Clinical trials: sponsored by Tongji Hospital
Cervical Intraepithelial Neoplasia Grade 3
Exploratory Study of the Efficacy of HAL-PDT in CIN 3
This is a prospective, multicenter, biomarker-guided Phase II study evaluating the efficacy and safety of hexaminolevulinate-mediated cervical photodynamic therapy (HAL-PDT) in women with cervical intraepithelial neoplasia grade…
- Trial name
- Lumiteg-I (NCT07891338)
- Testing
- Hexaminolevulinate (HAL)
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Tongji Hospital
Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
RWS of PDT for CIN 2
This is a prospective, observational, multicenter real-world study designed to evaluate the effectiveness and safety of photodynamic therapy (PDT) in women with cervical intraepithelial neoplasia grade 2 (CIN2).
- Trial name
- Lumiteg-R (NCT07885566)
- Testing
- Hexaminolevulinate (HAL)
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Solid Tumors
Lenvatinib Plus PD-1 Inhibitor for Advanced Solid Tumors With 11q13 Amplification
The goal of this clinical trial is to learn if the combination of lenvatinib and a PD-1 inhibitor (a type of immunotherapy) works to treat advanced solid tumors that have a specific genetic change called "11q13 amplification".
- Trial name
- NCT07417501
- Testing
- Lenvatinib plus PD-1 Inhibitor
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Frequent Episodic Tension-Type Headache
Treatment of Tension-type Headache by Zhixuan Analgesic Tablets
The goal of this clinical trial is to learn if Zhixuan Analgesic Tablet works to treat frequent episodic tension-type headache in adults aged 18-60 years. It will also learn about the safety of Zhixuan Analgesic Tablet.
- Trial name
- NCT07872943
- Testing
- Zhixuan Analgesic Tablet
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Tongji Hospital
Uterine Fibroid, Uterine Sarcoma
A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma
In our previous study, based on the multi-center clinical big data collected from January 2012 to January 2025, we have completed the construction of a multimodal early warning model for the malignant transformation of uterine…
- Conditions
- Uterine Fibroid, Uterine Sarcoma, AI (Artificial Intelligence), Radiomic
- Trial name
- NCT07269535
- Testing
- No intervention (observational study)
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Muscle-Invasive Bladder Cancer (MIBC)
Response-Guided Bladder Preservation With Trastuzumab Rezetecan, Adebrelimab, and Concurrent Bladder Radiotherapy in HER2-Expressing Muscle-Invasive Bladder Cancer
This prospective, multicenter, open-label phase II study will evaluate a response-guided bladder-preservation strategy in patients with HER2-expressing muscle-invasive bladder cancer.
- Trial name
- RG-BP-MIBC (NCT07865611)
- Testing
- Trastuzumab Rezetecan, Adebrelimab, Concurrent Bladder Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Tongji Hospital
Uterine Fibroid, Uterine Sarcoma
Radiomics-Based Non-Invasive MRI Differentiation of Uterine Sarcomas and Fibroids
This retrospective case-control study aims to develop and validate a diagnostic model based on multimodal big data and artificial intelligence to differentiate uterine leiomyoma from uterine sarcoma.
- Conditions
- Uterine Fibroid, Uterine Sarcoma, Diagnose Disease, AI (Artificial Intelligence)
- Trial name
- NCT07129005
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Tongji Hospital
Anxiety, Pain
Mindfulness Intervention on Minimally Invasive Vascular Surgery
The goal of this clinical trial is to learn whether a virtual reality (VR)-based mindfulness intervention can reduce anxiety and pain in adults undergoing minimally invasive surgery for lower-extremity varicose veins under local…
- Conditions
- Anxiety, Pain, Varicose Veins of Lower Limb
- Trial name
- NCT07463638
- Testing
- VR-Based Mindfulness Intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tongji Hospital
Chronic Hepatitis b
Combination of ETV, TQ-A3334 and TQ-B2450 for CHB (Neptune Study)
This study is a single-center, randomized, prospective, open-label Phase 2 Clinical trial to evaluate efficacy and safety of ETV and TQ-A3334 combinated with/without inhibitor of TQ-B2450 versus ETV alone in chronic hepatitis B…
- Trial name
- Neptune (NCT04202653)
- Testing
- ETV, TQ-A3334, TQ-B2450
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Tongji Hospital
Diabetes Mellitus, Type 2, Impaired Glucose Tolerance
Efficacy and Safety of Sanggua Tablets in the Treatment of Patients With Impaired Glucose Tolerance and Mild Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) and impaired glucose tolerance (IGT) are growing public health challenges. Early intervention in mild T2DM and IGT is essential to prevent disease progression and severe complications.
- Trial name
- NCT06964620
- Testing
- Sanggua tablets
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Tongji Hospital
Parkinson s Disease
Temporal Interference Stimulation for Motor and Non-motor Symptoms in Parkinson's Disease
This study aims to evaluate the efficacy of tTIS treatment in improving motor function in patients with Parkinson's disease (PD), as well as its effects on mood, activities of daily living, sleep, cognition, and other functional…
- Trial name
- NCT07857824
- Testing
- transcranial temporal interference stimulation (tTIS)
- Volunteers
- 50 people
- Sponsor
- Tongji Hospital
Epidural Anesthesia, Percutaneous Nephrolithotomy (PCNL)
Predictors of Epidural Depth in Percutaneous Nephrolithotomy and Model Development
Accurate estimation of epidural depth is critical for safe epidural anesthesia during percutaneous nephrolithotomy (PCNL). Although various imaging modalities can predict epidural depth, they increase healthcare burden and are…
- Trial name
- NCT07697053
- Where
- China
- Volunteers
- 3,278 people
- Sponsor
- Tongji Hospital
Lung Cancer (NSCLC)
Cardiorespiratory Fitness After Lobectomy Versus Sublobar Resection
This observational study will compare changes in cardiorespiratory fitness after lobectomy and sublobar resection. Sublobar resection includes segmentectomy and wedge resection.
- Trial name
- NCT07841249
- Testing
- Lobectomy, Sublobar Resection
- Where
- China
- Volunteers
- 604 people
- Sponsor
- Tongji Hospital
Hepatocellular Carcinoma (HCC), Treatment Response
Multimodalomics-based Construction of Spatiotemporal Characteristics of Dynamic Liver Cancer Microenvironment to Characterize the Clinical Application of Immune Mechanisms in Liver Cancer
This study aims to explore whether adding an additional MRI sequence to routine liver scans can better characterize the immune microenvironment of liver cancer.
- Trial name
- NCT07838415
- Testing
- time-dependent diffusion MRI and Cest sequence
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tongji Hospital
Non-Small Cell Lung Cancer
Adjuvant EGFR-TKI Therapy After Surgery for EGFR-Mutant High-Risk Stage IA2-IIB NSCLC
This prospective, multicenter patient registry is designed to evaluate the effectiveness and safety of postoperative EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients with completely resected EGFR-mutant high-risk…
- Trial name
- NCT07837739
- Testing
- Adjuvant EGFR-TKI Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Fatty Pancreas, Overweight
Efficacy of Mazdutide on Fatty Pancreas
This is a randomized, double-blind, placebo-controlled, parallel-group, single-center clinical trial designed to evaluate the efficacy and safety of mazdutide in improving fatty pancreas in patients with overweight or obesity.
- Conditions
- Fatty Pancreas, Overweight, Obesity
- Trial name
- NCT07803705
- Testing
- mazdutide
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Tongji Hospital
Parkinson Disease (PD)
MRI-Guided Temporal Interference Stimulation for Parkinson's Disease
This study aims to evaluate the efficacy and safety of tTIS treatment in patients with Parkinson's disease (PD). The study will enroll eligible PD patients and randomly assign them to two groups: Group A will first receive…
- Trial name
- NCT07827456
- Testing
- Temporal Interference Stimulation (130 Hz)
- Volunteers
- 26 people
- Sponsor
- Tongji Hospital
Neuromyelitis Optica Spectrum Disorders
The Safety and Efficacy of NouvSoma001 in Neuromyelitis Optica Spectrum Disorders
This is a single-center, randomized, open-label, placebo-controlled, dose-escalation trial. The objective of this research is to evaluate the safety, tolerability, and efficacy of intrathecal administration of human-induced…
- Trial name
- NCT06620809
- Testing
- Extracellular vesicles derived from human-induced neural stem cells for intrathecal injection
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Tongji Hospital
Resectable Hepatocellular Carcinoma With High Risk of Recurrence
Iparomlimab and Tuvonralimab as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With High Risk of Recurrence
The purpose of this study is to evaluate the impact of iparomlimab and tuvonralimab as preoperative neoadjuvant therapy on recurrence-free survival (RFS), along with its potential improvement in overall survival (OS), in patients…
- Trial name
- CCGLC-017 (NCT06954116)
- Testing
- Iparomlimab and Tuvonralimab (QL1706), Partial hepatectomy
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Tongji Hospital
Fospropofol Disodium
Effects of Fospropofol Disodium TIVA and IVIH on Surgical Field Quality in Adult ESS
Endoscopic sinus surgery (ESS) is a primary surgical approach for treating chronic rhinosinusitis, nasal polyps, and other conditions that are unresponsive to conservative therapy.
- Trial name
- NCT07788157
- Testing
- Fospropofol disodium, Propofol
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Tongji Hospital