headache (CDH). GONB has been used for many years in the treatment of headaches.
- Trial name
- NCT00203294
- Testing
- lidocaine, bupivicaine and saline, lidocaine plus bupivicaine plus triamcinolone (steroid)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Thomas Jefferson University
no Primary Disease; ICU Patient Who Require Enteral Nutrition
A Research Study to Test (2) Two Different Types of Feeding Tubes Used in the Intensive Care Unit
The purpose of this study is to compare the success rates of two types of feeding tubes, specifically the standard gastric feeding tube to a small bowel feeding tube.
- Trial name
- NCT00245687
- Testing
- Tiger Tube
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Thomas Jefferson University
Antidepressant Induced Excessive Sweating
Pilot Study of Terazosin in Treatment of Antidepressant Induced Excessive Sweating
This study is based on the hypothesis that terazosin, a blocker of alpha-1 receptors, will be effective in reducing excessive sweating caused by antidepressant treatment, and will have minimal adverse effects.
- Trial name
- NCT00237510
- Testing
- terazosin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Thomas Jefferson University
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Metastatic Melanoma
RATIONALE: Vaccines may make the body build an immune response to kill melanoma cells. PURPOSE: Phase I/II trial to study the effectiveness of vaccine therapy in treating patients with metastatic melanoma.
- Trial name
- NCT00002817
- Testing
- sargramostim, vaccinia-GM-CSF vaccine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Prostate Cancer
Dutasteride Followed By Ultrasound-Guided Biopsy in Finding Prostate Cancer
RATIONALE: Diagnostic procedures, such as ultrasound-guided biopsy, may help find prostate cancer. Dutasteride may improve the ability of ultrasound-guided biopsy to find prostate cancer.
- Trial name
- NCT00398281
- Testing
- dutasteride
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Depression, Macular Degeneration
Preventing Depression in Patients With Macular Degeneration
This study will evaluate the effectiveness of a Problem Solving Treatment in preventing depression in elderly patients with age-related macular degeneration (AMD).
- Trial name
- NCT00042211
- Testing
- Problem Solving Treatment, Control
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Thomas Jefferson University
Spinal Cord Injury
The Effects of Two Functional Electrical Stimulation Cycling Paradigms
Background: People with spinal cord injury (SCI) are at risk for many health conditions, some of which can be decreased with exercise. Cycling with Functional Electrical Stimulation (FES) is one way to obtain exercise after SCI.
- Trial name
- NCT01244594
- Testing
- Cycling with functional electrical stimulation
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Thomas Jefferson University